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Original Article

Apoptosis in hippocampal tissue induced by oxidative stress in testosterone deprived male rats

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Pages 1598-1610 | Received 26 Aug 2020, Accepted 15 Feb 2021, Published online: 10 Mar 2021

References

  • Uddin MS, Al Mamun A, Jakaria M, et al. Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. Sci Total Environ. 2020;707:135624.
  • Rahman S, Archana A, Jan AT, et al. Dissecting endoplasmic reticulum unfolded protein response (UPRER) in managing clandestine modus operandi of Alzheimer’s disease. Front Aging Neurosci. 2018;10:30.
  • Abushouk AI, Negida A, Ahmed H, et al. Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: future applications in Parkinson’s disease. Biomed Pharmacother. 2017;85:635–645.
  • Tan BL, Norhaizan ME, Liew WPP, et al. Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Front Pharmacol. 2018;9:1162.
  • Uddin MS, Kabir MT, Al Mamun A, et al. APOE and Alzheimer’s disease: evidence mounts that targeting APOE4 may combat Alzheimer’s pathogenesis. Mol Neurobiol. 2019;56(4):2450–2l465.
  • Uttara B, Singh AV, Zamboni P, et al. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 2009;7(1):65–74.
  • Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24(10):R453–R462.
  • Farhat Z, Browne RW, Bonner MR, et al. How do glutathione antioxidant enzymes and total antioxidant status respond to air pollution exposure? Environ Int. 2018;112:287–293.
  • Seppan P, Muhammed I, Mohammad ZIK, et al. Pathobiology of ischiocavernosus and bulbospongiosus muscles in long-term diabetic male rats and its implication on erectile dysfunction. Aging Male. 2019;1:1–12.
  • Celec P, Ostatníková D, Hodosy J. On the effects of testosterone on brain behavioral functions. Front Neurosci. 2015;9:12.
  • Wang X, Michaelis EK. Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci. 2010;2:12.
  • Pan W, Han S, Kang L, et al. Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice. Exp Ther Med. 2016;12(3):1455–1463.
  • Lei Y, Renyuan Z. Effects of androgens on the amyloid-β protein in Alzheimer’s disease. Endocrinology. 2018;159(12):3885–3894. [cited 2020 Feb 11]Available from: https://academic.oup.com/endo/article/159/12/3885/5094961.
  • CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol. 2003;35:257–274.
  • Sestakova N, Puzserova A, Kluknavsky M, et al. Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide. Interdiscip Toxicol. 2013;6(3):126–135.
  • Baldo B, Petersén Å. Analysis of nonmotor features in murine models of Huntington disease. Movement disorders. 2nd ed. Amsterdam, Netherlands: Elsevier; 2015. p. 583–602.
  • Abhijit S, Tripathi SJ, Bhagya V, et al. Antioxidant action of grape seed polyphenols and aerobic exercise in improving neuronal number in the hippocampus is associated with decrease in lipid peroxidation and hydrogen peroxide in adult and middle-aged rats. Exp Gerontol. 2018;101:101–112.
  • Jyoti A, Sharma D. Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain. Neurotoxicology. 2006;27(4):451–457.
  • Doungue HT, Kengne APN, Kuate D. Neuroprotective effect and antioxidant activity of Passiflora edulis fruit flavonoid fraction, aqueous extract, and juice in aluminum chloride-induced Alzheimer’s disease rats. Nutrire. 2018;43(1):23.
  • Popović N, Stojiljković V, Pejić S, et al. Modulation of hippocampal antioxidant defense system in chronically stressed rats lithium. Oxid Med Cell Longev. 2019;2019:8745376.
  • Hasegawa N, Mochizuki M. Improved effect of Pycnogenol on impaired spatial memory function in partial androgen deficiency rat model. Phytother Res. 2009;23(6):840–843.
  • Nagashima R, Sano S, Huong NQ, et al. Enhanced expression of glutathione S-transferase in the hippocampus following acute treatment with trimethyltin in vivo. J Pharmacol Sci. 2010;113(3):267–270.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254.
  • Hartmans C, Comijs H, Jonker C. Cognitive functioning and its influence on sexual behavior in normal aging and dementia. Int J Geriatr Psychiatry. 2014;29(5):441–446.
  • Hodosy J, Zelmanová D, Majzúnová M, et al. The anxiolytic effect of testosterone in the rat is mediated via the androgen receptor. Pharmacol Biochem Behav. 2012;102(2):191–195.
  • Wagner BA, Braddick VC, Batson CG, et al. Effects of testosterone dose on spatial memory among castrated adult male rats. Psychoneuroendocrinology. 2018;89:120–130.
  • Cunningham RL, Lumia AR, McGinnis MY. Androgen receptors, sex behavior, and aggression. Neuroendocrinology. 2012;96(2):131–140.
  • Carrier N, Saland SK, Duclot F, et al. The anxiolytic and antidepressant-like effects of testosterone and estrogen in gonadectomized male rats. Biol Psychiatry. 2015;78(4):259–269. [cited 2020 Dec 16]Available from: https://www.sciencedirect.com/science/article/pii/S0006322315000402.
  • Osborne DM, Edinger K, Frye CA. Chronic administration of androgens with actions at estrogen receptor beta have anti-anxiety and cognitive-enhancing effects in male rats. Age (Dordr). 2009;31(2):119–126.
  • Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014:360438.
  • Uchida K. Role of reactive aldehyde in cardiovascular diseases. Free Radic Biol Med. 2000;28(12):1685–1696.
  • Petrou AL, Petrou PL, Ntanos T, et al. A possible role for singlet oxygen in the degradation of various antioxidants. A meta-analysis and review of literature data. Antioxidants. 2018;7(3):35.
  • Meydan S, Kus I, Tas U, et al. Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus. J Chem Neuroanat. 2010;40(4):281–285.
  • Cruz-Topete D, Dominic P, Stokes KY. Uncovering sex-specific mechanisms of action of testosterone and redox balance. Redox Biol. 2020;31:101490.
  • Ahmed H, Abushouk AI, Gabr M, et al. Parkinson’s disease and pesticides: a meta-analysis of disease connection and genetic alterations. Biomed Pharmacother. 2017;90:638–649.
  • Wang F, Yang J, Sun J, et al. Testosterone replacement attenuates mitochondrial damage in a rat model of myocardial infarction. J Endocrinol. 2015;225(2):101–111.
  • Lee KH, Cha M, Lee BH. Neuroprotective effect of antioxidants in the brain. Int J Mol Sci. 2020;21(19):7152.
  • Holmes S, Singh M, Su C, et al. Effects of oxidative stress and testosterone on pro-inflammatory signaling in a female rat dopaminergic neuronal cell line. Endocrinology. 2016;157(7):2824–2835.
  • Marí M, Morales A, Colell A, et al. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013;1830(5):3317–3328.
  • Couto N, Wood J, Barber J. The role of glutathione reductase and related enzymes on cellular redox homeostasis network. Free Radic. Biol. Med. 2016;95:27–42.
  • Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem. 2014;289(13):8735–8741.
  • Carvour M, Song C, Kaul S, et al. Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration. Ann NY Acad Sci. 2008;1139:197–205.
  • Hu K, Li S, Xiao B, et al. Protective effects of quercetin against status epilepticus induced hippocampal neuronal injury in rats: involvement of X-linked inhibitor of apoptosis protein. Acta Neurol Belg. 2011;111(3):205–212.
  • Altucci L, Gronemeyer H. Nuclear receptors in cell life and death. Trends Endocrinol Metab. 2001;12(10):460–468.
  • Nguyen TV, Yao M, Pike CJ. Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. J Neurochem. 2005;94(6):1639–1651.
  • Matsumoto AM. Is high dosage testosterone an effective male contraceptive agent? Fertil Steril. 1988;50(2):324–328.

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