Ionising radiation and childhood leukaemia revisited

References

• Adkins, B., T. Williamson, P. Guevara, and Y. Bu. 2003. “Early Cell Murine Neonatal Lymphocytes Show Rapid Cycle Entry and Cell Division.” Journal of Immunology (Baltimore, MD: 1950) 170: 4548–4556.
   PubMed Web of Science ®Google Scholar
• Aurengo, A., D. Averbeck, A. Bonnin, B. Le Guen, R. Masse, R. Monier, M. Tubiana, A.-J. Valleron, and F. de Vathaire. 2005. Dose-Effect Relationships and Estimation of the Carcinogenic Effects of Low Doses of Ionizing Radiation. Académie des Sciences 2005; Académie Nationale de Médecine. Accessed 30 March 2005.
   Google Scholar
• Azzam, E. I., J. P. Jay-Gerin, and D. Pain. 2012. “Ionizing Radiation-Induced Metabolic Oxidative Stress and Prolonged Cell Injury.” Cancer Letters 327: 48–60. doi:10.1016/j.canlet.2011.12.012.
   PubMed Web of Science ®Google Scholar
• Bazyka, D., A. Prysyazhnyuk, N. Gudzenko, I. Dyagil, D. Belyi, V. Chumak, and V. Buzunov. 2018. “Epidemiology of Late Health Effects in Ukrainian Chornobyl Cleanup Workers.” Health Physics 115: 161–169. doi:10.1097/HP.0000000000000868.
   PubMed Web of Science ®Google Scholar
• Belkaid, Y., and T. Hand. 2014. “Role of the Microbiota in Immunity and Inflammation.” Cell 157: 121–141. doi:10.1016/j.cell.2014.03.040.
   PubMed Web of Science ®Google Scholar
• Bertell, R. 1998. Tuesday, 21 April. “Testimony before the Unites States Senate Committee on Veterans’ Affairs.” Accessed October 2018. http://www.ccnr.org/rosalie_testimony.html
   Google Scholar
• Bithell, J. F., M. F. G. Murphy, C. A. Stiller, E. Toumpakari, T. Vincent, and R. Wakeford. 2013. “Leukaemia in Young Children in the Vicinity of British Nuclear Power Plants: A Case–Control Study.” British Journal of Cancer 109: 2880–2885. doi:10.1038/bjc.2013.623.
   PubMed Web of Science ®Google Scholar
• Black, S. D. 1984. Investigation of the Possible Increased Incidence of Cancer in West Cumbria – Report of the Independent Advisory Group. HMSO London
   Google Scholar
• Blumenberg, L., and J. A. Skok. 2015. “RAG Off-Target Activity Is in the Loop.” Trends in Molecular Medicine 21: 733–735. doi:10.1016/j.molmed.2015.10.007.
   PubMed Web of Science ®Google Scholar
• Bohlander, S. K. 2005. “ETV6: A Versatile Player in Leukaemogenesis.” Seminars in Cancer Biology 15: 162–174. doi:10.1016/j.semcancer.2005.01.008.
   PubMed Web of Science ®Google Scholar
• Bull, M. J., and N. T. Plummer. 2014. “Part 1: The Human Gut Microbiome in Health and Disease.” Integrative Medicine 13: 17–22.
   Google Scholar
• Bunch, K. J., T. J. Vincent, R. J. Black, M. S. Pearce, R. J. McNally, P. A. McKinney, L. Parker, A. W. Craft, and M. F. Murphy. 2014. “Updated Investigations of Cancer Excesses in Individuals Born or Resident in the Vicinity of Sellafield and Dounreay.” British Journal of Cancer 111: 1814–1823. doi:10.1038/bjc.2014.348.
   PubMed Web of Science ®Google Scholar
• Cancer Research UK. 2010. Website Leukaemia Incidence. Accessed March 2018. https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/leukaemia/incidence
   Google Scholar
• C-H, P., and R. Mv. 2000. “Topoisomerase II Inhibitor‐Related Acute Myeloid Leukaemia.” British Journal of Haematology 109: 13–29.
   PubMed Web of Science ®Google Scholar
• Clavel, J., C. Sermage-Faure, S. Goujon-Bellec, J. Rudant, A. Guyot-Goubin, M. Chartier, D. Laurier, and D. Hemon. 2012. “Childhood Leukemia around French Nuclear Power Plants the Geocap Study, 2002–2007. Responses to Letters.” International Journal of Cancer. Journal International Du Cancer 131: 2974–2975. doi:10.1002/ijc.27592.
   Web of Science ®Google Scholar
• Committee on Medical Aspects of Radiation in the Environment (COMARE). 1986. First Report; Chairman, M Bobrow. The Implications of the New Data on the Releases from Sellafield in the 1950’s for the Conclusions of the Report on the Investigations of the Possible Increased Incidence of Cancer in West Cumbria.
   Google Scholar
• Committee on Medical Aspects of Radiation in the Environment (COMARE). 1996. Fourth Report; Chairman, BA Bridges. The Incidence of Cancer and Leukaemia in Young People in the Vicinity of the Sellafield site, West Cumbria: Further Studies and an Update of the Situation since the Report of the Black Advisory Group in 1984
   Google Scholar
• Committee on Medical Aspects of Radiation in the Environment (COMARE). 2005. 10th Report; Chairman, BA Bridges. The Incidence of Childhood Cancer Around Nuclear Installations in Great Britain.
   Google Scholar
• Committee on Medical Aspects of Radiation in the Environment (COMARE). 2011. 14th Report; Chairman, A.T.Elliott. Further Consideration of the Incidence of Childhood Leukaemia around Nuclear Power Plants in Great Britain.
   Google Scholar
• Committee on Medical Aspects of Radiation in the Environment (COMARE). 2016. 17th Report; Chairmen, A.T.Elliott and C.J.Gibson. Further Consideration of the Incidence of Cancers around the Nuclear Installations at Sellafield and Dounreay.
   Google Scholar
• Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilities-Phase I. 2012 Analysis of Cancer Risks in Populations near Nuclear Facilities: National Research Council Washington (DC): 2. Effluent Releases from Nuclear Power Plants and Fuel-Cycle Facilities. US: National Academies Press. https://www.ncbi.nlm.nih.gov/books/NBK201991/
   Google Scholar
• Cooke, J. V. 1942. “The Incidence of Acute Leukemia in Children.” JAMA 119: 547–550. doi:10.1001/jama.1942.02830240011004.
   Google Scholar
• Csinady, E., V. H. J. van der Velden, R. Joas, S. Fischer, J. F. de Vries, H. B. Beverloo, M. König, et al. 2009. “Chromosome 14 Copy Number-Dependent IGH Gene Rearrangement Patterns in High Hyperdiploid Childhood B-Cell Precursor ALL: Implications for Leukemia Biology and Minimal Residual Disease Analysis.” Leukemia 23: 870–876. doi:10.1038/leu.2008.390.
   PubMed Web of Science ®Google Scholar
• Darby, S. C., J. H. Olsen, R. Doll, B. Thakrar, P. N. Brown, H. H. Storm, L. Barlow, F. Langmark, L. Teppo, and H. Tuliniu. 1992. “Trends in Childhood Leukaemia in the Nordic Countries in Relation to Fallout from Atmospheric Nuclear Weapons Testing.” BMJ 304: 1005–1009.
   PubMedGoogle Scholar
• de Vries, E., S. de Bruin-Versteeg, W. M. Comans-Bitter, R. de Groot, W. C. J. Hop, G. J. M. Boerma, F. K. Lotgering, and J. J. M. van Dongen. 2000. “Longitudinal Survey of Lymphocyte Subpopulations in the First Year of Life.” Pediatric Research 47: 528–537. doi:10.1203/00006450-200004000-00019.
   PubMed Web of Science ®Google Scholar
• Dickinson, H. O., J. T. Hodgson, and L. Parker. 2003. “Comparison of HSE and Cumbrian Birth Cohort Studies of leukaemia/non-Hodgkin’s Lymphoma in Relation to Paternal Preconceptional Irradiation.” Journal of Radiological Protection 23: 385–403. doi:10.1088/0952-4746/23/4/003.
   PubMed Web of Science ®Google Scholar
• Dietert, R. R. 2009. “Developmental Immunotoxicity (DIT), Postnatal Immune Dysfunction and Childhood Leukemia.” Blood Cells, Molecules, and Diseases 42: 108–112. doi:10.1016/j.bcmd.2008.10.005.
   PubMed Web of Science ®Google Scholar
• Dockerty, J. D., B. Cox, and M. G. Cockburn. 1996. “Childhood Leukaemias in New Zealand: Time Trends and Ethnic Differences.” British Journal of Cancer 73: 1141–1147.
   PubMed Web of Science ®Google Scholar
• Draper, G. D., M. P. Little, T. Sorahan, L. J. Kinlen, K. J. Bunch, A. J. Conquest, G. M. Kendall, et al. 1997. “Cancer in the Offspring of Radiation Workers: A Record Linkage Study.” BMJ 315: 1181–1184.
   PubMed Web of Science ®Google Scholar
• Elahi, S., J. M. Ertelt, J. M. Kinder, T. T. Jiang, X. Zhang, L. Xin, V. Chaturvedi, et al. 2013. “Immunosuppressive CD71+ Erythroid Cells Compromise Neonatal Host Defence against Infection”. Nature 504: 158–162. doi:10.1038/nature12675.
   PubMed Web of Science ®Google Scholar
• Fairlie, I. 2014. “A Hypothesis to Explain Childhood Cancers near Nuclear Power Plants.” Journal of Environmental Radioactivity 133: 10–17. doi:10.1016/j.jenvrad.2013.07.024.
   PubMed Web of Science ®Google Scholar
• Fairlie, I., and A. Körblein. 2010. “Review of Epidemiology Studies of Childhood Leukemia near Nuclear Facilities: Commentary on Laurier et al.” Radiation Protection Dosimetry 138: 194–195. doi:10.1093/rpd/ncp246.
   PubMed Web of Science ®Google Scholar
• Fairlie, I., and A. Körblein. 2015. “Comment on ‘Updated Investigations of Cancer Excesses in Individuals Born or Resident in the Vicinity of Sellafield and Dounreay’: Premature All-Clear for Nuclear Power.” British Journal of Cancer 112: 1836–1837. doi:10.1038/bjc.2014.581.
   PubMed Web of Science ®Google Scholar
• Folley, J. H., W. Borges, and T. Yamawaki. 1952. “Incidence of Leukemia in Survivors of the Atomic Bomb in Hiroshima and Nagasaki, Japan.” The American Journal of Medicine 13: 311–321.
   PubMed Web of Science ®Google Scholar
• Fuxa, M., J. Skok, A. Souabni, G. Salvagiotto, E. Roldan, and M. Busslinger. 2004. “Pax5 Induces V-to-DJ Rearrangements and Locus Contraction of the Immunoglobulin Heavy-Chain Gene.” Genes & Development 18: 411–422. doi:10.1101/gad.291504.
   PubMed Web of Science ®Google Scholar
• Gardner, M. J. 1991. “Father’s Occupational Exposure to Radiation and the Raised Level of Childhood Leukemia near the Sellafield Nuclear Plant.” Environmental Health Perspectives 94: 5–7. doi:10.1289/ehp.94-1567974.
   PubMed Web of Science ®Google Scholar
• Greaves, M. F. 2018. “A Causal Mechanism for Childhood Acute Lymphoblastic Leukaemia.” NATURE Reviews Cancer 18 (8): 526. doi:10.1038/s41568-018-0029-0.
   PubMed Web of Science ®Google Scholar
• Greaves, M. F., A. T. Maia, J. L. Wiemels, and A. M. Ford. 2003. “Leukemia in Twins: Lessons in Natural History.” Blood 102: 2321–2333. doi:10.1182/blood-2002-12-3817.
   PubMed Web of Science ®Google Scholar
• Grosche, B., P. Kaatsch, B. Heinzow, and H. E. Wichmann. 2017. “The Krümmel (Germany) Childhood Leukaemia Cluster: A Review and Update.” Journal of Radiological Protection: Official Journal of the Society for Radiological Protection 37: R43–R58. doi:10.1088/1361-6498/aa8ce9.
   PubMed Web of Science ®Google Scholar
• Harley, N. H., and E. S. Robbins. 2009. “Radon and Leukemia in the Danish Study: Another Source of Dose.” Health Physics 97: 343–347. doi:10.1097/HP.0b013e3181ad8018.
   PubMed Web of Science ®Google Scholar
• Harrison, C. J., A. V. Moorman, C. Schwab, I. Iacobucci, and C. Mullighan. 2017. “Chapter 4. Cytogenetics and Molecular Genetics. In Childhood Acute Lymphoblastic Leukaemia, edited by A. Vora, 61–98. Switzerland: Springer International Publishing. ISBN 978-3-319-39707-8.
   Google Scholar
• Hemplemann, L. H. 1960. “Epidemiological Studies of Leukemia in Persons Exposed to Ionizing Radiation.” Cancer Research 20: 18–27.
   PubMed Web of Science ®Google Scholar
• Hewitt, D. 1955. “Some Features of Leukaemia Mortality.” British Journal of Preventive and Social Medicine 9: 81–88.
   PubMedGoogle Scholar
• Heylmann, D., F. Rödel, T. Kindler, and B. Kaina. 2014. “Radiation Sensitivity of Human and Murine Peripheral Blood Lymphocytes, Stem and Progenitor Cells.” Biochimica et biophysica acta 1846: 121–129.
   PubMed Web of Science ®Google Scholar
• Heyssel, R., A. B. Brill, A. Woodbury, E. T. Nishimura, T. Chose, T. Hoshino, and M. Yamasa. 1960. “Leukemia in Hiroshima Atomic Bomb Survivors.” Blood 60: 313–331.
   Google Scholar
• Hjalgrim, L. L., K. Rostgaard, K. Schmiegelow, S. Söderhäll, S. Kolmannskog, K. Vettenranta, J. Kristinsson, et al. 2003. “Age- and Sex-Specific Incidence of Childhood Leukemia by Immunophenotype in the Nordic Countries”. Journal of the National Cancer Institute 95: 1539–1544. doi:10.1093/jnci/djg064.
   PubMed Web of Science ®Google Scholar
• Horai, M., S. Satoh, M. Matsuo, M. Iwanaga, K. Horio, T. Jo, Y. Takasaki, et al. 2018. “Chromosomal Analysis of Myelodysplastic Syndromes among Atomic Bomb Survivors in Nagasaki”. British Journal of Haematology 80: 381–390. doi:10.1111/bjh.2018.180.issue-3.
   Google Scholar
• Inagaki, A., S. Schoenmakers, and W. M. Baarends. 2010. “DNA Double Strand Break Repair, Chromosome Synapsis and Transcriptional Silencing in Meiosis.” Epigenetics 5: 255–266.
   PubMed Web of Science ®Google Scholar
• Irving, J. 2017. “Chapter 3. Diagnostic Flow Cytometry and Immunophenotypic Classification. In Childhood Acute Lymphoblastic Leukaemia, edited by A. Vora, 49–59. Switzerland: Springer International Publishing. ISBN 978-3-319-39707-8.
   Google Scholar
• Javadekar, S. M., and S. C. Raghavan. 2015. “Snaps and Mends: DNA Breaks and Chromosomal Translocations.” FEBS Journal 282: 2627–2645. doi:10.1111/febs.13311.
   PubMed Web of Science ®Google Scholar
• Kaatsch, P., C. Spix, R. Schulze‐Rath, S. Schmiedel, and M. Blettner. 2008. “Leukaemia in Young Children Living in the Vicinity of German Nuclear Power Plants.” International Journal of Cancer 1220: 721–726. doi:10.1002/ijc.23330.
   Web of Science ®Google Scholar
• Katanoda, K., A. Shibata, T. Matsuda, M. Hori, K. Nakata, Y. Narita, C. Ogawa, W. Munakata, A. Kawai, and H. Nishimoto. 2017. “Childhood, Adolescent and Young Adult Cancer Incidence in Japan in 2009–2011.” Japanese Journal of Clinical Oncology 47: 762–771. doi:10.1093/jjco/hyx070.
   PubMed Web of Science ®Google Scholar
• Kendall, G. M., T. P. Fell, and J. D. Harrison. 2009. “Dose to Red Bone Marrow of Infants, Children and Adults from Radiation of Natural Origin.” Journal of Radiological Protection 29: 123–138. doi:10.1088/0952-4746/29/2/001.
   PubMed Web of Science ®Google Scholar
• Kinlen, L. 1988. “Evidence for an Infective Cause of Childhood Leukaemia: Comparison of a Scottish New Town with Nuclear Reprocessing Sites in Britain.” Lancet 332 (8624): 1323–1327. doi:10.1016/S0140-6736(88)90867-7.
   Google Scholar
• Kinlen, L. J. 1995. “Epidemiological Evidence for an Infective Basis in Childhood Leukaemia.” British Journal of Cancer 71 (1): 1–5.
   PubMed Web of Science ®Google Scholar
• Kinlen, L. J. 2012. “An Examination, with a Meta-Analysis, of Studies of Childhood Leukaemia in Relation to Population Mixing.” British Journal of Cancer 107 (7): 1163–1168. doi:10.1038/bjc.2012.402.
   PubMed Web of Science ®Google Scholar
• Kinlen, L. J., M. Dickson, and C. A. Stiller. 1995. “Childhood Leukaemia and non-Hodgkin’s Lymphoma near Large Rural Construction Sites, with a Comparison with Sellafield Nuclear Site.” BMJ 310: 763–768.
   PubMedGoogle Scholar
• Körblein, A., and I. Fairlie. 2012. “French Geocap Study Confirms Increased Leukemia Risks in Young Children near Nuclear Power Plants.” International Journal of Cancer 131: 2970–2971. doi:10.1002/ijc.27592.
   PubMed Web of Science ®Google Scholar
• Kroll, M. E., C. A. Stiller, M. F. G. Murphy, and L. M. Carpenter. 2011. “Childhood Leukaemia and Socioeconomic Status in England and Wales 1976–2005: Evidence of Higher Incidence in Relatively Affluent Communities Persists over Time.” British Journal of Cancer 105: 1783–1787. doi:10.1038/bjc.2011.415.
   PubMed Web of Science ®Google Scholar
• Laurier, D., and D. Bard. 1999. “Epidemiologic Studies of Leukemia among Persons under 25 Years of Age Living near Nuclear Sites.” Epidemiologic Reviews 21: 188–206. doi:10.1093/oxfordjournals.epirev.a017996.
   PubMed Web of Science ®Google Scholar
• Laurier, D., D. Hemon, and J. Clavel. 2008a. “Childhood Leukaemia Incidence below the Age of 5 Years near French Nuclear Power Plants.” Journal of Radiological Protection 28: 401–403. doi:10.1088/0952-4746/28/3/N01.
   PubMed Web of Science ®Google Scholar
• Laurier, D., S. Jacob, M. O. Bernier, K. Leuraud, C. Metz, E. Samson, and P. Laloi. 2008b. “Epidemiological Studies of Leukaemia in Children and Young Adults around Nuclear Facilities: A Critical Review.” Radiation Protection Dosimetry 132: 182–190. doi:10.1093/rpd/ncn262.
   PubMed Web of Science ®Google Scholar
• Laurier, D., S. Jacob, and P. Laloi. 2010. “Review of Epidemiology Studies of Childhood Leukaemia near Nuclear Facilities: Answer to the Commentary from Fairlie and Körblein.” Radiation Protection Dosimetry 138: 195–197. doi:10.1093/rpd/ncp247.
   Web of Science ®Google Scholar
• Leuraud, K., D. B. Richardson, E. Cardis, R. D. Daniels, M. Gillies, J. A. O’Hagan, G. B. Hamra, et al. 2015. “Ionising Radiation and Risk of Death from Leukaemia and Lymphoma in Radiation-Monitored Workers (INWORKS): An International Cohort Study.” Lancet Haematology 2: e276–281. doi:10.1016/S2352-3026(15)00094-0.
   PubMed Web of Science ®Google Scholar
• Lin, S., R. T. Luo, A. Ptasinska, J. Kerry, S. A. Assi, M. Wunderlich, T. Imamura, et al. 2016. “Instructive Role of MLL-Fusion Proteins Revealed by a Model of T(4;11) Pro-B Acute Lymphoblastic Leukemia”. Cancer Cell 30: 737–749. doi:10.1016/j.ccell.2016.10.008.
   PubMed Web of Science ®Google Scholar
• Linka, Y., S. Ginzel, M. Krüger, A. Novosel, M. Gombert, E. Kremmer, J. Harbott, et al. 2013. “The Impact of TEL-AML1 (ETV6-RUNX1) Expression in Precursor B Cells and Implications for Leukaemia Using Three Different Genome-Wide Screening Methods”. Blood Cancer Journal 3: e151. doi:10.1038/bcj.2013.48.
   PubMed Web of Science ®Google Scholar
• Little, M. P., D. Kwon, K. Doi, S. L. Simon, D. L. Preston, M. M. Doody, T. Lee, et al. 2014. “Association of Chromosome Translocation Rate with Low Dose Occupational Radiation Exposures in U.S. Radiologic Technologists.” Radiation Research 182: 1–17. doi:10.1667/RR13413.1.
   PubMed Web of Science ®Google Scholar
• March, H. C. 1944. “Leukemia in Radiologists.” Radiology 43: 275–278. doi:10.1148/43.3.275.
   Google Scholar
• Market, E., and F. N. Papavasiliou. 2003. “V(D)J Recombination and the Evolution of the Adaptive Immune System.” PLoS Biology. Published13 October 2003. doi:10.1371/journal.pbio.0000016.
   PubMed Web of Science ®Google Scholar
• Martin-Lorenzo, A., J. Hauer, C. Vicente-Duenas, F. Auer, I. Gonzalez-Herrero, I. Garcia-Ramirez, S. Ginzel, et al. 2015. “Infection Exposure Is a Causal Factor in B-Cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5 -Inherited Susceptibility.” Cancer Discovery 5: 1328–1343. doi:10.1158/2159-8290.CD-15-0892.
   PubMed Web of Science ®Google Scholar
• Mateos, M. K., D. Barbaric, S.-A. Byatt, R. Sutton, and G. M. Marshall. 2015. “Down Syndrome and Leukemia: Insights into Leukemogenesis and Translational Targets.” Translational Pediatrics 4: 76–92.
   Google Scholar
• Matsuoka, S., B. A. Ballif, A. Smogorzewska, E. R. McDonald, K. E. Hurov, J. Luo, C. E. Bakalarski, et al. 2007. “ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage.” Science 316: 1160–1166. doi:10.1126/science.1140321.
   PubMed Web of Science ®Google Scholar
• McLaughlin, J. R., E. A. Clarke, T. W. Anderson, and W. King (1992). Occupational Exposure of Fathers to Ionizing radiation and the Risk of Leukaemia in Offspring (INFO–0424). Canada Ottowa: Atomic Energy Control Board 1992. (AECB project No 7.157.1.)
   Google Scholar
• McWilliams, L., K.-Y. Su, X. Liang, D. Liao, S. Floyd, J. Amos, M. A. Moody, G. Kelsoe, and M. Kuraoka. 2013. “The Human Fetal Lymphocyte Lineage: Identification by CD27 and LIN28B Expression in B Cell Progenitor.” Journal of Leukocyte Biology 94: 991–1001. doi:10.1189/jlb.1212619.
   PubMed Web of Science ®Google Scholar
• Medvedovic, J., A. Ebert, H. Tagoh, and M. Busslinger. 2011. “Pax5: A Master Regulator of B Cell Development and Leukemogenesis.” Advances in Immunology 111: 179–206. doi:10.1016/B978-0-12-385991-4.00005-2.
   PubMed Web of Science ®Google Scholar
• Mehta, A., and J. E. Haber. 2014. “Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair.” Cold Spring Harbor Perspectives Biology 6: a016428. doi:10.1101/cshperspect.a016428.
   PubMed Web of Science ®Google Scholar
• Melo, J. V. 1996. “The Molecular Biology of Chronic Myeloid Leukaemia.” Leukemia 10: 751–756.
   PubMed Web of Science ®Google Scholar
• Metayer, C., L. Zhang, J. L. Wiemels, K. Bartley, J. Schiffman, X. Ma, M. C. Aldrich, et al. 2013. “Tobacco Smoke Exposure and the Risk of Childhood Acute Lymphoblastic and Myeloid Leukemias by Cytogenetic Subtype.” Cancer Epidemiol Biomarkers and Prevention 22: 1600–1611. doi:10.1158/1055-9965.EPI-13-0350.
   PubMed Web of Science ®Google Scholar
• Milne, E., K. R. Greenop, R. J. Scott, H. D. Bailey, J. Attia, L. Dalla-Pozza, N. H. de Klerk, and B. K. Armstrong. 2012. “Parental Prenatal Smoking and Risk of Childhood Acute Lymphoblastic Leukemia.” American Journal of Epidemiology 175: 43–53. doi:10.1093/aje/kwr275.
   PubMed Web of Science ®Google Scholar
• Moppett, J., and R. Dommett. 2017. “Chapter 2. Clinical Presentation and Prognostic Factors.” In Childhood Acute Lymphoblastic Leukaemia, edited by A. Vora, 29–48. Switzerland: Springer International Publishing. ISBN 978-3-319-39707-8.
   Google Scholar
• Mori, H., S. M. Colman, Z. Xiao, A. M. Ford, L. E. Healy, C. Donaldson, J. M. Hows, et al. 2002. “Chromosome Translocations and Covert Leukemic Clones are Generated during Normal Fetal Development.” Proceedings of the National Academy of Sciences USA 99: 8242–8247. doi:10.1073/pnas.112218799.
   PubMed Web of Science ®Google Scholar
• Moriyama, T., M. L. Metzger, G. Wu, R. Nishii, M. Qian, M. Devidas, W. Yang, et al. 2015. “Germline Genetic Variation in ETV6 and Risk of Childhood Acute Lymphoblastic Leukaemia: A Systematic Genetic Study.” The Lancet Oncology 16: 1659–1666. doi:10.1016/S1470-2045(15)00369-1.
   PubMed Web of Science ®Google Scholar
• Motea, E. A., and A. J. Berdis. 2010. “Terminal Deoxynucleotidyl Transferase: The Story of a Misguided DNA Polymerase.” Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics 1804: 1151–1166. doi:10.1016/j.bbapap.2009.06.030.
   PubMed Web of Science ®Google Scholar
• Mueller, M. A. W., and C. Gilham. 2015. “Childhood Leukemia and Proximity to Nuclear Power Plants: A Systematic Review and Meta-Analysis.” Journal of Cancer Policy 6: 44–56. doi:10.1016/j.jcpo.2015.10.003.
   Web of Science ®Google Scholar
• Murphy, K., and C. Weaver. 2017. Janeway’s Immunobiology. 9th ed. New York, NY: Garland Science/Taylor & Francis Group, LLC. 3 Park Square, Milton Park, Abingdon, OX14 4RN, UK.
   Google Scholar
• NCBI Resources. 2018. https://www.ncbi.nlm.nih.gov/gene/5079
   Google Scholar
• Nussenzweig, A., and M. C. Nussenzweig. 2010. “Origin of Chromosomal Translocations in Lymphoid Cancer.” Cell 141: 27–38. doi:10.1016/j.cell.2010.03.016.
   PubMed Web of Science ®Google Scholar
• Nutt, S. L., B. Heavey, A. G. Rolink, and M. Busslinger. 1999. “Commitment to the B-Lymphoid Lineage Depends on the Transcription Factor Pax.5.” Nature 401: 556–562. doi:10.1038/44076.
   PubMed Web of Science ®Google Scholar
• Okada, H., C. Kuhn, H. Feillet, and J.-F. Bach. 2010. “The ‘Hygiene Hypothesis’ for Autoimmune and Allergic Diseases: An Update.” Clinical and Experimental Immunology 160: 1–9. doi:10.1111/j.1365-2249.2010.04139.x.
   PubMed Web of Science ®Google Scholar
• Papaemmanuil, E., I. Rapado, Y. Li, N. E. Potter, D. C. Wedge, J. Tubio, L. B. Alexandrov, et al. 2014. “RAG-mediated Recombination Is the Predominant Driver of Oncogenic Rearrangement in ETV6-RUNX1 Acute Lymphoblastic Leukemia”. Nature Genetics 46: 116–125. doi:10.1038/ng.2874.
   PubMed Web of Science ®Google Scholar
• Parkin, D. M., L. Boyd, and L. C. Walker. 2011. “The Fraction of Cancer Attributable to Lifestyle and Environmental Factors in the UK in 2010.” British Journal of Cancer 105: S77–S81. doi:10.1038/bjc.2011.489.
   PubMed Web of Science ®Google Scholar
• Parkin, D. M., and S. C. Darby. 2011. “Cancers in 2010 Attributable to Ionising Radiation Exposure in the UK.” British Journal of Cancer 105: S57– S65. doi:10.1038/bjc.2011.485.
   PubMed Web of Science ®Google Scholar
• Patterson, W. C. 1978. “The Windscale Report – A Nuclear Apologia.” Bulletin Atomic Scientists 34: 43–49. doi:10.1080/00963402.1978.11458522.
   Web of Science ®Google Scholar
• Pearce, M. S., J. A. Salotti, M. P. Little, K. McHugh, C. Lee, K. P. Kim, N. L. Howe, et al. 2012. “Radiation Exposure from CT Scans in Childhood and Subsequent Risk of Leukaemia and Brain Tumours: A Retrospective Cohort Study.” Lancet 380: 499–505. doi:10.1016/S0140-6736(12)60815-0.
   PubMed Web of Science ®Google Scholar
• Preston Martin, S., and J. M. Pogoda. 2003. “Estimation of Radiographic Doses in a Case Control Study of Acute Myelogenous Leukemia.” Health Physics 84: 245–259.
   PubMed Web of Science ®Google Scholar
• Ran, D., W.-J. Shia, M.-C. Lo, J.-B. Fan, D. A. Knorr, P. I. Ferrell, Z. Ye, et al. 2013. “RUNX1a Enhances Hematopoietic Lineage Commitment from Human Embryonic Stem Cells and Inducible Pluripotent Stem Cells”. Blood 121: 2882–2890. doi:10.1182/blood-2012-08-451641.
   PubMed Web of Science ®Google Scholar
• Reisz, J. A., N. Bansal, J. Qian, W. Zhao, and C. M. Furdui. 2014. “Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection.” Antioxidants & Redox Signaling 21: 260–292. doi:10.1089/ars.2013.5489.
   PubMed Web of Science ®Google Scholar
• Richardson, D. B., E. Cardis, R. D. Daniels, M. Gillies, J. A. O’Hagan, G. B. Hamra, and R. Haylock, et al. 2015. “Risk of Cancer from Occupational Exposure to Ionising Radiation: Retrospective Cohort Study of Workers in France, and the United Kingdom, and the United States (INWORKS). BMJ 351: h53–59. doi:10.1136/bmj.h5359.
   Google Scholar
• Rjq, M., K. J. Bunch, A. W. Craft, and M. F. G. Murphy. 2015. “Response To: Comment on ’Updated Investigations of Cancer Excesses in Individuals Born or Resident in the Vicinity of Sellafield and Dounreay’.” British Journal of Cancer 112: 1837. doi:10.1038/bjc.2014.582.
   PubMed Web of Science ®Google Scholar
• Rodríguez-Hernandez, G., J. Hauer, A. Martín-Lorenzo, A. Borkhardt, C. Bartenhagen, I. García-Ramírez, F. Auer, et al. 2017. “Infection Exposure Promotes ETV6-RUNX1 Precursor B-Cell Leukemia via Impaired H3K4 Demethylases”. Cancer Research 77: 4365–4377. doi:10.1158/0008-5472.CAN-17-0701.
   PubMed Web of Science ®Google Scholar
• Rook, G. A., C. L. Raison, and C. A. Lowry. 2014. “Microbial ‘Old Friends’, Immunoregulation and Socioeconomic Status.” Clinical and Experimental Immunology 177: 1–12. doi:10.1111/cei.12269.
   PubMed Web of Science ®Google Scholar
• Rudant, J., L. Orsi, F. Menegaux, A. Petit, A. Baruchel, Y. Bertrand, A. Lambilliotte, A. Robert, G. Michel, and G. Margueritte. 2010. “Childhood Acute Leukemia, Early Common Infections, and Allergy: The ESCALE Study.” American Journal of Epidemiology 172: 1015–1027. doi:10.1093/aje/kwq233.
   PubMed Web of Science ®Google Scholar
• Sadofsky, M. J. 2001. “The RAG Proteins in V(D)J Recombination: More than Just a Nuclease.” Nucleic Acids Research 29: 1399–1409. doi:10.1093/nar/29.7.1399.
   PubMed Web of Science ®Google Scholar
• Schipler, A., V. Mladenova, A. Soni, V. Nikolov, J. Saha, E. Mladenov, and G. Iliakis. 2016. “Chromosome Thripsis by DNA Double Strand Break Clusters Causes Enhanced Cell Lethality, Chromosomal Translocations and 53bp1-Recruitment.” Nucleic Acids Research 44: 7673–7690. doi:10.1093/nar/gkw487.
   PubMed Web of Science ®Google Scholar
• Sermage-Faure, C., D. Laurier, S. Goujon-Bellec, M. Chartier, A. Guyot-Goubin, J. Rudant, D. Hémon, and J. Clavel. 2012. “Childhood Leukemia around French Nuclear Power Plants – The Geocap Study, 2002–2007.” International Journal of Cancer 131: 2970–2971. doi:10.1002/ijc.27592.
   PubMed Web of Science ®Google Scholar
• Sharma, V., L. B. Collins, T.-H. Chen, N. Herr, S. Takeda, W. Sun, J. A. Swenberg, and J. Nakamura. 2016. “Oxidative Stress at Low Levels Can Induce Clustered DNA Lesions Leading to NHEJ Mediated Mutations.” Oncotarget 18: 25377–25390.
   Google Scholar
• Sigurdson, A. J., P. Bhatti, D. L. Preston, M. M. Doody, D. Kampa, B. H. Alexander, D. Petibone, et al. 2008. “Routine Diagnostic X-Ray Examinations and Increased Frequency of Chromosome Translocations among US Radiologic Technologists.” Cancer Research 68: 8825–8831. doi:10.1158/0008-5472.CAN-08-1691.
   PubMed Web of Science ®Google Scholar
• Sigurdson, A. J., M. Ha, H. Hauptmann, P. Bhatti, R. J. Sram, O. Beskid, E. J. Tawn, et al. 2008. “International Study of Factors Affecting Human Chromosome Translocations”. Mutation Research 652: 112–121. doi:10.1016/j.mrgentox.2008.01.005.
   PubMed Web of Science ®Google Scholar
• Simon, A. K., G. A. Hollander, and A. McMichael. 2015. “Evolution of the Immune System in Humans from Infancy to Old Age.” Proceedings of the Royal Society B 282: 20143085. doi:10.1098/rspb.2014.3085.
   PubMed Web of Science ®Google Scholar
• Smith, M. A., R. Simon, H. D. Strickler, G. McQuillan, L. A. Gloeckler Ries, and M. S. Linet. 1998. “Evidence that Childhood Acute Lymphoblastic Leukemia Is Associated with an Infectious Agent Linked to Hygiene Conditions.” Cancer Causes & Control : CCC 9: 285–298.
   PubMed Web of Science ®Google Scholar
• Studd, J. B., J. Vijayakrishnan, M. Yang, G. Migliorini, K. Paulsson, and R. S. Houlston. 2017. “Genetic and Regulatory Mechanism of Susceptibility to High-Hyperdiploid Acute Lymphoblastic Leukaemia at 10p21.2.” Nature Communications 8: 14616. doi:10.1038/ncomms14616.
   PubMed Web of Science ®Google Scholar
• Sun, C., L. Chang, and X. Zhu. 2017. “Pathogenesis of ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia and Mechanisms Underlying Its Relapse.” Oncotarget 8: 35445–35459.
   PubMedGoogle Scholar
• Swaminathan, S., L. Klemm, E. Park, E. Papaemmanuil, A. Ford, S.-M. Kweon, D. Trageser, et al. 2015. “Mechanisms of Clonal Evolution in Childhood Acute Lymphoblastic Leukemia.” Nature Immunology 16: 766–774. doi:10.1038/ni.3160.
   PubMed Web of Science ®Google Scholar
• Teng, G., Y. Maman, W. Resch, L. G. Cowell, R. Casellas, and D. G. Schatz. 2015. “RAG Represents a Widespread Threat to the Lymphocyte Genome.” Cell 162: 751–765. doi:10.1016/j.cell.2015.07.009.
   PubMed Web of Science ®Google Scholar
• Teppo, S., S. Laukkanen, T. Liuksiala, J. Nordlund, M. Oittinen, K. Teittinen, T. Grönroos, et al. 2016. “Genome-Wide Repression of eRNA and Target Gene Loci by the ETV6-RUNX1 Fusion in Acute Leukemia”. Genome Research 26: 1468–1477. doi:10.1101/gr.193649.115.
   PubMed Web of Science ®Google Scholar
• Tubbs, A., and A. Nussenzweig. 2017. “Endogenous DNA Damage as a Source of Genomic Instability in Cancer.” Cell 168: 644–656. doi:10.1016/j.cell.2017.01.002.
   PubMed Web of Science ®Google Scholar
• Tulstrup, M., U. K. Stoltze, K. Schmiegelow, and J. J. Yang. 2017. “Chapter 1. Epidemiology and Etiology of Childhood ALL. In Childhood Acute Lymphoblastic Leukaemia, edited by A. Vora, 1–27. Switzerland: Springer International Publishing. ISBN 978-3-319-39707-8.
   Google Scholar
• UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation). 2000. Sources and Effects of Ionizing Radiation. UNSCEAR 2000 Report to the Assembly, General, with Scientific Annexes. Volume 1, Sources. New York, NY: United Nations.
   Google Scholar
• UNSCEAR. 2008. “Sources and Effects of Ionizing Radiation.” Report to the General Assembly, with Scientific Annexes United Nations, New York, 2010 Volume I. http://www.unscear.org/docs/reports/2008/09-86753_Report_2008_GA_Report.pdf
   Google Scholar
• Wakeford, R. 2002. “Cancer in Offspring after Paternal Preconceptional Irradiation.” Journal of Radiological Protection 22: 191–194. doi:10.1088/0952-4746/22/2/602.
   PubMedGoogle Scholar
• Wakeford, R. 2013. “The Risk of Childhood Leukaemia Following Exposure to Ionising Radiation – A Review.” Journal of Radiological Protection 33: 1–25. doi:10.1088/0952-4746/33/1/1.
   PubMed Web of Science ®Google Scholar
• Wakeford, R. 2014. “The Risk of Leukaemia in Young Children from Exposure to Tritium and Carbon-14 in the Discharges of German Nuclear Power Stations and in the Fallout from Atmospheric Nuclear Weapons Testing.” Radiation and Environmental Biophysics 53: 365–379. doi:10.1007/s00411-014-0516-y.
   PubMed Web of Science ®Google Scholar
• Wakeford, R., G. M. Kendall, and M. P. Little. 2009. “The Proportion of Childhood Leukaemia Incidence in Great Britain that May Be Caused by Natural Background Ionizing Radiation.” Leukemia 23: 770–776. doi:10.1038/leu.2008.342.
   PubMed Web of Science ®Google Scholar