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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 114, 2008 - Issue 3
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Review

Prostanoid function and cardiovascular disease

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Pages 201-209 | Received 06 Feb 2008, Accepted 20 Mar 2008, Published online: 10 Oct 2008

References

  • Alfranca A, Iniguez M A, Fresno M, Redondo J M. Prostanoid signal transduction and gene expression in the endothelium: role in cardiovascular diseases. Cardiovasc Res 2006; 70(3)446–456
  • Babaev V R, Ding L, Reese J, Morrow J D, Breyer M D, Dey S K, Fazio S, Linton M F. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 2006; 113(1)108–117
  • Banfi C, Colli S, Eligini S, Mussoni L, Tremoli E. Oxidized LDLs influence thrombotic response and cyclooxygenase 2. Prostaglandins Leukot Essent Fatty Acids 2002; 67(2–3)169–173
  • Belton O, Fitzgerald D. Cyclooxygenase-2 inhibitors and atherosclerosis. J Am Coll Cardiol 2003; 41(10)1820–1822
  • Belton O, Fitzgerald D J. Cyclooxygenase isoforms and atherosclerosis. Expert Rev Mol Med 2003; 2003: 1–18
  • Berger J, Moller D E. The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409–435
  • Blanco J C, Contursi C, Salkowski C A, DeWitt D L, Ozato K, Vogel S N. Interferon regulatory factor (IRF)- 1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression. J Exp Med 2000; 191(12)2131–2144
  • Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz M B, Hawkey C J, Hochberg M C, Kvien T K, Schnitzer T J. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000; 343(21)1520–1528, (2 pages following 1528)
  • Bunting S, Moncada S, Vane J R. The prostacyclin-thromboxane A2 balance: pathophysiological and therapeutic implications. Br Med Bull 1983; 39(3)271–276
  • Burleigh M E, Babaev V R, Oates J A, Harris R C, Gautam S, Riendeau D, Marnett L J, Morrow J D, Fazio S, Linton M F. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation 2002; 105(15)1816–1823
  • Burleigh M E, Babaev V R, Yancey P G, Major A S, McCaleb J L, Oates J A, Morrow J D, Fazio S, Linton M F. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J Mol Cell Cardiol 2005; 39(3)443–452
  • Caldwell B, Aldington S, Weatherall M, Shirtcliffe P, Beasley R. Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis. J R Soc Med 2006; 99(3)132–140
  • Cipollone F, Fazia M, Iezzi A, Ciabattoni G, Pini B, Cuccurullo C, Ucchino S, Spigonardo F, De Luca M, Prontera C, Chiarelli F, Cuccurullo F, Mezzetti A. Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. Arterioscler Thromb Vasc Biol 2004; 24(7)1259–1265
  • Cipollone F, Prontera C, Pini B, Marini M, Fazia M, De Cesare D, Iezzi A, Ucchino S, Boccoli G, Saba V, Chiarelli F, Cuccurullo F, Mezzetti A. Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability. Circulation 2001; 104(8)921–927
  • Coruzzi G, Venturi N, Spaggiari S. Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors and beyond. Acta Biomed 2007; 78(2)96–110
  • Chandrasekharan N V, Dai H, Roos K L, Evanson N K, Tomsik J, Elton T S, Simmons D L. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci USA 2002; 99(21)13926–13931
  • Cheng Y, Austin S C, Rocca B, Koller B H, Coffman T M, Grosser T, Lawson J A, FitzGerald G A. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002; 296(5567)539–541
  • Cheng Y, Wang M, Yu Y, Lawson J, Funk C D, Fitzgerald G A. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest 2006; 116(5)1391–1399
  • Dannhardt G, Kiefer W. Cyclooxygenase inhibitors – current status and future prospects. Eur J Med Chem 2001; 36(2)109–126
  • Davidge S T. Prostaglandin H synthase and vascular function. Circ Res 2001; 89(8)650–660
  • Diaz-Cazorla M, Perez-Sala D, Ros J, Jimenez W, Fresno M, Lamas S. Regulation of cyclooxygenase-2 expression in human mesangial cells – transcriptional inhibition by IL-13. Eur J Biochem 1999; 260(1)268–274
  • Egan K M, Lawson J A, Fries S, Koller B, Rader D J, Smyth E M, Fitzgerald G A. COX-2-derived prostacyclin confers atheroprotection on female mice. Science 2004; 306(5703)1954–1957
  • FitzGerald G A. COX-2 and beyond: Approaches to prostaglandin inhibition in human disease. Nat Rev Drug Discov 2003; 2(11)879–890
  • FitzGerald G A, Austin S, Egan K, Cheng Y, Pratico D. Cyclo-oxygenase products and atherothrombosis. Ann Med 2000; 32(Suppl 1)21–26
  • FitzGerald G A, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001; 345(6)433–442
  • Flavahan N A. Balancing prostanoid activity in the human vascular system. Trends Pharmacol Sci 2007; 28(3)106–110
  • Fosslien E. Cardiovascular complications of non-steroidal anti-inflammatory drugs. Ann Clin Lab Sci 2005; 35(4)347–385
  • Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim H S, Rockman H A, FitzGerald G A, Koller B H, Coffman T M. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab 2005; 2(3)201–207
  • Fuse I, Higuchi W, Aizawa Y. Pathogenesis of a bleeding disorder characterized by platelet unresponsiveness to thromboxane A2. Semin Thromb Hemost 2000; 26(1)43–45
  • Grau R, Iniguez M A, Fresno M. Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. Cancer Res 2004; 64(15)5162–5171
  • Hansson G K, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 2006; 6(7)508–519
  • Hata A N, Breyer R M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol Ther 2004; 103(2)147–166
  • Helliwell R J, Adams L F, Mitchell M D. Prostaglandin synthases: recent developments and a novel hypothesis. Prostaglandins Leukot Essent Fatty Acids 2004; 70(2)101–113
  • Hirata T, Kakizuka A, Ushikubi F, Fuse I, Okuma M, Narumiya S. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. J Clin Invest 1994; 94(4)1662–1667
  • Ide T, Egan K, Bell-Parikh L C, FitzGerald G A. Activation of nuclear receptors by prostaglandins. Thromb Res 2003; 110(5–6)311–315
  • Iniguez M A, Martinez-Martinez S, Punzon C, Redondo J M, Fresno M. An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J Biol Chem 2000; 275(31)23627–23635
  • Iniguez M A, Punzon C, Fresno M. Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors. J Immunol 1999; 163(1)111–119
  • Iniguez M A, Rodriguez A, Volpert O V, Fresno M, Redondo J M. Cyclooxygenase-2: a therapeutic target in angiogenesis. Trends Mol Med 2003; 9(2)73–78
  • Kabashima K, Narumiya S. The DP receptor, allergic inflammation and asthma. Prostaglandins Leukot Essent Fatty Acids 2003; 69(2–3)187–194
  • Kanaoka Y, Urade Y. Hematopoietic prostaglandin D synthase. Prostaglandins Leukot Essent Fatty Acids 2003; 69(2–3)163–167
  • Karim S, Habib A, Levy-Toledano S, Maclouf J. Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. J Biol Chem 1996; 271(20)12042–12048
  • Kearney P M, Baigent C, Godwin J, Halls H, Emberson J R, Patrono C. Do selective cyclooxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ 2006; 332(7553)1302–1308
  • Kobayashi T, Tahara Y, Matsumoto M, Iguchi M, Sano H, Murayama T, Arai H, Oida H, Yurugi-Kobayashi T, Yamashita J K, Katagiri H, Majima M, Yokode M, Kita T, Narumiya S. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest 2004; 114(6)784–794
  • Kujubu D A, Herschman H R. Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J Biol Chem 1992; 267(12)7991–7994
  • Lopez J A, Armstrong M L, Harrison D G, Piegors D J, Heistad D D. Vascular responses to leukocyte products in atherosclerotic primates. Circ Res 1989; 65(4)1078–1086
  • Martinez-Gonzalez J, Badimon L. Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks. Curr Pharm Des 2007; 13(22)2215–2227
  • McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. Jama 2006; 296(13)1633–1644
  • Morita I. Distinct functions of COX-1 and COX-2. Prostaglandins Other Lipid Mediat 2002; 68–69: 165–175
  • Murakami M, Kambe T, Shimbara S, Kudo I. Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways. J Biol Chem 1999; 274(5)3103–3115
  • Murakami M, Nakashima K, Kamei D, Masuda S, Ishikawa Y, Ishii T, Ohmiya Y, Watanabe K, Kudo I. Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2. J Biol Chem 2003; 278(39)37937–37947
  • Murakami M, Nakatani Y, Tanioka T, Kudo I. Prostaglandin E synthase. Prostaglandins Other Lipid Mediat 2002; 68/69: 383–399
  • Murata T, Ushikubi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y, Ichikawa A, Aze Y, Tanaka T, Yoshida N, Ueno A, Oh-ishi S, Narumiya S. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997; 388(6643)678–682
  • Niiro H, Otsuka T, Izuhara K, Yamaoka K, Ohshima K, Tanabe T, Hara S, Nemoto Y, Tanaka Y, Nakashima H, Niho Y. Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 1997; 89(5)1621–1628
  • Norata G D, Callegari E, Inoue H, Catapano A L. HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase coupling. Arterioscler Thromb Vasc Biol 2004; 24(5)871–877
  • Pratico D, Tillmann C, Zhang Z B, Li H, FitzGerald G A. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc Natl Acad Sci USA 2001; 98(6)3358–3363
  • Ray W A, Stein C M, Daugherty J R, Hall K, Arbogast P G, Griffin M R. COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. Lancet 2002; 360(9339)1071–1073
  • Reiss A B, Edelman S D. Recent insights into the role of prostanoids in atherosclerotic vascular disease. Curr Vasc Pharmacol 2006; 4(4)395–408
  • Rocca B, Loeb A L, Strauss J F, 3rd, Vezza R, Habib A, Li H, FitzGerald G A. Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation. Nat Med 2000; 6(2)219–221
  • Ross R. Atherosclerosis – an inflammatory disease. N Engl J Med 1999; 340(2)115–126
  • Rostom A, Muir K, Dube C, Jolicoeur E, Boucher M, Joyce J, Tugwell P, Wells G W. Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review. Clin Gastroenterol Hepatol 2007; 5(7)818–828, 828 e1–5; quiz 768
  • Rudic R D, Brinster D, Cheng Y, Fries S, Song W L, Austin S, Coffman T M, FitzGerald G A. COX-2-derived prostacyclin modulates vascular remodeling. Circ Res 2005; 96(12)1240–1247
  • Samuelsson B, Morgenstern R, Jakobsson P J. Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol Rev 2007; 59(3)207–224
  • Scher J U, Pillinger M H. 15d-PGJ2: the anti-inflammatory prostaglandin. Clin Immunol 2005; 114(2)100–109
  • Simmons D L, Botting R M, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 2004; 56(3)387–437
  • Smith W L, DeWitt D L, Garavito R M. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000; 69: 145–182
  • Smyth E M, FitzGerald G A. Human prostacyclin receptor. Vitam Horm 2002; 65: 149–165
  • Straus D S, Glass C K. Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev 2001; 21(3)185–210
  • Subbaramaiah K, Dannenberg A J. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 2003; 24(2)96–102
  • Tanabe T, Tohnai N. Cyclooxygenase isozymes and their gene structures and expression. Prostaglandins Other Lipid Mediat 2002; 68/69: 95–114
  • Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem 2000; 275(42)32775–32782
  • Tegeder I, Pfeilschifter J, Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. Faseb J 2001; 15(12)2057–2072
  • Thomas D W, Mannon R B, Mannon P J, Latour A, Oliver J A, Hoffman M, Smithies O, Koller B H, Coffman T M. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest 1998; 102(11)1994–2001
  • Topper J N, Cai J, Falb D, Gimbrone M A, Jr. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 1996; 93(19)10417–10422
  • Tsuboi K, Sugimoto Y, Ichikawa A. Prostanoid receptor subtypes. Prostaglandins. Other Lipid Mediat 2002; 68/69: 535–556
  • Ueno N, Takegoshi Y, Kamei D, Kudo I, Murakami M. Coupling between cyclooxygenases and terminal prostanoid synthases. Biochem Biophys Res Commun 2005; 338(1)70–76
  • Urade Y, Hayaishi O. Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase. Biochim Biophys Acta 2000; 1482(1–2)259–271
  • Vane J R. Biomedicine. Back to an aspirin a day? Science 2002; 296(5567)474–475
  • Vila L. Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis. Med Res Rev 2004; 24(4)399–424
  • Wang L H, Kulmacz R J. Thromboxane synthase: structure and function of protein and gene. Prostaglandins Other Lipid Mediat 2002; 68/69: 409–422
  • Wang M, Zukas A M, Hui Y, Ricciotti E, Pure E, FitzGerald G A. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci USA 2006; 103(39)14507–14512
  • Warner T D, Giuliano F, Vojnovic I, Bukasa A, Mitchell J A, Vane J R. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999; 96(13)7563–7568
  • Warner T D, Mitchell J A. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. Faseb J 2004; 18(7)790–804
  • Watanabe K. Prostaglandin F synthase. Prostaglandins Other Lipid Mediat 2002; 68/69: 401–407
  • Williams C S, Mann M, DuBois R N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999; 18(55)7908–7916
  • Wu K K, Liou J Y. Cellular and molecular biology of prostacyclin synthase. Biochem Biophys Res Commun. 2005
  • Yamada M, Numaguchi Y, Okumura K, Harada M, Naruse K, Matsui H, Ito T, Hayakawa T. Prostacyclin synthase gene transfer modulates cyclooxygenase-2-derived prostanoid synthesis and inhibits neointimal formation in rat balloon-injured arteries. Arterioscler Thromb Vasc Biol 2002; 22(2)256–262
  • Yokoyama C, Yabuki T, Shimonishi M, Wada M, Hatae T, Ohkawara S, Takeda J, Kinoshita T, Okabe M, Tanabe T. Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. Circulation 2002; 106(18)2397–2403
  • Yu Y, Cheng Y, Fan J, Chen X S, Klein-Szanto A, Fitzgerald G A, Funk C D. Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest 2005; 115(4)986–995

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