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Research Articles

Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite

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Pages 652-662 | Received 21 Jun 2023, Accepted 22 Oct 2023, Published online: 06 Nov 2023

References

  • Abdullahi A, Yusuf N, Debella A, Eyeberu A, Deressa A, Bekele H, Ketema I, Abdulahi IM, Weldegebreal F. 2022. Seasonal variation, treatment outcome, and its associated factors among the snakebite patients in Somali region, Ethiopia. Front Public Health. 10(10):901414. doi: 10.3389/fpubh.2022.901414
  • Abu Baker MA, Al-Saraireh M, Amr Z, Amr SS, Warrell DA. 2022. Snakebites in Jordan: A clinical and epidemiological study. Toxicon. 208:18–30. doi: 10.1016/j.toxicon.2022.01.005
  • Aktar F, Tekin R. 2017. Mean platelet volume, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in determining the diagnosis or outcome in children with snakebite. Arch Argent Pediatr. 115(6):576–580. doi: 10.5546/aap.2017.eng.576
  • Aktas G. 2021. Hematological predictors of novel Coronavirus infection. Rev Assoc Med Bras (1992)). 67(Suppl 1):1–2. doi: 10.1590/1806-9282.67.Suppl1.20200678
  • Aktas G, Cakirogulo B, Sit M, et al. 2013. Mean platelet volume: a simple indicator of chronic prostatitis. Acta Med Mediterr. 29:551–554.
  • Aktas G, Duman T, Atak B, Kurtkulagi O, Bilgin S, Basaran E, Demirkol M, Kosekli M. 2020. Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters. Fam Med Primary Care Rev. 22(2):107–110. doi: 10.5114/fmpcr.2020.95311
  • Aktas G, Kocak MZ, Taslamacioglu Duman T, Erkus E, Atak BM, Sit M, Savli H. 2018. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Med J. 7(3):650–653. doi: 10.15562/bmj.v7i3.806
  • Aktas G, Sit M, Dikbas O, Erkol H, Altinordu R, Erkus E, Savli H. 2017. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis. Rev Assoc Med Bras (1992)). 63(12):1065–1068. doi: 10.1590/1806-9282.63.12.1065
  • Allichandi R, Kurahatti M. 2020. Determination of prognosis of snake bite cases by neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Global Journal for Research Analysis. 9(11):1–5. doi: 10.36106/gjra/7309361
  • Aslan N, Yildizdaş D, Özgür Horoz Ö, Ekinci F, Arslan D, Bilen S, Yilmaz HL. 2019. The relationship between neutrophil lymphocyte ratio and clinical outcomes after snakebite in pediatric patients. Cukurova Med J. 44(3):1040–1045. doi: 10.1620/tjem.2022.J037
  • Atak B, Aktas G, Duman TT, Erkus E, Kocak MZ, Savli H. 2019. Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Rev Assoc Med Bras. 65(1):38–42. PMID: 30758418. doi: 10.1590/1806-9282.65.1.38
  • Balci S, Aktas G. 2022. A comprehensive review of the role of hemogram derived inflammatory markers in gastrointestinal conditions. Iran J Colorectal Res. 10(3):75–86. doi: 10.30476/ACRR.2022.97244.1160
  • Benjamin J, Abo B, Brandehoff N. 2020. Snake envenomation in Africa. Curr Trop Med Rep. 7(1):1–10. doi: 10.1007/s40475-020-00198-y
  • Bickler P. 2020. Amplification of snake venom toxicity by endogenous signaling pathways. Toxins (Basel). 12(2):68. doi: 10.3390/toxins12020068
  • Bilgin S, Tel BMA, Kahveci G, Duman TT, Kurtkulagi O, Yurum S, Erturk A, Balci B, Aktas G. 2021. Hypothyroidism is strongly correlated with mean platelet volume and red cell distribution width. Natl J Health Sci. 6(1):7–10. doi: 10.21089/njhs.61.0007
  • Cakir L, Aktas G, Enginyurt O. 2014. Mean platelet volume increases in type 2 diabetes mellitus independent of HbA1c level. Acta Med Mediterr. 30:425–428.
  • Cakir L, Aktas G, Mercimek B. 2016. Are red cell distribution width and mean platelet volume associated with rheumatoid arthritis? Biomed Res. 27 (2):292–294.
  • Carrasco C, Carrasco D, Godoy K, del Sol M, Sandoval C. 2020. Comparative study on erythrogram parameters of Cell-Dyn Ruby and Humacount 5L. Int J Morphol. 38(6):1618–1622. doi: 10.4067/S0717-95022020000601618
  • Cheng X, Zhang X. 2018. The analysis of the treatment of rhabdomyolysis by snake bites. Yangtze Med . 02(02):89–94. doi: 10.4236/ym.2018.22010
  • da Silva Souza A, de Almeida Gonçalves Sachett J, Alcântara JA, Freire M, Alecrim M. d G C, Lacerda M, de Lima Ferreira LC, Fan HW, de Souza Sampaio V, Monteiro WM, et al. 2018. Snakebites as cause of deaths in the Western Brazilian Amazon: why and who dies? Deaths from snakebites in the Amazon. Toxicon. 145:15–24. doi: 10.1016/j.toxicon.2018.02.041
  • Dave M, Jain S, Nath H. 2020. Demographic profile and prognostic value of neutrophilic lymphocytic ratio in snake bite patients. Int J Curr Res. 12(05):11585–11588. doi: 10.24941/ijcr.38683.05.2020
  • Elawady E, Tawfik H. 2019. Evaluation of the early prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in snakebite poisoned patients. Egypt J Forensic Sci Appl Toxicol. 16:1–16. doi: 10.21608/ejfsat.2016.41636
  • Elbey B, Baykal B, Yazgan ÜC, Zengin Y. 2017. The prognostic value of the neutrophil/lymphocyte ratio in patients with snake bites for clinical outcomes and complications. Saudi J Biol Sci. 24(2):362–366. doi: 10.1016/j.sjbs.2015.10.002
  • Erge E, Kiziltunc C, Balci SB, Atak Tel BM, Bilgin S, Duman TT, Aktas G. 2023. A novel inflammatory marker for the diagnosis of Hashimoto’s thyroiditis: platelet-count-to-lymphocyte-count ratio. Diseases. 11(1):15. doi: 10.3390/diseases11010015
  • Essafti M, Fajri M, Rahmani C, Abdelaziz S, Mouaffak Y, Younous S. 2022. Snakebite envenomation in children: an ongoing burden in Morocco. Ann Med Surg (Lond)). 77:103574. doi: 10.1016/j.amsu.2022.103574
  • Forget P, Khalifa C, Defour J-P, Latinne D, Van Pel M-C, De Kock M. 2017. What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Res Notes. 10(1):12. doi: 10.1186/s13104-016-2335-5
  • Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. 2019. The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med. 39(4):345–357. doi: 10.3343/alm.2019.39.4.345
  • Gerardo CJ, Vissoci JRN, Evans CS, Simel DL, Lavonas EJ. 2019. Does this patient have a severe snake envenomation?: The rational clinical examination systematic review. JAMA Surg. 154(4):346–354. doi: 10.1001/jamasurg.2018.5069
  • Gutiérrez JM, Rucavado A, Escalante T, Herrera C, Fernández J, Lomonte B, Fox JW. 2018. Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms. Toxicon. 148:123–131. doi: 10.1016/j.toxicon.2018.04.016
  • Herath HMNJ, Wazil AWM, Abeysekara DTDJ, Jeewani NDC, Weerakoon KGAD, Ratnatunga NVI, Bandara EHCK, Kularatne SAM. 2012. Chronic kidney disease in snake envenomed patients with acute kidney injury in Sri Lanka: a descriptive study. Postgrad Med J. 88(1037):138–142. doi: 10.1136/postgradmedj-2011-130225
  • Hernandez MC, Traynor M, Bruce JL, Bekker W, Laing GL, Aho JM, Kong VY, Klinkner DB, Zielinski MD, Clarke DL, et al. 2019. Surgical considerations for pediatric snake bites in low- and middle-income countries. World J Surg. 43(7):1636–1643. doi: 10.1007/s00268-019-04953-9
  • Hunter CJ, Piechazek K-H, Nyarang’o PM, Rennie T. 2019. Snakebite envenoming. Lancet. 393(10167):129–131. doi: 10.1016/S0140-6736(18)32762
  • Ibrahim N, El-Kady E. 2016. Antigenic cross-reactivity and species-specific identification of Pseudocerastes persicus fieldi snake venom. Toxicon. 119:194–202. doi: 10.1016/j.toxicon.2016.06.011
  • Karabacak M, Turkdogan KA, Coskun A, Akpinar O, Duman A, Kapci M, Eren SH, Karabacak P. 2015. Detection of neutrophil-lymphocyte ratio as a serum marker associated with inflammations by acute carbon monoxide poisoning. J Acute Dis. 4(4):305–308. doi: 10.1016/j.joad.2015.06.009
  • Karagoz I, Aktas G, Yoldas H, Yildiz I, Ogun MN, Bilgi M, Demirhan A. 2019. Association between hemogram parameters and survival of critically ill patients. J Intensive Care Med. 34(6):511–513. doi: 10.1177/0885066617703348
  • Khalid A, Ali Jaffar M, Khan T, Abbas Lail R, Ali S, Aktas G, Waris A, Javaid A, Ijaz N, Muhammad N, et al. 2021. Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis. Hematology. 26(1):529–542. doi: 10.1080/16078454.2021.1950898
  • Kim JS, Yang JW, Kim MS, Han ST, Kim BR, Shin MS, Lee JI, Han BG, Choi SO. 2008. Coagulopathy in patients who experience snakebite. Korean J Intern Med. 23(2):94–99. doi: 10.3904/kjim.2008.23.2.94
  • Knudsen C, Jürgensen JA, Føns S, Haack AM, Friis RUW, Dam SH, Bush SP, White J, Laustsen AH. 2021. Snakebite envenoming diagnosis and diagnostics. Front Immunol. 12:661457. doi: 10.3389/fimmu.2021.661457
  • Kocak MZ, Aktas G, Erkus E, Duman TT, Atak BM, Savli H. 2018. Mean platelet volume to lymphocyte ratio as a novel marker for diabetic nephropathy. J Coll Physicians Surg Pak. 28 (11):844–847. doi: 10.29271/jcpsp.2018.11.844
  • Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. 2019. Mean platelet volume (MPV): new perspectives for an old marker in the course and prognosis of inflammatory conditions. Mediators Inflamm. 2019:9213074. doi: 10.1155/2019/9213074
  • Kumar M, Arcot Thanjan M, Gopalakrishnan N, Jeyachandran D, Thanigachalam D, Ramanathan S. 2022. Snake envenomation-induced acute kidney injury: prognosis and long-term renal outcomes. Postgrad Med J. 98(1158):264–268. doi: 10.1136/postgradmedj-2020-139021
  • Kumar KS, Narayanan S, Udayabhaskaran V, Thulaseedharan NK. 2018. Clinical and epidemiologic profile and predictors of outcome of poisonous snake bites – an analysis of 1,500 cases from a tertiary care center in Malabar, North Kerala, India. Int J Gen Med. 11:209–216. doi: 10.2147/IJGM.S136153
  • Kurt N, Orak M, Ustundag M. 2018. Neutrophil–lymphocyte/platelet–lymphocyte ratio in snakebites. Eurasian J Med Invest. 2(2):65–69. doi: 10.14744/ejmi.2018;40085
  • Lee JS, Kim NY, Na SH, Youn YH, Shin CS. 2018. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine. 97(26):e11138. doi: 10.1097/MD.0000000000011138
  • Lin J, Xue B, Li J, Xu H, Huang X, Yao Z, Li X, Xia J. 2017. Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD. Neurol Sci. 38(10):1859–1863. doi: 10.1007/s10072-017-3068-5
  • Mahmood MA, Halliday D, Cumming R, Thwin KT, Myitzu M, White J, Alfred S, Warrell DA, Bacon D, Naing W, et al. 2019. Inadequate knowledge about snakebite envenoming symptoms and application of harmful first aid methods in the community in high snakebite incidence areas of Myanmar. PLoS Negl Trop Dis. 13(2):e0007171. doi: 10.1371/journal.pntd.0007171
  • Masroori S, Balushi F, Abri S. 2022. Evaluation of risk factors of snake envenomation and associated complications presenting to two emergency departments in Oman. Oman Med J. 37(2):e349. doi: 10.5001/omj.2022.46
  • Medeiros JM, Oliveira IS, Ferreira IG, Alexandre-Silva GM, Cerni FA, Zottich U, B. Pucca M. 2020. Fatal rattlesnake envenomation in Northernmost Brazilian Amazon: a case report and Literature Overview. Reports. 3(2):9. doi: 10.3390/reports3020009
  • Moon JM, Chun BJ, Cho YS, Lee SM. 2019. Diagnostic value of parameters related to white blood cell counts for troponin I elevation in CO poisoning. Cardiovasc Toxicol. 19(4):334–343. doi: 10.1007/s12012-018-09501-w
  • Mubarak R, Mohapatra B. 2021. Study of coagulation disorder following haemotoxic snake envenomation in a tertiary care centre. Int J Res Med Sci. 9(6):1641–1647. doi: 10.18203/2320-6012.ijrms20212230
  • Narvencar K, Favas T, Dias A. 2022. Predictors of complications in venomous snakebites. Int J Mol Sci. 74(2):86–92. doi: 10.25259/IJMS_328_2021
  • Oliveira SS, Alves EC, Santos AS, Pereira JPT, Sarraff LKS, Nascimento EF, de-Brito-Sousa JD, Sampaio VS, Lacerda MVG, Sachett JAG, et al. 2019. Factors associated with systemic bleeding in bothrops envenomation in a tertiary hospital in the Brazilian Amazon. Toxins (Basel). 11(1):22. doi: 10.3390/toxins11010022
  • Otero-Patiño R. 2009. Epidemiological, clinical and therapeutic aspects of Bothrops asper bites. Toxicon. 54(7):998–1011. doi: 10.1016/j.toxicon.2009.07.001
  • Padhiyar R, Chavan S, Dhampalwar S, Trivedi T, Moulick N. 2018. Snake bite envenomation in a tertiary care centre. J Assoc Physicians India. 66(3):55–59. PMID: 30341870.
  • Paniagua D, Vergara I, Román R, Romero C, Benard-Valle M, Calderón A, Jiménez L, Bernas MJ, Witte MH, Boyer LV, et al. 2019. Antivenom effect on lymphatic absorption and pharmacokinetics of coral snake venom using a large animal model. Clin Toxicol (Phila)). 57(8):727–734. doi: 10.1080/15563650.2018.1550199
  • Rajkumar B, Vishwanath Vinod K, Kar R, Ramasubramani P. 2022. Venom induced consumption coagulopathy and performance of 20-min whole blood clotting test for its detection in viperid envenomation. J R Coll Physicians Edinb. 52(3):232–239. doi: 10.1177/14782715221126770
  • Ratnayake I, Mohamed F, Buckley NA, Gawarammana IB, Dissanayake DM, Chathuranga U, Munasinghe M, Maduwage K, Jayamanne S, Endre ZH, et al. 2019. Early identification of acute kidney injury in Russell’s viper (Daboia russelii) envenoming using renal biomarkers. PLoS Negl Trop Dis. 13(7):e0007486. doi: 10.1371/journal.pntd.0007486
  • Razok A, Shams A, Yousaf Z. 2020. Cerastes cerastes snakebite complicated by coagulopathy and cardiotoxicity with electrocardiographic changes. Toxicon. 188:1–4. doi: 10.1016/j.toxicon.2020.10.003
  • Sahin S, Sarikaya S, Alcelik, A, Erdem, A, Taşlıyurt, T, Akyol, L, Altunkaş, F, Aktaş G. 2013. Neutrophil to lymphocyte ratio is a useful predictor of atrial fibrillation in patients with diabetes mellitus. Acta Med Mediterr. 29:847–851.
  • Salah Eldin H, Hafez R. 2017. Clinical and laboratory parameters associated with acute kidney injury in viper envenomed cases. Ain Shams J Forensic Med Clin Toxicol. 29(2):80–88. doi: 10.21608/ajfm.2017.18212
  • Samuel SP, Chinnaraju S, Williams HF, Pichamuthu E, Subharao M, Vaiyapuri M, Arumugam S, Vaiyapuri R, Baksh MF, Patel K, et al. 2020. Venomous snakebites: rapid action saves lives a multifaceted community education programme increases awareness about snakes and snakebites among the rural population of Tamil Nadu, India. PLoS Negl Trop Dis. 14(12):e0008911. doi: 10.1371/journal.pntd.0008911
  • Santhosh MS, Thushara RM, Hemshekhar M, Sunitha K, Devaraja S, Kemparaju K, Girish KS. 2013. Alleviation of viper venom induced platelet apoptosis by crocin (Crocus sativus): Implications for thrombocytopenia in viper bites. J Thromb Thrombolysis. 36(4):424–432. doi: 10.1007/s11239-013-0888-x
  • Sit M, Aktas G, Ozer B, Kocak MZ, Erkus E, Erkol H, Yaman S, Savli H. 2019. Mean platelet volume: an overlooked herald of malignant thyroid nodules. Acta Clin Croat. 58(3):417–420. doi: 10.20471/acc.2019.58.03.03
  • Teixeira C, Fernandes CM, Leiguez E, Chudzinski-Tavassi AM. 2019. Inflammation induced by platelet-activating viperid snake venoms: perspectives on thromboinflammation. Front Immunol. 10:2082. doi: 10.3389/fimmu.2019.02082
  • Tirosh-Levy S, Solomovich R, Comte J, Sutton GA, Steinman A. 2017. Daboia (Vipera) palaestinae envenomation in horses: Clinical and hematological signs, risk factors for mortality and construction of a novel severity scoring system. Toxicon. 137:58–64. doi: 10.1016/j.toxicon.2017.07.007
  • Torrez PPQ, Said R, Quiroga MMM, Duarte MR, França FOS. 2014. Forest pit viper (Bothriopsis bilineata bilineata) bite in the Brazilian Amazon with acute kidney injury and persistent thrombocytopenia. Toxicon. 85:27–30. doi: 10.1016/j.toxicon.2014.04.001
  • Wahby A, Abdel-Aty A, El-Kady E. 2012. Purification of hemorrhagic SVMPs from venoms of three vipers of Egypt. Toxicon. 59(2):329–337. doi: 10.1016/j.toxicon.2011.11.014
  • Williams HF, Layfield HJ, Vallance T, Patel K, Bicknell AB, Trim SA, Vaiyapuri S. 2019. The urgent need to develop novel strategies for the diagnosis and treatment of snakebites. Toxins (Basel). 11(6):363. doi: 10.3390/toxins11060363
  • Zuliani J, Soares A, Gutiérrez J. 2020. Polymorphonuclear neutrophil leukocytes in snakebite envenoming. Toxicon. 187:188–197. doi: 10.1016/j.toxicon.2020.09.006

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