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Short communication

AZT 5′-triphosphate nanoformulation suppresses human immunodeficiency virus type 1 replication in peripheral blood mononuclear cells

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Pages 343-347 | Received 09 Apr 2009, Published online: 27 Aug 2009

References

  • Antonelli G, Turriziani O, Verri A, Narcisco P, Ferri F, D'Offizi G, Dianzani F. Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase. AIDS Res Hum Retrovir 1996; 12: 223–228
  • Bacri JC, Perzynski R, Salin D, Cabuil V, Massart R. Ionic ferrofluids: a crossing of chemistry and physics. J Magn Magn Mater 1990; 85: 27–32
  • Chertok B, Moffat BA, David AE, Yu F, Bergemann C, Ross BD, Yang VC. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 2008; 29: 487–496
  • Furman PA, Fyfe JA, St Clair MH, Weinhold K, Rideout JL, Freeman GA, Lehrman SN, Bolognesi DP, Broder S, Mitsuya H. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci USA 1986; 83: 8333–8337
  • Ito A, Shinkai M, Honda H, Kobayashi T. Medical application of functionalized magnetic nanoparticles. J Biosci Bioeng 2005; 100: 1–11
  • Kohli E, Han HY, Zeman AD, Vinogradov SV. Formulations of biodegradable nanogel carriers with 5′-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity. J Control Release 2007; 121: 19–27
  • Koneracká M, Kopcanský P, Timko M, Ramchand CN, Saiyed ZM, Trevan M, e'Sequeira A. Immobilization of enzymes on magnetic particles. Immobilization of enzymes and cells2nd ed, JM. Guisan. Humana Press, New Jersey 2006; 217–228
  • Kreller DI, Gibson G, Novak W, Van Loon GW, Horton JH. Competitive adsorption of phosphate and carboxylate with natural organic matter on hydrous iron oxides as investigated by chemical force microscopy. Physiochem Eng Aspects 2003; 212: 249–264
  • Lavie A, Schlichting I, Vetter IR, Konrad M, Reinstein J, Goody RS. The bottleneck in AZT activation. Nat Med 1997; 3: 922–924
  • Magnani M, Rossi L, Fraternale A, Silvotti L, Quintavalla F, Piedimonte G, Matteucci D, Baldinotti F, Bendinelli M. Feline immunodeficiency virus infection of macrophages: in vitro and in vivo inhibition by dideoxycytidine-5′-triphosphate-loaded erythrocytes. AIDS Res Hum Retrovir 1994; 10: 1179–1186
  • Nair MPN, Saiyed ZM, Nair N, Gandhi N, Rodriguez JW, Boukli N, Vasquez E, Malow RM, Burbano MJM. Methamphetamine enhances HIV-1 infectivity in monocytes derived dendritic cells. J Neuroimmune Pharmacol 2009; 4: 129–139
  • Pardridge WM. Blood brain barrier delivery. Today 2007; 12: 54–61
  • Potula R, Ramirez S, Knipe B, Leibhart J, Schall K, Heilman D, Morsey B, Mercer A, Papugani A, Dou H, Persidsky Y. Peroxisome proliferator-activated receptor-γ activation suppresses HIV-1 replication in an animal model of encephalitis. AIDS 2008; 22: 1539–1549
  • Riviere C, Martina MS, Tomita Y, Wilhelm C, Dinh AT, Menager C, Pinard E, Lesieur E, Gazeau F, Seylaz J. Magneting targeting of nanometric magnetic fluid loaded liposomes to specific brain intravascular areas: A dynamic imaging study in mice. Radiology 2007; 244: 439–448
  • Saiyed ZM, Sharma S, Godawat R, Telang SD, Ramchand CN. Activity and stability of alkaline phosphatase (ALP) immobilized onto magnetic nanoparticles. J Biotechnol 2007; 131: 240–244
  • Saiyed ZM, Telang SD, Ramchand CN. Application of magnetic techniques in the field of drug discovery and biomedicine. BioMagn Res Technol 2003; 1: 1–8
  • Szebeni J, Wahl SM, Betageri GV, Wahl LM, Gartner S, Popovic M, Parker RJ, Black CD, Weinstein JN. Inhibition of HIV-1 in monocyte/macrophage cultures by 2′,3′-dideoxycytidine-5′-triphosphate, free and in liposomes. AIDS Res Hum Retrovir 1990; 6: 691–702
  • Vinogradov SV. Polymeric nanogel formulations of nucleoside analogs. Expert Opin Drug Deliv 2007; 4: 5–17
  • Vinogradov SV, Kohli E, Zeman AD. Crosslinked polymeric nanogel formulation of 5′-triphosphates of nucleoside analogs: role of the cellular membrane in drug release. Mol Pharmacol 2005; 2: 449–461
  • Wagner CR, Iyer VV, McIntee EJ. Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides. Med Res Rev 2000; 20: 417–451
  • Wohrl BM, Loubiere L, Brundiers R, Goody RS, Klatzmann D, Konrad M. Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition. J Gen Virol 2005; 86: 757–764

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