Physiological testosterone replacement effects on male aged rats with orchiectomy-induced osteoporosis in advanced stage: a tomographic and biomechanical pilot study

References

• Misiorowski W. Osteoporosis in men. Prz Menopauzalny. 2017;16(2):70–73.
   PubMedGoogle Scholar
• Johnston CB, Dagar M. Osteoporosis in older adults. Med Clin North Am. 2020;104(5):873–884.
   PubMed Web of Science ®Google Scholar
• Stein E, Shane E. Secondary osteoporosis. Endocrinol Metab Clin North Am. 2003;32(1):115–134.
   PubMed Web of Science ®Google Scholar
• Harper KD, Weber TJ. Secondary osteoporosis. Diagnostic considerations. Endocrinol Metab Clin North Am. 1998;27(2):325–348.
   PubMed Web of Science ®Google Scholar
• Gennari L, Bilezikian JP. Osteoporosis in men. Endocrinol Metab Clin North Am. 2007;36(2):399–419.
   PubMed Web of Science ®Google Scholar
• Napoli N, Chandran M, Pierroz DD, et al. Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol. 2017;13(4):208–219.
   PubMed Web of Science ®Google Scholar
• Mohamad NV, Soelaiman IN, Chin KY. A concise review of testosterone and bone health. Clin Interv Aging. 2016;11:1317–1324.
   PubMed Web of Science ®Google Scholar
• Golds G, Houdek D, Arnason T. Male hypogonadism and osteoporosis: the effects, clinical consequences, and treatment of testosterone deficiency in bone health. Int J Endocrinol. 2017;2017:4602129.
   PubMed Web of Science ®Google Scholar
• Mendoza FA, Le Roux M, Ahmed I. Primary osteoporosis in men: an unmet medical need. Fertil Steril. 2019;112(5):791–798.
   PubMed Web of Science ®Google Scholar
• Vanderschueren D, Vandenput L, Boonen S, et al. Androgens and bone. Endocr Rev. 2004;25(3):389–425.
   PubMed Web of Science ®Google Scholar
• Clarke BL, Khosla S. Androgens and bone. Steroids. 2009;74(3):296–305.
   PubMed Web of Science ®Google Scholar
• Rochira V. Late-onset hypogonadism: Bone health. Andrologia. 2020;8(6):1539–1550.
   Google Scholar
• Tracz MJ, Sideras K, Bolona ER, et al. Testosterone use in men and its effects on bone health: a systematic review and meta-analysis of randomized placebo-controlled trials. J Clin Endocrinol Metab. 2006;91(6):2011–2016.
   PubMed Web of Science ®Google Scholar
• Chin KY, Ima-Nirwana S. The effects of orchidectomy and supraphysiological testosterone administration on trabecular bone structure and gene expression in rats. Aging Male. 2015;18(1):60–66.
   PubMed Web of Science ®Google Scholar
• Lee MJ, Ryu HK, An SY, et al. Testosterone replacement and bone mineral density in male pituitary tumor patients. Endocrinol Metab. 2014;29(1):48–53.
   Google Scholar
• Ryu SJ, Ryu DS, Kim JY, et al. Bone mineral density changes after orchiectomy using a scrotal approach in Rats. Korean J Spine. 2015;12(2):55–59.
   PubMedGoogle Scholar
• Ryu SJ, Ryu DS, Kim JY, et al. Changes in bone metabolism in young castrated male rats. Yonsei Med J. 2016;57(6):1386–1394.
   PubMed Web of Science ®Google Scholar
• Martin-Fernandez M, Garzon-Marquez FM, Diaz-Curiel M, et al. Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats. Aging Male. 2018;2018:1–13.
   Google Scholar
• Yeh PS, Lee YW, Chang WH, et al. Biomechanical and tomographic differences in the microarchitecture and strength of trabecular and cortical bone in the early stage of male osteoporosis. PLoS One. 2019;14(8):e0219718.
   PubMed Web of Science ®Google Scholar
• de Paiva Goncalves V, Ortega AAC, Steffens JP, et al. Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model. J Periodontol. 2018;89(4):466–475.
   PubMed Web of Science ®Google Scholar
• Callies F, Kollenkirchen U, von Zur MC, et al. Testosterone undecanoate: a useful tool for testosterone administration in rats. Exp Clin Endocrinol Diabetes. 2003;111(4):203–208.
   PubMed Web of Science ®Google Scholar
• Steffens JP, Coimbra LS, Rossa C, Jr, et al. Androgen receptors and experimental bone loss – an in vivo and in vitro study. Bone. 2015;81:683–690.
   PubMed Web of Science ®Google Scholar
• Rosales Rocabado JM, Kaku M, Nozaki K, et al. A multi-factorial analysis of bone morphology and fracture strength of rat femur in response to ovariectomy. J Orthop Surg Res. 2018;13(1):318.
   PubMedGoogle Scholar
• Tajul Ariff AS, Soelaiman IN, Pramanik J, et al. Effects of eurycoma longifolia on testosterone level and bone structure in an aged orchidectomised rat model. Evid Based Complement Alternat Med. 2012;2012:818072.
   PubMed Web of Science ®Google Scholar
• Prakasam G, Yeh JK, Chen MM, et al. Effects of growth hormone and testosterone on cortical bone formation and bone density in aged orchiectomized rats. Bone. 1999;24(5):491–497.
   PubMed Web of Science ®Google Scholar
• Shuid AN, El-Arabi E, Effendy NM, et al. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012;12(1):152.
   PubMedGoogle Scholar
• Ramli R, Khamis MF, Shuid AN. Bone Micro-CT assessments in an orchidectomised rat model supplemented with eurycoma longifolia. Evid Based Complement Alternat Med. 2012;2012:501858.
   PubMed Web of Science ®Google Scholar
• Keller TS, Mao Z, Spengler DM. Young’s modulus, bending strength, and tissue physical properties of human compact bone. J Orthop Res. 1990;8(4):592–603.
   PubMed Web of Science ®Google Scholar
• Vandenput L, Boonen S, Van Herck E, et al. Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone. J Bone Miner Res. 2002;17(11):2080–2086.
   PubMed Web of Science ®Google Scholar
• Jamsa T, Jalovaara P, Peng Z, et al. Comparison of three-point bending test and peripheral quantitative computed tomography analysis in the evaluation of the strength of mouse femur and tibia. Bone. 1998;23(2):155–161.
   PubMed Web of Science ®Google Scholar
• Vanderschueren D, Van Herck E, Suiker AM, et al. Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency. Endocrinology. 1992;130(5):2906–2916.
   PubMed Web of Science ®Google Scholar
• Zhang G, Wang S, Xu S, et al. The effect of formalin preservation time and temperature on the material properties of bovine femoral cortical bone Tissue. Ann Biomed Eng. 2019;47(4):937–952.
   PubMed Web of Science ®Google Scholar
• Fiedler IAK, Casanova M, Keplinger T, et al. Effect of short-term formaldehyde fixation on raman spectral parameters of bone quality. J Biomed Opt. 2018;23(11):1–6.
   PubMed Web of Science ®Google Scholar
• Schmidt C, Priemel M, Kohler T, et al. Precision and accuracy of peripheral quantitative computed tomography (pQCT) in the mouse skeleton compared with histology and microcomputed tomography (microCT). J Bone Miner Res. 2003;18(8):1486–1496.
   PubMed Web of Science ®Google Scholar
• Kanis JA, Johnell O, De Laet C, et al. A Meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004;35(2):375–382.
   PubMed Web of Science ®Google Scholar
• Borst SE, Conover CF, Carter CS, et al. Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase. Am J Physiol Endocrinol Metab. 2007;293(2):E507–14.
   PubMed Web of Science ®Google Scholar
• Borst SE, Lee JH, Conover CF. Inhibition of 5α-reductase blocks prostate effects of testosterone without blocking anabolic effects. Am J Physiol Endocrinol Metab. 2005;288(1):E222–7.
   PubMed Web of Science ®Google Scholar