3,741
Views
67
CrossRef citations to date
0
Altmetric
Original Articles

Systematic review of non-pharmacologic interventions to delay functional decline in community-dwelling patients with dementia

, &
Pages 655-666 | Received 27 Oct 2012, Accepted 16 Feb 2013, Published online: 23 Apr 2013

References

  • Ayalon , L. , Gum , A. M. , Feliciano , L. and Arean , P. A. 2006 . Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: A systematic review . Archives of Internal Medicine , 166 : 2182 – 2188 . doi: 10.1001/archinte.166.20.2182
  • Banerjee , S. , Hellier , J. , Dewey , M. , Romeo , R. , Ballard , C. , Baldwin , R. and Burns , A. 2011 . Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomised, multicentre, double-blind, placebo-controlled trial . Lancet , 378 : 403 – 411 . doi: 10.1016/S0140-6736(11)60830-1
  • Burgener , S. C. , Bakas , T. , Murray , C. , Dunahee , J. and Tossey , S. 1998 . Effective caregiving approaches for patients with Alzheimer's disease . Geriatric Nursing , 19 ( 3 ) : 121 – 126 . doi: 10.1016/S0197-4572(98)90055-6
  • Callahan , C. M. , Boustani , M. A. , Unverzagt , F. W. , Austrom , M. G. , Damush , T. M. , Perkins , A. J. and Hendrie , H. C. 2006 . Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: A randomized controlled trial . JAMA , 295 ( 18 ) : 2148 – 2157 . doi: 10.1001/jama.295.18.2148
  • Cohen , J. 1988 . Statistical power analysis for the behavioral sciences , Hillsdale , NJ : Lawrence Erlbaum Associates .
  • Eysenck , H. 1994 . Systematic reviews: Meta-analysis and its problems . British Medical Journal , 309 : 789 doi: 10.1136/bmj.309.6957.789
  • Ferruci , L. , Guralnik , J. M. , Studenski , S. , Fried , L. P. , Cutler , G. B. Jr and Walston , J. D. 2004 . Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: A consensus report . Journal of American Geriatrics Society , 52 : 625 – 634 . doi: 10.1111/j.1532-5415.2004.52174.x
  • Fox , C. C.M. , Maidment , I. , Auestad , B. H. , Coulton , S. , Treloar , A. , Ballard , C. and Livingston , G. 2012 . Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial . PLoS One , 7 : e35185 doi: 10.1371/journal.pone.0035185
  • Gavrilova , S. I. , Ferri , C. P. , Mikhaylova , N. , Sokolova , O. , Banerjee , S. and Prince , M. 2009 . Helping carers to care – The 10/66 dementia research group's randomized control trial of a caregiver intervention in Russia . International Journal of Geriatric Psychiatry , 24 ( 4 ) : 347 – 354 . doi: 10.1002/gps.2126
  • Gill , T. M. 2010 . Assessment of function and disability in longitudinal studies . Journal of the American Geriatrics Society , 58 ( 2 ) : 308 – 312 . doi: 10.1111/j.1532-5415.2010.02914.x
  • Gitlin , L. N. , Corcoran , M. , Winter , L. , Boyce , A. and Hauck , W. W. 2001 . A randomized, controlled trial of a home environmental intervention: Effect on efficacy and upset in caregivers and on daily function of persons with dementia . Gerontologist , 41 ( 1 ) : 4 – 14 . doi: 10.1093/geront/41.1.4
  • Gitlin , L. N. , Hauck , W. W. , Dennis , M. P. and Winter , L. 2005 . Maintenance of effects of the home environmental skill-building program for family caregivers and individuals with Alzheimer's disease and related disorders . Journals of Gerontology Series A – Biological Sciences & Medical Sciences , 60 ( 3 ) : 368 – 374 . doi: 10.1093/gerona/60.3.368
  • Gitlin , L. N. , Winter , L. , Burke , J. , Chernett , N. , Dennis , M. P. and Hauck , W. W. 2008 . Tailored activities to manage neuropsychiatric behaviors in persons with dementia and reduce caregiver burden: A randomized pilot study . American Journal of Geriatric Psychiatry , 16 ( 3 ) : 229 – 239 . doi: 10.1097/JGP.0b013e318160da72
  • Gitlin , L. N. , Winter , L. , Corcoran , M. , Dennis , M. P. , Schinfeld , S. and Hauck , W. W. 2003 . Effects of the home environmental skill-building program on the caregiver-care recipient dyad: 6-month outcomes from the Philadelphia REACH Initiative . Gerontologist , 43 ( 4 ) : 532 – 546 . doi: 10.1093/geront/43.4.532
  • Gitlin , L. N. , Winter , L. , Dennis , M. P. , Hodgson , N. and Hauck , W. W. 2010a . A biobehavioral home-based intervention and the well-being of patients with dementia and their caregivers: The COPE randomized trial . JAMA , 304 ( 9 ) : 983 – 991 . doi: 10.1001/jama.2010.1253
  • Gitlin , L. N. , Winter , L. , Dennis , M. P. , Hodgson , N. and Hauck , W. W. 2010b . Targeting and managing behavioral symptoms in individuals with dementia: A randomized trial of a nonpharmacological intervention . Journal of the American Geriatrics Society , 58 ( 8 ) : 1465 – 1474 . doi: 10.1111/j.1532-5415.2010.02971.x
  • Graff , M. J. , Vernooij-Dassen , M. J. , Thijssen , M. , Dekker , J. , Hoefnagels , W. H. and Olderikkert , M. G. 2007 . Effects of community occupational therapy on quality of life, mood, and health status in dementia patients and their caregivers: A randomized controlled trial . Journals of Gerontology Series A – Biological Sciences & Medical Sciences , 62 ( 9 ) : 1002 – 1009 . doi: 10.1093/gerona/62.9.1002
  • Graff , M. J. , Vernooij-Dassen , M. J. , Thijssen , M. , Dekker , J. , Hoefnagels , W. H. and Rikkert , M. G. 2006 . Community based occupational therapy for patients with dementia and their care givers: Randomised controlled trial . BMJ , 333 ( 7580 ) : 1196 doi: 10.1136/bmj.39001.688843.BE
  • Guralnik , J. M. and Ferruci , L. 2003 . Assessing the building blocks of function: Utilizing measures of functional limitation . American Journal of Preventive Medicine , 25 ( 3 ) : 112 – 121 . doi: 10.1016/S0749-3797(03)00174-0
  • Guyatt , G. H. , Oxman , A. D. , Vist , G. , Kunz , R. , Brozek , J. , Alonso-Coello , P. and Schunemann , H. J. 2010 . GRADE guidelines: 4. Rating the quality of evidenced study limitations (risk of bias) . Journal of Clinical Epidemiology , 64 : 407 – 415 . doi: 10.1016/j.jclinepi.2010.07.017
  • Hauer , K. , Schwenk , M. , Zieschang , T. , Essig , M. , Becker , C. and Oster , P. 2012 . Physical training improves motor performance in people with dementia: A randomized controlled trial. [Comparative Study Randomized Controlled Trial Research Support, Non-U.S. Govt.] . Journal of the American Geriatrics Society , 60 ( 1 ) : 8 – 15 . http://dx.doi.org/ doi: 10.1111/j.1532-5415.2011.03778.x
  • Koroknay , V. J. , Werner , P. , Cohen-Mansfield , J. and Braun , J. V. 1995 . Maintaining ambulation in the frail nursing home resident: A nursing administered walking program . Journal of Gerontological Nursing , 21 ( 11 ) : 18 – 24 .
  • Kraemer , H. and Kupfer , D. J. 2006 . Size of treatment effects and their importance to clinical research and practice . Biological Psychiatry , 59 : 990 – 996 . doi: 10.1016/j.biopsych.2005.09.014
  • Kwak , Y. S. , Um , S. Y. , Son , T. G. and Kim , D. J. 2008 . Effect of regular exercise on senile dementia patients . International Journal of Sports Medicine , 29 ( 6 ) : 471 – 474 . doi: 10.1055/s-2007-964853
  • Martin-Cook , K. , Davis , B. A. , Hynan , L. S. and Weiner , M. F. 2005 . A randomized, controlled study of an Alzheimer's caregiver skills training program . American Journal of Alzheimer's Disease & Other Dementias , 20 ( 4 ) : 204 – 210 . doi: 10.1177/153331750502000411
  • Netz , Y. , Axelrad , S. and Argov , E. 2007 . Group physical activity for demented older adults feasibility and effectiveness . Clinical Rehabilitation , 21 ( 11 ) : 977 – 986 . doi: 10.1177/0269215507078318
  • Nobili , A. , Riva , E. , Tettamanti , M. , Lucca , U. , Liscio , M. , Petrucci , B. and Porro , G. S. 2004 . The effect of a structured intervention on caregivers of patients with dementia and problem behaviors: A randomized controlled pilot study . Alzheimer Disease & Associated Disorders , 18 ( 2 ) : 75 – 82 . doi: 10.1097/01.wad.0000126618.98867.fc
  • Nourhashemi , F. , Andrieu , S. , Gillette-Guyonnet , S. , Giraudeau , B. , Cantet , C. , Coley , N. and Vellas , B. 2010 . Effectiveness of a specific care plan in patients with Alzheimer's disease: Cluster randomised trial (PLASA study) . BMJ , 340 : c2466 doi: 10.1136/bmj.c2466
  • Olazaran , J. , Muniz , R. , Reisberg , B. , Pena-Casanova , J. , del Ser , T. , Cruz-Jentoft , A. J. and Sevilla , C. 2004 . Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease . Neurology , 63 ( 12 ) : 2348 – 2353 . doi: 10.1212/01.WNL.0000147478.03911.28
  • Owens , D. , Lohr , K. , Atkins , D. , Treadwell , J. , Reston , J. , Bass , E. and Helfand , M. 2010 . AHRQ Series Paper 5: Grading the strength of a body of evidence when comparing medical interventions: AHRQ and the Effective Health Care Program . Journal of Clinical Epidemiology , 63 : 513 – 523 . doi: 10.1016/j.jclinepi.2009.03.009
  • Perera , S. , Mody , S. H. , Woodman , R. C. and Studenski , S. A. 2006 . Meaningful change and responsiveness in common physical performnace measures in older adults . Journal of the American Geriatrics Society , 54 : 743 – 749 . doi: 10.1111/j.1532-5415.2006.00701.x
  • Pinquart , M. and Sorensen , S. 2006 . Helping caregivers of persons with dementia: Which interventions work and how large are their effects? [Meta-Analysis Research Support, N.I.H., Extramural] . International Psychogeriatrics , 18 ( 4 ) : 577 – 595 . doi: 10.1017/S1041610206003462
  • Plassman , B. L. 2007 . Prevalence of dementia in the United States: The aging, demographics, and memory study . Neuroepidemiology , 29 : 125 – 132 . doi: 10.1159/000109998
  • Raina , P. , Santaguida , P. , Ismaila , A. , Patterson , C. , Cowan , D. , Levine , M. and Oremus , M. 2008 . Effectiveness of cholinesterase inhibitors and memantine for treating dementia: Evidence review for a clinical practice guideline . Annals of Internal Medicine , 148 : 379 – 397 . doi: 10.7326/0003-4819-148-5-200803040-00009
  • Rios , L. , Ye , C. and Thabane , L. 2010 . Association between framing of the research question using the PICOT format and reporting quality of randomized controlled trials . BMC Medical Research Methodology , 10 : 11 doi: 10.1186/1471-2288-10-11
  • Rockwood , K. and MacKnight , C. 2001 . Assessing the clinical importance of statistically significant improvement in anti-dementia drug trials . Neuroepidemiology , 20 : 51 – 56 . doi: 10.1159/000054761
  • Rolland , Y. , Pillard , F. , Klapouszczak , A. , Reynish , E. , Thomas , D. , Andrieu , S. and Vellas , B. 2007 . Exercise program for nursing home residents with Alzheimer's disease: A 1-year randomized, controlled trial . Journal of the American Geriatrics Society , 55 ( 2 ) : 158 – 165 . doi: 10.1111/j.1532-5415.2007.01035.x
  • Samsa , G. , Edelman , D. , Rothman , M. L. , Williams , R. , Lipscomb , J. and Matchar , D. 1999 . Determining clinically important differences in health status measures . Pharmacoeconomics , 15 : 141 – 155 . doi: 10.2165/00019053-199915020-00003
  • Schneider , L. , Dagerman , K. S. and Insel , P. 2005 . Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials . JAMA , 294 : 1934 – 1943 . doi: 10.1001/jama.294.15.1934
  • Schneider , L. S. , Tariot , P. N. , Dagerman , K. S. , Davis , S. M. , Hsiao , J. K. , Ismail , M. and Lieberman , J. 2006 . Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease . New England Journal of Medicine (NEJM) , 355 : 1525 – 1538 . doi: 10.1056/NEJMoa061240
  • Schulz , R. , O’Brien , A. and Czaja , S. 2002 . Dementia caregiver intervention research: In search of clinical significance . Gerontologist , 42 : 589 – 602 . doi: 10.1093/geront/42.5.589
  • Schwenk , M. , Zieschang , T. , Oster , P. and Hauer , K. 2010 . Dual-task performances can be improved in patients with dementia: A randomized controlled trial . Neurology , 74 ( 24 ) : 1961 – 1968 . doi: 10.1212/WNL.0b013e3181e39696
  • Sink , K. , Holden , K. F. and Yaffe , K. 2005 . Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence . JAMA , 293 : 596 – 608 . doi: 10.1001/jama.293.5.596
  • Smits , C. H. , de Lange , J. , Dröes , R. M. , Meiland , F. , Vernooij-Dassen , M. and Pot , A. M. 2007 . Effects of combined intervention programmes for people with dementia living at home and their caregivers: A systematic review . International Journal of Geriatric Psychiatry , 22 : 1181 – 1193 . doi: 10.1002/gps.1805
  • Steinberg , M. , Leoutsakos , J. -M.S. , Podewils , L. J. and Lyketsos , C. G. 2009 . Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: The Maximizing Independence in Dementia (MIND) study. [Randomized Controlled Trial Research Support, Non-U.S. Govt.] . International Journal of Geriatric Psychiatry , 24 ( 7 ) : 680 – 685 . doi: 10.1002/gps.2175
  • Tappen , R. M. , Roach , K. E. , Applegate , E. B. and Stowell , P. 2000 . Effect of a combined walking and conversation intervention on functional mobility of nursing home residents with Alzheimer disease . Alzheimer Disease & Associated Disorders , 14 ( 4 ) : 196 – 201 . doi: 10.1097/00002093-200010000-00002
  • Teri , L. , Gibbons , L. E. , McCurry , S. M. , Logsdon , R. G. , Buchner , D. M. , Barlow , W. E. and Larson , E. B. 2003 . Exercise plus behavioral management in patients with Alzheimer disease: A randomized controlled trial. [Clinical Trial Randomized Controlled Trial Research Support, U.S. Govt., P.H.S.] . JAMA , 290 ( 15 ) : 2015 – 2022 . doi: 10.1001/jama.290.15.2015
  • Thompson , C. , Spilsbury , K. , Hall , J. , Birks , Y. , Barnes , C. and Adamson , J. 2007 . Systematic review of information and support interventions for caregivers of people with dementia . BMC Geriatrics , 7 ( 18 )
  • Trinh , N. , Hoblyn , J. , Mohanty , S. and Yaffe , K. 2003 . Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis . Journal of the American Medical Association , 289 : 210 – 216 . doi: 10.1001/jama.289.2.210
  • Verbrugge , L. and Jette , A. M. 1994 . The disablement process . Social Science & Medicine , 38 ( 1 ) : 1 – 14 . doi: 10.1016/0277-9536(94)90294-1
  • Vitaliano , P. , Zhang , J. and Scanlan , J. M. 2003 . Is caregiving hazardous to one's physical health? A meta-analysis . Journal of Gerontology: Psychological Sciences , 57B ( 5 ) : 453 – 460 .
  • Wattmo , C. , Wallin , A. K. , Londos , E. and Minthon , L. 2011 . Risk factors for nursing home placement in Alzheimer's disease: A longitudinal study of cognition, ADL, service utilization, and cholinesterase inhibitor treatment . Gerontologist , 51 ( 1 ) : 17 – 27 . doi: 10.1093/geront/gnq050
  • Weintraub , D. , Rosenberg , P. B. , Drye , L. T. , Martin , B. K. , Frangakis , C. , Mintzer , J. E. and Lyketsos , C. G. 2010 . Sertraline for the treatment of depression in Alzheimer disease: Week-24 outcomes . American Journal of Geriatric Psychiatry , 18 ( 4 ) : 332 – 340 . doi: 10.1097/JGP.0b013e3181cc0333

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.