Sex hormones, SHBG and cognitive performance among older Australian women: an observational study

References

• Australian burden of disease study: impact and causes of illness and death in Australia 2015. In: 2019. AIoHaW, editor. Australian Burden of Disease Canberra: Australian Institute of Health and Welfare; 2019. https://www.aihw.gov.au/reports/burden-of-disease/burden-disease-study-illness-death-2015/summary.
   Google Scholar
• Kassebaum NJ, Arora M, Barber RM, et al. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the global burden of disease study 2015. The Lancet. 2016;388(10053):1603–1658.
   PubMed Web of Science ®Google Scholar
• The Lancet. Dementia burden coming into focus. 2017;390:2606. doi:10.1016/s0140-6736(17)33304-4
   Google Scholar
• Hogervorst E. Effects of gonadal hormones on cognitive behaviour in elderly men and women. J Neuroendocrinol. 2013;25(11):1182–1195.
   PubMed Web of Science ®Google Scholar
• Pike CJ, Carroll JC, Rosario ER, et al. Protective actions of sex steroid hormones in Alzheimer’s disease. Front Neuroendocrinol. 2009;30(2):239–258.
   PubMed Web of Science ®Google Scholar
• Pike CJ, Rosario ER. Testosterone regulates Alzheimer’s disease pathogenesis. Hormones, cognition and the brain. Cambridge: Cambridge University Press Cambridge; 2009.
   Google Scholar
• Hogervorst E, Henderson VW, Gibbs RB, et al. Hormones, cognition and dementia: state of the art and emergent therapeutic strategies. Cambridge: Cambridge University Press; 2009.
   Google Scholar
• Charalampopoulos I, Alexaki VI, Tsatsanis C, et al. Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging. Ann NY Acad Sci. 2006;1088(1):139–152.
   PubMedGoogle Scholar
• Hojo Y, Higo S, Kawato S, et al. Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity. Front Endocrinol. 2011;2:43.
   PubMedGoogle Scholar
• Carcaillon L, Brailly-Tabard S, Ancelin ML, et al. High plasma estradiol interacts with diabetes on risk of dementia in older postmenopausal women [Research Support, Non-U.S. Gov’t]. Neurology. 2014;82(6):504–511.
   PubMed Web of Science ®Google Scholar
• Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521–574.
   PubMed Web of Science ®Google Scholar
• Schmitz D, Ek WE, Berggren E, et al. Genome-wide association study of estradiol levels and the causal effect of estradiol on bone mineral density. J Clin Endocrinol Metabol. 2021;106(11):e4471–e4486.
   PubMed Web of Science ®Google Scholar
• Yaffe K, Lui LY, Grady D, et al. Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet. 2000;356(9231):708–712.
   PubMed Web of Science ®Google Scholar
• Ravaglia G, Forti P, Maioli F, et al. Endogenous sex hormones as risk factors for dementia in elderly men and women [Research Support, Non-U.S. Gov’t]. J Gerontol A Biol Sci Med Sci. 2007;62(9):1035–1041.
   PubMed Web of Science ®Google Scholar
• Davis SR, Martinez-Garcia A, Robinson PJ, et al. Estrone is a strong predictor of circulating estradiol in women age 70 years and older. J Clin Endocrinol Metabol. 2020;105(9):e3348–e3354.
   PubMed Web of Science ®Google Scholar
• Wolf OT, Kirschbaum C. Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Horm Behav. 2002;41(3):259–266.
   PubMed Web of Science ®Google Scholar
• Drake E, Henderson V, Stanczyk F, et al. Associations between circulating sex steroid hormones and cognition in normal elderly women. Neurology. 2000;54(3):599–603.
   PubMed Web of Science ®Google Scholar
• Rosner W, Auchus RJ, Azziz R, et al. Position statement: utility, limitations, and pitfalls in measuring testosterone: an endocrine society position statement. J Clin Endocrinol Metab. 2007;92(2):405–413.
   PubMed Web of Science ®Google Scholar
• Sultana F, Davis SR, Bell RJ, et al. Association between testosterone and cognitive performance in postmenopausal women: a systematic review of observational studies. Climacteric. 2022;2022:1–10.
   Google Scholar
• Davis SR, Bell RJ, Robinson PJ, et al. Testosterone and estrone increase from the age of 70 years; findings from the sex hormones in older women study. J Clin Endocrinol Metab. 2019;104(12):6291–6300.
   PubMed Web of Science ®Google Scholar
• Study design of ASPirin in reducing events in the elderly (ASPREE): a randomized, controlled trial] Contemp Clin Trials. 2013;36(2):555–564.
   PubMed Web of Science ®Google Scholar
• McNeil JJ, Woods RL, Nelson MR, et al. Baseline characteristics of participants in the ASPREE (ASPirin in reducing events in the elderly) study. J Gerontol A Biol Sci Med Sci. 2017;72(11):1586–1593.
   PubMed Web of Science ®Google Scholar
• Teng EL, Chui HC. The modified Mini-Mental state (3MS) examination. J Clin Psychiatry. 1987;48(8):314–318.
   PubMed Web of Science ®Google Scholar
• von Elm E, Altman DG, Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–349.
   PubMed Web of Science ®Google Scholar
• Davis SR, Bell RJ, Robinson PJ, et al. Testosterone and estrone increase from the age of 70 years: findings from the sex hormones in older women study. J Clin Endocrinol Metabol. 2019;104(12):6291–6300.
   PubMed Web of Science ®Google Scholar
• Hsu B, Cumming RG, Hirani V, et al. Temporal trend in androgen status and Androgen-Sensitive outcomes in older men. J Clin Endocrinol Metab. 2016;101(4):1836–1846.
   PubMed Web of Science ®Google Scholar
• Benedict RHB, Schretlen D, Groninger L, et al. Hopkins verbal learning test – revised: normative data and analysis of Inter-Form and Test-Retest reliability. Clin Neuropsychol. 1998;12(1):43–55.
   Web of Science ®Google Scholar
• Shapiro AM, Benedict RH, Schretlen D, et al. Construct and concurrent validity of the Hopkins verbal learning test–revised. Clin Neuropsychol. 1999;13(3):348–358.
   PubMed Web of Science ®Google Scholar
• Benton A, Hamsher K, Sivan A. Controlled oral word association test (COWAT). Multilingual aphasia examination, 3rd ed. Iowa City, IA: AJA Associates; 1983.
   Google Scholar
• Tombaugh TN, Kozak J, Rees L. Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming. Arch Clin Neuropsychol. 1999;14(2):167–177.
   PubMed Web of Science ®Google Scholar
• Ruff R, Light R, Parker S, et al. Benton controlled oral word association test: reliability and updated norms. Arch Clin Neuropsychol. 1996;11(4):329–338.
   PubMed Web of Science ®Google Scholar
• Smith A, JHelmuth J. The symbol-digit modalities test: a neuropsychologic test of learning and other cerebral disorders. Learn Disord. 1968;83:91.
   Google Scholar
• Hinton-Bayre A, Geffen G. Comparability, reliability, and practice effects on alternate forms of the digit symbol substitution and symbol digit modalities tests. Psychol Assess. 2005;17(2):237–241.
   PubMed Web of Science ®Google Scholar
• Strauss E, Sherman EM, Spreen O. A compendium of neuropsychological tests: administration, norms, and commentary. New York: American Chemical Society; 2006.
   Google Scholar
• Wolfe R, Murray AM, Woods RL, et al. The aspirin in reducing events in the elderly trial: statistical analysis plan. London, England: SAGE Publications Sage UK; 2018.
   Google Scholar
• Wåhlin-Jacobsen S, Pedersen AT, Kristensen E, et al. Is there a correlation between androgens and sexual desire in women? J Sexual Med. 2015;12(2):358–373.
   PubMed Web of Science ®Google Scholar
• Ryan J, Stanczyk FZ, Dennerstein L, et al. Hormone levels and cognitive function in postmenopausal midlife women. Neurobiol Aging. 2012;33(7):1138–1147.
   PubMed Web of Science ®Google Scholar
• Henderson VW, St. John JA, Hodis HN, et al. Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause Proceedings of the National Academy of Sciences of the United States of America. Proc Natl Acad Sci USA. 2013. 110(50):20290–20295.
   PubMed Web of Science ®Google Scholar
• Dong X, Jiang H, Li S, et al. Low serum testosterone concentrations are associated with poor cognitive performance in older men but not women. Front Aging Neurosci. 2021;13:712237.
   PubMed Web of Science ®Google Scholar
• Fukai S, Akishita M, Yamada S, et al. Association of plasma sex hormone levels with functional decline in elderly men and women [Research Support, Non-U.S. Gov’t]. Geriatr Gerontol Int. 2009;9(3):282–289.
   PubMed Web of Science ®Google Scholar
• Hogervorst E, Matthews FE, Brayne C. Are optimal levels of testosterone associated with better cognitive function in healthy older women and men? Biochim Biophys Acta. 2010;1800(10):1145–1152.
   PubMed Web of Science ®Google Scholar
• Bojar I, Pinkas J, Gujski M, et al. Postmenopausal cognitive changes and androgen levels in the context of apolipoprotein E polymorphism. Arch Med Sci. 2017;13(5):1148–1159.
   PubMed Web of Science ®Google Scholar
• de Menezes KJ, Peixoto C, Nardi AE, et al. Dehydroepiandrosterone, its sulfate and cognitive functions. Clin Pract. 2016;12(1):24–37.
   Google Scholar
• Boss L, Kang DH, Marcus M, et al. Endogenous sex hormones and cognitive function in older adults: a systematic review. West J Nurs Res. 2014;36(3):388–426.
   PubMed Web of Science ®Google Scholar
• Muller M, den Tonkelaar I, Thijssen JH, et al. Endogenous sex hormones in men aged 40–80 years. Eur J Endocrinol. 2003;149(6):583–589.
   PubMed Web of Science ®Google Scholar
• Lecomte P, Lecureuil N, Lecureuil M, et al. Sex differences in the control of sex-hormone-binding globulin in the elderly: role of insulin-like growth factor-I and insulin. Eur J Endocrinol. 1998;139(2):178–183.
   PubMed Web of Science ®Google Scholar
• Qu X, Donnelly R. Sex hormone-binding globulin (SHBG) as an early biomarker and therapeutic target in polycystic ovary syndrome. Int J Mol Sci. 2020;21(21):8191.
   PubMed Web of Science ®Google Scholar
• Muller M, Grobbee DE, Den Tonkelaar I, et al. Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab. 2005;90(5):2618–2623.
   PubMed Web of Science ®Google Scholar
• Xu W, Su B-J, Shen X-N, et al. Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal alzheimer’s disease. Aging. 2020;12(14):14528–14541.
   PubMedGoogle Scholar
• Muller M, Schupf N, Manly JJ, et al. Sex hormone binding globulin and incident Alzheimer’s disease in elderly men and women. Neurobiol Aging. 2010;31(10):1758–1765.
   PubMed Web of Science ®Google Scholar
• Handelsman DJ. Free testosterone: pumping up the tires or ending the free ride? Endocr Rev. 2017;38(4):297–301.
   PubMed Web of Science ®Google Scholar
• Hogervorst E, Craig J, O’Donnell E. Cognition and mental health in menopause: a review. Best Pract Res Clin Obstet Gynaecol. 2022;81:69–84.
   PubMedGoogle Scholar
• Wolfe R, Murray AM, Woods RL, et al. The aspirin in reducing events in the elderly trial: statistical analysis plan. Int J Stroke. 2018;13(3):335–338.
   PubMed Web of Science ®Google Scholar