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Original Articles

Cardiac autonomic tone, plasma BDNF levels and paroxetine response in newly diagnosed patients of generalised anxiety disorder

, , , &
Pages 135-142 | Received 07 Jun 2019, Accepted 24 Jan 2020, Published online: 05 Feb 2020

References

  • Bakhla AK, Verma V, Hembram M, Praharaj SK, Sinha VK. 2013. Internal consistency and factor structure of 12-item general health questionnaire in visually impaired students. Ind Psychiatry J. 22(2):109–113. doi:10.4103/0972-6748.132918
  • Ball S, Marangell LB, Lipsius S, Russell JM. 2013. Brain-derived neurotrophic factor in generalized anxiety disorder: results from a duloxetine clinical trial. Prog Neuropsychopharmacol Biol Psychiatry. 43:217–221. doi:10.1016/j.pnpbp.2013.01.002
  • Bandelow B, Baldwin D, Abelli M, Bolea-Alamanac B, Bourin M, Chamberlain SR, Cinosi E, Davies S, Domschke K, Fineberg N, et al. 2017. Biological markers for anxiety disorders, OCD and PTSD: a consensus statement. Part II: neurochemistry, neurophysiology and neurocognition. World J Biol Psychiatry. 18(3):162–214. doi:10.1080/15622975.2016.1190867
  • Bus BAA, Molendijk ML, Penninx BJWH, Buitelaar JK, Kenis G, Prickaerts J, Elzinga BM, Voshaar RCO. 2011. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology. 36(2):228–239. doi:10.1016/j.psyneuen.2010.07.013
  • Bus BA, Molendijk ML, Tendolkar I, Penninx BW, Prickaerts J, Elzinga BM, Voshaar RC. 2015. Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time. Mol Psychiatry. 20(5):602–608. doi:10.1038/mp.2014.83
  • Calabrese F, Molteni R, Cattaneo A, Macchi F, Racagni G, Gennarelli M, Ellenbroek BA, Riva MA. 2010. Long-term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Mol Pharmacol. 77(5):846–853. doi:10.1124/mol.109.063081
  • Carbone DL, Handa RJ. 2013. Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor. Neurosci. 239:295–303. doi:10.1016/j.neuroscience.2012.10.073
  • Carlino D, Francavilla R, Baj G, Kulak K, d’Adamo P, Ulivi S, Cappellani S, Gasparini P, Tongiorgi E. 2015. Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism. Peer J. 3:e1252–26539329. doi:10.7717/peerj.1252
  • Chalmers JA, Quintana DS, Abbott M-A, Kemp AH. 2014. Anxiety disorders are associated with reduced heart rate variability: a meta-analysis. Front Psychiatry. 5:80. doi:10.3389/fpsyt.2014.00080
  • Chang HA, Chang CC, Tzeng NS, Kuo TBJ, Lu RB, Huang SY. 2013. Generalized anxiety Disorder, comorbid major depression and heart rate variability: a case-control study in Taiwan. Psychiatry Investig. 10(4):326–335. doi:10.4306/pi.2013.10.4.326
  • Duman RS, Monteggia LM. 2006. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 59(12):1116–1127. doi:10.1016/j.biopsych.2006.02.013
  • Friedman BH. 2007. An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone. Biol Psychol. 74(2):185–199. doi:10.1016/j.biopsycho.2005.08.009
  • Golderberg D, Williams P. 1988. A user’s guide to the General Health questionnaire. Windsor, UK: NFER-Nelson.
  • Guy W, editor. 1976. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: US Department of Health, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration.
  • Hamilton M. 1959. The assessment of anxiety states by rating. Br J Med Psychol. 32(1):50–55. doi:10.1111/j.2044-8341.1959.tb00467.x
  • Hammel JC, Smitherman TA, McGlynn FD, Mulfinger AMM, Lazarte AA, Gothard KD. 2011. Vagal influence during worry and cognitive challenge. Anxiety Stress Coping. 24(2):121–136. doi:10.1080/10615806.2010.490912
  • Janszky I, Ahnve S, Lundberg I, Hemmingsson T. 2010. Early-onset depression, anxiety, and risk of subsequent coronary heart disease: 37-year follow-up of 49,321 young Swedish men. J Am Coll Cardiol. 56(1):31–37. doi:10.1016/j.jacc.2010.03.033
  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. 2005. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 62(6):593–602. doi:10.1001/archpsyc.62.6.593
  • Kim K, Lee S, Kim JH. 2016. Diminished autonomic neurocardiac function in patients with generalized anxiety disorder. NDT. 12:3111–3118. doi:10.2147/NDT.S121533
  • Kollai M, Kollai B. 1992. Cardiac vagal tone in generalised anxiety disorder. Br J Psychiatry. 161(6):831–835. doi:10.1192/bjp.161.6.831
  • Licht CM, de Geus EJ, van Dyck R, Penninx BW. 2009. Association between anxiety disorders and heart rate variability in the Netherlands study of depression and anxiety (NESDA). Psychosom Med. 71(5):508–518. doi:10.1097/PSY.0b013e3181a292a6
  • Lyonfields JD, Borkovec TD, Thayer JF. 1995. Vagal tone in generalized anxiety disorder and the effects of aversive imagery and worrisome thinking. Behav Ther. 26(3):457–466. doi:10.1016/S0005-7894(05)80094-2
  • Molendijk ML, Bus BAA, Spinhoven P, Penninx BWJH, Kenis G, Prickaerts J, Voshaar RO, Elzinga BM. 2011. Serum levels of brain-derived neurotrophic factor in major depressive disorder: State-trait issues, clinical features and pharmacological treatment. Mol Psychiatry. 16(11):1088–1095. doi:10.1038/mp.2010.98
  • Molendijk ML, Bus BAA, Spinhoven P, Penninx BWJH, Prickaerts J, Oude Voshaar RC, Elzinga BM. 2012. Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety. World J Biol Psychiatry. 13(7):535–543. doi:10.3109/15622975.2011.587892
  • Newman M, et al. 2013. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC: American Psychiatric Association.
  • Ouakinin SR. 2016. Anxiety as a risk factor for cardiovascular diseases. Front Psychiatry. 7:25. doi:10.3389/fpsyt.2016.00025
  • Pallanti S, Tofani T, Zanardelli M, Di Cesare Mannelli L, Ghelardini C. 2014. BDNF and Artemin are increased in drug-naïve non-depressed GAD patients: preliminary data. Int J Psychiatry Clin Pract. 18(4):255–60. doi:10.3109/13651501.2014.940051
  • Pittig A, Arch JJ, Lam CWR, Craske MG. 2013. Heart rate and heart rate variability in panic, social anxiety, obsessive-compulsive, and generalized anxiety disorders at baseline and in response to relaxation and hyperventilation. Int J Psychophysiol. 87(1):19–27. doi:10.1016/j.ijpsycho.2012.10.012
  • Ranjbar F, Akbarzadeh F, Zakeri F, Farahbakhsh M, Ali Nazari M. 2015. citalopram on heart rate variability in women with generalized anxiety disorder. ARYA Atheroscler. 11(3):196–203.
  • Remes O, Brayne C, van der Linde R, Lafortune L. 2016. A systematic review of reviews on the prevalence of anxiety disorders in adult populations. Brain Behav. 6(7):e00497–27458547. doi:10.1002/brb3.497
  • Roest AM, Martens EJ, de Jonge P, Denollet J. 2010. Anxiety and risk of incident coronary heart disease. J Am Coll Cardiol. 56(1):38–46. doi:10.1016/j.jacc.2010.03.034
  • Shinba T. 2017. Major depressive disorder and generalized anxiety disorder show different autonomic dysregulations revealed by heart-rate variability analysis in first-onset drug-naïve patients without comorbidity. Psychiatry Clin Neurosci. 71(2):135–145. doi:10.1111/pcn.12494
  • Smith MA, Makino S, Kvetnansky R, Post RM. 1995. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 15(3):1768–1777. doi:10.1523/JNEUROSCI.15-03-01768.1995
  • Suliman S, Hemmings SMJ, Seedat S. 2013. Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Front Integr Neurosci. 7:55. doi:10.3389/fnint.2013.00055
  • Sztajzel J. 2004. Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly. 134(35–36):514–522.
  • Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. 1996. Circulation. 93(5):1043–1065. doi:10.1161/01.CIR.93.5.1043
  • Thayer JF. 2007. What the heart says to the brain (and vice versa) and why we should listen. Psychol Top. 16:241–250.
  • Thayer JF, Friedman BH, Borkovec TD. 1996. Automatic characteristics of generalized anxiety disorder and worry. Biol Psychiatry. 39(4):255–266. doi:10.1016/0006-3223(95)00136-0
  • van Zyl LT, Hasegawa T, Nagata K. 2008. Effects of antidepressant treatment on heart rate variability in major depression: A quantitative review. Biopsychosoc Med. 2:12. doi:10.1186/1751-0759-2-12
  • Rg W, Manual A. 2003. Clinical Global Impression (CGI). Assessment. 1:125–126.
  • Wang Y, Zhang H, Li Y, Wang Z, Fan Q, Yu S, Lin Z, Xiao Z. 2015. BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder. J Affect Disord. 186:7–12. doi:10.1016/j.jad.2015.07.023

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