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Review

Toll-like receptors as key mediators in innate antifungal immunity

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Pages 485-498 | Published online: 09 Jul 2009

References

  • Calderone RA. Introduction and historical perspectives. In: Calderone RA (ed.). Candida and Candidiasis. Washington DC: ASM Press, 2002: 3–13.
  • Hultmark D. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet 1993; 9: 178–183.
  • Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973–983.
  • Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defence: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997; 94: 614–619.
  • Hedengren-Olcott M, Olcott MC, Mooney DT, et al. Differ-ential activation of the NF-kappaB-like factors relish and Dif in drosophila melanogaster by fungi and gram-positive bacteria. J Biol Chem 2004; 279: 121–127.
  • Gottar M, Gobert V, Michel T, et al. The Drosophila immune response against Gramnegative bacteria is mediated by a peptidoglycan recognition protein. Nature 2002; 416: 640–644.
  • Ligoxygakis P, Pelte N, Hoffmann JA, Reichhart JM. Activation of Drosophila Toll during fungal infection by a blood serine protease. Science 2002; 297: 114–116.
  • Williams MJ, Rodriguez A, Kimbrell DA, Eldon ED. The 18-wheeler mutation reveals complex antibacterial gene regula-tion in Drosophila host defence. EMBO J 1997; 16: 120–130.
  • Tauszig S, Jouanguy E, Hoffmann JA, Imler JL. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci USA 2000; 97: 520–525.
  • Alarco AM, Marcil A, Chen J, et al. Immune-deficient Drosophila melanogaster: a model for the innate immune response to human fungal pathogens. J Immunol 2004; 172: 5622–5628.
  • Apidianakis Y, Rahme LG, Heitman J, et al. Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell 2004; 3: 413–419.
  • Janeway CA, Jr, Medzhitov R. Innate immune recognition. Ann Rev Immunol 2002; 20: 197–216.
  • Hornung V, Rothenfusser S, Britsch S, et al. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168: 4531–4537.
  • Faure E, Equils 0, Sieling PA, et al. Bacterial lipopolysaccharide activates NF-kappaB through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J Biol Chem 2000; 275: 1058–1063.
  • Blander JM, Medzhitov R. Regulation of phagosome matura-tion by signals from Toll-like receptors. Science 2004; 304: 1014–1018.
  • Michelsen KS, Aicher A, Mohaupt M, et al. The role of Toll-like receptors (TLR) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J Biol Chem 2001; 276: 680–686.
  • Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Ann Rev Immunol 2000; 18: 767–811.
  • Zhang D, Zhang G, Hayden MS, et al. A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 2004; 303: 1522–1526.
  • Tabeta K, Georgel P, Janssen E, et al. Toll-like receptors 9 and 3 as essential components of innate immune defence against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 2004; 101: 3516–3521.
  • Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406: 782–787.
  • Akashi S, Saitoh S, Wakabayashi Y, et al. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med 2003; 198: 1035–1042.
  • Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduc-tion. J Biol Chem 2003; 278: 313–320.
  • Schromm AB, Lien E, Henneke P, et al. Molecular genetic analysis of an endotoxin non-responder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signalling. J Exp Med 2001; 194: 79–88.
  • Kennedy MN, Mullen GE, Leifer CA, et al. A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4. J Biol Chem 2004; 279: 698–704.
  • Kawasaki K, Nogawa H, Nishijima M. Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis. J Immunol 2003; 170: 413–420.
  • Haynes LM, Moore DD, Kurt-Jones EA, Finberg RW, Ander-son LJ, Tripp RA. Involvement of Toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol 2001; 75: 10730–10737.
  • Sasu S, LaVerda D, Qureshi N, Golenbock DT, Beasley D. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via Toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res 2001; 89: 244–250.
  • Okamura Y, Watari M, Jerud ES, et al. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 2001; 276: 229–233.
  • Gao B, Tsan MF. Recombinant human heat shock protein 60 does not induce the release of tumour necrosis factor alpha from murine macrophages. J Biol Chem 2003; 278: 523–529.
  • Takeda K, Kaisho T, Akira S. Toll-like receptors. Ann Rev Immunol 2003; 21: 335–376.
  • Werts C, Tapping RI, Mathison JC, et al. Leptospiral lipopo-lysaccharide activates cells through a TLR2-dependent mechan-ism. Nat Immunol 2001; 2: 346–352.
  • Hirschfeld M, Weis JJ, Toshchakov V, et al. Signalling by Toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun 2001; 69: 1477–1482.
  • Sau K, Mambula SS, Latz E, et al. The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem 2003; 278: 561–568.
  • Ozinsky A, Underhill DM, Fontenot JD, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766–13771.
  • Takeda K, Takeuchi 0, Akira S. Recognition of lipopeptides by Toll-like receptors. J Endotoxin Res 2002; 8: 459–463.
  • Bauer S, Wagner H. Bacterial CpG-DNA licenses TLR9. Curr Top Microbiol Immunol 2002; 270: 145–154. © 2004 SHAM, Medical Mycology, 42, 485-498
  • Chu W, Gong X, Li Z, et al. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 2000; 103: 909–918.
  • Doyle SE, O'Connell R, Vaidya SA, et al. Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor
  • J Immunol 2003; 170: 3565–3571.
  • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413: 732–738.
  • Oshiumi H, Matsumoto M, Funami K, et al. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003; 4: 161–167.
  • Hemmi H, Kaisho T, Takeuchi 0, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signalling pathway. Nat Immunol 2002; 3: 196–200.
  • Jurk M, Heil F, Vollmer J, et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 2002; 3: 499.
  • Heil F, Ahmad-Nejad P, Hemmi H, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relation-ship within the TLR7, 8 and 9 subfamily. Eur J Immunol 2003; 33: 2987–2997.
  • Lee J, Chuang TH, Redecke V, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003; 100: 6646–6651.
  • Heil F, Hemmi H, Hochrein H, et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 2004; 303: 1526–1529.
  • Diebold SS, Kaisho T, Hemmi H, et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529–1531.
  • Lund JM, Alexopoulou L, Sato A, et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 2004; 101: 5598–5603.
  • Gewirtz AT, Simon PO Jr, Schmitt CK, et al. Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinfiammatory response. J Clin Invest 2001; 107: 99–109.
  • Means TK, Hayashi F, Smith KD, et al. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003; 170: 5165–5175.
  • Hawn TR, Verbon A, Lettinga KD, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signalling and is associated with susceptibility to Legionnaires' disease. J Exp Med 2003; 198: 1563–1572.
  • Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defence. Sci STKE 2003: 3.
  • Medzhitov R, Preston-Hurlburt P, Kopp E, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signalling pathways. Mol Cell 1998; 2: 253–258.
  • Burns K, Clatworthy J, Martin L, et al. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2000; 2: 346–351.
  • Yamamoto M, Sato S, Hemmi H, et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signalling pathway. Science 2003; 301: 640–643.
  • Wang C, Deng L, Hong M, et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001; 412: 346–351.
  • Sharma S, tenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300: 1148–1151.
  • Fitzgerald KA, McWhirter SM, Faia KL, et al. IKKepsilon and TBK1 are essential components of the IRF3 signalling pathway. Nat Immunol 2003; 4: 491–496.
  • Perry AK, Chow EK, Goodnough JB, et al. Differential Requirement for TANK-binding kinase-1 in type in interferon responses to toll-like receptor activation and viral infection. J Exp Med 2004; 199: 1651-1658.
  • Hemmi H, Takeuchi 0, Sato S, et al. The roles of two ikappab kinase-related kinases in lipopolysaccharide and double stranded RNA signalling and viral infection. J Exp Med 2004; 199: 1641–1650.
  • Takeuchi 0, Akira S. MyD88 as a bottle neck in Toll/IL-1 signalling. Curr Top Microbiol Immunol 2002; 270: 155–167.
  • Kawai T, Adachi 0, Ogawa T, et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11: 115–122.
  • Kawai T, Takeuchi 0, Fujita T, et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 2001; 167: 5887–5894.
  • O'Neill LA, Fitzgerald KA, Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol 2003; 24: 286–290.
  • Horng T, Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signalling pathway. Nat Immunol 2001; 2: 835–841.
  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG, et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413: 78–83.
  • Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 2002; 420: 329–333.
  • Yamamoto M, Sato S, Hemmi H, et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002; 420: 324–329.
  • Yamamoto M, Sato S, Mori K, et al. Cutting edge: a novel Toll/ IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signalling. J Immunol 2002; 169: 6668–6672.
  • Hoebe K, Du X, Georgel P, et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003; 424: 743–748.
  • Yamamoto M, Sato S, Hemmi H, et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-indepen-dent signalling pathway. Nat Immunol 2003; 4: 1144–1150.
  • Oshiumi H, Sasai M, Shida K, et al. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem 2003; 278: 49751–49762.
  • Fitzgerald KA, Rowe DC, Barnes BJ, et al. LPS-TLR4 signal-ling to IRF-3/7 and NF-kappaB involves the Toll adapters TRAM and TRIF. J Exp Med 2003; 198: 1043–1055.
  • Netea MG, Van der Graaf CA, Vonk AG, Verschueren I, Van der Meer JW, Kullberg BJ. The role of Toll-like receptor (TLR) 2 and TLR4 in the host defence against disseminated candidiasis. J Infect Dis 2002; 185: 1483–1489.
  • Netea MG, Sutmuller R, Hermann C, et al. Toll-like recep-tor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol 2004; 172: 3712–3718.
  • Villamon E, Gozalbo D, Roig P, et al. Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microb Infect 2004; 6: 1–7.
  • Villamon E, Gozalbo D, Roig P, et al. Toll-like receptor 2 is dispensable for acquired host immune resistance to Candida albicans in a murine model of disseminated candidiasis. Microb Infect 2004; 6: 542–548.
  • Roeder A, Kirschning CJ, Schaller M, et al. Induction of nuclear factor-kappab and c-jun/activator protein-1 via Toll-like receptor 2 in macrophages by antimycotic-treated Candida albicans. J Infect Dis 2004; 190: 1318–1326.
  • Deva R, Shankaranarayanan P, Ciccoli R, Nigam S. Candida albicans induces selectively transcriptional activation of cycloox-ygenase-2 in HeLa cells: pivotal roles of Toll-like receptors, p38 mitogen-activated protein kinase, and NF-kappa B. J Immunol 2003; 171: 3047–3055.
  • Wang JE, Warns A, Ellingsen EA, et al. Involvement of CD14 and Toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect Immun 2001; 69: 2402–2406.
  • Mambula SS, Sau K, Henneke P, et al. Toll-like receptor (TLR) signalling in response to Aspergillus fumigatus. J Biol Chem 2002; 277: 39320–39326.
  • Meier A, Kirschning CJ, Nikolaus T, et al. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus -induced activa-tion of murine macrophages. Cell Microbiol 2003; 5: 561–570.
  • Netea MG, Warns A, Van Der Meer JW, et al. Aspergillus fumigatus evades immune recognition during germination through loss of Toll-like receptor-4-mediated signal transduc-tion. J Infect Dis 2003; 188: 320–326.
  • Bellocchio S, Montagnoli C, Bozza S, et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 2004; 172: 3059–3069.
  • Man KA, Balajee SA, Hawn TR, et al. Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun 2003; 71: 5280–5286.
  • Chaffin WL, Lopez-Ribot JL, Casanova M, et al. Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiol Mol Biol Rev 1998; 62: 130–180.
  • Jouault T, Ibata-Ombetta S, Takeuchi 0, et al. Candida albicans phospholipomannan is sensed through Toll-like receptors. J Infect Dis 2003; 188: 165–172.
  • Tada H, Nemoto E, Shimauchi H, et al. Saccharomyces cerevisiae- and Candida albicans-derived mannan induced pro-duction of tumour necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner. Microbiol Immunol 2002; 46: 503–512.
  • Shoham S, Huang C, Chen JM, et al. Toll-like receptor 4 mediates intracellular signalling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule. J Immunol 2001; 166: 4620–4626.
  • Monari C, Retini C, Casadevall A, et al. Differences in outcome of the interaction between Cryptococcus neoformans glucuro-noxylmannan and human monocytes and neutrophils. Eur J Immunol 2003; 33: 1041–1051.
  • Ellerbroek PM, Ulfman LH, Hoepelman Al, Coenjaerts FE. Cryptococcal glucuronoxylmannan interferes with neutrophil rolling on the endothelium. Cell Microbiol 2004; 6: 581–592.
  • Yauch LE, Mansour MK, Shoham S, et al. Involvement of CD14, Toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo. Infect Immun 2004; 72: 5373–5382.
  • Klis FM, De Groot P, Hellingwerf K. Molecular organization of the cell wall of Candida albicans. Med Mycol 2001; 39\Suppl. 1: 1–8.
  • Kataoka K, Muta T, Yamazaki S, Takeshige K. Activation of macrophages by linear (lright-arrow3)-beta-D-glucans. Implica-tions for the recognition of fungi by innate immunity. J Biol Chem 2002; 277: 36825–36831.
  • Lebron F, Vassallo R, Puri V, Limper AH. Pneumocystis carinii cell wall beta-glucans initiate macrophage inflammatory re-sponses through NF-kappaB activation. J Biol Chem 2003; 278: 25001–25008.
  • Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003; 197: 1107–1117.
  • Steele C, Marrero L, Swain S, et al. Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor. J Exp Med 2003; 198: 1677–1688.
  • Herre J, Marshall AS, Caron E, et al. Dectin-1 utilizes novel mechanisms for yeast phagocytosis in macrophages. Blood 2004 (in press).
  • Fidel PL Jr. Distinct protective host defenses against oral and vaginal candidiasis. Med Mycol 2002; 40: 359–375.
  • Pivarcsi A, Bodai L, Rethi B, et al. Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol 2003; 15: 721–730.
  • Perera PY, Mayadas TN, Takeuchi 0, et al. CD1 lb/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol 2001; 166: 574–581.
  • Noubir S, Hmama Z, Reiner NE. Dual receptors and distinct pathways mediate interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide. Involvement of CD14/TLR4, CR3, and phosphatidylinositol 3-kinase. J Biol Chem 2004; 279: 25189–25195.
  • Lee KY, You HJ, Jeong HG, et al. Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages. Int Immunopharmacol 2004; 4: 1029–1038.
  • Szolnoky G, Bata-Csorgo Z, Kenderessy AS, et al. A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans. J Invest Dermatol 2001; 117: 205–213.
  • Romani L, Montagnoli C, Bozza S, et al. The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans. Int Immunol 2004; 16: 149–161.
  • Cambi A, Gijzen K, de Vries JM, et al. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol 2003; 33: 532–538.
  • Taylor PR, Brown GD, Herm J, et al. The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the non-opsonic recogni-tion of yeast by specific macrophages. J Immunol 2004; 172: 1157–1162.
  • Underhill DM. Toll-like receptors and microbes take aim at each other. Curr Opin Immunol 2004; 16: 483–487.

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