Association between the methylations of RUNX3 in peripheral blood and lung cancer: a case-control study

References

• Balogh P, Adelman ER, Pluvinage JV, Capaldo BJ, Freeman KC, Singh S, Elagib KE, Nakamura Y, Kurita R, Sashida G, et al. 2020. RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance. Haematologica. 105(4):905–913. doi:10.3324/haematol.2018.208918
   PubMed Web of Science ®Google Scholar
• Breitling LP, Yang R, Korn B, Burwinkel B, Brenner H. 2011. Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. Am J Hum Genet. 88(4):450–457. doi:10.1016/j.ajhg.2011.03.003
   PubMed Web of Science ®Google Scholar
• Castro M, Grau L, Puerta P, Gimenez L, Venditti J, Quadrelli S, Sánchez-Carbayo M. 2010. Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer. J Transl Med. 8(1):86. doi:10.1186/1479-5876-8-86
   PubMedGoogle Scholar
• Chenarani N, Emamjomeh A, Allahverdi A, Mirmostafa S, Afsharinia MH, Zahiri J. 2021. Bioinformatic tools for DNA methylation and histone modification: a survey. Genomics. 113(3):1098–1113. doi:10.1016/j.ygeno.2021.03.004
   PubMed Web of Science ®Google Scholar
• Chiappinelli KB, Baylin SB. 2022. Inhibiting DNA methylation improves antitumor immunity in ovarian cancer. J Clin Invest. 132(14):e160186. doi:10.1172/JCI160186
   PubMed Web of Science ®Google Scholar
• Dobre M, Salvi A, Pelisenco IA, Vasilescu F, De Petro G, Herlea V, Milanesi E. 2021. Crosstalk between DNA methylation and gene mutations in colorectal cancer. Front Oncol. 11:697409. doi:10.3389/fonc.2021.697409
   PubMed Web of Science ®Google Scholar
• Estécio MR, Maddipoti S, Bueso-Ramos C, DiNardo CD, Yang H, Wei Y, Kondo K, Fang Z, Stevenson W, Chang KS, et al. 2015. RUNX3 promoter hypermethylation is frequent in leukaemia cell lines and associated with acute myeloid leukaemia inv(16) subtype. Br J Haematol. 169(3):344–351. doi:10.1111/bjh.13299
   PubMed Web of Science ®Google Scholar
• Gao C, Qiao T, Yuan S, Zhuang X. 2021. The preliminary study for postoperative radiotherapy survival associated with RUNX3 and TLR9 expression in lung cancer. Cancer Manag Res. 13:4497–4507. doi:10.2147/CMAR.S305452
   PubMed Web of Science ®Google Scholar
• Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, Nicholson AG, Groome P, Mitchell A, Bolejack V, International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Participating Institutions. 2016. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 11(1):39–51. doi:10.1016/j.jtho.2015.09.009
   PubMed Web of Science ®Google Scholar
• Huang X, Wu C, Fu Y, Guo L, Kong X, Cai H. 2018. Methylation analysis for multiple gene promoters in non-small cell lung cancers in high indoor air pollution region in China. Bull Cancer. 105(9):746–754. doi:10.1016/j.bulcan.2018.05.004
   PubMed Web of Science ®Google Scholar
• Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, et al. 2019. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nat Commun. 10(1):1893. doi:10.1038/s41467-019-09671-3
   PubMedGoogle Scholar
• Lee SH, Hyeon DY, Yoon SH, Jeong JH, Han SM, Jang JW, Nguyen MP, Chi XZ, An S, Hyun KG, et al. 2021. RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis. Cell Death Differ. 28(4):1251–1269. doi:10.1038/s41418-020-00647-1
   PubMed Web of Science ®Google Scholar
• Li N, Geng F, Liang SM, Qin X. 2022. USP7 inhibits TIMP2 by up-regulating the expression of EZH2 to activate the NF-κB/PD-L1 axis to promote the development of cervical cancer. Cell Signal. 96:110351. doi:10.1016/j.cellsig.2022.110351
   PubMed Web of Science ®Google Scholar
• Li Z, Li B, Yu H, Wang P, Wang W, Hou P, Li M, Chu S, Zheng J, Mao L, et al. 2022. DNMT1-mediated epigenetic silencing of TRAF6 promotes prostate cancer tumorigenesis and metastasis by enhancing EZH2 stability. Oncogene. 41(33):3991–4002. doi:10.1038/s41388-022-02404-9
   PubMed Web of Science ®Google Scholar
• Li Y, Liu B, Yin X, Jiang Z, Fang C, Chen N, Zhang B, Dai L, Yin Y. 2022. Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression. Clin Epigenetics. 14(1):92. doi:10.1186/s13148-022-01308-5
   PubMed Web of Science ®Google Scholar
• Li M, Qiao R, Zhong R, Wei Y, Wang J, Zhang Z, Wang L, Xu T, Wang Y, Dai L, et al. 2022. FYB methylation in peripheral blood as a potential marker for the early-stage lung cancer: a case-control study in Chinese population. Biomarkers. 27(1):79–85. doi:10.1080/1354750X.2021.2016970
   PubMed Web of Science ®Google Scholar
• Lin S, Liu Y, Goldin LR, Lyu C, Kong X, Zhang Y, Caporaso NE, Xiang S, Gao Y. 2019. Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ. 10(1):2. doi:10.1186/s13293-018-0213-7
   PubMedGoogle Scholar
• Liu W, Tan S, Bai X, Ma S, Chen X. 2021. Long non-coding RNA LINC01215 promotes epithelial-mesenchymal transition and lymph node metastasis in epithelial ovarian cancer through RUNX3 promoter methylation. Transl Oncol. 14(8):101135. doi:10.1016/j.tranon.2021.101135
   PubMed Web of Science ®Google Scholar
• Ma Z, Zhu C, Wang H, Ji M, Huang Y, Wei X, Zhang J, Wang Y, Yin R, Dai J, et al. 2023. Association between biological aging and lung cancer risk: Cohort study and Mendelian randomization analysis. iScience. 26(3):106018. doi:10.1016/j.isci.2023.106018
   PubMed Web of Science ®Google Scholar
• Miao J, Zhao C, Tang K, Xiong X, Wu F, Xue W, Duan B, Zhang H, Jing X, Li W, et al. 2022. TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis. Int J Biol Sci. 18(6):2527–2539. doi:10.7150/ijbs.69266
   PubMed Web of Science ®Google Scholar
• Parma B, Wurdak H, Ceppi P. 2022. Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins. Drug Resist Updat. 65:100888. doi:10.1016/j.drup.2022.100888
   PubMed Web of Science ®Google Scholar
• Qiao R, Di F, Wang J, Wei Y, Xu T, Dai L, Gu W, Han B, Yang R. 2023. Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer. J Genet Genomics. 50(8):573–581. doi:10.1016/j.jgg.2023.02.014
   PubMed Web of Science ®Google Scholar
• Qiao R, Di F, Wang J, Wei Y, Zhang Y, Xu T, Wang Y, Gu W, Han B, Yang R. 2020. The association between RAPSN methylation in peripheral blood and early stage lung cancer detected in case-control cohort. Cancer Manag Res. 12:11063–11075. doi:10.2147/CMAR.S275321
   PubMed Web of Science ®Google Scholar
• Qiao R, Li M, Zhong R, Wei Y, Wang J, Zhang Z, Wang L, Xu T, Wang Y, Dai L, et al. 2021. The association between PNPLA2 methylation in peripheral blood and early-stage lung cancer in a case-control study. Cancer Manag Res. 13:7919–7927. doi:10.2147/CMAR.S329629
   PubMed Web of Science ®Google Scholar
• Qiao R, Zhong R, Liu C, Di F, Zhang Z, Wang L, Xu T, Wang Y, Dai L, Gu W, et al. 2022. Novel blood-based hypomethylation of SH3BP5 is associated with very early-stage lung adenocarcinoma. Genes Genomics. 44(4):445–453. doi:10.1007/s13258-021-01190-0
   PubMed Web of Science ®Google Scholar
• Qiao R, Zhu Q, Di F, Liu C, Song Y, Zhang J, Xu T, Wang Y, Dai L, Gu W, et al. 2023. Hypomethylation of DYRK4 in peripheral blood is associated with increased lung cancer risk. Mol Carcinog. 62(11):1745–1754. doi:10.1002/mc.23612
   PubMed Web of Science ®Google Scholar
• Richiardi L, Fiano V, Vizzini L, De Marco L, Delsedime L, Akre O, Tos AG, Merletti F. 2009. Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients. J Clin Oncol. 27(19):3161–3168. doi:10.1200/JCO.2008.18.2485
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71(3):209–249. doi:10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Um SW, Kim Y, Lee BB, Kim D, Lee KJ, Kim HK, Han J, Kim H, Shim YM, Kim DH. 2018. Genome-wide analysis of DNA methylation in bronchial washings. Clin Epigenetics. 10(1):65. doi:10.1186/s13148-018-0498-8
   PubMedGoogle Scholar
• Varela-Rey M, Woodhoo A, Martinez-Chantar ML, Mato JM, Lu SC. 2013. Alcohol, DNA methylation, and cancer. Alcohol Res. 35(1):25–35.
   PubMed Web of Science ®Google Scholar
• Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, et al. 2020. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Med. 12(1):105. doi:10.1186/s13073-020-00810-w
   PubMed Web of Science ®Google Scholar
• Wang D, Guo C, Li Y, Zhou M, Wang H, Liu J, Chen P. 2022. Oestrogen up-regulates DNMT1 and leads to the hypermethylation of RUNX3 in the malignant transformation of ovarian endometriosis. Reprod Biomed Online. 44(1):27–37. doi:10.1016/j.rbmo.2021.06.030
   PubMed Web of Science ®Google Scholar
• Wang YQ, Li HZ, Gong WW, Chen YY, Zhu C, Wang L, Zhong JM, Du LB. 2021. Cancer incidence and mortality in Zhejiang Province, Southeast China, 2016: a population-based study. Chin Med J (Engl)). 134(16):1959–1966. doi:10.1097/CM9.0000000000001666
   PubMed Web of Science ®Google Scholar
• Wolff EM, Liang G, Cortez CC, Tsai YC, Castelao JE, Cortessis VK, Tsao-Wei DD, Groshen S, Jones PA. 2008. RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Res. 68(15):6208–6214. doi:10.1158/0008-5472.CAN-07-6616
   PubMed Web of Science ®Google Scholar
• Yanagawa N, Tamura G, Oizumi H, Kanauchi N, Endoh M, Sadahiro M, Motoyama T. 2007. Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer. 58(1):131–138. doi:10.1016/j.lungcan.2007.05.011
   PubMed Web of Science ®Google Scholar
• Yi X, Guo J, Guo J, Sun S, Yang P, Wang J, Li Y, Xie L, Cai J, Wang Z. 2017. EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion. Sci Rep. 7(1):3568. doi:10.1038/s41598-017-03362-z
   PubMedGoogle Scholar
• Yin Q, Qiao R, Xu T, Dai L, Han B, Gu W, Yang R. 2023. The influence of blood sample processing on blood-based DNA methylation signatures. Clin Biochem. 115:116–125. doi:10.1016/j.clinbiochem.2022.06.013
   PubMed Web of Science ®Google Scholar
• Yuan Z, Yu X, Chen W, Chen D, Cai J, Jiang Y, Liu X, Wu Z, Wang L, Grady WM, et al. 2022. Epigenetic silencing and tumor suppressor gene of HAND2 by targeting ERK signaling in colorectal cancer. Cell Commun Signal. 20(1):111. doi:10.1186/s12964-022-00878-4
   PubMed Web of Science ®Google Scholar
• Zappa C, Mousa SA. 2016. Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res. 5(3):288–300. doi:10.21037/tlcr.2016.06.07
   PubMed Web of Science ®Google Scholar
• Zhang P, Wu Y, Piao C, Song Y, Zhao Y, Lyu Y, Sun Q, Liu J. 2023. Alteration of genome-wide DNA methylation in non-uranium miners induced by high level radon exposure. Mutat Res Genet Toxicol Environ Mutagen. 891:503683. doi:10.1016/j.mrgentox.2023.503683
   PubMed Web of Science ®Google Scholar
• Zhao N, Ruan M, Koestler DC, Lu J, Marsit CJ, Kelsey KT, Platz EA, Michaud DS. 2022. Epigenome-wide scan identifies differentially methylated regions for lung cancer using pre-diagnostic peripheral blood. Epigenetics. 17(4):460–472. doi:10.1080/15592294.2021.1923615
   PubMed Web of Science ®Google Scholar
• Zheng J, Mei Y, Xiang P, Zhai G, Zhao N, Xu C, Liu M, Pan Z, Tang K, Jia D. 2018. DNA methylation affects metastasis of renal cancer and is associated with TGF-β/RUNX3 inhibition. Cancer Cell Int. 18(1):56. doi:10.1186/s12935-018-0554-7
   PubMedGoogle Scholar
• Zheng J, Mei Y, Zhai G, Zhao N, Jia D, Fan Y. 2020. Downregulation of RUNX3 has a poor prognosis and promotes tumor progress in kidney cancer. Urol Oncol. 38(9):740.e711–740.e720.
   Web of Science ®Google Scholar
• Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, et al. 2016. Genome-wide analysis of DNA methylation and cigarette smoking in a Chinese population. Environ Health Perspect. 124(7):966–973. doi:10.1289/ehp.1509834
   PubMed Web of Science ®Google Scholar