Usefulness of routine assessment of free testosterone for the diagnosis of functional male hypogonadism

References

• Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2018;103(5):1715–1744.
   PubMed Web of Science ®Google Scholar
• Corona G, Goulis DG, Huhtaniemi I, et al. European academy of andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: endorsing organization: European society of endocrinology. Andrologia. 2020;8(5):970–987.
   PubMed Web of Science ®Google Scholar
• Salonia A, Bettocchi C, Carvalho J, et al. EAU guidelines on sexual and reproductive health. In: European Association of Urology guidelines. Arnhem, The Netherlands: EAU Guidelines Office; 2020. Available at: https://uroweb.org/guideline/sexual-and-reproductive-health/
   Google Scholar
• Grossmann M, Matsumoto AM. A perspective on Middle-Aged and older men with functional hypogonadism: focus on holistic management. J Clin Endocrinol Metab. 2017;102(3):1067–1075.
   PubMed Web of Science ®Google Scholar
• Rastrelli G, Lotti F, Reisman Y, et al. Metabolically healthy and unhealthy obesity in erectile dysfunction and male infertility. Expert Rev Endocrinol Metab. 2019;14(5):321–334.
   PubMed Web of Science ®Google Scholar
• Corona G, Maseroli E, Rastrelli G, et al. Is late-onset hypogonadotropic hypogonadism a specific age-dependent disease, or merely an epiphenomenon caused by accumulating disease-burden? Minerva Endocrinol. 2016;41(2):196–210.
   PubMed Web of Science ®Google Scholar
• Corona G, Monami M, Rastrelli G, et al. Type 2 diabetes mellitus and testosterone: a meta-analysis study. Int J Androl. 2011;34(6pt1):528–540.
   PubMedGoogle Scholar
• Pezzaioli LC, Porcelli T, Delbarba A, et al. Impact of hypogonadism on bone mineral density and vertebral fractures in HIV-infected men. J Endocrinol Invest. 2022;45(2):433–443.
   PubMed Web of Science ®Google Scholar
• Quiros-Roldan E, Porcelli T, Pezzaioli LC, et al. Hypogonadism and liver fibrosis in HIV-infected patients. J Endocrinol Invest. 2021;44(9):1971–1979.
   PubMed Web of Science ®Google Scholar
• Wu FC, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010;363(2):123–135.
   PubMed Web of Science ®Google Scholar
• Rastrelli G, Corona G, Maggi M. Testosterone and sexual function in men. Maturitas. 2018;112:46–52.
   PubMed Web of Science ®Google Scholar
• Foresta C, Ferlin A, Lenzi A, et al. The great opportunity of the andrological patient: cardiovascular and metabolic risk assessment and prevention. Andrology. 2017;5(3):408–413.
   PubMed Web of Science ®Google Scholar
• Pezzaioli LC, Quiros-Roldan E, Paghera S, et al. The importance of SHBG and calculated free testosterone for the diagnosis of symptomatic hypogonadism in HIV-infected men: a single-centre real-life experience. Infection. 2021;49(2):295–303.
   PubMed Web of Science ®Google Scholar
• Ferlin A, Foresta C. Infertility: practical clinical issues for routine investigation of the male partner. J Clin Med. 2020;9(6):1644.
   PubMed Web of Science ®Google Scholar
• Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84(10):3666–3672. Oct
   PubMed Web of Science ®Google Scholar
• Ferlin A, Garolla A, Ghezzi M, et al. Sperm count and hypogonadism as markers of general male health. Eur Urol Focus. 2021;7(1):205–213.
   PubMedGoogle Scholar
• Tajar A, Forti G, O'Neill TW, et al. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European male ageing study. J Clin Endocrinol Metab. 2010;95(4):1810–1818.
   PubMed Web of Science ®Google Scholar
• Antonio L, Wu FC, O'Neill TW, et al. Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone. J Clin Endocrinol Metab. 2016;101(7):2647–2657.
   PubMed Web of Science ®Google Scholar
• Boeri L, Capogrosso P, Ventimiglia E, et al. Does calculated free testosterone overcome total testosterone in protecting from sexual symptom impairment? Findings of a cross-sectional study. J Sex Med. 2017;14(12):1549–1557.
   PubMed Web of Science ®Google Scholar
• Yeap BB, Almeida OP, Hyde Z, et al. In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The health in men study. Eur J Endocrinol. 2007;156(5):585–594.
   PubMed Web of Science ®Google Scholar
• Arathimos R, Millard LAC, Bell JA, et al. Impact of sex hormone-binding globulin on the human phenome. Hum Mol Genet. 2020;29(11):1824–1832.
   PubMed Web of Science ®Google Scholar
• Coviello AD, Zhuang WV, Lunetta KL, et al. Circulating testosterone and SHBG concentrations are heritable in women: the Framingham heart study. J Clin Endocrinol Metab. 2011;96(9):E1491–E1495. Sep
   PubMed Web of Science ®Google Scholar
• Harris JA, Vernon PA, Boomsma DI. The heritability of testosterone: a study of Dutch adolescent twins and their parents. Behav Genet. 1998;28(3):165–171.
   PubMed Web of Science ®Google Scholar
• Coviello AD, Haring R, Wellons M, et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genet. 2012;8(7):e1002805.
   PubMed Web of Science ®Google Scholar
• Ohlsson C, Wallaschofski H, Lunetta KL, et al. Genetic determinants of serum testosterone concentrations in men. PLoS Genet. 2011;7(10):e1002313. Oct
   PubMed Web of Science ®Google Scholar
• Li Y, Si S, Hou L, et al. Causal effect of sex hormone-binding globulin and testosterone on coronary heart disease: a multivariable and network Mendelian randomization analysis. Int J Cardiol. 2021;339:179–184.
   PubMed Web of Science ®Google Scholar
• Simó R, Sáez-López C, Barbosa-Desongles A, et al. Novel insights in SHBG regulation and clinical implications. Trends Endocrinol Metab. 2015;26(7):376–383.
   PubMed Web of Science ®Google Scholar
• Morley JE, Patrick P, Perry HM. Evaluation of assays available to measure free testosterone. Metabolism. 2002;51(5):554–559.
   PubMed Web of Science ®Google Scholar
• Shea JL, Wong PY, Chen Y. Free testosterone: clinical utility and important analytical aspects of measurement. Adv Clin Chem. 2014;63:59–84.
   PubMed Web of Science ®Google Scholar