Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer

References

• Bogani G, Chiappa V, Lopez S, Salvatore C, Interlenghi M, D’Oria O, Giannini A, Leone Roberti Maggiore U, Chiarello G, Palladino S, et al. 2022. Radiomics and molecular classification in endometrial cancer (The ROME Study): a step forward to a simplified precision medicine. Healthcare . 10(12):2464. doi: 10.3390/healthcare10122464
   Web of Science ®Google Scholar
• Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N. 2022. Endometrial cancer. Lancet. 399(10333):1412–1428. doi: 10.1016/S0140-6736(22)00323-3
   PubMed Web of Science ®Google Scholar
• Di Donato V, Giannini A, Bogani G. 2023. Recent advances in endometrial cancer management. J Clin Med. 12(6):2241. doi: 10.3390/jcm12062241
   PubMed Web of Science ®Google Scholar
• Do HT, Zhang N, Pati D, Gilbertson SR. 2016. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 26(18):4446–4450. doi: 10.1016/j.bmcl.2016.07.080
   PubMed Web of Science ®Google Scholar
• Kandoth C, Schultz N, Cherniack AD, et al. 2013. Integrated genomic characterization of endometrial carcinoma. Nature. 497(7447):67–73.
   PubMed Web of Science ®Google Scholar
• Kumar R. 2017. Separase: function beyond cohesion cleavage and an emerging oncogene. J Cell Biochem. 118(6):1283–1299. doi: 10.1002/jcb.25835
   PubMed Web of Science ®Google Scholar
• Liu JHui, Wan Y, Li S, Qiu HDe, Jiang Y, Ma X, Zhou SLin, Cheng WJun. 2020. Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis. Cancer Med. 9(10):3522–3536. doi: 10.1002/cam4.2956
   PubMed Web of Science ®Google Scholar
• Liu L, Lin J, He H. 2019. Identification of potential crucial genes associated with the pathogenesis and prognosis of endometrial cancer. Front Genet. 10:373. doi: 10.3389/fgene.2019.00373
   PubMed Web of Science ®Google Scholar
• Liu X, Zeng W, Zheng D, Tang M, Zhou W. 2022. Let-7c-5p restrains cell growth and induces apoptosis of lung adenocarcinoma cells via targeting ESPL1. Mol Biotechnol. 64(12):1367–1375. doi: 10.1007/s12033-022-00511-2
   PubMed Web of Science ®Google Scholar
• Luo S, Tong L. 2021. Structure and function of the separase-securin complex. Subcell Biochem. 96:217–232. doi: 10.1007/978-3-030-58971-4_4
   PubMedGoogle Scholar
• Makker V, MacKay H, Ray-Coquard I, Levine DA, Westin SN, Aoki D, Oaknin A. 2021. Endometrial cancer. Nat Rev Dis Primers. 7(1):88. doi: 10.1038/s41572-021-00324-8
   PubMed Web of Science ®Google Scholar
• McAleenan A, Clemente-Blanco A, Cordon-Preciado V, Sen N, Esteras M, Jarmuz A, Aragón L. 2013. Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin. Nature. 493(7431):250–254. doi: 10.1038/nature11630
   PubMed Web of Science ®Google Scholar
• Mukherjee M, Byrd T, Brawley VS, Bielamowicz K, Li X-N, Merchant F, Maitra S, Sumazin P, Fuller G, Kew Y, et al. 2014. Overexpression and constitutive nuclear localization of cohesin protease separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. J Neurooncol. 119(1):27–35. doi: 10.1007/s11060-014-1458-6
   PubMed Web of Science ®Google Scholar
• Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. 2014. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary ­adenocarcinomas. Oncogene. 33(48):5511–5522. doi: 10.1038/onc.2013.493
   PubMed Web of Science ®Google Scholar
• Nakamura A, Arai H, Fujita N. 2009. Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement. J Cell Biol. 187(5):607–614. doi: 10.1083/jcb.200906019
   PubMed Web of Science ®Google Scholar
• Nie Z, Pu T, Han Z, Wang C, Pan C, Li P, Ma X, Yao Y, Zhao Y, Wang C, et al. 2022. Extra spindle pole bodies-like 1 serves as a prognostic biomarker and promotes lung adenocarcinoma metastasis. Front Oncol. 12:930647. doi: 10.3389/fonc.2022.930647
   PubMed Web of Science ®Google Scholar
• Pan HW, Su HH, Hsu CW, Huang GJ, Wu TT. 2017. Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancer. Onco Targets Ther. 10:3531–3543. doi: 10.2147/OTT.S136491
   PubMed Web of Science ®Google Scholar
• Richie CT, Bembenek JN, Chestnut B, Furuta T, Schumacher JM, Wallenfang M, Golden A. 2011. Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans. J Cell Sci. 124(Pt 17):2903–2913. doi: 10.1242/jcs.073379
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. 2018. Cancer statistics, 2018. CA Cancer J Clin. 68(1):7–30. doi: 10.3322/caac.21442
   PubMed Web of Science ®Google Scholar
• Song R, Huang J, Yang C, Li Y, Zhan G, Xiang B. 2022. ESPL1 is elevated in hepatocellular carcinoma and predicts prognosis. Int J Gen Med. 15:8381–8398. doi: 10.2147/IJGM.S381188
   PubMedGoogle Scholar
• Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. 2005. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 102(43):15545–15550. doi: 10.1073/pnas.0506580102
   PubMed Web of Science ®Google Scholar
• Sun Y, Yu H, Zou H. 2006. Nuclear exclusion of separase prevents cohesin cleavage in interphase cells. Cell Cycle. 5(21):2537–2542. doi: 10.4161/cc.5.21.3407
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 2021. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71(3):209–249. doi: 10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Yang Q, Yu B, Sun J. 2020. TTK, CDC25A, and ESPL1 as prognostic biomarkers for endometrial cancer. Biomed Res Int. 2020:4625123–13. doi: 10.1155/2020/4625123
   PubMed Web of Science ®Google Scholar
• Ye J, Chen J, Wang J, Xia Z, Jia Y. 2022. Association of the timeless gene with prognosis and clinical characteristics of human lung cancer. Diagnostics 12(11):2681. doi: 10.3390/diagnostics12112681
   Web of Science ®Google Scholar
• Zhang J, Yang C, Wang C, Liu D, Lao G, Liang Y, Sun K, Luo H, Tan Q, Ren M, et al. 2016. AGE-induced keratinocyte MMP-9 expression is linked to TET2-mediated CpG demethylation. Wound Repair Regen. 24(3):489–500. doi: 10.1111/wrr.12426
   PubMed Web of Science ®Google Scholar
• Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao Y-J, Li X-N, Cai W-W, El-Naggar AK, et al. 2008. Overexpression of separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 105(35):13033–13038. doi: 10.1073/pnas.0801610105
   PubMed Web of Science ®Google Scholar
• Zhang N, Pati D. 2017. Biology and insights into the role of cohesin protease separase in human malignancies. Biol Rev Camb Philos Soc. 92(4):2070–2083. doi: 10.1111/brv.12321
   PubMed Web of Science ®Google Scholar
• Zhang N, Sarkar AK, Li F, Demerzhan SA, Gilbertson SR, Pati D. 2020. Stability and pharmacokinetics of separase inhibitor-sepin-1 in Sprague-Dawley rats. Biochem Pharmacol. 174:113808. doi: 10.1016/j.bcp.2020.113808
   PubMed Web of Science ®Google Scholar
• Zhang N, Sarkar AK, Pati D. 2020. Toxicity study of separase inhibitor-sepin-1 in Sprague-Dawley rats. Pathol Res Pract. 216(1):152730. doi: 10.1016/j.prp.2019.152730
   PubMed Web of Science ®Google Scholar
• Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC, Pati D, et al. 2014. Identification and characterization of separase inhibitors (Sepins) for cancer therapy. J Biomol Screen. 19(6):878–889. doi: 10.1177/1087057114520972
   PubMedGoogle Scholar
• Zhong Y, Zheng C, Zhang W, Wu H, Wang M, Zhang Q, Feng H, Wang G. 2023. Pan-Cancer analysis and experimental validation identify the oncogenic nature of ESPL1: potential therapeutic target in colorectal cancer. Front Immunol. 14:1138077. doi: 10.3389/fimmu.2023.1138077
   PubMed Web of Science ®Google Scholar