Does genistein lower plasma lipids and homocysteine levels in postmenopausal women? A meta-analysis

References

• Gierach M, Gierach J, Junik R. The evaluation of lipid profile in patients with metabolic syndrome according to the cardiovascular risk calculated on the basis of SCORE chart. Endokrynol Pol 2016 Feb 17. Epub ahead of print
   PubMed Web of Science ®Google Scholar
• Alwan A. Global status report on noncommunicable diseases 2010. Geneva: World Health Organization, 2011
   Google Scholar
• Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials 2012;7:47–70
   PubMedGoogle Scholar
• Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med 2008;168:1568–75
   PubMed Web of Science ®Google Scholar
• Witteman J, Grobbee DE, Kok FJ, Hofman A, Valkenburg HA. Increased risk of atherosclerosis in women after the menopause. BMJ 1989;298:642–44
   PubMed Web of Science ®Google Scholar
• Stevenson JC, Crook D, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83–90
   PubMed Web of Science ®Google Scholar
• Jacobs DR, Mebane IL, Bangdiwala SI, Criqui MH, Tyroler HA. High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women: the follow-up study of the Lipid Research Clinics Prevalence Study. Am J Epidemiol 1990;131:32–47
   PubMed Web of Science ®Google Scholar
• Manson JE, Bassuk SS. Biomarkers of cardiovascular disease risk in women. Metab Clin Exp 2015;64:S33–9
   Google Scholar
• Hak AE, Polderman KH, Westendorp IC, et al. Increased plasma homocysteine after menopause. Atherosclerosis 2000;149:163–8
   PubMed Web of Science ®Google Scholar
• Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G. Homocysteine, coagulation, platelet function, and thrombosis. Semin Thromb Hemostasis 2000;26:243–54
   PubMed Web of Science ®Google Scholar
• He Y, Li Y, Chen Y, Feng L, Nie Z. Homocysteine level and risk of different stroke types: A meta-analysis of prospective observational studies. Nutr Metab Cardiovasc Dis 2014;24:1158–65
   PubMed Web of Science ®Google Scholar
• Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA 1997;277:1775–81
   PubMed Web of Science ®Google Scholar
• Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230–7
   PubMed Web of Science ®Google Scholar
• Madsen JS, Kristensen SR, Klitgaard NA, et al. Effect of long-term hormone replacement therapy on plasma homocysteine in postmenopausal women: a randomized controlled study. Am J Obstet Gynecol 2002;187:33–9
   PubMed Web of Science ®Google Scholar
• Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–33
   PubMed Web of Science ®Google Scholar
• Pines A, Shapiro S. Long-term menopausal hormone therapy and health consequences – how to choose sides? Climacteric 2015;18:441–3
   PubMed Web of Science ®Google Scholar
• Taggu W, Lloyd G. Treating cardiovascular disease in women. Menopause Int 2007;13:159–64
   PubMedGoogle Scholar
• Zhang X, Shu XO, Gao Y-T, et al. Soy food consumption is associated with lower risk of coronary heart disease in Chinese women. J Nutr 2003;133:2874–8
   PubMed Web of Science ®Google Scholar
• Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation 2007;116:2553–62
   PubMed Web of Science ®Google Scholar
• Saita E, Kondo K, Momiyama Y. Anti-Inflammatory diet for atherosclerosis and coronary artery disease: antioxidant foods. Clin Med Insights Cardiol 2015;8(Suppl 3):61–5
   PubMedGoogle Scholar
• Setchell KD, Cassidy A. Dietary isoflavones: biological effects and relevance to human health. J Nutr 1999;129:758–67S
   PubMed Web of Science ®Google Scholar
• Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004;79:727–47
   PubMed Web of Science ®Google Scholar
• Liu Zm, Ho SC, Chen YM, et al. Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: A 6-month randomized, double-blind, and placebo-controlled trial in equol-producing postmenopausal women. Molec Nutr Food Res 2014;58:709–17
   PubMed Web of Science ®Google Scholar
• Altavilla D, Crisafulli A, Marini H, et al. Cardiovascular effects of the phytoestrogen genistein. Curr Med Chem-Cardiovas Hematol Agents 2004;2:179–86
   PubMedGoogle Scholar
• Marini H, Bitto A, Altavilla D, et al. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008;93:4787–96
   PubMed Web of Science ®Google Scholar
• Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 1998;139:4252–63
   PubMed Web of Science ®Google Scholar
• Wenzel U, Fuchs D, Daniel H. Protective effects of soy-isoflavones in cardiovascular disease. Identification of molecular targets. Hamostaseologie 2008;28:85–8
   PubMed Web of Science ®Google Scholar
• Fuchs D, Erhard P, Turner R, Rimbach G, Daniel H, Wenzel U. Genistein reverses changes of the proteome induced by oxidized-LDL in EA.hy 926 human endothelial cells. J Proteome Res 2005;4:369–76
   PubMed Web of Science ®Google Scholar
• Ambra R, Rimbach G, de Pascual Teresa S, et al. Genistein affects the expression of genes involved in blood pressure regulation and angiogenesis in primary human endothelial cells. Nutr Metab Cardiovasc Dis 2006;16:35–43
   PubMed Web of Science ®Google Scholar
• Potter SM. Soy protein and serum lipids. Curr Opin Lipidol 1996;7:260–4
   PubMed Web of Science ®Google Scholar
• Bitto A, Altavilla D, Bonaiuto A, et al. Effects of aglycone genistein in a rat experimental model of postmenopausal metabolic syndrome. J Endocrinol 2009;200:367–76
   PubMed Web of Science ®Google Scholar
• Bitto A, Polito F, Atteritano M, et al. Genistein aglycone does not affect thyroid function: results from a three-year, randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2010;95:3067–72
   PubMed Web of Science ®Google Scholar
• Irace C, Marini H, Bitto A, et al. Genistein and endothelial function in postmenopausal women with metabolic syndrome. Eur J Clin Invest 2013;43:1025–31
   PubMed Web of Science ®Google Scholar
• Squadrito F, Marini H, Bitto A, et al. Genistein in the metabolic syndrome: results of a randomized clinical trial. J Clin Endocrinol Metab 2013;98:3366–74
   PubMed Web of Science ®Google Scholar
• Yildiz MF, Kumru S, Godekmerdan A, Kutlu S. Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women. Int J Gynecol Obstet 2005;90:128–33
   PubMed Web of Science ®Google Scholar
• Kaygusuz I, Turhan NO, Duvan CI, Koca C, Aydin M. Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study. Fertil Steril 2010;94:764–6
   PubMed Web of Science ®Google Scholar
• Squadrito F, Altavilla D, Morabito N, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339–47
   PubMed Web of Science ®Google Scholar
• Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from: www.cochrane-handbook.org
   Google Scholar
• Follmann D, Elliott P, Suh I, Cutler J. Variance imputation for overviews of clinical trials with continuous response. J Clinical Epidemiol 1992;45:769–73
   PubMed Web of Science ®Google Scholar
• Marini H, Bitto A, Altavilla D, et al. Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: a follow-up study. Nutr Metab Cardiovasc Dis 2010;20:332–40
   PubMed Web of Science ®Google Scholar
• Atteritano M, Marini H, Minutoli L, et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2007;92:3068–75
   PubMed Web of Science ®Google Scholar
• D'Anna R, Baviera G, Corrado F, Cancellieri F, Crisafulli A, Squadrito F. The effect of the phytoestrogen genistein and hormone replacement therapy on homocysteine and C-reactive protein level in postmenopausal women. Acta Obstet Gynecol Scand 2005;84:474–7
   PubMed Web of Science ®Google Scholar
• Arunkumar E, Karthik D, Anuradha CV. Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat–high-fructose diet-fed mice. Pharmaceut Biol 2013;51:815–24
   PubMed Web of Science ®Google Scholar
• Tang C, Zhang K, Zhao Q, Zhang J. Effects of dietary genistein on plasma and liver lipids, hepatic gene expression, and plasma metabolic profiles of hamsters with diet-induced hyperlipidemia. J Agricult Food Chem 2015;63:7929–36
   PubMed Web of Science ®Google Scholar
• Lee J-S. Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sci 2006;79:1578–84
   PubMed Web of Science ®Google Scholar
• Anthony MS, Clarkson TB, Hughes Jr CL, Morgan TM, Burke GL. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr 1996;126:43–50
   PubMed Web of Science ®Google Scholar
• Hanson LN, Engelman HM, Alekel DL, Schalinske KL, Kohut ML, Reddy MB. Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am J Clin Nutr 2006;84:774–80
   PubMed Web of Science ®Google Scholar
• Jenkins DJ, Kendall CW, Jackson C-JC, et al. Effects of high-and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 2002;76:365–72
   PubMed Web of Science ®Google Scholar
• Sanders TA, Dean TS, Grainger D, Miller GJ, Wiseman H. Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor β1 concentrations and hemostatic risk factors for coronary heart disease in healthy subjects. Am J Clin Nutr 2002;76:373–7
   PubMed Web of Science ®Google Scholar