104
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Protective effect of grape seed extract and exercise training on tissues toxicities in doxorubicin-treated healthy rat

, , , , & ORCID Icon
Pages 544-554 | Received 13 Jun 2023, Accepted 06 Aug 2023, Published online: 23 Aug 2023

References

  • Abdel-Wahab, M.H., et al., 2003. Influence of P-coumaric acid on doxorubicin-induced oxidative stress in rat’s heart. Pharmacological research, 48 (5), 461–465.
  • Abe, J., et al., 2018. Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium. Journal of controlled release: official journal of the controlled release society, 269, 177–188.
  • Aebi, H., 1984. Catalase in vitro. Methods in enzymology, 105, 121–126.
  • Ahmadian, M., Dabidi Roshan, V., and Leicht, A.S., 2018. Age-related effect of aerobic exercise 1training on antioxidant and oxidative markers in the liver challenged by doxorubicin in rats. Free radical research, 52 (7), 775–782.
  • Al-Majed, A.A., et al., 2002. Alphalipoic acid ameliorates myocardial toxicity induced by doxorubicin. Pharmacological research, 46 (6), 499–503.
  • Alves, C.R., et al., 2015. Aerobic exercise training as therapy for cardiac and cancer cachexia. Life sciences, 125, 9–14.
  • Ascensão, A., et al., 2011. Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats. Clinical science (London, England: 1979), 120 (1), 37–49.
  • Ascensão, A., et al., 2006. Endurance exercise training attenuates morphological signs of cardiac muscle damage induced by doxorubicin in male mice. Basic and applied myology, 16 (1), 27–35.
  • Ascensão, A., et al., 2005. Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice. International journal of cardiology, 100 (3), 451–460.
  • Ascensão, A., Oliveira, P.J., and Magalhães, J., 2012. Exercise as a beneficial adjunct therapy during doxorubicin treatment – role of mitochondria in cardioprotection. International journal of cardiology, 156 (1), 4–10.
  • Bagchi, D., et al., 2000. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology, 148 (2–3), 187–197.
  • Baiomy, A.A., 2016. Protective role of grape seeds extract against cadmium toxicity in the lung of male wistar rats. Journal of cytology and histology, S5, 004.
  • Boghdady, N.A., 2013. Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell biochemistry and function, 31 (4), 344–351.
  • Bredahl, E.C., et al., 2016. Effects of exercise on doxorubicin-induced skeletal muscle dysfunction. Medicine and science in sports and exercise, 48 (8), 1468–1473.
  • Brown, D.A., et al., 2003. Exercise training preserves coronary flow and reduces infarct size following ischemia-reperfusion in rat heart. Journal of applied physiology (Bethesda, Md.: 1985), 95 (6), 2510–2518.
  • Cappetta, D., et al., 2016. SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy. International journal of cardiology, 205, 99–110.
  • Carter, S.K., 1975. Adriamycin-a review. Journal of the national cancer institute, 55 (6), 1265–1274.
  • Cetin, A., et al., 2008. Role of grape seed extract on methotrexate induced oxidative stress in rat liver. American journal of Chinese medicine, 36 (5), 861–872.
  • Cusack, B.J., et al., 2006. Prevention of chronic anthracycline cardiotoxicity in the adult Fischer 344 rat by dexrazoxane and effects on iron metabolism. Cancer chemotherapy and pharmacology, 58 (4), 517–526.
  • Davies, K.J., and Doroshow, J.H., 1986. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. Journal of biological chemistry, 261 (7), 3060–3067.
  • De Beer, E.L., et al., 1992. Doxorubicin interacts directly with skinned single skeletal muscle fibres. European journal of pharmacology, 214 (1), 97–100.
  • Draper, H.H., and Hadley, M., 1990. Malondialdehyde determination as index of lipid peroxidation. Methods in enzymology, 186, 421–431.
  • Dziegiel, P., et al., 2003. Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxication. Journal of pineal research, 35 (3), 183–187.
  • Ellman, G.L., 1959. Tissue sulfhydryl groups. Archives of biochemistry and biophysics, 82 (1), 70–77.
  • Filip, G.A., et al., 2013. Inhibition of uvb-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, erk/nf-kb signaling pathway and apoptosis, in skh-1 mice. Food and chemical toxicology: an international journal published for the British industrial biological research association, 57, 296–306.
  • Flohé, L., and Günzler, W.A., 1984. Assays of glutathione peroxidase. Methods in enzymology, 105, 114–120.
  • Gilliam, L.A., et al., 2011. Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy. Muscle & nerve, 43 (1), 94–102.
  • Guigni, B.A., et al., 2018. Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress. American journal of physiology. Cell physiology, 315 (5), C744–C756.
  • Hatefi, Y., 1978. Preparation and properties of NADH: ubiquinone oxidoreductase (complex I), EC 1.6.5.3. Methods in enzymology., 53, 11–14.
  • Hiensch, A.E., et al., 2020. Doxorubicin-induced skeletal muscle atrophy: elucidating the underlying molecular pathways. Acta physiologica (Oxford, England), 229 (2), e13400.
  • Hoene, M., and Weigert, C., 2010. The stress response of the liver to physical exercise. Exercise immunology review, 16, 163–183.
  • Howell, B.F., McCune, S., and Schaffer, R., 1979. Lactate-to-pyruvate or pyruvate-to-lactate assay for lactate dehydrogenase: a re-examination. Clinical chemistry, 25 (2), 269–272.
  • Jabłońska-Trypuć, A., Krętowski, R., and Kalinowska, M., 2018. Possible mechanisms of the prevention of doxorubicin toxicity by cichoric acid antioxidant nutrient. Nutrients, 10 (1), 44.
  • Kadri, S., et al., 2020. Preventive and curative effects of grape seed powder on stroke using in vitro and in vivo models of cerebral ischemia/reperfusion. Biomedicine & pharmacotherapy = biomedecine & pharmacotherapie, 125, 109990.
  • Kalantari, A., et al., 2017. Impact of four week swimming exercise with alpha-tocopherol supplementation on fertility potential in healthy rats. Journal of urology, 14, 5023–5026.
  • Katsuhisa, S., et al., 2006. Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats. Asian Pacific journal of cancer prevention, 7, 599–603.
  • Kim, A.Y., et al., 2017. Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion. Neuroscience, 340, 487–500.
  • King, T.E., 1967. Preparation of succinate dehydrogenase and reconstitution of succinate oxidase. Methods in enzymology, 10, 322–331.
  • Krisman, C.R., 1962. A method for the colorimetric estimation of glycogen with iodine. Analytical biochemistry, 4, 17–23.
  • Kwon, I., 2020. Protective effects of endurance exercise on skeletal muscle remodeling against doxorubicin-induced myotoxicity in mice. Physical activity and nutrition, 24 (2), 11–21.
  • Leardi, A., et al., 1998. Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells. British journal of haematology, 102 (3), 746–752.
  • Liang, L.P., and Patel, M., 2004. Iron-sulfur enzyme mediated mitochondrial superoxide toxicity in experimental Parkinson’s disease. Journal of neurochemistry, 90 (5), 1076–1084.
  • Lima, F.D., et al., 2013. Swimming training induces liver mitochondrial adaptations to oxidative stress in rats submitted to repeated exhaustive swimming bouts. PLoS one, 8 (2), e55668.
  • Liu, Y., et al., 1997. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. Journal of neurochemistry, 69 (2), 581–593.
  • Lódi, M., et al., 2019. Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy. Journal of translational medicine, 17 (1), 229.
  • Mannervik, B., 2001. Measurement of glutathione reductase activity, Curr Protoc Toxicol. Chapter 7: Unit 7.2.
  • Marinetti, G.V., 1962. Chromatographic separation, identification, and analysis of phosphatides. Journal of lipid research, 3, 1–20.
  • Massey, V., 1960. The composition of the ketoglutarate dehydrogenase complex. Biochimica et biophysica acta, 38, 447–460.
  • Mete, R., et al., 2016. Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats. Toxicology and industrial health, 32 (3), 551–557.
  • Min, K., et al., 2015. Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy. Journal of physiology, 593 (8), 2017–2036.
  • Misra, H.P., and Fridovich, I., 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of biological chemistry., 247 (10), 3170–3175.
  • Mokni, M., et al., 2015. Efficacy of grape seed and skin extract against doxorubicin-induced oxidative stress in rat liver. Pak J pharm sci, 28 (6), 1971–1978.
  • Mokni, M., et al., 2012. Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart. Cardiovascular toxicology, 12 (2), 158–165.
  • Montalvo, R.N., et al., 2020. Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle. American journal of physiology. Regulatory, integrative and comparative physiology, 318 (2), R227–R233.
  • Mrozek, E., et al., 2005. Phase I trial of liposomal encapsulated doxorubicin (Myocet; D-99) and weekly docetaxel in advanced breast cancer patients. Annals of oncology: official journal of the European society for medical oncology, 16 (7), 1087–1093.
  • Myburgh, K.H., Kruger, M.J., and Smith, C., 2012. Accelerated skeletal muscle recovery after in vivo polyphenol administration. Journal of nutritional biochemistry, 23 (9), 1072–1079.
  • NIH guidelines 1985. Guide for the care and the use of laboratory national research council.
  • Olson, H.M., et al., 1974. Electrolyte and morphologic alterations of myocardium in adriamycin-treated rabbits. American journal of pathology, 77 (3), 439–454.
  • Omobowale, T.O., et al., 2018. Ameliorative effect of gallic acid in doxorubicin-induced hepatotoxicity in Wistar rats through antioxidant defense system. Journal of dietary supplements, 15 (2), 183–196.
  • Ohnishi, S.T., and Barr, J.K., 1978. A simplified method of quantitating protein using the biuret and phenol reagents. Analytical biochemistry, 86 (1), 193–200.
  • Pajuelo, D., et al., 2011. Acute administration of grape seed proanthocyanidin extract modulates energetic metabolism in skeletal muscle and BAT mitochondria. Journal of agricultural and food chemistry, 59 (8), 4279–4287.
  • Polidori, M.C., et al., 2000. Physical activity and oxidative stress during aging. International journal of sports medicine, 21 (3), 154–157.
  • Racker, E., 1950. Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids. Biochimica et biophysica acta, 4 (1–3), 211–214.
  • Ray, S.D., et al., 2000. In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract. Research communications in molecular pathology and pharmacology, 107, 137–166.
  • Rice-Evans, C.A., Miller, N.J., and Paganga, G., 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free radical biology & medicine, 20 (7), 933–956.
  • Saeed, N.M., et al., 2015. Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: a mechanistic study. Biochemical pharmacology, 95 (3), 145–155.
  • Scott, J.M., et al., 2013. The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics. Oncologist, 18 (2), 221–231.
  • Sergazy, S., et al., 2020. Cardioprotective effect of grape polyphenol extract against doxorubicin induced cardiotoxicity. Scientific reports, 10 (1), 14720.
  • Sin, T.K., et al., 2016. Acute treatment of resveratrol alleviates doxorubicin-induced myotoxicity in aged skeletal muscle through SIRT1-dependent mechanisms. Journals of gerontology. Series A, biological sciences and medical sciences, 71 (6), 730–739.
  • Smuder, A.J., et al., 2011a. Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle. Journal of applied physiology, 111 (4), 1190–1198.
  • Smuder, A.J., et al., 2011b. Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle. Journal of applied physiology (Bethesda, Md.: 1985), 110 (4), 935–942.
  • Stathopoulos, G.P., et al., 1996. An increase of serum lipids after cumulative doses of doxorubicin and epirubicin in experimental animals. Anticancer research, 16, 3429–3433.
  • Stern, J., and Lewis, W.H., 1957. The colorimetric estimation of calcium in serum with ocresolphthalein complexone. Clinica chimica acta, 2 (6), 576–580.
  • Tangpong, J., et al., 2011. Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana. Neuroscience, 175, 292–299.
  • Taylor, R.P., Ciccolo, J.T., and Starnes, J.W., 2003. Effect of exercise training on the ability of the rat heart to tolerate hydrogen peroxide. Cardiovascular research, 58 (3), 575–581.
  • Trinder, P., 1969. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. Journal of clinical pathology, 22 (2), 158–161.
  • Vasili, A., et al., 2016. The effect of aerobic exercise on hepatotoxicity induced by intratracheal instillation of iron oxide nanoparticles in Wistar rats. General physiology and biophysics, 35 (1), 35–43.
  • Wehr, N.B., and Levine, R.L., 2013. Quantification of protein carbonylation. Methods in molecular biology (Clifton, N.J.), 965, 265–281.
  • Yesair, D.W., et al., 1972. Comparative pharmacokinetics of daunomycin and adriamycin in several animal species. Cancer research, 32 (6), 1177–1183.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.