Association between testosterone and cognitive performance in postmenopausal women: a systematic review of observational studies

References

• Nichols E, Abd‐Allah F, Abdoli A, et al. Global mortality from dementia: application of a new method and results from the Global Burden of Disease Study 2019. Alzheimers Dement (NY). 2021;7(1):e12200.
   PubMedGoogle Scholar
• Tisher A, Salardini A. A comprehensive update on treatment of dementia. Semin Neurol. 2019;39(2):167–178.
   PubMed Web of Science ®Google Scholar
• Kawas C, Gray S, Brookmeyer R, et al. Age-specific incidence rates of Alzheimer’s disease: the Baltimore Longitudinal Study of Aging. Neurology. 2000;54(11):2072–2077.
   PubMed Web of Science ®Google Scholar
• Zonderman AB. Predicting Alzheimer’s disease in the Baltimore longitudinal study of aging. J Geriatr Psychiatry Neurol. 2005;18(4):192–195.
   PubMed Web of Science ®Google Scholar
• Pike CJ, Carroll JC, Rosario ER, et al. Protective actions of sex steroid hormones in alzheimer’s disease. Front Neuroendocrinol. 2009;30(2):239–258.
   PubMed Web of Science ®Google Scholar
• Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987;325(6106):733–736.
   PubMed Web of Science ®Google Scholar
• Yao M, Nguyen TV, Rosario ER, et al. Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. J Neurochem. 2008;105(6):2477–2488.
   PubMed Web of Science ®Google Scholar
• Drake EB, Henderson VW, Stanczyk FZ, et al. Associations between circulating sex steroid hormones and cognition in normal elderly women [Research Support, U.S. Gov’t, P.H.S.]. Neurology. 2000;54(3):599–603.
   PubMed Web of Science ®Google Scholar
• Wolf OT, Kirschbaum C. Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Horm Behav. 2002;41(3):259–266.
   PubMed Web of Science ®Google Scholar
• Lv W, Du N, Liu Y, et al. Low testosterone level and risk of Alzheimer’s disease in the elderly men: a systematic review and meta-analysis. Mol Neurobiol. 2016;53(4):2679–2684.
   PubMed Web of Science ®Google Scholar
• Davis SR, Jane F, Robinson PJ, et al. Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy. Clin Endocrinol (Oxf). 2014;81(4):621–628.
   PubMed Web of Science ®Google Scholar
• Shah S, Bell RJ, Savage G, et al. Testosterone aromatization and cognition in women: a randomized, placebo-controlled trial. Menopause. 2006;13(4):600–608.
   PubMed Web of Science ®Google Scholar
• Islam RM, Bell RJ, Green S, et al. Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data. Lancet Diabetes Endocrinol. 2019;7(10):754–766.
   PubMed Web of Science ®Google Scholar
• Davis SR, Bell RJ, Robinson PJ, et al. Testosterone and estrone increase from the age of 70 years: findings from the sex hormones in older women study. J Clin Endocrinol Metab. 2019;104(12):6291–6300.
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10(1):1–11.
   PubMed Web of Science ®Google Scholar
• Hoy D, Brooks P, Woolf A, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65(9):934–939.
   PubMed Web of Science ®Google Scholar
• Aromataris E, Fernandez RS, Godfrey C, et al. Methodology for JBI umbrella reviews. Joanna Briggs Institute Reviewers' Manual: 2014 edition / Supplement (pp. 1-34). Australia: The Joanna Briggs Institute; 2014.
   Google Scholar
• Dong X, Jiang H, Li S, et al. Low serum testosterone concentrations are associated with poor cognitive performance in older men but not women. Front Aging Neurosci. 2021;13:712237.
   PubMed Web of Science ®Google Scholar
• Yaffe K, Lui LY, Grady D, et al. Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet. 2000;356(9231):708–712.
   PubMed Web of Science ®Google Scholar
• Henderson VW, St. John JA, Hodis HN, et al. Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013;110(50):20290–20295.
   PubMed Web of Science ®Google Scholar
• Koyama AK, Tworoger SS, Eliassen AH, et al. Endogenous sex hormones and cognitive function in older women [Research Support, N.I.H., Extramural]. Alzheimers Dement. 2016;12(7):758–765.
   PubMed Web of Science ®Google Scholar
• Barrett-Connor E, Goodman-Gruen D. Cognitive function and endogenous sex hormones in older women [Research Support, U.S. Gov’t, P.H.S.]. J Am Geriatr Soc. 1999;47(11):1289–1293.
   PubMed Web of Science ®Google Scholar
• Ryan J, Stanczyk FZ, Dennerstein L, et al. Hormone levels and cognitive function in postmenopausal midlife women. Neurobiol Aging. 2012;33(7):1138–1147.
   PubMed Web of Science ®Google Scholar
• Bojar I, Pinkas J, Gujski M, et al. Postmenopausal cognitive changes and androgen levels in the context of apolipoprotein E polymorphism. Arch Med Sci. 2017;13(5):1148–1159.
   PubMed Web of Science ®Google Scholar
• Fukai S, Akishita M, Yamada S, et al. Association of plasma sex hormone levels with functional decline in elderly men and women [Research Support, Non-U.S. Gov’t]. Geriatr Gerontol Int. 2009;9(3):282–289.
   PubMed Web of Science ®Google Scholar
• Hogervorst E, Matthews FE, Brayne C. Are optimal levels of testosterone associated with better cognitive function in healthy older women and men? Biochim Biophys Acta. 2010;1800(10):1145–1152.
   PubMed Web of Science ®Google Scholar
• Cunningham CJ, Sinnott M, Denihan A, et al. Endogenous sex hormone levels in postmenopausal women with Alzheimer’s disease. J Clin Endocrinol Metab. 2001;86(3):1099–1103.
   PubMed Web of Science ®Google Scholar
• Rosner W, Auchus RJ, Azziz R, et al. Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab. 2007;92(2):405–413.
   PubMed Web of Science ®Google Scholar
• Kiely KM. Cognitive function. In: Michalos AC, editor. Encyclopedia of quality of life and well-being research. Dordrecht: Springer Netherlands; 2014. p. 974–978.
   Google Scholar
• Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198.
   PubMed Web of Science ®Google Scholar
• Tombaugh TN, McIntyre NJ. The mini‐mental state examination: a comprehensive review. J Am Geriatr Soc. 1992;40(9):922–935.
   PubMed Web of Science ®Google Scholar
• Palmqvist S, Hansson O, Minthon L, et al. Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer’s disease with common cognitive tests. Int J Geriatr Psychiatry. 2009;24(12):1405–1412.
   PubMed Web of Science ®Google Scholar
• Jefferson AL, Cosentino SA, Ball SK, et al. Errors produced on the mini-mental state examination and neuropsychological test performance in Alzheimer’s disease, ischemic vascular dementia, and Parkinson’s disease. J Neuropsychiatry Clin Neurosci. 2002;14(3):311–320.
   PubMed Web of Science ®Google Scholar
• Ala TA, Hughes LF, Kyrouac GA, et al. The Mini‐Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2002;17(6):503–509.
   PubMed Web of Science ®Google Scholar
• Bojar I, Owoc J, Raczkiewicz D, et al. Postmenopausal cognitive deficit in relation to androgens’ level aswell as apolipoprotein e polymorphism. Am J Geriatr Psychiatry. 2016;24(3):S143–S144.
   Web of Science ®Google Scholar
• Elias-Sonnenschein LS, Viechtbauer W, Ramakers IH, et al. Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82(10):1149–1156.
   PubMed Web of Science ®Google Scholar
• Boss L, Kang DH, Marcus M, et al. Endogenous sex hormones and cognitive function in older adults: a systematic review. West J Nurs Res. 2014;36(3):388–426.
   PubMed Web of Science ®Google Scholar
• Hogervorst E, Bandelow S, Moffat S. Increasing testosterone levels and effects on cognitive functions in elderly men and women: a review. Curr Drug Targets CNS Neurol Disord. 2005;4(5):531–540.
   PubMedGoogle Scholar
• Ma LH, Lin GZ, Wang M. Association between estrogen and female patients with Alzheimer’s disease: a meta-analysis. Int J Clin Exp Med. 2017;10(1):135–141.
   Web of Science ®Google Scholar
• Xu J, Xia LL, Song N, et al. Testosterone, estradiol, and sex hormone-binding globulin in Alzheimer’s disease: a meta-analysis. Curr Alzheimer Res. 2016;13(3):215–222.
   PubMed Web of Science ®Google Scholar
• Somboonporn W, Davis S, Seif MW, et al. Testosterone for peri- and postmenopausal women. Cochrane Database Syst Rev. 2005;(4):CD004509.
   Google Scholar
• Mezzullo M, Fazzini A, Gambineri A, et al. Parallel diurnal fluctuation of testosterone, androstenedione, dehydroepiandrosterone and 17OHprogesterone as assessed in serum and saliva: validation of a novel liquid chromatography-tandem mass spectrometry method for salivary steroid profiling. Clin Chem Lab Med. 2017;55(9):1315–1323.
   PubMed Web of Science ®Google Scholar