441
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Could gonadal and adrenal androgen deficiencies contribute to the depressive symptoms in men with systolic heart failure?

, , , , , , , , & show all
Pages 221-230 | Received 04 Jan 2016, Accepted 17 Jun 2016, Published online: 20 Sep 2016

References

  • Rutledge T, Reis VA, Linke SE, et al. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol 2006;48:1527–37
  • Himelhoch S, Weller WE, Wu AW, et al. Chronic medical illness, depression, and use of acute medical services among Medicare beneficiaries. Med Care 2004;42:512–21
  • Freedland KE, Carney RM, Rich MW, et al. Depression in elderly patients with congestive heart failure. J Geriatr Psychiatry 1991;24:59–71
  • Gottlieb SS, Khatta M, Friedmann E, et al. The influence of age, gender, and race on the prevalence of depression in heart failure patients. J Am Coll Cardiol 2004;43:1542–9
  • Bekelman DB, Havranek EP, Becker DM, et al. Symptoms, depression, and quality of life in patients with heart failure. J Card Fail 2007;13:643–8
  • Carels RA. The association between disease severity, functional status, depression and daily quality of life in congestive heart failure patients. Qual Life Res 2004;13:63–72
  • Skotzko CE, Krichten C, Zietowski G, et al. Depression is common and precludes accurate assessment of functional status in elderly patients with congestive heart failure. J Card Fail 2000;6:300–5
  • Jiang W, Alexander J, Christopher E, et al. Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch Intern Med 2001;161:1849–56
  • Sherwood A, Blumenthal JA, Trivedi R, et al. Relationship of depression to death or hospitalization in patients with heart failure. Arch Intern Med 2007;167:367–73
  • Murberg TA, Bru E, Svebak S, et al. Depressed mood and subjective health symptoms as predictors of mortality in patients with congestive heart failure: a two-years follow-up study. Int J Psychiatry Med 1999;29:311–26
  • Junger J, Schellberg D, Muller-Tasch T, et al. Depression increasingly predicts mortality in the course of congestive heart failure. Eur J Heart Fail 2005;7:261–7
  • Konstam V, Moser DK, De Jong MJ. Depression and anxiety in heart failure. J Card Fail 2005;11:455–63
  • Silver MA. Depression and heart failure: an overview of what we know and don't know. Cleve Clin J Med 2010;77:S7–S11
  • Joynt KE, Whellan DJ, O’Connor CM. Why is depression bad for the failing heart? A review of the mechanistic relationship between depression and heart failure. J Card Fail 2004;10:258–71
  • Joshi D, van Schoor NM, de Ronde W, et al. Low free testosterone levels are associated with prevalence and incidence of depressive Symptoms in older men. Clin Endocrinol (Oxf) 2010;72:232–40
  • Morsink LF, Vogelzangs N, Nicklas BJ, et al. Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: results from the Health ABC study. Psychoneuroendocrinology 2007;32:874–83
  • Shores MM, Sloan KL, Matsumoto AM, et al. Increased incidence of diagnosed depressive illness in hypogonadal older men. Arch Gen Psychiatry 2004;61:162–7
  • Bain J. Testosterone and the aging male: to treat or not to treat? Maturitas 2010;66:16–22
  • Lunenfeld B, Mskhalaya G, Zitzmann M, et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male 2015;18:5–15
  • Moriyama Y, Yasue H, Yoshimura M, et al. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab 2000;85:1834–40
  • Amini Lari M, Parsa N, Marzban M, et al. Depression, testosterone concentration, sexual dysfunction and methadone use among men with hypogonadism and HIV infection. AIDS Behav 2012;16:2236–43
  • Debigaré R, Marquis K, Côté CH, et al. Catabolic/anabolic balance and muscle wasting in patients with COPD. Chest 2003;124:83–9
  • Halabi S, Collins EG, Thorevska N, et al. Relationship between depressive symptoms and hypogonadism in men with COPD. COPD 2011;8:346–53
  • Jankowska EA, Drohomirecka A, Ponikowska B, et al. Deficiencies in circulating testosterone and dehydroepiandrosterone sulphate, and depression in men with systolic chronic heart failure. Eur J Heart Fail 2010;12:966–73
  • Pope HG, Jr Cohane GH, Kanayama G, et al. Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. Am J Psychiatry 2003;160:105–11
  • Khera M, Bhattacharya RK, Blick G, et al. The effect of testosterone supplementation on depression symptoms in hypogonadal men from the Testim Registry in the US (TRiUS). Aging Male 2012;15:14–21
  • Pugh PJ, Jones RD, West JN, et al. Testosterone treatment for men with chronic heart failure. Heart 2004;90:446–7
  • Jankowska EA, Biel B, Majda J, et al. Anabolic Deficiency in men with chronic heart failure prevalence and detrimental impact on survival. Circulation 2006;114:1829–37
  • Brink TL, Yesavage JA, Lum O, et al. Screening tests for geriatric depression. Clinical Gerontologist 1982;1:37–44
  • Mitchell AJ, Bird V, Rizzo M, Meader N. Which version of the geriatric depression scale is most useful in medical settings and nursing homes? Diagnostic validity meta-analysis. Am J Geriatr Psychiatry 2010;18:1066–77
  • Rule BG, Harvey HZ, Dobbs AR. Reliability of GDS in adult population. Clinical Gerontologist 1989;9:37–43
  • Mohr BA, Guay AT, O’Donnell AB, McKinlay JB. Normal, bound and nonbound testosterone levels in normally ageing men: results from the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf) 2005;62:64–73
  • Elmlinger MW, Kuhnel W, Ranke MB. Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adults. Clin Chem Lab Med 2002;40:1151–60
  • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666–72
  • Kalyani RR, Gavini S, Dobs AS. Male hypogonadism in systemic disease. Endocrinol Metab Clin North Am 2007;36:333–48
  • Anker SD, Chua TP, Ponikowski P, et al. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia. Circulation 1997;96:526–34
  • Nestler JE. Regulation of human dehydroepiandrosterone metabolism by insulin. Ann NY Acad Sci 1995;774:73–81
  • Tappler B, Katz M. Pituitary-gonadal dysfunction in low-output cardiac failure. Clin. Endocrinol (Oxf) 1979;10:219–26
  • Maninger N, Wolkowitz OM, Reus VI, et al. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA Sulfate (DHEAS). Front Neuroendocrinol 2009;30:65–91
  • Allolio B, Arlt W. DHEA treatment: myth or reality? Trends Endocrinol Metab 2002;13:288–94
  • Kimonides VG, Khatibi NH, Svendsen CN, et al. Dehydroepiandrosterone (DHEA) and DHEA(S) ulfate (DHEAS) protecthippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci USA 1998;95:1852–7
  • Robichaud M, Debonnel G. Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids. J Endocrinol 2004;182:11–21
  • Traish AM, Kang HP, Saad F, Guay AT. Dehydroepiandrosterone(DHEA)—a precursor steroid or an active hormone in human physiology. J Sex Med 2011;8:2960–82
  • Baulieu EE, Robel P, Schumacher M. Neurosteroids: beginning of the story. Int Rev Neurobiol 2001;46:1–32
  • Melcangi RC, Garcia-Segura LM, Mensah-Nyagan AG. Neuroactive steroids: state of the art and new perspectives. Cell Mol Life Sci 2008;65:777–97
  • Wierman ME. Sex steroid effects at target tissues: mechanisms of action. Adv Physiol Educ 2007;31:26–33
  • Wu FCW, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010;363:123–35
  • Tivesten A, Moverare-Skrtic S, Chagin A, et al. Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats. J Bone Miner Res 2004;19:1833–9
  • Ferruci L, Maggio M, Bandinelli S, et al. Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med 2006;166:1380–8
  • Baker JR, Bemben MG, Anderson MA, Bemben DA. Effects of age on testosterone responses to resistance exercise and musculoskeletal variables in men. J Strength Cond Res 2006;20:874–81
  • Azad N, Pitales S, Barres WE, et al. Testosterone treatment enhances regional brain perfusion in hypogonadal men. J Clin Endocrinol Metab 2003;88:3064–8
  • Alderson LM, Baum MJ. Differential effects of gonadal steroids on dopamine metabolism in mesolimbic and nigro-striatal pathways of male rat brain. Brain Res 1981;218:189–206
  • Robichaud M, Debonnel G. Oestrogen and testosterone modulate the firing activity of dorsal raphe nucleus serotonergic neurones in both male and female rats. J Neuroendocrinol 2005;17:179–85
  • Roselli CE, Horton LE, Resko JA. Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system. Endocrinology 1985;117:2471–7
  • Selmanoff MK, Brodkin LD, Weiner RI, Siiteri PK. Aromatization and 5alpha-reduction of androgens in discrete hypothalamic and limbic regions of the male and female rat. Endocrinology 1977;101:841–8
  • Lephart ED, Lund TD, Horvath TL. Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Res Rev 2001;37:25–37
  • Rubin RT, Poland RE, Lesser IM, et al. Neuroendocrine aspects of primary endogenous depression. I. Cortisol secretory dynamics in patients and matched controls. Arch Gen Psychiatry 1987;44:328–36
  • Bambino TH, Hsueh AJ. Direct inhibitory effect of glucocorticoids upon testicular lutenizing hormone receptor and steroidogenesis in vivo and in vitro. Endocrinology 1981;108:2142–8
  • Cumming DC, Quigley ME, Yen SC. Acute suppression of circulating testosterone levels by cortisol in men. J Clin Endocrinol Metab 1983;57:671–3
  • Lund TD, Hinds LR, Handa RJ. The androgen 5alpha-dihydrotestosterone and its metabolite 5alphaandrostan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus. J Neurosci 2006;26:1448–56
  • Osterlund MK, Witt MR, Gustafsson JA. Estrogen action in mood and neurodegenerative disorders: estrogenic compounds with selective properties-the next generation of therapeutics. Endocrine 2005;28:235–42
  • Krezel W, Dupont S, Krust A, et al. Increased anxiety and synaptic plasticity in estrogen receptor beta-deficient mice. Proc Natl Acad Sci USA 2005;98:12278–82
  • Tajar A, Forti G, O'Neill TW, et al. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab 2010;95:1810–18
  • McIntyre RS, Mancini D, Eisfeld BS, et al. Calculated bioavailable testosterone levels and depression in middle-aged men. Psychoneuroendocrinology 2006;31:1029–35
  • Sharma R, Coats AJ, Anker SD. The role of inflammatory mediators in chronic heart failure: cytokines, nitric oxide, and endothelin-1. Int J Cardiol 2000;72:175–86
  • Sharma R, Anker SD. Immune and neurohormonal pathways in chronic heart failure. Congest Heart Fail 2002;8:23–8
  • Malkin CJ, Pugh PJ, West JN, et al. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 2006;27:57–64
  • Jankowska EA, Filippatos G, Ponikowska B, et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. J Cardiac Fail 2009;15:442–50
  • Seidman SN, Araujo AB, Roose SP, et al. Low testosterone levels in elderly men with dysthymic disorder. Am J Psychiatry 2002;159:456–9
  • Wang C, Alexander G, Berman N, et al. Testosterone replacement therapy improves mood in hypogonadal men—a clinical research center study. J Clin Endocrinol Metab 1996;81:3578–83
  • Schmidt PJ, Daly RC, Bloch M, et al. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry 2005;62:154–62
  • Stout M, Tew GA, Doll H, et al. Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study. Am Heart J 2012;164:893–901
  • Vaccarino V, Kasl SV, Abramson J, Krumholz HM. Depressive symptoms and risk of functional decline and death in patients with heart failure. J Am Coll Cardiol 2001;38:199–205
  • Freedland KE, Rich MW, Skala JA, et al. Prevalence of depression in hospitalized patients with congestive heart failure. Psychosom Med 2003;65:119–28
  • van Manen JG, Bindels PJE, Dekker FW, et al. Risk of depression in patients with chronic obstructive pulmonary disease and its determinants. Thorax 2002;57:412–16
  • Schneider C, Jick SS, Bothner U, Meier CR. COPD and the risk of depression. Chest 2010 Feb;137:341–7
  • Stewart R, Prince M, Mann A, et al. Stroke, vascular risk factors and depression: cross-sectional study in a UK Caribbean-born population. Br J Psychiatry 2001;178:23–8
  • Hackett ML, Yapa C, Parag V, Craig S. Frequency of depression after stroke a systematic review of observational studies by Anderson. Stroke 2005;36:1330–40
  • Lesman-Leegte I, Jaarsman T, Sanderman R, et al. Depressive symptoms are prominent among elderly hospitalised heart failure patients. Eur J Heart Fail 2006;8:634–40
  • Onder G, Penninx BW, Cesari M, et al. Anemia is associated with depression in older adults: results from the InCHIANTI study. J Gerontol a Biol Sci Med Sci 2005;60:1168–72
  • Steptoe A, Wikman A, Molloy GJ, Kaski JC. Anaemia and the development of depressive symptoms following acute coronary syndrome: longitudinal clinical observational study. BMJ Open 2012;2:e000551–3
  • Skarstein J, Bjelland I, Dahl AA, et al. Is there an association between haemoglobin, depression, and anxiety in cancer patients? J Psychosom Res 2005;58:477–83
  • Albert NM, Fonarow GC, Abraham WT, et al. Depression and clinical outcomes in heart failure: an OPTIMIZE-HF analysis. Am J Med 2009;122:366–73
  • Jiang W, Kuchibhatla M, Cuffe MS, et al. Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation 2004;110:3452–6
  • Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Internal Med 1999;130:461–70

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.