The effect of nocebo explanation and empathy on side-effect expectations of medication use following a fictional GP consultation

References

• Aslaksen, P. M., Myrbakk, I. N., Høifødt, R. S., & Flaten, M. A. (2007). The effect of experimenter gender on autonomic and subjective responses to pain stimuli. Pain, 129(3), 260–268. https://doi.org/10.1016/j.pain.2006.10.011
   PubMed Web of Science ®Google Scholar
• Barnes, K., Faasse, K., Geers, A. L., Helfer, S. G., Sharpe, L., Colloca, L., & Colagiuri, B. (2019). Can positive framing reduce nocebo side effects? current evidence and recommendation for future research. Frontiers in Pharmacology, 10, 167–167. https://doi.org/10.3389/fphar.2019.00167
   PubMed Web of Science ®Google Scholar
• Barsky, A. J., Saintfort, R., Rogers, M. P., & Borus, J. F. (2002). Nonspecific medication side effects and the nocebo phenomenon. Journal of the American Medical Association, 287(5), 622–627. https://doi.org/10.1001/jama.287.5.622
   PubMed Web of Science ®Google Scholar
• Benjamins, M. R., Middleton, M., & Koniaris, L. G. (2019). Perceived discrimination in medical settings and perceived quality of care: A population-based study in Chicago. PloS One, 14(4), e0215976. https://doi.org/10.1371/journal.pone.0215976
   PubMed Web of Science ®Google Scholar
• Cohen, S. (2014). The nocebo effect of informed consent. Bioethics, 28(3), 147–154. https://doi.org/10.1111/j.1467-8519.2012.01983.x
   PubMed Web of Science ®Google Scholar
• Crichton, F., & Petrie, K. J. (2015). Health complaints and wind turbines: The efficacy of explaining the nocebo response to reduce symptom reporting. Environmental Research, 140, 449–455. https://doi.org/10.1016/j.envres.2015.04.016
   PubMed Web of Science ®Google Scholar
• Cutler, R. L., Fernandez-Llimos, F., Frommer, M., Benrimoj, C., & Garcia-Cardenas, V. (2018). Economic impact of medication non-adherence by disease groups: A systematic review. BMJ Open, 8(1), e016982. https://doi.org/10.1136/bmjopen-2017-016982
   PubMed Web of Science ®Google Scholar
• Derksen, F., Bensing, J., & Lagro-Janssen, A. (2013). Effectiveness of empathy in general practice: A systematic review. British Journal of General Practice, 63(606), e76–84. https://doi.org/10.3399/bjgp13X660814
   PubMed Web of Science ®Google Scholar
• Duerden, M., Avery, T., Millson, D., & Smart, S. (2011). Quality of GP Prescribing. King’s Fund Report, March 2011.
   Google Scholar
• Heisig, S. R., Shedden Mora, M. C., Hidalgo, P., & Nestoriuc, Y. (2015). Framing and personalizing informed consent to prevent negative expectations: An experimental pilot study. Health Psychology, 34(10), 1033–1037. https://doi.org/10.1037/hea0000217
   PubMed Web of Science ®Google Scholar
• Horne, R., Chapman, S. C. E., Parham, R., Freemantle, N., Forbes, A., Cooper, V., & Xia, Y. (2013). Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the necessity-concerns framework. PloS One, 8(12), e80633. https://doi.org/10.1371/journal.pone.0080633
   PubMed Web of Science ®Google Scholar
• Horne, R., Faasse, K., Cooper, V., Diefenbach, M. A., Leventhal, H., E, L., & Petrie, K. J. (2013). The perceived sensitivity to medicines (PSM) scale: An evaluation of validity and reliability. British Journal of Health Psychology, 18(1), 18–30. https://doi.org/10.1111/j.2044-8287.2012.02071.x
   PubMed Web of Science ®Google Scholar
• Howe, L. C., Goyer, J. P., & Crum, A. J. (2017). Harnessing the placebo effect: Exploring the influence of physician characteristics on placebo response. Health Psychology, 36(11), 1074–1082. https://doi.org/10.1037/hea0000499
   PubMed Web of Science ®Google Scholar
• Howick, J., Steinkopf, L., Ulyte, A., Roberts, N., & Meissner, K. (2017). How empathic is your healthcare practitioner? A systematic review and meta-analysis of patient surveys. BMC Medical Education, 17(1), 136. https://doi.org/10.1186/s12909-017-0967-3
   PubMedGoogle Scholar
• Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., Park, M., Rivers, A. L., McManus, C., Kokkotou, E., Drossman, D. A., Goldman, P., & Lembo, A. J. (2008). Components of placebo effect: Randomised controlled trial in patients with irritable bowel syndrome. BMJ, 336(7651), 999–1003. https://doi.org/10.1136/bmj.39524.439618.25
   PubMed Web of Science ®Google Scholar
• Kardas, P., Lewek, P., & Matyjaszczyk, M. (2013). Determinants of patient adherence: A review of systematic reviews. Frontiers in Pharmacology, 4, 91. https://doi.org/10.3389/fphar.2013.00091
   PubMed Web of Science ®Google Scholar
• Kleinsinger, F. (2018). The unmet challenge of medication nonadherence. The Permanente Journal, 22(3), 18–033. https://doi.org/10.7812/tpp/18-033
   PubMedGoogle Scholar
• Kornhaber, R., Walsh, K., Duff, J., & Walker, K. (2016). Enhancing adult therapeutic interpersonal relationships in the acute health care setting: An integrative review. Journal of Multidisciplinary Healthcare, 9, 537–546. https://doi.org/10.2147/JMDH.S116957
   PubMed Web of Science ®Google Scholar
• MacKrill, K., Morrison, Z., & Petrie, K. J. (2021). Increasing and dampening the nocebo response following medicine-taking: A randomised controlled trial. Journal of Psychosomatic Research, 150, 110630. https://doi.org/10.1016/j.jpsychores.2021.110630
   PubMed Web of Science ®Google Scholar
• Manaï, M., van Middendorp, H., Veldhuijzen, D. S., Huizinga, T. W. J., & Evers, A. W. M. (2019). How to prevent, minimize, or extinguish nocebo effects in pain: A narrative review on mechanisms, predictors, and interventions. Pain Reports, 4(3), e699–e699. https://doi.org/10.1097/PR9.0000000000000699
   PubMedGoogle Scholar
• Mercer, S. W., Maxwell, M., Heaney, D., & Watt, G. C. (2004). The consultation and relational empathy (CARE) measure: Development and preliminary validation and reliability of an empathy-based consultation process measure. Family Practice, 21(6), 699–705. https://doi.org/10.1093/fampra/cmh621
   PubMed Web of Science ®Google Scholar
• Necka, E. A., Amir, C., Dildine, T. C., & Atlas, L. Y. (2021). Expectations about pain and analgesic treatment are shaped by medical providers’ facial appearances: Evidence from five online clinical simulation experiments. Social Science & Medicine, 281, 114091. https://doi.org/10.1016/j.socscimed.2021.114091
   PubMed Web of Science ®Google Scholar
• Pan, Y., Kinitz, T., Stapic, M., & Nestoriuc, Y. (2019). Minimizing drug adverse events by informing about the nocebo effect—an experimental study. Frontiers in Psychiatry, 10504. https://doi.org/10.3389/fpsyt.2019.00504
   Web of Science ®Google Scholar
• Petrie, K. J., & Rief, W. (2019). psychobiological mechanisms of placebo and nocebo effects: pathways to improve treatments and reduce side effects. Annual Review of Psychology, 70(1), 599–625. https://doi.org/10.1146/annurev-psych-010418-102907
   PubMed Web of Science ®Google Scholar
• RCGP. (2021). GP Consultations Post-COVID Should Be a Combination of Remote and Face to Face, Depending on Patient Need, Says College. https://www.rcgp.org.uk/about-us/news/2021/may/gp-consultations-post-covid.aspx
   Google Scholar
• Stepien, K. A., & Baernstein, A. (2006). Educating for empathy. A review. Journal of General Internal Medicine, 21(5), 524–530. https://doi.org/10.1111/j.1525-1497.2006.00443.x
   PubMed Web of Science ®Google Scholar
• Webster, R. K., & Rubin, G. J. (2021). Predicting expectations of side-effects for those which are warned versus not warned about in patient information leaflets. Annals of Behavioral Medicine, 55(22), 1253–1261. https://doi.org/10.1093/abm/kaab015
   PubMedGoogle Scholar
• Webster, R. K., Weinman, J., & Rubin, G. J. (2016). A systematic review of factors that contribute to nocebo effects. Health Psychology, 35(12), 1334–1355. https://doi.org/10.1037/hea0000416
   PubMed Web of Science ®Google Scholar
• Webster, R. K., Weinman, J., & Rubin, G. J. (2018). Positively framed risk information in patient information leaflets reduces side effect reporting: a double-blind randomized controlled trial. Annals of Behavioral Medicine, 52(11), 920–929. https://doi.org/10.1093/abm/kax064
   PubMed Web of Science ®Google Scholar
• Wells, R. E., & Kaptchuk, T. J. (2012). To tell the truth, the whole truth, may do patients harm: the problem of the nocebo effect for informed consent. The American Journal of Bioethics, 12(3), 22–29. https://doi.org/10.1080/15265161.2011.652798
   PubMed Web of Science ®Google Scholar