Pathogenesis of Human Immunodeficiency Virus-Induced Neurological Disease

References

• Adamson DC, Kopnisky KL, Dawson TM, Dawson VL (1999). Mechanisms and structural determinants of HIV-1 coat protein. Gp41 induced neurotoxicity. J Neu-rosci 19: 64–71.
   Google Scholar
• Ahlquist P (2002). RNA-dependent RNA polymerases, viruses and RNA silencing. Science 296: 1270–1273.
   PubMed Web of Science ®Google Scholar
• Bagasra O, Lavi E, Bobroski L, Khalili K, Pestaner JP, Tawadros R, Pomerantz RJ (1996). Cellular reservoirs of HIV-1 in the central nervous system of infected in-dividuals: identification by the combination of in situ polymerase chain reaction and i=unohistochemistry. AIDS 10: 573–585.
   Google Scholar
• Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001). CXCR4-activated astrocyte glutamate release via TNF alpha: amplification by microglia trig-gers neurotoxicity. Nat Neurosci 4: 676–678.
   Google Scholar
• Bragg DC, Childers TA, Tompkins MB, Tompkins W, Meeker RB (2002). Infection of the choroids plexus by feline immunodeficiency virus. J NeuroVirol 8: 211–224.
   Web of Science ®Google Scholar
• Chen W, Sulcove J, Frank I, Jailer S, Ozdener H, Kolson DL (2002). Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bc1-2/Bc1-xL-sensitive intrinsic apoptosis pathway. J Virol 76: 9407–9419.
   Google Scholar
• Edinger AL, Blanpain C, Kunstrnan KJ, Wolinsky SM, Parmentier M, Doms RW (1999). Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains. J Virol 73: 62–73.
   Google Scholar
• Gendelman HE, Lipton SA, Tardiru M, Bukrinsky MI, Nottet HSLM (1994). The neuropathogenesis of HIV-1 infection. J Leukoc Biol 56: 389–398.
   PubMed Web of Science ®Google Scholar
• Georgsson G (1994). Neuropathologic aspects of lentiviral infections. Ann N Y Acad Sci 724: 50–67.
   PubMed Web of Science ®Google Scholar
• Gorry PR, Taylor J, Holm GH, Mehle A, Morgan T, Cayabyab M, Farzan M, Wang H, Bell JE, Kunstmann K, Moore JP, Wolinsky SM, Gabuzda D (2002). Increased CCR5 affin-ity and reduced CCR5/CD4 dependence of a neurovir-ulent primary human immunodeficiency virus type 1 isolate. J Virol 76: 6277–6292.
   Google Scholar
• Gray F, Lescs M, Keihane C, Paraire F, Marc B, Durigon M, Gherardi R (1992). Early brain changes in HIV in-fecton: neuropathological study of 11 HIV seropositive non-AIDS cases. J Neuropathol Exp Neurol 51: 177–185.
   PubMed Web of Science ®Google Scholar
• Harouse JM, Wroblewska Z, Laughlin MA, Hickey WF, Schonwetter BS, González-Scarano F (1989). Human choroid plexus cells can be latently infected with hu-man immunodeficiency virus. Ann Neurol 25: 406–411.
   PubMed Web of Science ®Google Scholar
• Johnston JB, Zhang K, Silva C, Shalinsky DR, Conant K, Ni W, Corbett D, Young VW, Power C (2001). HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors. Ann Neurol 49: 230–241.
   PubMed Web of Science ®Google Scholar
• Kanmogne GD, Kennedy RC, Gramas P (2002). HIV-1 gp120 proteins and gp160 peptides are toxic to brain endothe-lial cells and neurons: possible pathway for HIV en-try into the brain and HIV-associated dementia. J Neu-ropathol Exp Neurol 61: 992–1000.
   PubMed Web of Science ®Google Scholar
• Kaul M, Lipton SA (1999). Chemokines and activated macrophages in HIV gp120-induced neuronal apopto-sis. Proc Natl Acad Sci USA 96: 8212–8216.
   PubMed Web of Science ®Google Scholar
• Kelder W, McArthur JC, Nance-Sproson T, McClemon D, Griffin DE (1998). /3-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of pa-tients with human immunodeficiency virus-associated dementia. Ann Neurol 44: 831–835.
   PubMed Web of Science ®Google Scholar
• Kennedy DW, Abkowitz JL (1997). Kinetics of central ner-vous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90: 986–993.
   PubMed Web of Science ®Google Scholar
• Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS (1986). Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233: 1089–1093.
   PubMed Web of Science ®Google Scholar
• Kolchinsky P, Kiprilov E, Bartley P, Rubinstein R, Sodroski J (2001). Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 in-fection by altering the position of the gp120 V1/V2 vari-able loops. J Virol 75: 3435–3443.
   PubMed Web of Science ®Google Scholar
• Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H, Parren PWIH, Robinson J, Van Ryk D, Wang L, Burton DR, Freire E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J (2002). HIV-1 evades antibody-mediated neutralization through conforma-tional masking of receptor-binding sites. Nature 420: 678–682.
   PubMed Web of Science ®Google Scholar
• Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M (2002). Human im-munodeficiency virus type 1 enters brain microvascu-lar endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol 76: 6689–6700.
   Google Scholar
• Liu Y, Tang XP, McArthur JC, Scott J, Gartner S (2000). Anal-ysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain. J NeuroVirol 6: S70–S81.
   Google Scholar
• Martin J, LaBranche CC, Gonzalez-Scarano F (2001). Differ-ential CD4/CCR5 utilization, gp120 conformation and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate. J Virol 75: 3568–3580.
   PubMed Web of Science ®Google Scholar
• Maschke M, Kastrup O, Esser S, Ross B, Hengge U, Hufnagel A (2000). Incidence and prevalence of neurological dis-orders associated with HIV since the introduction of highly active anti-retroviral therapy (HAART). I Neurol Neurosurg Psychiatry 69: 257–260.
   Google Scholar
• Masliah E, DeTeresa RM, Mallory ME, Hansen LA (2000). Changes in pathological findings at autopsy in AIDS cases for the last 5 years. AIDS 14: 69–74.
   PubMed Web of Science ®Google Scholar
• Massari FE, Poli G, Schnitrnan SM, Psallidopoulous MC, Darvey V, Fauci AS (1990). In vivo T lymphocyte origin of macrophage-tropic strains of HIV. Role of monocytes during in vitro isolation and in vivo infection. JImmunol 144: 4628–4632.
   Google Scholar
• Mayhan WG (2002). Cellular mechanisms by which tumor necrosis factor-alpha produces disruption of the blood-brain barrier. Brain Res 927: 144–152.
   PubMed Web of Science ®Google Scholar
• Mayne M, Holden CP, Nath A, Geiger JD (2000). Release of calcium from inositol 1,4,5-triphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha pro-duction in human macrophages. J Immunol 164: 6538–6542.
   Google Scholar
• McArthur JC, Hoover DR, Bacellar H, et al (1993). Dementia in AIDS patients: incidence and risk factors. Neurology 43: 2245–2251.
   PubMed Web of Science ®Google Scholar
• McManus CM, Weidenheim K, Woodman SE, Nunez J, Hesselgesser J, Nath A, Berman JW (2000). Chemokine and chemokine-receptor expression in human glial ele-ments: induction by the HIV protein Tat, and chemokine autoregulation. Am J Pathol 156: 1441–1453.
   PubMed Web of Science ®Google Scholar
• Miller G (2002). Breaking down barriers. Science 297: 1116–1118.
   PubMed Web of Science ®Google Scholar
• Mukhtar M, Harley S, Chen P, BouHamdan M, Patel C, Acheampong E, Pomerantz R (2002). Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN. Virology 297: 78–88.
   PubMed Web of Science ®Google Scholar
• Nath A (1999). Pathobiology of human immunodeficiency virus dementia. Semin Neurol 19: 113–127.
   Google Scholar
• Patel CA, Mukhtar M, Harley S, Kulkosky J, Pomerantz RJ (2002). Lentiviral expression of HIV-1 Vpr induces apop-tosis in human neurons. J NeuroVirol 8: 86–99.
   PubMed Web of Science ®Google Scholar
• Petito CK, Chen H, Mesta AR, Torres-Munoz J, Roberts B, Wood C (1999). HIV infection of choroid plexus in AIDS and asymptomatic HIV-infected patients suggests that the choroid plexus may be a reservoir of productive in-fection. J NeuroVirol 5: 670–677.
   Web of Science ®Google Scholar
• Powderly WG (2000). Current approaches to treatment for HIV-1 infection. J NeuroVirol 6(suppl 1): S8–S13.
   Google Scholar
• Prendergast MA, Rogers DT, Mulholland PJ, Littleton JM, Wilkins LJ Jr, Self RL, Nath A (2002). Neurotoxic effects of the human immunodeficiency virust type-1 transcrip-tion factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain Res 954: 300–307.
   Web of Science ®Google Scholar
• Puffer BA, Pohlmann S, Edinger AL, Carlin D, Sanchez MD, Reitter J, Watry DD, Fox HS, Desrosiers RC, Doms RW (2002). CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity. J Virol 76: 2595-2605.
   Google Scholar
• Romero IAM, Prevost MC, Perret E, Adamson P, Greenwood J, Couraud PO, Ozden S (2000). Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral en-try into the central nervous system. J Virol 74: 6021–6030.
   Google Scholar
• Ryzhova EV, Crino P, Shawver L, Westmoreland SV, Lackner AA, Gonzalez-Scarano F (2002). Simian im-munodeficiency virus encephalitis: analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples. Virology 297: 57–67.
   PubMed Web of Science ®Google Scholar
• Sacktor N, McDermott MP, Marder K, Schifitto G, Selnes OA, McArthur JC, Stern Y, Albert S, Palumbo D, Kieburtz K, De Marcaida JA, Cohen B, Epstein L (2002). HIV-associated cognitive impairment before and after the ad-vent of combination therapy. J NeuroVirol 8: 136–142.
   Google Scholar
• Sinclair E, Gray F, Ciardi A, Scaravilli F (1994). I=unohis-tochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV positive patients. J Neuropath Exp Neurol 53: 43–50.
   PubMed Web of Science ®Google Scholar
• Smith DG, Guillemin GJ, Pemberton L, Kerr S, Nath A, Smythe GA, Brew BJ (2001). Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef, and Tat. J NeuroVirol 7: 56–60.
   PubMed Web of Science ®Google Scholar
• Strizki JM, Albright AV, Sheng H, O'Connor M, Perrin L, Gonzalez-Scarano F (1996). Infection of primary human microglia and monocyte-derived macrophages with hu-man immunodeficiency virus type 1 isolates: evidence of differential tropism. J Virol 70: 7654–7662.
   PubMedGoogle Scholar
• Thomas SA, Bye A, Segal MB (2001). Transport characteris-tics of the anti-human immunodeficiency virus nucleo-side analog, abacavir, into brain and cerebrospinal fluid. J Pharm Exp Therapeu 298: 947–953.
   Google Scholar
• Wiley CA, Schrier RD, Nelson JA, Lamper PW, Oldstone MBA (1986). Cellular localization of human immunod-eficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Nati Acad Sci USA 83: 7089–7093.
   PubMed Web of Science ®Google Scholar
• Williams KC, Corey S, Westmoreland SV, Pauley D, Knight H, deBakker C, Alvarez X, Lackner AA (2001). Perivas-cular macrophages are the primary cell type produc-tively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogen-esis of AIDS. J Exp Med 193: 905–915.
   PubMed Web of Science ®Google Scholar
• Williams KC, Hickey WF (2002). Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annu Rev Neurosci 25: 537–562.
   PubMed Web of Science ®Google Scholar
• Wong JK, Ignacio CC, Torriani F, Havlir D, Fitch NJ, Richman DD (1997). In vivo compartmentalization of human immunodeficiency virus: evidence from the ex-amination of pol sequences from autopsy tissues. J Virol 71: 2059–2071.
   Google Scholar
• Zhang PF, Bouma P, Park EJ, Margolick JB, Robinson JE, Zolla-Pazner S, Flora MN, Quinnan GV Jr (2002). A vari-able region 3 (V3) mutation determines a global neutral-ization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope as-sociated with a broadly cross-reactive, primary virus-neutralizing antibody response. Virol 76: 644–655.
   Google Scholar