81
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects

, , , , &
Pages 519-530 | Received 16 Jan 2023, Accepted 04 Jun 2023, Published online: 13 Jul 2023

References

  • Almeida, N.A., et al., 2009. Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor. Endocrinology, 150 (1), 546–554. [InsertedFromOnline]
  • Bannu, K., 2020. A study on association of single nucleotide polymorphisms in Uygur atrial fibrillation in Xinjiang region. China health care & nutrition, 30, 26–27.
  • Benes, J., Jr., et al., 2014. The role of connexin40 in developing atrial conduction. FEBS letters, 588 (8), 1465–1469. [InsertedFromOnline]
  • Benjamin, E.J., et al., 1994. Independent risk factors for atrial fibrillation in a population-based cohort. JAMA, 271 (11), 840–844. Framingham Heart Study. JAMA,
  • Carballo, S., et al., 2018. Differential association of Cx37 and Cx40 genetic variants in atrial fibrillation with and without underlying structural heart disease. International journal of molecular sciences, 19 (1), 295.
  • Chaldoupi, S.M., et al., 2012. Reduced connexin40 protein expression in the right atrial appendage of patients bearing the minor connexin40 allele (-44 G –> A). Europace, 14 (8), 1199–1205. [InsertedFromOnline]
  • Chaldoupi, S.M., et al., 2009. Absence of connexin 40 gene polymorphism, as a marker of undetected atrial fibrillation in patients with unexplained cerebral ischemic events. European journal of cardiovascular prevention and rehabilitation, 16 (5), 616–620. [InsertedFromOnline]
  • Christophersen, I.E., et al., 2013. Rare variants in GJA5 are associated with early-onset lone atrial fibrillation. The Canadian journal of cardiology, 29 (1), 111–116.
  • Dupays, L., et al., 2003. Genomic organization and alternative transcripts of the human Connexin40 gene. Gene, 305 (1), 79–90.
  • Fakuade, F.E., Tomsits, P., and Voigt, N., 2021. Connexin hemichannels in atrial fibrillation: orphaned and irrelevant? Cardiovascular research, 117 (1), 4–6. [InsertedFromOnline]
  • Feng, Y., et al., 2015. A study of the association between the connexin 40 rs35594137 polymorphism and atrial fibrillation in Xinjiang Chinese Han and Uygur populations. Genetics and molecular research, 14 (4), 15705–15712. [InsertedFromOnline]
  • Firouzi, M., et al., 2006. The human Cx40 promoter polymorphism -44G–>A differentially affects transcriptional regulation by Sp1 and GATA4. Biochimica et biophysica acta, 1759 (10), 491–496. [InsertedFromOnline]
  • Firouzi, M., et al., 2004. Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation. Circulation research, 95 (4), e29–e33.
  • Gemel, J., et al., 2014. Connexin40 abnormalities and atrial fibrillation in the human heart. Journal of molecular and cellular cardiology, 76, 159–168. [InsertedFromOnline]
  • Gemel, J., et al., 2017. Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC cell biology, 18 (Suppl 1), 7. [InsertedFromOnline]
  • Go, A.S., et al., 2001. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA, 285 (18), 2370–2375. [InsertedFromOnline]
  • Groenewegen, W.A., et al., 2003. A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circulation research, 92 (1), 14–22. [InsertedFromOnline]
  • Gros, D., et al., 1994. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Circulation research, 74 (5), 839–851. [InsertedFromOnline]
  • Hailati, J., et al., 2016. Association between -44G/A and +71A/G polymorphisms in the connexin 40 gene and atrial fibrillation in Uyghur and Han populations in Xinjiang, China. Genetics and molecular research, 15 (4), 1–11.
  • Higgins, J.P., 2008. Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. International journal of epidemiology, 37 (5), 1158–1160. [InsertedFromOnline]
  • Higgins, J.P., Thompson, S.G., and Spiegelhalter, D.J., 2009. A re-evaluation of random-effects meta-analysis. Journal of the royal statistical society. Series A, (statistics in society), 172 (1), 137–159. [InsertedFromOnline]
  • Hou, S., et al., 2015. Association of atrial fibrillation with gene polymorphisms of connexin 40 and angiotensin II receptor type 1 in Chongming adults of Shanghai. International journal of clinical and experimental medicine, 8, 11803–11810.
  • Juang, J.M., et al., 2007. The association of human connexin 40 genetic polymorphisms with atrial fibrillation. International journal of cardiology, 116 (1), 107–112. [InsertedFromOnline]
  • Kirchhof, P., et al., 2016. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European heart journal, 37 (38), 2893–2962.
  • Li, S., et al., 2017. MicroRNA-208a-3p contributes to connexin40 remolding in human chronic atrial fibrillation. Experimental and therapeutic medicine, 14 (6), 5355–5362. [InsertedFromOnline]
  • Lippi, G., Sanchis-Gomar, F., and Cervellin, G., 2021. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. International journal of stroke, 16 (2), 217–221. [InsertedFromOnline]
  • Mantel, N., and Haenszel, W., 1959. Statistical aspects of the analysis of data from retrospective studies of disease. Journal of nationall cancer institute, 22, 719–748.
  • Miyasaka, Y., et al., 2006. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation, 114 (2), 119–125. [InsertedFromOnline]
  • Niu, Y.M., et al., 2015. Increased risks between Interleukin-10 gene polymorphisms and haplotype and head and neck cancer: a meta-analysis. Scientific reports, 5, 17149. [InsertedFromOnline]
  • Peters, J.L., et al., 2006. Comparison of two methods to detect publication bias in meta-analysis. JAMA, 295 (6), 676–680. [InsertedFromOnline]
  • Pfenniger, A., Chanson, M., and Kwak, B.R., 2013. Connexins in atherosclerosis. Biochimica et biophysica acta, 1828 (1), 157–166. [InsertedFromOnline]
  • Pfenniger, A., Wohlwend, A., and Kwak, B.R., 2011. Mutations in connexin genes and disease. European journal of clinical investigation, 41 (1), 103–116. [InsertedFromOnline]
  • Polontchouk, L., et al., 2001. Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. Journal of the American college of cardiology, 38 (3), 883–891. [InsertedFromOnline]
  • Rosenberg, M.A., et al., 2012. A novel transgenic mouse model of cardiac hypertrophy and atrial fibrillation. Journal of atrial fibrillation, 4 (5), 415. [InsertedFromOnline]
  • Sawaya, S.E., et al., 2007. Downregulation of connexin40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor. American journal of physiology heart and circulatory physiology, 292 (3), H1561–H1567. [InsertedFromOnline]
  • Sun, Y.L., et al., 2018. Valsartan reduced the vulnerability to atrial fibrillation by preventing action potential prolongation and conduction slowing in castrated male mice. Journal of cardiovascular electrophysiology, 29 (10), 1436–1443. [InsertedFromOnline]
  • Wang, K., Zhao, J., and Guo, Z., 2022. Interaction of KCNA5, CX43, and CX40 proteins in the atrial muscle of patients with atrial fibrillation. Cell biology international, 46 (11), 1834–1840. [InsertedFromOnline]
  • Wirka, R.C., et al., 2011. A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Circulation arrhythmia and electrophysiology, 4 (1), 87–93. [InsertedFromOnline]
  • Zhihong, L., 2017. Study on Cx40 gene single nucleotide polymorphism in patients with atrial fibrillation. China journal of modern medicine, 27, 28–33.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.