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Review Articles

The effects of selective serotonin reuptake inhibitors on male and female fertility: a brief literature review

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Pages 43-49 | Received 14 Sep 2020, Accepted 02 Jan 2021, Published online: 22 Jan 2021

References

  • Aisenberg Romano G, Fried Zaig I, Halevy A, Azem F, Amit A, Bloch M. 2019. Prophylactic SSRI treatment for women suffering from mood and anxiety symptoms undergoing in vitro fertilization-a prospective placebo-controlled study. Arch Womens Ment Health. 22(4):503–510.
  • Akasheh G, Sirati L, Noshad Kamran AR, Sepehrmanesh Z. 2014. Comparison of the effect of sertraline with behavioral therapy on semen parameters in men with primary premature ejaculation. Urology. 83(4):800–804.
  • Alzahrani HA. 2012. Sister chromatid exchanges and sperm abnormalities produced by antidepressant drug fluoxetine in mouse treated in vivo. Eur Rev Med Pharmacol Sci. 16(15):2154–2161.
  • Baillie HS, Pacey AA, Warren MA, Scudamore IW, Barratt CL. 1997. Greater numbers of human spermatozoa associate with endosalpingeal cells derived from the isthmus compared with those from the ampulla. Hum Reprod. 12(9):1985–1992.
  • Bala A, Nguyen HMT, Hellstrom WJG. 2018. Post-SSRI sexual dysfunction: a literature review. Sex Med Rev. 6(1):29–34.
  • Bataineh HN, Daradka T. 2007. Effects of long-term use of fluoxetine on fertility parameters in adult male rats. Neuro Endocrinol Lett. 28(3):321–325.
  • Berger MH, Messore M, Pastuszak AW, Ramasamy R. 2016. Association between infertility and sexual dysfunction in men and women. Sex Med Rev. 4(4):353–365.
  • Bezerra MS, Martins ABM, Trajano FMG, Pontes T. H d A, Gomes L. T d C, Gavioli EC, Silva Junior E. D d. 2019. Fluoxetine and sertraline effects on rat distal cauda epididymis contraction, sperm count and sperm transit time trough epididymis. Eur J Pharmacol. 865:172774.
  • Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM. 1999. Sexual functioning in depressed outpatients taking mirtazapine. Depress Anxiety. 9(4):175–179.
  • Câmara ML, Almeida TB, de Santi F, Rodrigues BM, Cerri PS, Beltrame FL, Sasso-Cerri E. 2019. Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death? Biomed Pharmacother. 109:1126–1139.
  • Casilla-Lennon MM, Meltzer-Brody S, Steiner AZ. 2016. The effect of antidepressants on fertility. Am J Obstet Gynecol. 215(3):314.e1–314.e3145.
  • Cavariani MM, de Almeida Kiguti LR, de Lima Rosa J, de Araújo Leite GA, Silva PVE, Pupo AS, De Grava Kempinas W. 2015. Bupropion treatment increases epididymal contractility and impairs sperm quality with no effects on the epididymal sperm transit time of male rats. J Appl Toxicol. 35(9):1007–1016.
  • Csemiczky G, Landgren BM, Collins A. 2000. The influence of stress and state anxiety on the outcome of IVF-treatment: psychological and endocrinological assessment of Swedish women entering IVF-treatment. Acta Obstet Gynecol Scand. 79(2):113–118.
  • Domar AD, Moragianni VA, Ryley DA, Urato AC. 2013. The risks of selective serotonin reuptake inhibitor use in infertile women: a review of the impact on fertility, pregnancy, neonatal health and beyond. Hum Reprod. 28(1):160–171.
  • Downing SJ, Tay JI, Maguiness SD, Watson A, Leese HJ. 2002. Effect of inflammatory mediators on the physiology of the human Fallopian tube. Hum Fertil. 5(2):54–60.
  • Ekerhovd E, Norström A. 2004. Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of fallopian tube contractility. Gynecol Endocrinol. 19(5):239–246.
  • Elnazer HY, Baldwin DS. 2014. Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review. Acta Neuropsychiatr. 26(2):125–129.
  • Ferguson JM. 2001. SSRI antidepressant medications: adverse effects and tolerability. Prim Care Companion J Clin Psychiatry. 3(1):22–27.
  • Fitzgerald KT, Bronstein AC. 2013. Selective serotonin reuptake inhibitor exposure. Top Companion Anim Med. 28(1):13–17.
  • Friedman BE, Rogers JL, Shahine LK, Westphal LM, Lathi RB. 2009. Effect of selective serotonin reuptake inhibitors on in vitro fertilization outcome. Fertil Steril. 92(4):1312–1314.
  • Healy D, Le Noury J, Mangin D. 2019. Post-SSRI sexual dysfunction: patient experiences of engagement with healthcare professionals. Int J Risk Saf Med. 30(3):167–178.
  • Hermanny A, Bahamondes MV, Fazano F, Marchi NM, Ortiz ME, Genghini MHRR, Croxatto HB, Bahamondes L. 2012. In vitro assessment of some sperm function following exposure to levonorgestrel in human fallopian tubes. Reprod Biol Endocrinol. 10:8.
  • Hernandez-Nieto C, Lee J, Nazem T, Gounko D, Copperman A, Sandler B. 2017. Embryo aneuploidy is not impacted by selective serotonin reuptake inhibitor exposure. Fertil Steril. 108(6):973–979.
  • Huang I, Jones J, Khorram O. 2006. Human seminal plasma nitric oxide: correlation with sperm morphology and testosterone. Med Sci Monit. 12(3):CR103–CR106.
  • Ickowicz D, Finkelstein M, Breitbart H. 2012. Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases. Asian J Androl. 14(6):816–821.
  • Jasović V, Jasović-Siveska E. 2012. Success rate of intrauterine insemination in patients with unknown infertility. Vojnosanit Pregl. 69(4):301–307.
  • Jing E, Straw-Wilson K. 2016. Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: A narrative literature review. Ment Health Clin. 6(4):191–196.
  • Kennedy SH, Eisfeld BS, Dickens SE, Bacchiochi JR, Bagby RM. 2000. Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry. 61(4):276–281.
  • Klock SC, Sheinin S, Kazer R, Zhang X. 2004. A pilot study of the relationship between selective serotonin reuptake inhibitors and in vitro fertilization outcome. Fertil Steril. 82(4):968–969.
  • Kondoh N. 2012. Ejaculatory dysfunction as a cause of infertility. Reprod Med Biol. 11(1):59–64.
  • Koyuncu H, Serefoglu EC, Yencilek E, Atalay H, Akbas NB, Sarıca K. 2011. Escitalopram treatment for premature ejaculation has a negative effect on semen parameters. Int J Impot Res. 23(6):257–261.
  • Kumar VSK, Sharma VL, Tiwari P, Singh D, Maikhuri JP, Gupta G, Singh MM. 2006. The spermicidal and antitrichomonas activities of SSRI antidepressants. Bioorg Med Chem Lett. 16(9):2509–2512.
  • Kunz G, Beil D, Huppert P, Leyendecker G. 2007. Oxytocin–a stimulator of directed sperm transport in humans. Reprod Biomed Online. 14(1):32–39.
  • Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC. 2018. Prevalence of depression in the community from 30 countries between 1994 and 2014. Sci Rep. 8(1):2861.
  • Lyons RA, Saridogan E, Djahanbakhch O. 2006. The reproductive significance of human fallopian tube cilia. Hum Reprod Update. 12(4):363–372.
  • Mastroianni L. Jr 1999. The fallopian tube and reproductive health. J Pediatr Adolesc Gynecol. 12(3):121–126.
  • McMahon CG. 2011. Efficacy of dapoxetine in the treatment of premature ejaculation. Clin Med Insights Reprod Health. 5:25–39.
  • Meeker JD, Godfrey-Bailey L, Hauser R. 2007. Relationships between serum hormone levels and semen quality among men from an infertility clinic. J Androl. 28(3):397–406.
  • Milosavljević MN, Janković SV, Janković SM, Djurić J, Protrka Z, Arsenijević S, Folić M, Stojadinović D, Dimitrijević A. 2019. Effects of selective serotonin reuptake inhibitors on motility of isolated fallopian tube. Clin Exp Pharmacol Physiol. 46(8):780–787.
  • Modell JG, Katholi CR, Modell JD, DePalma RL. 1997. Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clin Pharmacol Ther. 61(4):476–487.
  • Monteiro Filho WO, de Torres SM, Amorim MJAAL, Andrade AJM, de Morais RN, Tenorio BM, da Silva Junior VA. 2014. Fluoxetine induces changes in the testicle and testosterone in adult male rats exposed via placenta and lactation. Syst Biol Reprod Med. 60(5):274–281.
  • Nuojua- Huttunen S, Tomas C, Bloigu R, et al. 1999. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod. 14(3)698–703.
  • Reichenpfader U, Gartlehner G, Morgan LC, Greenblatt A, Nussbaumer B, Hansen RA, Van Noord M, Lux L, Gaynes BN. 2014. Sexual dysfunction associated with second-generation antidepressants in patients with major depressive disorder: results from a systematic review with network meta-analysis. Drug Saf. 37(1):19–31.
  • Relwani R, Berger D, Santoro N, Hickmon C, Nihsen M, Zapantis A, Werner M, Polotsky AJ, Jindal S. 2011. Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci. 18(4):391–397.
  • Russel LD, Ettlin RA, Sinha Hikim AP. 1990. Mammalian spermatogenesis. In Russel LD, Ettlin RA, Hikim SAP, editors. Histological and histopathological evaluation of the testis. Clearwater, FL: Cache River Press; p. 1–40.
  • Safarinejad MR. 2008. Sperm DNA damage and semen quality impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin structure assay. J Urol. 180(5):2124–2128.
  • Sakr SA, Mahran HA, El-Deeb MM. 2013. Ameliorative effect of curcumin on fluoxetine-induced reproductive toxicity and oxidative stress in male albino rats. Oxid Antioxid Med Sci. 2(1):29–35.
  • Serafini P, Lobo DS, Grosman A, Seibel D, Rocha AM, Motta ELA. 2009. Fluoxetine treatment for anxiety in women undergoing in vitro fertilization. Int J Gynaecol Obstet. 105(2):136–139.
  • Stojaković M, Zorić D, Mišković M, Zivlak N. 2003. Mirtazapine and sexual activity in depressed outpatients. Engrami. 25(1-2):69–76.
  • Suarez SS, Pacey AA. 2006. Sperm transport in the female reproductive tract. Hum Reprod Update. 12(1):23–37.
  • Sylvester C, Menke M, Gopalan P. 2019. Selective serotonin reuptake inhibitors and fertility: considerations for couples trying to conceive. Harv Rev Psychiatry. 27(2):108–118.
  • Tanrikut C, Feldman AS, Altemus M, Paduch DA, Schlegel PN. 2010. Adverse effect of paroxetine on sperm. Fertil Steril. 94(3):1021–1026.
  • Tanrikut C, Schlegel PN. 2007. Antidepressant-associated changes in semen parameters. Urology. 69(1):185.e5–185.e7.
  • Verhaak CM, Smeenk JM, Kremer JA, et al. 2002. De emotionele belasting van kunstmatige voortplanting: meer angst en depressie na een mislukte eerste behandeling [The emotional burden of artificial insemination: increased anxiety and depression following an unsuccessful treatment]. Ned Tijdschr Geneeskd. 146(49):2363–2366.
  • Verhaak CM, Smeenk JMJ, van Minnen A, Kremer JAM, Kraaimaat FW. 2005. A longitudinal, prospective study on emotional adjustment before, during and after consecutive fertility treatment cycles. Hum Reprod. 20(8):2253–2260.
  • Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B. 2004. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res. 16(4):369–381.
  • Wilcox AJ, Weinberg CR, Baird DD. 1995. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med. 333(23):1517–1521.
  • Yardimci A, Ulker N, Bulmus O, Kaya N, Colakoglu N, Ozcan M, Canpolat S, Kelestimur H. 2019. Effects of long-term paroxetine or bupropion treatment on puberty onset, reproductive and feeding parameters in adolescent male rats. Andrologia. 51(6):e13268.

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