213
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Exploring the potential of humanin as a biomarker for early breast cancer detection: a study of serum levels and diagnostic performance

ORCID Icon, , , &
Pages 555-561 | Received 13 May 2023, Accepted 06 Aug 2023, Published online: 13 Aug 2023

References

  • Bray, F., et al., 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68, 394–424.
  • Bulut, F., et al., 2023. Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis. Behavioural brain research, 452, 114584.
  • Cohen, P., 2014. New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. JNCI: Journal of the national cancer ınstitute, 106, dju006.
  • Eriksson, E., et al., 2014. Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment. Journal of the national cancer ınstitute, 106 (3), djt459.
  • Euhus, D., Di Carlo, P.A., and Khouri, N.F., 2015. Breast cancer screening. The surgical clinics of North america, 95 (5), 991–1011.
  • Galizia, D., et al., 2018. Self‐evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study. Cancer medicine, 7 (9), 4339–4344.
  • Gottardo, M.F., et al., 2014. Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis. PloS one, 9 (10), e111548.
  • Gottardo, M.F., et al., 2017. Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation. Journal of cell communication and signaling, 11 (4), 329–340.
  • Hanahan, D., and Weinberg, R.A., 2011. Hallmarks of cancer: the next generation. Cell, 144 (5), 646–674.
  • Harbeck, N., et al., 2019. Breast cancer. Nature reviews. Disease primers, 5 (1), 66.
  • Hashimoto, Y., et al., 2001. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Aβ. Proceedings of the national academy of sciences of the united states of america, 98 (11), 6336–6341.
  • Hsu, C.C., Tseng, L.M., and Lee, H.C., 2016. Role of mitochondrial dysfunction in cancer progression. Experimental biology and medicine (maywood, N.J.), 241 (12), 1281–1295.
  • Jia, Y., et al., 2015. The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis : an international journal on programmed cell death, 20 (4), 551–561.
  • LeBleu, V.S., et al., 2014. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nature cell biology, 16 (10), 992–1003.
  • Lee, H.-C., Chang, C.-M., and Chi, C.-W., 2010. Somatic mutations of mitochondrial DNA in aging and cancer progression. Ageing research reviews, 9(Suppl 1), S47–S58.
  • Lu, X., et al., 2010. Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. The journal of biological chemistry, 285 (13), 9317–9321.
  • Luciano, F., et al., 2005. Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. The journal of biological chemistry, 280 (16), 15825–15835.
  • Lunetti, P., et al., 2019. Metabolic reprogramming in breast cancer results in distinct mitochondrial bioenergetics between luminal and basal subtypes. The FEBS journal, 286 (4), 688–709.
  • Matsunaga, D., et al., 2016. Humanin protects RPE cells from endoplasmic reticulum stress-induced apoptosis by upregulation of mitochondrial glutathione. PloS one, 11 (10), e0165150.
  • McCormack, V.A., and dos Santos Silva, I., 2006. Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer epidemiology, biomarkers & prevention : a publication of the American association for cancer research, cosponsored by the American society of preventive oncology, 15 (6), 1159–1169.
  • Moreno Ayala, M.A., et al., 2020. Humanin promotes tumor progression in experimental triple negative breast cancer. Scientific reports, 10 (1), 8542.
  • Mottaghi-Dastjerdi, N., et al., 2014. Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance. Daru : journal of faculty of pharmacy, Tehran university of medical sciences, 22 (1), 14.
  • Munsell, M.F., et al., 2014. Body mass index and breast cancer risk according to postmenopausal estrogen-progestin use and hormone receptor status. Epidemiologic reviews, 36 (1), 114–136.
  • Omar, N.N., et al., 2017. Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness. Journal of the egyptian national cancer ınstitute, 29 (2), 69–76.
  • Ortega, M.A., et al., 2022. Patients with Invasive lobular carcinoma show a significant ıncrease in IRS-4 expression compared to ınfiltrative ductal carcinoma—a histopathological study. Medicina, 58 (6), 722.
  • Paharkova, V., et al., 2015. Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. Molecular and cellular endocrinology, 413, 96–100.
  • Pekarek, L., et al., 2023. Clinical and Translational Applications of Serological and Histopathological Biomarkers in Metastatic Breast Cancer: A Comprehensive Review. International journal of molecular sciences, 24, 8396.
  • Qin, Q., et al., 2018. Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells. Biochemical and biophysical research communications, 497 (1), 292–297.
  • Sandhu, D., et al., 2010. Profile of breast cancer patients at a tertiary care hospital in north India. Indian journal of cancer, 47 (1), 16–22.
  • Smith, R.A., et al., 2003. American Cancer Society guidelines for breast cancer screening: update 2003. CA: a cancer journal for clinicians, 53 (3), 141–169.
  • Song, B.-I., Kim, H.W., and Won, K.S., 2017. Predictive value of 18 F-FDG PET/CT for axillary lymph node metastasis in invasive ductal breast cancer. Annals of surgical oncology, 24 (8), 2174–2181.
  • Surampudi, P., et al., 2015. Humanin protects against chemotherapy‐induced stage‐specific male germ cell apoptosis in rats. Andrology, 3 (3), 582–589.
  • Vyas, S., Zaganjor, E., and Haigis, M.C., 2016. Mitochondria and cancer. Cell, 166 (3), 555–566.
  • Wallace, D.C., 2013. A mitochondrial bioenergetic etiology of disease. The journal of clinical investigation, 123 (4), 1405–1412.
  • Widmer, R.J., et al., 2013. Circulating humanin levels are associated with preserved coronary endothelial function. American journal of physiology. Heart and circulatory physiology, 304 (3), H393–H397.
  • Zapała, B., et al., 2010. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. Pharmacological reports : PR, 62 (5), 767–777.
  • Zuccato, C.F., et al., 2019. Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases. Expert opinion on therapeutic targets, 23 (2), 117–126.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.