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Culture, Health & Sexuality
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Research Article

Qualitative accounts of PrEP discontinuation from the general population in Eswatini

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Pages 1198-1214 | Received 12 Jul 2019, Accepted 13 May 2020, Published online: 07 Jul 2020

References

  • Aluisio, A., B. A. Richardson, R. Bosire, G. John-Stewart, D. Mbori-Ngacha, and C. Farquhar. 2011. “Male Antenatal Attendance and HIV Testing Are Associated with Decreased Infant HIV Infection and Increased HIV Free Survival.” Journal of Acquired Immune Deficiency Syndromes 56 (1): 76–90.
  • Amico, K. R., and L.-G. Bekker. 2019. “Global PrEP Roll-Out: Recommendations for Programmatic Success.” The Lancet HIV 6 (2): e137–e140. doi:10.1016/S2352-3018(19)30002-5
  • Arnold, T., L. Brinkley-Rubinstein, P. A. Chan, A. Perez-Brumer, E. S. Bologna, L. Beauchamps, K. Johnson, L. Mena, and A. Nunn. 2017. “Social, Structural, Behavioral and Clinical Factors Influencing Retention in Pre-Exposure Prophylaxis (PrEP) Care in Mississippi.” PLoS One 12 (2): e0172354. doi:10.1371/journal.pone.0172354
  • Auerbach, J. D., and T. A. Hoppe. 2015. “Beyond “Getting Drugs into Bodies”: Social Science Perspectives on Pre-Exposure Prophylaxis for HIV.” Journal of the International AIDS Society 18 (4 Suppl 3): 19983. doi:10.7448/IAS.18.4.19983
  • AVAC. 2017. “Ongoing and Planned PrEP Demonstration and Implementation Studies.” http://www.avac.org/resource/ongoing-and-planned-prep-demonstration-and-implementation-studies
  • Bärnighausen, K. E., S. Matse, C. E. Kennedy, C. L. Lejeune, A. B. Hughey, A. Hettema, T. W. Bärnighausen, and S. A. McMahon. 2019. “‘This Is Mine, This Is for Me.’ PrEP as a Source of Resilience among Women in Eswatini.” AIDS 33 (1): S45–S52. doi:10.1097/QAD.0000000000002178
  • Bassett, I. V., S. Regan, H. Mbonambi, J. Blossom, S. Bogan, B. Bearnot, M. Robine, et al. 2015. “Finding HIV in Hard to Reach Populations: Mobile HIV Testing and Geospatial Mapping in Umlazi Township.” AIDS & Behavior 19 (10): 1888–1895. doi:10.1007/s10461-015-1012-3
  • Browne, S. H., K. Barford, T. Ramela, and R. Dowse. 2019. “The Impact of Illustrated Side Effect Information on Understanding and Sustained Retention of Antiretroviral Side Effect Knowledge.” Research in Social and Administrative Pharmacy 15 (4): 469–473. doi:10.1016/j.sapharm.2018.05.012
  • Brooks, R., R. Kaplan, E. Lieber, R. Landovitz, S. Lee and A. Leibowitz. 2011 “Motivators, Concerns, and Barriers to Adoption of Preexposure Prophylaxis for HIV Prevention Among Gay and Bisexual Men in HIV-serodiscordant Male Relationships”, AIDS Care 23: 9. doi:10.1080/09540121.2011.554528
  • Buunk, B. P., and P. Dijkstra. 2001. “Rationalizations and Defensive Attributions for High-Risk Sex Among Heterosexuals.” Patient Education and Counseling 45 (2): 127–132. doi:10.1016/S0738-3991(01)00114-8
  • Chan, P. A., Mena, L., Patel, R., Oldenburg, C. E., Beauchamps, L., Perez-Brumer, A. G., and Parker, S, et al. 2016. “Retention in Care Outcomes for HIV Pre‐Exposure Prophylaxis Implementation Programmes Among Men Who Have Sex with Men in Three US Cities.” Journal of the International AIDS Society 19 (1): 20903. doi:10.7448/IAS.19.1.20903
  • Charmaz, K. 2006. Constructing Grounded Theory: A Practical Guide through Qualitative Analysis. London: Sage Publications.
  • Clinicaltrials.gov. 2017. “PrEP Demonstration Study in Swaziland.” Accessed April 3 2019. https://clinicaltrials.gov/ct2/show/NCT03254550
  • Collins, S. P., V. M. McMahan, and J. D. Stekler. 2017. “The Impact of HIV Pre-Exposure Prophylaxis (PrEP) Use on the Sexual Health of Men Who Have Sex with Men: A Qualitative Study in Seattle, WA.” International Journal of Sexual Health 29 (1): 55–68. doi:10.1080/19317611.2016.1206051
  • Corbin, J., and A. Strauss. 2008. Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory. Thousand Oaks, CA: SAGE.
  • Corneli, A., E. Namey, K. Ahmed, K. Agot, J. Headley, K. Mckenna, J. Skhosana, and J. Odhiambo. 2014. “Preparing for Risk-Reduction Counseling on Pre-Exposure Prophylaxis for Women in Kenya and South Africa.” AIDS Research and Human Retroviruses 30 (S1): A268–A269. doi:10.1089/aid.2014.5603.abstract
  • Corneli, A. L., K. McKenna, J. Headley, K. Ahmed, J. Odhiambo, J. Skhosana, M. Wang, and K. Agot. 2014. “A Descriptive Analysis of Perceptions of HIV Risk and Worry about Acquiring HIV Among FEM-PrEP Participants Who Seroconverted in Bondo, Kenya, and Pretoria, South Africa.” Journal of the International AIDS Society 17 (3 Suppl 2): 19152. doi:10.7448/IAS.17.3.19152
  • Cowan, F. M., S. Delany-Moretlwe, E. J. Sanders, N. R. Mugo, F. A. Guedou, M. Alary, L. Behanzin, O. Mugurungi, and L. G. Bekker. 2016. “PrEP Implementation Research in Africa: What Is New?” Journal of the International AIDS Society 19 (7(Suppl 6)): 21101. doi:10.7448/IAS.19.7.21101
  • Cremin, I., F. Morales, B. L. Jewell, K. R. O’Reilly, and T. B. Hallett. 2015. “Seasonal PrEP for Partners of Migrant Miners in Southern Mozambique: A Highly Focused PrEP Intervention.” Journal of the International AIDS Society 18 (4 Suppl 3): 19946. doi:10.7448/IAS.18.4.19946
  • Davis, M. 2015. “After the Clinic? Researching Sexual Health Technology in Context.” Culture, Health & Sexuality 17 (4): 398–411. doi:10.1080/13691058.2014.928371
  • Diamond-Smith, N., M. Campbell, and S. Madan. 2012. “Misinformation and Fear of Side-Effects of Family Planning.” Culture, Health & Sexuality 14 (4): 421–433. doi:10.1080/13691058.2012.664659
  • Dlamini-Simelane, T. T., and E. Moyer. 2016. “‘Lost to Follow Up’: Rethinking Delayed and Interrupted HIV Treatment Among Married Swazi Women.” Health Policy and Planning 32 (2): 248–256.
  • Dowse, R., K. Barford, and S. H. Browne. 2014. “Simple, Illustrated Medicines Information Improves ARV Knowledge and Patient Self-Efficacy in Limited Literacy South African HIV Patients.” AIDS Care 26 (11): 1400–1406. doi:10.1080/09540121.2014.931559
  • Dunbar, M. S., K. Kripke, J. Haberer, D. Castor, S. Dalal, W. Mukoma, S. Mullick, et al., 2018. “Understanding and Measuring Uptake and Coverage of Oral Pre-Exposure Prophylaxis Delivery Among Adolescent Girls and Young Women in Sub-Saharan Africa.” Sexual Health 15 (6): 513–521. doi:10.1071/SH18061
  • Elsesser, S. A., C. E. Oldenburg, K. B. Biello, M. J. Mimiaga, S. A. Safren, J. E. Egan, D. S. Novak, D. S. Krakower, R. Stall, and K. H. Mayer. 2016. “Seasons of Risk: Anticipated Behavior on Vacation and Interest in Episodic Antiretroviral Pre-Exposure Prophylaxis (PrEP) Among a Large National Sample of US Men Who Have Sex with Men (MSM).” AIDS & Behavior 20 (7): 1400–1407. doi:10.1007/s10461-015-1238-0
  • Ferrer, L., C. Folch, P. Fernandez-Davila, A. Garcia, A. Morales, J. Belda, A. R. Susperregui, and J. Casabona. 2016. “Awareness of Pre-Exposure Prophylaxis for HIV, Willingness to Use It and Potential Barriers or Facilitators to Uptake Among Men Who Have Sex with Men in Spain.” AIDS & Behavior 20 (7): 1423–1433. doi:10.1007/s10461-016-1379-9
  • Fielding-Miller, R., K. L. Dunkle, N. Jama-Shai, M. Windle, C. Hadley, and H. L. Cooper. 2016. “The Feminine Ideal and Transactional Sex: Navigating Respectability and Risk in Swaziland.” Social Science & Medicine 158: 24–33. doi:10.1016/j.socscimed.2016.04.005
  • Fonner, V. A., S. L. Dalglish, C. E. Kennedy, R. Baggaley, K. R. O’reilly, F. M. Koechlin, M. Rodolph, I. Hodges-Mameletzis, and R. M. Grant. 2016. “Effectiveness and Safety of Oral HIV Pre-Exposure Prophylaxis for All Populations.” AIDS 30 (12): 1973.
  • George, A. S., A. Amin, C. M. de Abreu Lopes, and T. S. Ravindran. 2020. “Structural Determinants of Gender Inequality: Why They Matter for Adolescent Girls’ Sexual and Reproductive Health.” BMJ 368: L6985.
  • Govender, E., L. Mansoor, K. MacQueen, and Q. Abdool Karim. 2017. “Secrecy, Empowerment and Protection: Positioning PrEP in KwaZulu-Natal, South Africa.” Culture, Health & Sexuality 19 (11): 1268–1285. doi:10.1080/13691058.2017.1309682
  • Haberer, J. E., D. R. Bangsberg, J. M. Baeten, K. Curran, F. Koechlin, K. R. Amico, P. Anderson, et al. 2015. “Defining Success with HIV Pre-Exposure Prophylaxis: A Prevention-Effective Adherence Paradigm.” AIDS 29 (11): 1277–1285. doi:10.1097/QAD.0000000000000647
  • Hall, K. S., C. L. Westhoff, and P. M. Castaño. 2013. “The Impact of an Educational Text Message Intervention on Young Urban Women’s Knowledge of Oral Contraception.” Contraception 87 (4): 449–454. doi:10.1016/j.contraception.2012.09.004
  • Harrison, A., C. J. Colvin, C. Kuo, A. Swartz, and M. Lurie. 2015. “Sustained High HIV Incidence in Young Women in Southern Africa: Social, Behavioral, and Structural Factors and Emerging Intervention Approaches.” Current HIV/AIDS Reports 12 (2): 207–215. doi:10.1007/s11904-015-0261-0
  • Hojilla, J. C., D. Vlahov, P.-C. Crouch, C. Dawson-Rose, K. Freeborn, and A. Carrico. 2018. “HIV Pre-Exposure Prophylaxis (PrEP) Uptake and Retention Among Men who have Sex with Men in a Community-Based Sexual Health Clinic.” AIDS & Behavior 22 (4): 1096–1099. doi:10.1007/s10461-017-2009-x
  • Holloway, I., R. Dougherty, J. Gildner, S. C. Beougher, C. Pulsipher, J. A. Montoya, et al. 2017. “PrEP Uptake, Adherence, and Discontinuation among California YMSM using Geosocial Networking Applications.” Journal of acquired immune deficiency syndromes (1999) 74 (1): 15.
  • Johnson, L. F., R. E. Dorrington, and H. Moolla. 2017. “Progress Towards the 2020 Targets for HIV Diagnosis and Antiretroviral Treatment in South Africa.” Southern African Journal of HIV Medicine 18 (1): 694–6751. doi:10.4102/sajhivmed.v18i1.694
  • Kadede, K., T. Ruel, J. Kabami, E. Ssemmondo, N. Sang, D. Kwarisiima, E. Bukusi, et al. 2016. “Increased Adolescent HIV Testing with a Hybrid Mobile Strategy in Uganda and Kenya.” AIDS 30 (14): 2121.
  • Koester, K., R. K. Amico, H. Gilmore, A. Liu, V. McMahan, K. Mayer, S. Hosek, and R. Grant. 2017. “Risk, Safety and Sex Among Male PrEP Users: Time for a New Understanding.” Culture, Health & Sexuality 19 (12): 1301–1313. doi:10.1080/13691058.2017.1310927
  • Kowalewski, M. R., K. D. Henson, and D. Longshore. 1997. “Rethinking Perceived Risk and Health Behavior: A Critical Review of HIV Prevention Research.” Health Education & Behavior 24 (3): 313–325. doi:10.1177/109019819702400305
  • Krippendorff, K. 2004. Content Analysis: An Introduction to its Methodology. Thousand Oaks, CA: SAGE.
  • Krishnaratne, S., B. Hensen, J. Cordes, J. Enstone, and J. R. Hargreaves. 2016. “Interventions to Strengthen the HIV Prevention Cascade: A Systematic Review of Reviews.” The Lancet HIV 3 (7): e307–e317. doi:10.1016/S2352-3018(16)30038-8
  • Kurasaki, K. S. 2000. “Intercoder Reliability for Validating Conclusions Drawn from Open-Ended Interview Data.” Field Methods 12 (3): 179–194. doi:10.1177/1525822X0001200301
  • Lafort, Y., D. Geelhoed, L. Cumba, C. d. D. M. Lázaro, W. Delva, S. Luchters, and M. Temmerman. 2010. “Reproductive Health Services for Populations at High Risk of HIV: Performance of a Night Clinic in Tete Province, Mozambique.” BMC Health Services Research 10 (1): 144. doi:10.1186/1472-6963-10-144
  • Lampe, M. A., D. K. Smith, G. J. Anderson, A. E. Edwards, and S. R. Nesheim. 2011. “Achieving Safe Conception in HIV-Discordant Couples: The Potential Role of Oral Pre-Exposure Prophylaxis (PrEP) in the United States.” American Journal of Obstetrics and Gynecology 204 (6): 488.e1–488.e8. doi:10.1016/j.ajog.2011.02.026
  • Leclerc-Madlala, S. 2008. “Age-Disparate and Intergenerational Sex in Southern Africa: The Dynamics of Hypervulnerability.” AIDS 22: S17–S25.
  • McMahon, S., and P. Winch. 2018. “Systematic Debriefing after Qualitative Encounters: An Essential Analysis Step in Applied Qualitative Research.” BMJ Global Health 3 (5): e000837. doi:10.1136/bmjgh-2018-000837
  • MOH (Ministry of Health). 2012. “I.” Accessed April 27 2019. http://files.icap.columbia.edu/shims/files/uploads/SHIMS_First_Findings_Report_w_Cover_2012.pdf
  • MOH (Ministry of Health). 2015. “I. Swaziland Ministry of Health.” Accessed May 1 2019. http://www.ihmafrica.org/images/annual-reports/2015/Hhohho%20Annual%20Final%20report%202015.pdf
  • Morgan, E., D. T. Ryan, M. E. Newcomb, and B. Mustanski. 2018. “High Rate of Discontinuation May Diminish PrEP Coverage Among Young Men Who Have Sex with Men.” AIDS & Behavior 22 (11): 3645–3648. doi:10.1007/s10461-018-2125-2
  • Morton, J. F., C. Celum, J. Njoroge, A. Nakyanzi, I. Wakhungu, E. Tindimwebwa, S. Ongachi, et al. 2017. “Counseling Framework for HIV-Serodiscordant Couples on the Integrated Use of Antiretroviral Therapy and Pre-Exposure Prophylaxis for HIV Prevention.” Journal of Acquired Immune Deficiency Syndromes 74 (1): 15.
  • Mugo, N. R., K. Ngure, M. Kiragu, E. Irungu, and N. Kilonzo. 2016. “PrEP for Africa: What We Have Learnt and What Is Needed to Move to Program Implementation.” Current Opinion in HIV and AIDS 11 (1): 80–86.
  • Mugweni, E., S. Pearson, and M. Omar. 2012. “Traditional Gender Roles, Forced Sex and HIV in Zimbabwean Marriages.” Culture, Health & Sexuality 14 (5): 577–590. doi:10.1080/13691058.2012.671962
  • Murray, E., S. Treweek, C. Pope, A. MacFarlane, L. Ballini, C. Dowrick, T. Finch, et al. 2010. “Normalisation Process Theory: A Framework for Developing, Evaluating and Implementing Complex Interventions.” BMC Medicine 8 (1): 63. doi:10.1186/1741-7015-8-63
  • Namey, E., K. Agot, K. Ahmed, J. Odhiambo, J. Skhosana, G. Guest, and A. Corneli. 2016. “When and Why Women Might Suspend PrEP Use According to Perceived Seasons of Risk: Implications for PrEP-Specific Risk-Reduction Counselling.” Culture, Health & Sexuality 18 (9): 1081–1091. doi:10.1080/13691058.2016.1164899
  • Ngure, K., R. Heffron, K. Curran, S. Vusha, M. Ngutu, N. Mugo, C. Celum, and J. M. Baeten. 2016. “I Knew I Would be Safer. Experiences of Kenyan HIV Serodiscordant Couples Soon After Pre-exposure Prophylaxis (PrEP) Initiation.” AIDS Patient Care and STDs 30 (2): 78–83. doi:10.1089/apc.2015.0259
  • Palanee-Phillips, T., S. T. Roberts, K. Reddy, V. Govender, L. Naidoo, S. Siva, Z. Gafoor, et al. 2018. “Impact of Partner-Related Social Harms on Women’s Adherence to the Dapivirine Vaginal Ring During a Phase III Trial.” Journal of Acquired Immune Deficiency Syndromes 79 (5): 580–589.
  • Patel, R. C., A. M. Leddy, J. Odoyo, K. Anand, G. Stanford-Moore, I. Wakhungu, E. A. Bukusi, J. M. Baeten, and J. M. Brown. 2018. “What Motivates Serodiscordant Couples to Prevent HIV Transmission Within Their Relationships: Findings from a PrEP Implementation Study in Kenya.” Culture, Health & Sexuality 20 (6): 625–639. doi:10.1080/13691058.2017.1367421
  • Persson, A. 2013. “Non/Infectious Corporealities: Tensions in the Biomedical Era of ‘HIV Normalisation’.” Sociology of Health & Illness 35 (7): 1065–1079. doi:10.1111/1467-9566.12023
  • Price, J. T., S. B. Wheeler, L. Stranix-Chibanda, S. G. Hosek, D. H. Watts, G. K. Siberry, H. M. Spiegel, J. S. Stringer, and B. H. Chi. 2016. “Cost-Effectiveness of Pre-Exposure HIV Prophylaxis During Pregnancy and Breastfeeding in Sub-Saharan Africa.” Journal of Acquired Immune Deficiency Syndromes 72 (2): 145.
  • QSR. 2018. NVivo Qualitative Data Analysis Software, 12. QSR International.
  • Simbayi, L. C., S. C. Kalichman, D. Skinner, S. Jooste, D. Cain, C. Cherry, V. Mathiti, et al. 2004. “Theory-Based HIV Risk Reduction Counseling for Sexually Transmitted Infection Clinic Patients in Cape Town, South Africa.” Sexually Transmitted Diseases 31 (12): 727–733. doi:10.1097/01.olq.0000145849.35655.f1
  • Squire, C. 2010. “Being Naturalised, Being Left Behind: The HIV Citizen in the Era of Treatment Possibility.” Critical Public Health 20 (4): 401–427. doi:10.1080/09581596.2010.517828
  • Tanser, F., T. Bärnighausen, E. Grapsa, J. Zaidi, and M.-L. Newell. 2013. “High Coverage of ART Associated with Decline in Risk of HIV Acquisition in Rural.” Science 339 (6122): 966–971. KwaZulu-Natal, South Africa.” doi:10.1126/science.1228160
  • Terefe, A., and C. P. Larson. 1993. “Modern Contraception Use in Ethiopia: Does Involving Husbands Make a Difference?” American Journal of Public Health 83 (11): 1567–1571. doi:10.2105/ajph.83.11.1567
  • UNAIDS. 2017. Databook. Geneva: UNAIDS.
  • Underhill, K., K. M. Morrow, C. Colleran, S. K. Calabrese, D. Operario, P. Salovey, and K. H. Mayer. 2016. “Explaining the Efficacy of Pre-Exposure Prophylaxis (PrEP) for HIV Prevention: A Qualitative Study of Message Framing and Messaging Preferences Among US Men Who Have Sex with Men.” AIDS & Behavior 20 (7): 1514–1526. doi:10.1007/s10461-015-1088-9
  • Van der Elst, E.M., J. Mbogua, D. Operario, G. Mutua, C. Kuo, P. Mugo, J. Kanungi, et al. 2013. “High Acceptability of HIV Pre-Exposure Prophylaxis but Challenges in Adherence and Use: Qualitative Insights from a Phase I Trial of Intermittent and Daily PrEP in At-Risk Populations in Kenya.” AIDS & Behavior 17 (6): 2162–2172. doi:10.1007/s10461-012-0317-8
  • van der Straten, A., J. Stadler, E. Montgomery, M. Hartmann, B. Magazi, F. Mathebula, K. Schwartz, N. Laborde, and L. Soto-Torres. 2014. “Women’s Experiences with Oral and Vaginal Pre-Exposure Prophylaxis: The VOICE-C Qualitative Study in Johannesburg, South Africa.” PLoS One 9 (2): e89118. doi:10.1371/journal.pone.0089118
  • Vernooij, E., M. Mehlo, A. Hardon, and R. Reis. 2016. “Access for All: Contextualising HIV Treatment as Prevention in Swaziland.” AIDS Care 28 (sup3): 7–13. doi:10.1080/09540121.2016.1178954
  • Whetham, J., S. Taylor, L. Charlwood, T. Keith, R. Howell, C. McInnes, E. Payne, J. Home, D. White, and Y. Gilleece. 2014. “Pre-Exposure Prophylaxis for Conception (PrEP-C) as a Risk Reduction Strategy in HIV-Positive Men and HIV-Negative Women in the UK.” AIDS Care 26 (3): 332–336. doi:10.1080/09540121.2013.819406
  • Whitfield, T. H., S. A. John, H. J. Rendina, C. Grov, and J. T. Parsons. 2018. “Why I Quit Pre-Exposure Prophylaxis (PrEP)? A Mixed-Method Study Exploring Reasons for PrEP Discontinuation and Potential Re-Initiation Among Gay and Bisexual Men.” AIDS & Behavior 22 (11): 3566–3575. doi:10.1007/s10461-018-2045-1
  • WHO (World Health Organization). 2015. “Policy Brief: Pre-Exposure Prophylaxis (PrEP): WHO Expands Recommendation on Oral Pre-Exposure Prophylaxis of HIV Infection (PrEP).” Accessed May 17 2019. https://apps.who.int/iris/handle/10665/197906
  • WHO (World Health Organization). 2017. “WHO Implementation Tool for Pre-Exposure Prophylaxis (PrEP). Accessed May 17 2019. https://www.who.int/hiv/pub/prep/prep-implementation-tool/en/

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