Multiple object tracking and pupillometry reveal deficits in both selective and intensive attention in unilateral spatial neglect

References

• Alnæs, D., Sneve, M. H., Espeseth, T., Endestad, T., de Pavert, S. H. P. V., & Laeng, B. (2014). Pupil size signals mental effort deployed during multiple object tracking and predicts brain activity in the dorsal attention network and the locus coeruleus. Journal of Vision, 14(4). doi:10.1167/14.4.1
   PubMed Web of Science ®Google Scholar
• Alvarez, G. A., & Franconeri, S. L. (2007). How many objects can you attentively track?: Evidence for a resource-limited tracking mechanism. Journal of Vision, 7(13), 1–10.
   Web of Science ®Google Scholar
• Alvarez, G. A., & Scholl, B. J. (2005). How does attention select and track spatially extended objects? New effects of attentional concentration and amplification. Journal of Experimental Psychology: General, 134, 461–476.
   PubMed Web of Science ®Google Scholar
• Aston-Jones, G., & Cohen, J. D. (2005). An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance. Annual Review of Neuroscience, 28, 403–450.
   PubMed Web of Science ®Google Scholar
• Beatty, J. (1982). Task-evoked pupillary responses, processing load, and the structure of processing resources. Psychological Bulletin, 91(2), 276–292.
   PubMed Web of Science ®Google Scholar
• Behrmann, M., Watt, S., Black, S. E., & Barton, J. J. S. (1997). Impaired visual search in patients with unilateral neglect: An oculographic analysis. Neuropsychologia, 35(11), 1445–1458.
   PubMed Web of Science ®Google Scholar
• Bonato, M. (2012). Neglect and extinction depend greatly on task demands: A review. Frontiers in Human Neuroscience, 6, 1–13.
   PubMed Web of Science ®Google Scholar
• Brainard, D. H. (1997). The Psychophysics Toolbox. Spatial Vision, 10, 433–436.
   PubMedGoogle Scholar
• Cavanagh, P., & Alvarez, G. A. (2005). Tracking multiple targets with multifocal attention. TRENDS in Cognitive Sciences, 9, 349–354.
   PubMed Web of Science ®Google Scholar
• Corbetta, M., Kincade, M. J., Lewis, C., Snyder, A. Z., & Sapir, A. (2005). Neural basis and recovery of spatial attention deficits in spatial neglect. Nature Neuroscience, 8, 1603–1610.
   PubMed Web of Science ®Google Scholar
• Corbetta, M., & Shulman, G. L. (2011). Spatial neglect and attention networks. Annual Review of Neuroscience., 34, 569–599.
   PubMed Web of Science ®Google Scholar
• DeGutis, J. M., & Van Vleet, T. M. (2010). Tonic and phasic alertness training: A novel behavioral therapy to improve spatial and non-spatial attention in patients with hemispatial neglect. Frontiers in Human Neuroscience, 4, 1–16.
   PubMed Web of Science ®Google Scholar
• Driver, J., & Pouget, A. (2000). Object-centered visual neglect, or relative egocentric neglect? Journal of Cognitive Neuroscience, 12(3), 542–545.
   PubMed Web of Science ®Google Scholar
• Duncan, J., Bundesen, C., Olson, A., Humphreys, G., Chavda, S., & Shibuya, H. (1999). Systematic analysis of deficits in visual attention. Journal of Experimental Psychology-General, 128(4), 450–478.
   PubMed Web of Science ®Google Scholar
• Granholm, E., Asarnow, R. F., Sarkin, A. J., & Dykes, K. L. (1996). Pupillary responses index cognitive resource limitations. Psychophysiology, 33(4), 457–461.
   PubMed Web of Science ®Google Scholar
• Habekost, T., & Bundesen, C. (2003). Patient assessment based on a theory of visual attention (TVA): Subtle deficits after a right frontal-subcortical lesion. Neuropsychologia, 41, 1171–1188.
   PubMed Web of Science ®Google Scholar
• Heilman, K. M., Schwartz, H. D., & Watson, R. T. (1978). Hypoarousal in patients with the neglect syndrome and emotional indefference. Neurology, 28, 229–232.
   PubMed Web of Science ®Google Scholar
• Heilman, K. M., & Valenstein, E. (1979). Mechanisms underlying hemispatial neglect. Annals of Neurology, 5(2), 166–170.
   PubMed Web of Science ®Google Scholar
• Heilman, K. M., Valenstein, E., & Watson, R. T. (2000). Neglect and related disorders. Seminars in Neurology, 20(4), 463–470.
   PubMed Web of Science ®Google Scholar
• Hess, E. H. (1965). Attitude and pupil size. Scientific American, 212(4), 46–55.
   PubMed Web of Science ®Google Scholar
• Hess, E. H., & Polt, J. M. (1964). Pupil size in relation to mental activity during simple problem solving. Science, 140, 1190–1192.
   Google Scholar
• Hjaltason, H., Tegner, R., Tham, K., Levander, M., & Ericson, K. (1996). Sustained attention and awareness of disability in chronic neglect. Neuropsychologia, 34(12), 1229–1233.
   PubMed Web of Science ®Google Scholar
• Holcombe, A., & Chen, W.-Y. (2013). Splitting attention reduces temporal resolution from 7 Hz for tracking one object to <3 Hz when tracking three. Journal of Vision, 13(1), 12, 1–19.
   PubMed Web of Science ®Google Scholar
• Husain, M., Mannan, S., Hodgson, T., Wojciulik, E., Driver, J., & Kennard, C. (2001). Impaired spatial working memory across saccades contributes to abnormal search in parietal neglect. Brain, 124(5), 941–952.
   PubMed Web of Science ®Google Scholar
• Husain, M., & Rorden, C. (2003). Non-spatially lateralized mechanisms in hemispatial neglect. Nature Reviews Neuroscience, 4(1), 26–36.
   PubMed Web of Science ®Google Scholar
• Husain, M., Shapiro, K., Martin, J., & Kennard, C. (1997). Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature, 385(6612), 154–156.
   PubMed Web of Science ®Google Scholar
• Joshi, S., Li, Y., Kalwani, R. M., & Gold, J. I. (2016). Relationships between pupil diameter and neuronal activity in the locus coeruleus, colliculi, and cingulate cortex. Neuron, 89(1), 221–234.
   PubMed Web of Science ®Google Scholar
• Just, M. A., & Carpenter, P. A. (1993). The intensity dimension of thought: Pupillometric indices of sentence processing. Canadian Journal of Experimental Psychology, 47, 310–339.
   PubMed Web of Science ®Google Scholar
• Just, M. A., Carpenter, P. A., & Miyake, A. (2003). Neuroindices of cognitive workload: Neuroimaging, pupillometric and event-related potential studies of brain work. Theoretical Issues in Ergonomics Science, 4, 56–88.
   Google Scholar
• Kahneman, D. (1973). Attention and effort. Englewood Cliffs, NJ: Prentice-Hall Inc.
   Google Scholar
• Kahneman, D. (2011). Thinking, fast and slow. New York: Farrar, Strauss, Giroux.
   Google Scholar
• Kahneman, D., & Beatty, J. (1966). Pupil diameter and load on memory. Science, 154, 1583–1585.
   PubMed Web of Science ®Google Scholar
• Kahneman, D., Tursky, B., Shapiro, D., & Crider, A. (1969). Pupillary, heart rate and skin resistance changes during a mental task. Journal of Experimental Psychology, 79, 164–167.
   PubMedGoogle Scholar
• Karnath, H.-O., Fruhmann Berger, M., Küker, W., & Rorden, C. (2004). The anatomy of spatial neglect based on voxelwise statistical analysis: A study of 140 patients. Cerebral Cortex, 14, 1164–1172.
   PubMed Web of Science ®Google Scholar
• Kim, M., Schwartz, R. L., & Heilman, K. M. (1999). Pupillographic findings in neglect. Journal of Neurology, Neurosurgery, and Psychiatry, 67, 82–85.
   PubMed Web of Science ®Google Scholar
• Kim, M. S., & Cave, K. R. (1999). Top-down and bottom-up attentional control: On the nature of interference from a salient distractor. Perception & Psychophysics, 61(6), 1009–1023.
   PubMed Web of Science ®Google Scholar
• Kleiner, M., Brainard, D., & Pelli, D., Ingling, A., Murray, R., & Broussard, C. (2007). What’s new in Psychtoolbox-3?. Perception, 36(14), 1–16.
   Web of Science ®Google Scholar
• Laeng, B., Brennen, T., & Espeseth, T. (2002). Fast responses to neglected targets in visual search reflect pre-attentive processes: An exploration of response times in visual neglect. Neuropsychologia, 40(9), 1622–1636.
   PubMed Web of Science ®Google Scholar
• Laeng, B., Sirois, S., & Gredeback, G. (2012). Pupillometry: A Window to the Preconscious? Perspectives on Psychological Science, 7(1), 18–27.
   Web of Science ®Google Scholar
• Lisi, M., Bonato, M., & Zorzi, M. (2015). Pupil dilation reveals top-down attentional load during spatial monitoring. Biological Psychology, 112, 39–45.
   PubMed Web of Science ®Google Scholar
• Loftus, G. R., & Masson, M. E. J. (1994). Using Confidence-Intervals in within-Subject Designs. Psychonomic Bulletin & Review, 1(4), 476–490.
   PubMed Web of Science ®Google Scholar
• Makovski, T., & Jiang, Y. V. (2009). Feature binding in attentive tracking of distinct objects. Visual Cognition, 17(1–2), 180–194.
   PubMed Web of Science ®Google Scholar
• Makovski, T., Vazquez, G. A., & Jiang, Y. V. (2008). Visual learning in multiple-object tracking. PLoS One, 3(5), e2228.
   PubMed Web of Science ®Google Scholar
• Mathôt, S., van der Linden, L., Grainger, J., & Vitu, F. (2013). The pupillary light response reveals the focus of covert visual attention. PLoS ONE, 8(10), e78168.
   PubMed Web of Science ®Google Scholar
• Matthias, E., Bublak, P., Mueller, H. J., Schneider, W. X., Krummenacher, J., & Finke, K. (2010). The influence of alertness on spatial and nonspatial components of visual attention. Journal of Experimental Psychology-Human Perception and Performance, 36(1), 38–56.
   PubMed Web of Science ®Google Scholar
• Mesulam, M. M. (1981). A cortical network for directed attention and unilateral neglect. Annals of Neurology, 10, 309–325.
   PubMed Web of Science ®Google Scholar
• Murphy, P. R., O’Connell, R. G., O’Sullivan, M., Robertson, I. H., & Balsters, J. H. (2014). Pupil diameter covaries with BOLD activity in human locus coeruleus. Human Brain Mapping, n/a-n/a. doi:10.1002/hbm.22466
   Web of Science ®Google Scholar
• Murphy, P. R., Robertson, I. H., Balsters, J. H., & O’Connell, R. G. (2011). Pupillometry and P3 index the locus coeruleus-noradrenergic arousal function in humans. Psychophysiology, 48, 1532–1543.
   PubMed Web of Science ®Google Scholar
• Parton, A., Malhotra, P., & Husain, M. (2004). Hemispatial Neglect. Journal of Neurology, Neurosurgery & Psychiatry, 75(13–21). PMID:14707298 PMC1757480.
   Google Scholar
• Peavler, W. S. (1974). Pupil size, information overload, and performance differences. Psychophysiology, 11, 559–566.
   PubMed Web of Science ®Google Scholar
• Pelli, D. G. (1997). The VideoToolbox software for visual psychophysics: Transforming numbers movies. Spatial Vision, 10, 437–442.
   PubMedGoogle Scholar
• Poock, G. K. (1973). Information processing vs pupil diameter. Perceptual and Motor Skills, 37(3), 1000–1002.
   PubMed Web of Science ®Google Scholar
• Posner, M. I., & Petersen, S. E. (1990). The attention system of the human brain. Annual Review of Neuroscience, 13, 25–42.
   PubMed Web of Science ®Google Scholar
• Posner, M. I., Walker, J. A., Friedrich, F. J., & Rafal, R. D. (1984). Effects of parietal injury on covert orienting of attention. Journal of Neuroscience, 4(7), 1863–1874.
   PubMed Web of Science ®Google Scholar
• Posner, M. I., Walker, J. A., Friedrich, F. J., & Rafal, R. D. (1987). How do the parietal lobes direct covert attention? Neuropsychologia, 25, 135–145. Pergamon Journals Ltd.
   PubMed Web of Science ®Google Scholar
• Raz, A., & Buhle, J. (2006). Typologies of attentional networks. Nature Reviews Neuroscience, 7(5), 367–379.
   PubMed Web of Science ®Google Scholar
• Robertson, I. H. (2001). Do we need the “lateral” in unilateral neglect? Spatially nonselective attention deficits in unilateral neglect and their implications for rehabilitation. Neuroimage, 14, 85–90.
   PubMed Web of Science ®Google Scholar
• Robertson, I. H., Manly, T., Beschin, N., Daini, R., Haeske-Dewick, H., Hömberg, V., … Weber, E. (1997). Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia, 35, 1527–1532.
   PubMed Web of Science ®Google Scholar
• Robertson, I. H., Mattingley, J. B., Rorden, C., & Driver, J. (1998). Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature, 395(6698), 169–172.
   PubMed Web of Science ®Google Scholar
• Robertson, I. H., Tegner, R., Tham, K., Lo, A., & Nimmo-Smith, I. (1995). Sustained attention training for unilateral neglect: Theoretical and rehabilitation implications. Journal of Clinical and Experimental Neuropsychology, 17, 416–430.
   PubMed Web of Science ®Google Scholar
• Rueckert, L., & Grafman, J. (1996). Sustained attention deficits in patients with right frontal lesions. Neuropsychologia, 34, 953–963.
   PubMed Web of Science ®Google Scholar
• Samuelsson, H., Hjelmquist, E., Jensen, C., Ekholm, S., & Blomstrand, C. (1998). Nonlateralized Attentional Deficits: An Important Component behind Persisting Visuospatial Neglect? Journal of Clinical and Experimental Neuropsychology, 20(1), 73–88.
   Google Scholar
• Sara, S. J. (2009). The locus coeruleus and noradrenergic modulation of cognition. Nature reviews. Neuroscience, 10(3), 211–223.
   PubMed Web of Science ®Google Scholar
• Scholl, B. J. (2009). What have we learned about attention from multiple-object tracking (and vice versa)? In D. Dedrick & L. Trick (Eds.), Computation, cognition, and Pylyshyn (pp. 49–77). Cambridge, MA: MIT Press.
   Google Scholar
• Stone, S. P., Halligan, P. W., & Greenwood, R. J. (1993). The incidence of neglect phenomena and related disorders in patients with an acute right or left hemisphere stroke. Age & Ageing, 22, 46–52.
   PubMed Web of Science ®Google Scholar
• Sturm, W., de Simone, A., Krause, B. J., Specht, K., Hesselmann, V., Radermacher, I., … Willmes, K. (1999). Functional anatomy of intrinsic alertness: Evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere. Neuropsychologia, 37(7), 797–805.
   PubMed Web of Science ®Google Scholar
• Sturm, W., & Willmes, K. (2001). On the functional neuroanatomy of intrinsic and phasic alertness. Neuroimage, 14(1), 76–S84.
   PubMed Web of Science ®Google Scholar
• Treisman, A. M., & Gelade, G. (1980). A feature-integration theory of attention. Cognitive Psychology, 12, 97–136.
   PubMed Web of Science ®Google Scholar
• Verdon, V., Schwartz, S., Lovblad, K. O., Hauert, C. A., & Vuilleumier, P. (2010). Neuroanatomy of hemispatial neglect and its functional components: A study using voxel-based lesion-symptom mapping. Brain, 133, 880–894.
   PubMed Web of Science ®Google Scholar
• Wahn, B., Ferris, D. P., Hairston, W. D., & Koènig, P. (2016). Pupil sizes scale with attentional load and task experience in a multiple object tracking task. PLoS ONE, 11(12), e0168087.
   PubMed Web of Science ®Google Scholar
• Weintraub, S., & Mesulam, M. M. (1987). Right cerebral dominance in spatial attention: Further evidence based on ipsilateral neglect. Archives of Neurology, 44, 621–625.
   PubMed Web of Science ®Google Scholar
• Wilkins, A. J., Shallice, T., & McCarthy, R. (1987). Frontal lesions and sustained attention. Neuropsychologia, 25, 359–365.
   PubMed Web of Science ®Google Scholar
• Wilson, B., Cockburn, J., & Halligan, P. (1987). Development of a behavioral test of visuospatial neglect. Archives of Physical Medicine and Rehabilitation, 68, 98–9102.
   PubMed Web of Science ®Google Scholar