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Review

Inducible genomic instability: Inducible genomic instability: New insights into the biological effects of ionizing radiation

Pages 117-130 | Accepted 23 Aug 1999, Published online: 22 Oct 2007

References

  • Lorimore , SA , Goodhead , DT and Wright , EG . 1993 . Inactivation of haemopoietic stem cells by slow alpha‐particles . Int J Radiat Biol , 63 : 655 – 60 .
  • Puck , TT and Marcus , PI . 1956 . Action of X‐rays on mammalian cells . J Exp Med , 103 : 653 – 66 .
  • Elkind , MM and Sutton , H . 1959 . X‐ray damage and recovery in mammalian cells in culture . Nature , 184 : 1293 – 5 .
  • Trott , KR and Hug , O . 1970 . Intraclonal recovery of division probability in pedigrees of single X‐irradiated mammalian cells . Int J Radiat Biol , 17 : 483 – 6 .
  • Thompson , LH and Suit , HD . 1969 . Proliferation kietics of X‐irradiated mouse L cells studies with time lapse photography. II . Int J Radiat Biol , 15 : 347 – 62 .
  • Seymour , CB , Mothersill , C and Alper , T . 1986 . High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation . Int J Radiat Biol , 50 : 167 – 79 .
  • Gorgojo , L and Little , JB . 1989 . Expression of lethal mutations in the progeny of irradiated mammalian cells . Int J Radiat Biol , 55 : 619 – 30 .
  • Brown , DC and Trott , KR . 1994 . Heterogeneity in the progeny of HeLa cells which survive X‐irradiation . Int J Radiat Biol , 66 : 151 – 5 .
  • Little , JB , Gorgojo , L and Vetros , H . 1990 . Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells . Int J Radiat Onco Biol Pbys , 19 : 1425 – 9 .
  • Chang , WP and Little , JB . 1992 . Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X irradiation: association with delayed reproductive death phenotype . Mutat Res , 270 : 191 – 9 .
  • Harper , K , Lorimore , SA and Wright , EG . 1997 . Delayed appearance of radiation‐induced mutations at the Hprt locus in murine haemopoietic cells . Exper Hematol , 25 : 263 – 9 .
  • Pampfer , S and Streffer , C . 1989 . Increased chromosome aberration levels in cells from mouse fetuses after zygote X‐irradiation . Int J Radiat Biol , 55 : 85 – 92 .
  • Kadhim , MA , Macdonald , DA , Goodhead , DT , Lorimore , SA , Marsden , SJ and Wright , EG . 1992 . Transmission of chromosomal instability after plutonium a‐particle irradiation . Nature , 355 : 738 – 40 .
  • Kadhim , MA , Lorimore , SA , Hepburn , MD , Goodhead , DT , Buckle , VJ and Wright , EG . 1994 . Alpha‐particle‐induced chromosomal instability in human bone marrow cells . Lancet , 344 : 987 – 8 .
  • Kadhim , MA , Lorimore , SA , Townsend , KM , Goodhead , DT , Buckle , VJ and Wright , EG . 1995 . Radiation‐induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells . Int J Radiat Biol , 67 : 287 – 93 .
  • Kadhim , MA , Marsden , SJ and Wright , EG . 1998 . Radiation‐induced chromosomal instability in human fibroblasts: temporal effects and the influence of radiation quality . Int J Radiat Biol , 78 : 143 – 8 .
  • Martins , MB , Sabatier , L , Ricoul , M , Pinton , A and Dutrillaux , B . 1993 . Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts . Mutat Res , 285 : 229 – 37 .
  • Holmberg , K , Fait , S , Johansson , A and Lambert , B . 1993 . Chromosome aberrations and genomic instability in X‐irradiated human T‐lymphocyte cultures . Mutat Res , 286 : 321 – 30 .
  • Holmberg , K , Meijer , AE , Auer , G and Lambert , B . 1995 . 1995. Delayed chromosomal instability in human T‐lymphocyte clones exposed to ionizing radiation . Int J Radiat Biol , 68 : 245 – 55 .
  • Marder , BA and Morgan , WF . 1993 . Delayed chromosomal instability induced by DNA damage . Mol Cell Biol , 13 : 6667 – 77 .
  • Durante , M , Grossi , GF and Yang , TC . 1996 . Radiation‐induced chromosomal instability in human mammary epithelial cells . Adv Space Res , 18 : 99 – 108 .
  • Ponnaiya , B , Cornforth , MN and Ullrich , RL . 1997 . Radiation‐induced chromosomal instability in BALB/c and C57BL/6 mice. The difference is as clear as black and white . Radiat Res , 147 : 121 – 5 .
  • Ponnaiya , B , Cornforth , MN and Ullrich , RL . 1997 . Induction of chromosomal instability in human mammary cells by neutrons and gamma rays . Radiat Res , 147 : 288 – 94 .
  • Watson , GE , Lorimore , SA , Clutton , SM , Kadhim , MA and Wright , EG . 1997 . Genetic factors influencing alpha‐particle‐induced chromosomal instability . Int. J Radiat Biol , 71 : 497 – 503 .
  • Little , JB , Nagasawa , H , Pfenning , T and Vetrovs , H . 1997 . Radiation‐induced genomic instability: delayed mutations and cytogenetic effects of X‐rays and alpha‐particles . Radiat Res , 148 : 299 – 307 .
  • Li , C ‐Y , Yandell , DW and Little , JB . 1992 . Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene . Mol Carcin , 5 : 270 – 7 .
  • Li , C‐Y , Yandell , DW and Little , JB . 1994 . Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus . Mol Cell Biol , 14 : 4373 – 9 .
  • Grosovsky , AJ , Parks , KK , Giver , CR and Nelson , SL . 1996 . Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation‐induced genetic instability . Mol Cell Biol , 16 : 6252 – 62 .
  • Watson , GE , Lorimore , SA and Wright , EG . 1996 . Long‐term in vivo transmission of alpha‐particle‐induced chromosomal instability in murine haemopoietic cells . Int J Radiat Biol , 69 : 175 – 82 .
  • Clutton , SM , Townsend , KM , Walker , C , Ansell , JD and Wright , EG . 1996 . Radiation‐induced genomic instability and persisting oxidative stress in bone marrow cultures . Carcinogenesi, , 17 : 1633 – 9 .
  • Lorimore , SA , Kadhim , MA , Pocock , DA , Papworth , D , Stevens , DL Goodhead , DT . 1998 . Chromosomal instability in the descendants of unirradiated surviving cells after ‐particle irradiation . Proc Natl Acad Sci USA , 95 : 5730 – 3 .
  • Nagasawa , H and Little , JB . 1992 . Induction of sister chromatid exchanges by extremely low doses of ‐particles . Cancer Res , 52 : 6394 – 6 .
  • Hickman , AW , Jaramillo , RJ , Lechner , JF and Johnson , NF . 1994 . α‐particle‐induced p53 protein expression in a rat lung epithelial cell strain . Cancer Res , 54 : 5797 – 800 .
  • Deshpande , A , Goodwin , EH , Bailey , SM , Marrone , BL and Lehnert , BE . 1996 . Alpha‐particle‐induced sister chromatid exchange in normal human lung fibroblasts: evidence for an extra‐nuclear target . Radiat Res , 145 : 260 – 7 .
  • Manti , L , Jamali , M , Prise , KM , Michael , BD and Trott , KR . 1997 . Genomic instability in Chinese hamster cells after exposure to X‐rays or alpha‐particles of different mean linear energy transfer . Radiat Res , 147 : 2 – 28 .
  • Wright , EG . 1999 . Inherited and inducible chromosomal instability: a fragile bridge between genome integrity mechanisms and tumourigenesis . J Pathol , 187 : 19 – 27 .
  • Emerit , I . 1994 . Reactive oxygen species, chromosome mutation and cancer: possible role of clastogenic factors in carcinogenesis . Free Radicals Biol Med , 16 : 99 – 109 .
  • Dizdaroglu , M , Olinski , R , Doroshow , JH and Akam , SA . 1993 . Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes . Cancer Res , 53 : 1269 – 72 .
  • Birnboim , HC . 1982 . DNA strand breakage in human leukocytes exposed to a tumour promotor, phorbol myristate acetate . Science , 215 : 1247 – 9 .
  • Schacter , E , Beecham , EJ , Covet , JM , Kohn , KW and Potter , M . 1988 . Activated neutrophils induce prolonged DNA damage in neighbouring cells . Carcinogenesis , 9 : 2297 – 304 .
  • Weitberg , AB , Weitzman , SA , Destrempes , M , Latt , SA and Stossel , TP . 1983 . Stimulated human phagocytes produce cytogenetic channges in cultured mammalian cells . N Eng J Med, , 308 : 26 – 30 .
  • Weitzman , SA , Weitberg , AB , Clark , EP and Stossel , TP . 1985 . Phagocytes as carcinogens: malignant transformation produced by human neutrophils . Science , 227 : 1231 – 3 .
  • Weitzman , SA and Stossel , TP . 1981 . Mutation caused by human phagocytes . Science , 212 : 546 – 7 .
  • Weitzman , SA and Gordon , LI . 1990 . Inflammation and cancer: role of phagocyte‐generated oxidants in carcinogenesis . Blood , 76 : 655 – 63 .
  • Dionian , J , Muirhead , CR , Wan , SL and Wrixon , AD . 1986 . The Risks of Leukaemia and Other Cancers in Thurso from Radiation Exposure , Didcot : National Radiological Protection Board . Report NRPB‐R196.
  • Richardson , RB , Eatough , JP and Henshaw , DL . 1991 . Dose to red bone marrow from natural radon and thoron exposure . Brit J Radiol , 64 : 608 – 24 .
  • Humphreys , ER , Loutit , JF , Major , IR and Stones , VA . 1985 . The inuction by 224Ra of myeloid leukaemia and osteocarcoma in CBA mice . Int J Radiat Biol , 47 : 239 – 47 .
  • Humpreys , ER , Loutit , JF and Stones , VA . 1987 . The inuction by 239Pu of myeloid leukaemia and osteosarcoma in CBA mice . Int J Radiat Biol , 51 : 331 – 9 .

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