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Anxiety and Depression in Patients with COVID-19

Presentation and management of anxiety in individuals with acute symptomatic or asymptomatic COVID-19 infection, and in the post-COVID-19 recovery phase

ORCID Icon, ORCID Icon &
Pages 115-131 | Received 05 Nov 2020, Accepted 03 Feb 2021, Published online: 26 Feb 2021

References

  • Abbing A, Baars EW, de Sonneville L, Ponstein AS, Swaab H. 2019. The effectiveness of art therapy for anxiety in adult women: a randomized controlled trial. Front Psychol. 10:1203.
  • Abrams MP, Wan EY, Waase MP, Morrow JP, Dizon JM, Yarmohammadi H, Berman JP, Rubin GA, Kushnir A, Poterucha TJ, et al. 2020. Clinical and cardiac characteristics of COVID-19 mortalities in a diverse New York City Cohort. J Cardiovasc Electrophysiol. 31:3086–3096.
  • Acuña-Castroviejo D, Escames G, Figueira JC, de la Oliva P, Borobia AM, Acuña-Fernández C. 2020. Clinical trial to test the efficacy of melatonin in COVID-19. J Pineal Res. 69:e12683.
  • Adell A. 2010. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. IDrugs. 13:10.
  • Ahmed H, Patel K, Greenwood DC, Halpin S, Lewthwaite P, Salawu A, Eyre L, Breen A, O'Connor R, Jones A, et al. 2020. Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: a systematic review and meta-analysis. J Rehabil Med. 52:jrm00063.
  • Aksan F, Nelson EA, Swedish KA. 2020. A COVID-19 patient with intense burning pain. J Neurovirol. 26:800–801.
  • Almqvist J, Granberg T, Tzortzakakis A, Klironomos S, Kollia E, Öhberg C, Martin R, Piehl F, Ouellette R, Ineichen BV. 2020. Neurological manifestations of coronavirus infections – a systematic review. Ann Clin Transl Neurol. 7:2057–2071.
  • Al-Sarraj S, Troakes C, Hanley B, Osborn M, Richardson MP, Hotopf M, Bullmore E, Everall IP. 2020. Invited Review: The spectrum of neuropathology in COVID-19. Neuropathol Appl Neurobiol. 47:3–16.
  • Alves de Lima K, Rustenhoven J, Da Mesquita S, Wall M, Salvador AF, Smirnov I, Martelossi Cebinelli G, Mamuladze T, Baker W, Papadopoulos Z, et al. 2020. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol. 21:1421–1429.
  • APA. 2013. DSM-5, Diagnostic and statistic manual of mental disorders. 5th ed. Washington (DC): APA.
  • Awasthi S, Pan H, LeDoux JE, Cloitre M, Altemus M, McEwen B, Silbersweig D, Stern E. 2020. The bed nucleus of the stria terminalis and functionally linked neurocircuitry modulate emotion processing and HPA axis dysfunction in posttraumatic stress disorder. Neuroimage Clin. 28:102442.
  • Baker A, Simon N, Keshaviah A, Farabaugh A, Deckersbach T, Worthington JJ, Hoge E, Fava M, Pollack MP. 2019. Anxiety Symptoms Questionnaire (ASQ): development and validation. Gen Psychiatr 32:e100144.
  • Baptista AF, Baltar A, Okano AH, Moreira A, Campos ACP, Fernandes AM, Brunoni AR, Badran BW, Tanaka C, de Andrade DC, et al. 2020. Applications of non-invasive neuromodulation for management of disorders related to COVID-19. Front Neurol. 11:1248.
  • Bate J, Malberg N. 2020. Containing the anxieties of children, parents and families from a distance during the coronavirus pandemic. J Contemp Psychother. 50:210–285.
  • Beerse ME, Van Lith T, Stanwood G. 2020. Therapeutic psychological and biological responses to mindfulness-based art therapy. Stress Health. 36:419–432.
  • Behan C. 2020. The benefits of meditation and mindfulness practices during times of crisis such as COVID-19. Ir J Psychol Med. 37:256–258.
  • Bienvenu OJ, Friedman LA, Colantuoni E, Dinglas VD, Sepulveda KA, Mendez-Tellez P, Shanholz C, Pronovost PJ, Needham DM. 2018. Psychiatric symptoms after acute respiratory distress syndrome: a 5-year longitudinal study. Intensive Care Med. 44:38–47.
  • Bjelland I, Dahl AA, Haug TT, Neckelmann D. 2002. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 52:69–77.
  • Boehmer TK, DeVies J, Caruso E, van Santen KL, Tang S, Black CL, Hartnett KP, Kite-Powell A, Dietz S, Lozier M, Gundlapalli AV. 2020. Changing age distribution of the COVID-19 pandemic – United States, May-August, 2020. MMWR Morb Mortal Wkly Rep. 69:7.
  • Brodin P. 2021. Immune determinants of COVID-19 disease presentation and severity. Nat Med. 27:28–33.
  • Buckner JD, Bernert RA, Cromer KR, Joiner TE, Schmidt NB. 2008. Social anxiety and insomnia: the mediating role of depressive symptoms. Depress Anxiety. 25:124–130.
  • Buemann B, Marazziti D, Uvnäs-Moberg K. 2020. Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients? World J Biol Psychiatry.
  • Casillo GM, Mansour AA, Raucci F, Saviano A, Mascolo N, Iqbal AJ, Maione F. 2020. Could IL-17 represent a new therapeutic target for the treatment and/or management of COVID-19-related respiratory syndrome? Pharmacol Res. 156:104791
  • Caspani M, Szekely P. 2021. US sets COVID-19 hospitalization record as states ramp up vaccination efforts. Mescape.
  • CDC. 2021 Jan 15. New COVID-19 variants. https://www.cdc.gov/coronavirus/2019-ncov/transmission/variant.html
  • Chandu VC, Pachava S, Vadapalli V, Marella Y. 2020. Development and initial validation of the COVID-19 Anxiety Scale. Indian J Public Health. 64:S201–s204.
  • Chouinard G. 2004. Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound. J Clin Psychiatry. 65:7–12.
  • Clodi M, Vila G, Geyeregger R, Riedl M, Stulnig TM, Struck J, Luger TA, Luger A. 2008. Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men. Am J Physiol Endocrinol Metab. 295:E686–E691.
  • Codella R, Chirico A, Lucidi F, Ferrulli A, La Torre A, Luzi L. 2020. The immune-modulatory effects of exercise should be favorably harnessed against COVID-19. J Endocrinol Invest.
  • Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, Turner RB. 2012. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 109:5995–5999.
  • Corum J, Carl Z. 2021. How nine Covid-19 vaccines work. The New York Times. New York, NY.
  • Dai LL, Wang X, Jiang TC, Li PF, Wang Y, Wu SJ, Jia LQ, Liu M, An L, Cheng Z. 2020. Anxiety and depressive symptoms among COVID-19 patients in Jianghan Fangcang Shelter Hospital in Wuhan, China. PLoS One. 15:e0238416.
  • Davide P, Andrea P, Martina O, Andrea E, Davide D, Mario A. 2020. The impact of the COVID-19 pandemic on patients with OCD: Effects of contamination symptoms and remission state before the quarantine in a preliminary naturalistic study. Psychiatry Res. 291:113213.
  • De Biasi S, Meschiari M, Gibellini L, Bellinazzi C, Borella R, Fidanza L, Gozzi L, Iannone A, Lo Tartaro D, Mattioli M, et al. 2020. Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia. Nat Commun. 11:3434.
  • Del Prete E, Francesconi A, Palermo G, Mazzucchi S, Frosini D, Morganti R, Coleschi P, Raglione LM, Vanni P, Ramat S, et al. 2020. Prevalence and impact of COVID-19 in Parkinson's disease: evidence from a multi-center survey in Tuscany region. J Neurol.
  • DePierro J, Katz CL, Marin D, Feder A, Bevilacqua L, Sharma V, Hurtado A, Ripp J, Lim S, Charney D. 2020. Mount Sinai's Center for Stress, Resilience and Personal Growth as a model for responding to the impact of COVID-19 on health care workers. Psychiatry Res. 293:113426.
  • Dijkstra-Kersten SMA, Kok L, Kerckhoffs MC, Cremer OL, de Lange DW, van Dijk D, Needham DM, Slooter AJC. 2020. Neuropsychiatric outcome in subgroups of Intensive Care Unit survivors: implications for after-care. J Crit Care. 55:171–176.
  • Dryden J. 2020. Podcast: Clinical trials launch to evaluate antimalarial, antidepressant drugs to treat COVID-19. Repurposing of FDA-approved drugs is fastest way to launch COVID-19 clinical trials. https://medicine.wustl.edu/news/podcast-clinical-trials-launch-to-evaluate-antimalarial-antidepressant-drugs-to-treat-covid-19/
  • Edén A, Kanberg N, Gostner J, Fuchs D, Hagberg L, Andersson LM, Lindh M, Price RW, Zetterberg H, Gisslén M. 2021. CSF biomarkers in patients with COVID-19 and neurologic symptoms: a case series. Neurology. 96:e294–e300.
  • Ellis R. 2021. COVID likely the third-leading cause of death in US, CDC Says. Medscape.
  • Esakandari H, Nabi-Afjadi M, Fakkari-Afjadi J, Farahmandian N, Miresmaeili SM, Bahreini E. 2020. A comprehensive review of COVID-19 characteristics. Biol Proced Online. 22:19.
  • Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, et al. 2020. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurol. 20:248.
  • FDA. 2019 December 19. FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR) When used with CNS depressants or in patients with lung problems. Silver Spring (MD): D. o. H. a. H. Services, U.S. FDA.
  • FDA. 2021. COVID-19 vaccines. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines
  • Felger JC. 2018. Imaging the role of inflammation in mood and anxiety-related disorders. Curr Neuropharmacol. 16:533–558.
  • Fineberg NA, Van Ameringen M, Drummond L, Hollander E, Stein DJ, Geller D, Walitza S, Pallanti S, Pellegrini L, Zohar J, et al. 2020. How to manage obsessive-compulsive disorder (OCD) under COVID-19: a clinician's guide from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) and the Obsessive-Compulsive and Related Disorders Research Network (OCRN) of the European College of Neuropsychopharmacology. Compr Psychiatry. 100:152174.
  • Fonseca E, Quintana M, Lallana S, Restrepo JL, Abraira L, Santamarina E, Seijo-Raposo I, Toledo M. 2020. Epilepsy in time of COVID-19: a survey-based study. Acta Neurol Scand. 142:545–554.
  • García LF. 2020. Immune Response, Inflammation, and the Clinical Spectrum of COVID-19. Front Immunol. 11:1441.
  • Garcia-Rill E. 2019. Chapter 5 – Posttraumatic stress and anxiety, the role of arousal. In: Garcia-Rill E, editor. Arousal in neurological and psychiatric diseases. London (UK): Academic Press; p. 67–81.
  • Ghazavi A, Ganji A, Keshavarzian N, Rabiemajd S, Mosayebi G. 2021. Cytokine profile and disease severity in patients with COVID-19. Cytokine. 137:155323.
  • Gonda X, Petschner P, Eszlari N, Sutori S, Gal Z, Koncz S, Anderson IM, Deakin B, Juhasz G, Bagdy G. 2019. Effects of different stressors are modulated by different neurobiological systems: the role of GABA-A versus CB1 receptor gene variants in anxiety and depression. Front Cell Neurosci. 13:138.
  • Grzadzinski R, Lord C, Sanders SJ, Werling D, Bal VH. 2018. Children with autism spectrum disorder who improve with fever: insights from the Simons Simplex Collection. Autism Res. 11:175–184.
  • Guadarrama-Ortiz P, Choreño-Parra JA, Sánchez-Martínez CM, Pacheco-Sánchez FJ, Rodríguez-Nava AI, García-Quintero G. 2020. Neurological aspects of SARS-CoV-2 infection: mechanisms and manifestations. Front Neurol. 11:1039.
  • Guo Q, Zheng Y, Shi J, Wang J, Li G, Li C, Fromson JA, Xu Y, Liu X, Xu H, et al. 2020. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study. Brain Behav Immun. 88:17–27.
  • Han D, Wang C, Feng X, Wu J. 2020. Delirium during recovery in patients with severe COVID-19: two case reports. Front Med. 7:710.
  • Hao F, Tan W, Jiang L, Zhang L, Zhao X, Zou Y, Hu Y, Luo X, Jiang X, McIntyre RS, et al. 2020. Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry. Brain Behav Immun. 87:100–106.
  • Ho JM, Tricco AC, Perrier L, Chen M, Juurlink DN, Straus SE. 2013. Risk of heart failure and edema associated with the use of pregabalin: a systematic review. Syst Rev. 2:25.
  • Hojyo S, Uchida M, Tanaka K, Hasebe R, Tanaka Y, Murakami M, Hirano T. 2020. How COVID-19 induces cytokine storm with high mortality. Inflamm Regen. 40:37.
  • Hollander E, Uzunova G. 2020. Faculty Opinions Recommendation of [Zhang R et al., Life Sci 2020 250:117583]. Faculty Opinions.
  • Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF Jr. 2010. Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry. 32:147–155.
  • Hosey MM, Needham DM. 2020. Survivorship after COVID-19 ICU stay. Nat Rev Dis Primers. 6:60.
  • Hu Y, Chen Y, Zheng Y, You C, Tan J, Hu L, Zhang Z, Ding L. 2020. Factors related to mental health of inpatients with COVID-19 in Wuhan, China. Brain Behav Immun. 89:587–593.
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506.
  • Imami AS, O'Donovan SM, Creeden JF, Wu X, Eby H, McCullumsmith CB, Uvnäs-Moberg K, McCullumsmith RE, Andari E. 2020. Oxytocin's anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach. Physiol Genomics. 52:401–407.
  • Iqbal Y, Al Abdulla MA, Albrahim S, Latoo J, Kumar R, Haddad PM. 2020. Psychiatric presentation of patients with acute SARS-CoV-2 infection: a retrospective review of 50 consecutive patients seen by a consultation-liaison psychiatry team. BJPsych Open. 6:e109.
  • Jang SH, Lee JH, Lee HJ, Lee SY. 2018. Effects of mindfulness-based art therapy on psychological symptoms in patients with coronary artery disease. J Korean Med Sci. 33:e88.
  • Jansen van Vuren E, Steyn SF, Brink CB, Moller M, Viljoen FP, Harvey BH. 2021. The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment. Biomed Pharmacother. 135:111200.
  • Jarrahi A, Ahluwalia M, Khodadadi H, da Silva Lopes Salles E, Kolhe R, Hess DC, Vale F, Kumar M, Baban B, Vaibhav K, et al. 2020. Neurological consequences of COVID-19: what have we learned and where do we go from here? J Neuroinflammation. 17:286.
  • Ji G, Wei W, Yue KC, Li H, Shi LJ, Ma JD, He CY, Zhou SS, Zhao Z, Lou T, et al. 2020. Effects of the COVID-19 pandemic on obsessive-compulsive symptoms among university students: prospective cohort survey study. J Med Internet Res. 22:e21915.
  • Jia H, Han Z, Zhang K, Tang Q, Sun K, Huang H, Qi F. 2020. Acupuncture and related interventions for anxiety in coronavirus disease 2019: a protocol for systematic review and meta-analysis. Medicine (Baltimore). 99:e21317.
  • Jordan RK, Shah SS, Desai H, Tripi J, Mitchell A, Worth RG. 2020. Variation of stress levels, burnout, and resilience throughout the academic year in first-year medical students. PLoS One. 15:e0240667.
  • Kassie GM, Kalisch Ellett LM, Nguyen TA, Roughead EE. 2019. Use of medicines that may precipitate delirium prior to hospitalisation in older Australians with delirium: an observational study. Australas J Ageing. 38:124–131.
  • Kelly BD. 2020. Coronavirus disease: challenges for psychiatry. Br J Psychiatry. 217:352–353.
  • Kempuraj D, Selvakumar GP, Ahmed ME, Raikwar SP, Thangavel R, Khan A, Zaheer SA, Iyer SS, Burton C, James D, et al. 2020. COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation. Neuroscientist. 26:402–414.
  • Kenyon C. 2020. The Forrest Gump approach to preventing severe COVID-19 - reverse the predisposing pro-inflammatory state with exercise. Microbes Infect. 22:151–153.
  • Khawam E, Khouli H, Pozuelo L. 2020. Treating acute anxiety in patients with COVID-19. Cleve Clin J Med.
  • Kim SW, Su KP. 2020. Using psychoneuroimmunity against COVID-19. Brain Behav Immun. 87:4–5.
  • Lee SA. 2020. Coronavirus Anxiety Scale: a brief mental health screener for COVID-19 related anxiety. Death Stud. 44:393–401.
  • Lee SA, Jobe MC, Mathis AA, Gibbons JA. 2020. Incremental validity of coronaphobia: coronavirus anxiety explains depression, generalized anxiety, and death anxiety. J Anxiety Disord. 74:102268.
  • Lee SA, Mathis AA, Jobe MC, Pappalardo EA. 2020. Clinically significant fear and anxiety of COVID-19: a psychometric examination of the Coronavirus Anxiety Scale. Psychiatry Res. 290:113112.
  • Leff Gelman P, Mancilla-Herrera I, Flores-Ramos M, Saravia Takashima MF, Cruz Coronel FM, Fuentes CC, Pérez Molina A, Hernández-Ruiz J, Silva-Aguilera FS, Farfan-Labonne B, et al. 2019. The cytokine profile of women with severe anxiety and depression during pregnancy. BMC Psychiatry. 19:104.
  • Levy J, Léotard A, Lawrence C, Paquereau J, Bensmail D, Annane D, Delord V, Lofaso F, Bessis S, Prigent H. 2020. A model for a ventilator-weaning and early rehabilitation unit to deal with post-ICU impairments following severe COVID-19. Ann Phys Rehabil Med. 63:376–378.
  • Li Z, Zheng C, Duan C, Zhang Y, Li Q, Dou Z, Li J, Xia W. 2020. Rehabilitation needs of the first cohort of post-acute COVID-19 patients in Hubei, China. Eur J Phys Rehabil Med. 56:339–344.
  • Liu D, Baumeister RF, Veilleux JC, Chen C, Liu W, Yue Y, Zhang S. 2020. Risk factors associated with mental illness in hospital discharged patients infected with COVID-19 in Wuhan, China. Psychiatry Res. 292:113297.
  • Liu Y, Ho RC, Mak A. 2012. The role of interleukin (IL)-17 in anxiety and depression of patients with rheumatoid arthritis. Int J Rheum Dis. 15:183–187.
  • Liu X, Lin H, Jiang H, Li R, Zhong N, Su H, Li Y, Zhao M. 2020. Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China. Gen Psychiatr. 33:e100222.
  • Luo XH, Zhu, J. Mao Y, Du RC. 2020. T-cell immunobiology and cytokine storm of COVID-19. Scand J Immunol. e12989.
  • Mazza MG, De Lorenzo R, Conte C, Poletti S, Vai B, Bollettini I, Melloni EMT, Furlan R, Ciceri F, Rovere-Querini P, et al., COVID-19 BioB Outpatient Clinic Study group. 2020. Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors. Brain Behav Immun. 89:594–600.
  • Mehler MF, Purpura DP. 2009. Autism, fever, epigenetics and the locus coeruleus. Brain Res Rev. 59:388–392.
  • Mehta ND, Haroon E, Xu X, Woolwine BJ, Li Z, Felger JC. 2018. Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: preliminary results. Brain Behav Immun. 73:725–730.
  • Merzon E, Green I, Shpigelman M, Vinker S, Raz I, Golan-Cohen A, Eldor R. 2020. Haemoglobin A1c is a predictor of COVID-19 severity in patients with diabetes. Diabetes Metab Res Rev. e3398.
  • Mohamed AA, Alawna M. 2020. Role of increasing the aerobic capacity on improving the function of immune and respiratory systems in patients with coronavirus (COVID-19): a review. Diabetes Metab Syndr. 14:489–496.
  • Moreno-Rius J. 2018. The cerebellum in fear and anxiety-related disorders. Prog Neuropsychopharmacol Biol Psychiatry. 85:23–32.
  • Mulchandani R, Lyngdoh T, Kakkar AK. 2020. Deciphering the COVID-19 cytokine storm: Systematic review and meta-analysis. Eur J Clin Invest. 51:e13429.
  • Musche V, Bäuerle A, Steinbach J, Schweda A, Hetkamp M, Weismüller B, Kohler H, Beckmann M, Herrmann K, Tewes M, et al. 2020. COVID-19-related fear and health-related safety behavior in oncological patients. Front Psychol. 11:1984.
  • Nalleballe K, Reddy Onteddu S, Sharma R, Dandu V, Brown A, Jasti M, Yadala S, Veerapaneni K, Siddamreddy S, Avula A, et al. 2020. Spectrum of neuropsychiatric manifestations in COVID-19. Brain Behav Immun. 88:71–74.
  • Newcombe VFJ, Spindler LRB, Das T, Winzeck S, Allinson K, Stamatakis EA, Menon DK, the Cambridge NeuroCovid Imaging Collaborators. 2021. Neuroanatomical substrates of generalized brain dysfunction in COVID-19. Intensive Care Med. 47:113–116.
  • Nie XD, Wang Q, Wang MN, Zhao S, Liu L, Zhu YL, Chen H. 2020. Anxiety and depression and its correlates in patients with coronavirus disease 2019 in Wuhan. Int J Psychiatry Clin Pract.
  • Nikayin S, Rabiee A, Hashem MD, Huang M, Bienvenu OJ, Turnbull AE, Needham DM. 2016. Anxiety symptoms in survivors of critical illness: a systematic review and meta-analysis. Gen Hosp Psychiatry. 43:23–29.
  • Nuss P, Ferreri F, Bourin M. 2019. An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action. Neuropsychiatr Dis Treat. 15:1781–1795.
  • Pallanti S. 2020. Importance of SARs-Cov-2 anosmia: from phenomenology to neurobiology. Compr Psychiatry. 100:152184.
  • Pallanti S, Grassi E, Makris N, Gasic GP, Hollander E. 2020. Neurocovid-19: a clinical neuroscience-based approach to reduce SARS-CoV-2 related mental health sequelae. J Psychiatr Res. 130:215–217.
  • Pallavi P, Sagar R, Mehta M, Sharma S, Subramanium A, Shamshi F, Sengupta U, Pandey RM, Mukhopadhyay AK. 2015. Serum cytokines and anxiety in adolescent depression patients: gender effect. Psychiatry Res. 229:374–380.
  • Parker C, Shalev D, Hsu I, Shenoy A, Cheung S, Nash S, Wiener I, Fedoronko D, Allen N, Shapiro PA. 2020. Depression, anxiety, and acute stress disorder among patients hospitalized with coronavirus disease 2019: a prospective cohort study. Psychosomatics.
  • Patel K, Straudi S, Sien NY, Fayed N, Melvin JL, Sivan M. 2020. Applying the WHO ICF framework to the outcome measures used in the evaluation of long-term clinical outcomes in coronavirus outbreaks. Int J Environ Res Public Health. 17:6476.
  • Paz C, Mascialino G, Adana-Díaz L, Rodríguez-Lorenzana A, Simbaña-Rivera K, Gómez-Barreno L, Troya M, Ignacia PM, Cárdenas J, Gerstner RM, Ortiz-Prado E. 2020. Anxiety and depression in patients with confirmed and suspected COVID-19 in Ecuador. Psychiatry Clin Neurosci. 74:2.
  • Plunkett R, Costello S, McGovern M, McDonald C, Hallahan B. 2020. Impact of the COVID-19 pandemic on patients with pre-existing anxiety disorders attending secondary care. Ir J Psychol Med.
  • Pozuelo L, Khawam Elias, Khouli H. 2020. A case-based window into treating acute anxiety in COVID-19 patients addressing the disease’s psychological impact can help promote recovery. Consult QD.
  • Pun BT, Badenes R, La Calle GH, Orun OM, Chen W, Raman R, Simpson BGK, Wilson-Linville S, Olmedillo BH, de la Cueva AV, et al. 2021. Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med.
  • Rajkumar RP. 2020. Ayurveda and COVID-19: Where psychoneuroimmunology and the meaning response meet. Brain Behav Immun. 87:8–9.
  • Ramezani M, Simani L, Karimialavijeh E, Rezaei O, Hajiesmaeili M, Pakdaman H. 2020. The role of anxiety and cortisol in outcomes of patients with Covid-19. Basic Clin Neurosci J. 11:179–184.
  • Ranasinghe C, Ozemek C, Arena R. 2020. Exercise and well-being during COVID 19 – time to boost your immunity. Expert Rev Anti Infect Ther. 18:1195–1200.
  • Reed MD, Yim YS, Wimmer RD, Kim H, Ryu C, Welch GM, Andina M, King HO, Waisman A, Halassa MM, et al. 2020. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 577:249–253.
  • Regeneron. 2020. Regeneron and Sanofi provide update on US phase 2/3 adaptive designed trial of Kevzara (Sarilumab) in hospitalized COVID-19 patients. https://investor.regeneron.com/news-releases/news-release-details/regeneron-and-sanofi-provide-update-us-phase-23-adaptive
  • Renjun G, Ziyun L, Xiwu Y, Wei W, Yihuang G, Chunbing Z, Zhiguang S. 2020. Psychological intervention on COVID-19: a protocol for systematic review and meta-analysis. Medicine (Baltimore). 99:e20335.
  • Robinson OJ, Pike AC, Cornwell B, Grillon C. 2019. The translational neural circuitry of anxiety. J Neurol Neurosurg Psychiatry. 90:1353–1360.
  • Rogers JP, Chesney E, Oliver D, Pollak TA, McGuire P, Fusar-Poli P, Zandi MS, Lewis G, David AS. 2020. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry. 7:611–627.
  • Rosen DA, Seki SM, Fernández-Castañeda A, Beiter RM, Eccles JD, Woodfolk JA, Gaultier A. 2019. Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med. 11:eaau5266.
  • Salari M, Zali A, Ashrafi F, Etemadifar M, Sharma S, Hajizadeh N, Ashourizadeh H. 2020. Incidence of anxiety in Parkinson's disease during the coronavirus disease (COVID-19) pandemic. Mov Disord. 35:1095–1096.
  • Sapra A, Bhandari P, Sharma S, Chanpura T, Lopp L. 2020. Using Generalized Anxiety Disorder-2 (GAD-2) and GAD-7 in a primary care setting. Cureus. 12:e8224.
  • Sarris J, Byrne GJ, Cribb L, Oliver G, Murphy J, Macdonald P, Nazareth S, Karamacoska D, Galea S, Short A, et al. 2019. L-Theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. J Psychiatr Res. 110:31–37.
  • Sebih F, Rousset M, Bellahouel S, Rolland M, de Jesus Ferreira MC, Guiramand J, Cohen-Solal C, Barbanel G, Cens T, Abouazza M, et al. 2017. Characterization of l-theanine excitatory actions on hippocampal neurons: toward the generation of novel N-methyl-d-aspartate receptor modulators based on its backbone. ACS Chem Neurosci. 8:1724–1734.
  • Sergeant A, van Reekum EA, Sanger N, Dufort A, Rosic T, Sanger S, Lubert S, Mbuagbaw L, Thabane L, Samaan Z. 2020. Impact of COVID-19 and other pandemics and epidemics on people with pre-existing mental disorders: a systematic review protocol and suggestions for clinical care. BMJ Open. 10:e040229.
  • Shibabaw T. 2020. Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy. J Inflamm Res. 13:673–680.
  • Shin LM, Liberzon I. 2010. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology. 35:169–191.
  • Shinjo SK, Brunoni AR, Okano AH, Tanaka C, Baptista AF. 2020. Transcranial direct current stimulation relieves the severe anxiety of a patient with COVID-19. Brain Stimul. 13:1352–1353.
  • Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. 2020. Mood, anxiety and olfactory dysfunction in COVID-19: evidence of central nervous system involvement? Laryngoscope. 130:2520–2525.
  • Steardo L Jr, Steardo L, Verkhratsky A. 2020. Psychiatric face of COVID-19. Transl Psychiatry. 10:261.
  • Stern AF. 2014. The hospital anxiety and depression scale. Occup Med (Lond). 64:393–394.
  • Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, Sun J, Liu Y, Yang C, Geng J, et al. 2020. The different clinical characteristics of corona virus disease cases between children and their families in China – the character of children with COVID-19. Emerg Microbes Infect. 9:707–713.
  • Taquet M, Luciano S, Geddes JR, Harrison PJ. 2020. Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA. Lancet Psychiatry. 8:130–140.
  • Taylor P. 2020. IL-6 Hypothesis Looking Shaky as Kevzara Fails COVID-19 Trial. Pharmaforum.
  • Termorshuizen JD, Watson HJ, Thornton LM, Borg S, Flatt RE, MacDermod CM, Harper LE, Furth EF, Peat CM, Bulik CM, et al. 2020. Early impact of COVID-19 on individuals with self-reported eating disorders: A survey of ∼1,000 individuals in the United States and the Netherlands. Int J Eat Disord. 53:1780–1790.
  • Theoharides TC, Conti P. 2020. COVID-19 and multisystem inflammatory syndrome, or is it mast cell activation syndrome? J Biol Regul Homeost Agents. 34:1633–1636.
  • Tomasoni D, Bai F, Castoldi R, Barbanotti D, Falcinella C, Mulè G, Mondatore D, Tavelli A, Vegni E, Marchetti G, et al. 2021. Anxiety and depression symptoms after virological clearance of COVID-19: a cross-sectional study in Milan, Italy. J Med Virol. 93:1175–1179.
  • Tovote P, Fadok JP, Lüthi A. 2015. Neuronal circuits for fear and anxiety. Nat Rev Neurosci. 16:317–331.
  • Troyer EA, Kohn JN, Hong S. 2020. Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Brain Behav Immun. 87:34–39.
  • Uzunova G, Burchi E, Hollander E. 2019. Oxytocin, empathy, relatedness, and attachment in psychotherapy. The American Psychoanalyst. 153.
  • Van Hees S, Siewe Fodjo JN, Wijtvliet V, Van den Bergh R, Faria de Moura Villela E, da Silva CF, Weckhuysen S, Colebunders R. 2020. Access to healthcare and prevalence of anxiety and depression in persons with epilepsy during the COVID-19 pandemic: a multicountry online survey. Epilepsy Behav. 112:107350.
  • Varatharaj A, Thomas N, Ellul MA, Davies NWS, Pollak TA, Tenorio EL, Sultan M, Easton A, Breen G, Zandi M, et al. 2020. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. 7:875–882.
  • Venkatraman A, Edlow BL, Immordino-Yang MH. 2017. The brainstem in emotion: a review. Front Neuroanat. 11:15.
  • Vieira MM, Ferreira TB, Pacheco PA, Barros PO, Almeida CR, Araújo-Lima CF, Silva-Filho RG, Hygino J, Andrade RM, Linhares UC, et al. 2010. Enhanced Th17 phenotype in individuals with generalized anxiety disorder. J Neuroimmunol. 229:212–218.
  • Vismara M, Girone N, Cirnigliaro G, Fasciana F, Vanzetto S, Ferrara L, Priori A, D'Addario C, Viganò C, Dell'Osso B. 2020. Peripheral biomarkers in DSM-5 anxiety disorders: an updated overview. Brain Sci. 10:564.
  • Visnola D, Sprudza D, Bake MA, Pike A. 2010. Effects of art therapy on stress and anxiety of employees. Proc Latv Acad Sci. 64:85–91.
  • Vozoris NT. 2014. Do benzodiazepines contribute to respiratory problems? Expert Rev Respir Med. 8:661–663.
  • Vozoris NT, Fischer HD, Wang X, Stephenson AL, Gershon AS, Gruneir A, Austin PC, Anderson GM, Bell CM, Gill SS, et al. 2014. Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD. Eur Respir J. 44:332–340.
  • Vozoris NT, Stephenson AL. 2015. Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD. Eur Respir J. 45:566–567.
  • Vuong QV, Bowyer MC, Roach PD. 2011. L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 91:1931–1939.
  • Wang TJ, Chau B, Lui M, Lam GT, Lin N, Humbert S. 2020b. Physical medicine and rehabilitation and pulmonary rehabilitation for COVID-19. Am J Phys Med Rehabil. 99:769–774.
  • Wang SH, Chen WS, Tang SE, Lin HC, Peng CK, Chu HT, Kao CH. 2018. Benzodiazepines associated with acute respiratory failure in patients with obstructive sleep apnea. Front Pharmacol. 9:1513.
  • Wang J, Jiang M, Chen X, Montaner LJ. 2020a. Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. J Leukoc Biol. 108:17–41.
  • Williams JL, Everett JM, D'Cunha NM, Sergi D, Georgousopoulou EN, Keegan RJ, McKune AJ, Mellor DD, Anstice N, Naumovski N. 2020. The effects of green tea amino acid L-theanine consumption on the ability to manage stress and anxiety levels: a systematic review. Plant Foods Hum Nutr. 75:12–23.
  • Worsham CM, Banzett RB, Schwartzstein R. 2020. Dyspnea, acute respiratory failure, psychological trauma, and post-ICU mental health: a caution and a call for research. Chest.
  • Yi K, Rong Y, Wang C, Huang L, Wang F. 2021. COVID-19: advance in laboratory diagnostic strategy and technology. Mol Cell Biochem.
  • Zhang R, Wang X, Ni L, Di X, Ma B, Niu S, Liu C, Reiter RJ. 2020. COVID-19: melatonin as a potential adjuvant treatment. Life Sci. 250:117583.
  • Zhang MF, Wen YS, Liu WY, Peng LF, Wu XD, Liu QW. 2015. Effectiveness of mindfulness-based therapy for reducing anxiety and depression in patients with cancer: a meta-analysis. Medicine (Baltimore). 94:e0897–e0890.
  • Zhang J, Yang Z, Wang X, Li J, Dong L, Wang F, Li Y, Wei R, Zhang J. 2020. The relationship between resilience, anxiety and depression among patients with mild symptoms of COVID-19 in China: a cross-sectional study. J Clin Nurs. 29:4020–4029.

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