G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation

References

• Cong M, Perry S J, Lin F T, Fraser I D, Hu L A, Chen W, Pitcher J A, Scott J D, Lefkowitz R J. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein akap79. J Biol Chem 2001; 276: 15192–15199
   PubMed Web of Science ®Google Scholar
• Defea K A. Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization. Annu Rev Physiol 2007; 69: 535–560
   PubMed Web of Science ®Google Scholar
• Elorza A, Sarnago S, Mayor F, Jr. Agonist-dependent modulation of G protein-coupled receptor kinase 2 by mitogen-activated protein kinases. Mol Pharmacol 2000; 57: 778–783
   PubMed Web of Science ®Google Scholar
• Elorza A, Penela P, Sarnago S, Mayor F, Jr. Mapk-dependent degradation of g protein-coupled receptor kinase 2. J Biol Chem 2003; 278: 29164–291673
   PubMedGoogle Scholar
• Hoefen R J, Berk B C. The multi-functional git family of proteins. J Cell Sci 2006; 119: 1469–1475
   PubMed Web of Science ®Google Scholar
• Jimenez-Sáinz M C, Murga C, Kavelaars A, Jurado-Pueyo M, Krakstad B F, Heijnen C J, Mayor F, Jr, Aragay A M. G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from g protein subunits. Mol Biol Cell 2006; 17: 25–31
   PubMed Web of Science ®Google Scholar
• Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse M J. Phosphorylation of GRK2 by protein kinase c abolishes its inhibition by calmodulin. J Biol Chem 2001; 276: 1911–1915
   PubMed Web of Science ®Google Scholar
• Kumar S, Boehm J, Lee J C. P38 map kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003; 2: 717–726
   PubMed Web of Science ®Google Scholar
• Leosco D, Fortunato F, Rengo G, Iaccarino G, Sanzari E, Golino L, Zincarelli C, Canonico V, Marchese M, Koch W J, Rengo F. Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease. Neurosci Lett 2007; 415: 279–282
   PubMed Web of Science ®Google Scholar
• Lombardi M S, Kavelaars A, Penela P, Scholtens E J, Roccio M, Schmidt R E, Schedlowski M, Mayor F, Jr, Heijnen C J. Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol Pharmacol 2002; 62: 379–388
   PubMed Web of Science ®Google Scholar
• Lombardi M S, Kavelaars A, Schedlowski M, Bijlsma J W, Okihara K L, Van de Pol M, Ochsmann S, Pawlak C, Schmidt R E, Heijnen C J. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J 1999; 13: 715–725
   PubMed Web of Science ®Google Scholar
• Lombardi M S, Kavelaars A, Cobelens P M, Schmidt R E, Schedlowski M, Heijnen C J. Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system. J Immunol 2001; 166: 1635–1640
   PubMed Web of Science ®Google Scholar
• Lombardi M S, Van den Tweel E, Kavelaars A, Groenendaal F, Van bel F, Heijnen C J. Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain. Stroke 2004; 35: 981–986
   Google Scholar
• Mariggio S, Garcia-Hoz C, Sarnago S, De Blasi A, Mayor F, Jr, Ribas C. Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-src modulates its interaction with galphaq. Cell Signal 2006; 18: 2004–2012
   PubMed Web of Science ®Google Scholar
• Penela P, Elorza A, Sarnago S, Mayor F, Jr. Beta-arrestin- and c-src-dependent degradation of G-protein-coupled receptor kinase 2. EMBO J 2001; 20: 5129–5138
   PubMedGoogle Scholar
• Penela P, Murga C, Ribas C, Tutor A S, Peregrin S, Mayor F, Jr. Mechanisms of regulation of G protein-coupled receptor kinases GRKs and cardiovascular disease. Cardiovasc Res 2006; 69: 46–56
   PubMed Web of Science ®Google Scholar
• Penela P, Ribas C, Mayor F, Jr. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 2003; 15: 973–981
   PubMed Web of Science ®Google Scholar
• Penela P, Ruiz-Gómez A, Castaño J G, Mayor F, Jr. Degradation of the g protein-coupled receptor kinase 2 by the proteasome pathway. J Biol Chem 1998; 273: 35238–35244
   PubMed Web of Science ®Google Scholar
• Peregrin S, Jurado-Pueyo M, Campos P M, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F, Jr, Murga C. Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38mapk. Curr Biol 2006; 16: 2042–2047
   PubMed Web of Science ®Google Scholar
• Pitcher J A, Tesmer J J, Freeman J L, Capel W D, Stone W C, Lefkowitz R J. Feedback inhibition of g protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. J Biol Chem 1999; 274: 34531–34534
   PubMed Web of Science ®Google Scholar
• Ramos-Ruiz R, Penela P, Penn R B, Mayor F, Jr. Analysis of the human g protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells. Circulation 2000; 101: 2083–2089
   Google Scholar
• Ribas C, Penela P, Murga C, Salcedo A, Garcia-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor F, Jr. The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta 2007; 1768: 913–922
   PubMed Web of Science ®Google Scholar
• Ridley A J, Schwartz M A, Burridge K, Firtel R A, Ginsberg M H, Borisy G, Parsons J T, Horwitz A R. Cell migration: integrating signals from front to back. Science 2003; 302: 1704–1709
   PubMed Web of Science ®Google Scholar
• Salcedo A, Mayor F, Jr, Penela P. Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J 2006; 25: 4752–4762
   PubMed Web of Science ®Google Scholar
• Sarnago S, Elorza A, Mayor F, Jr. Agonist-dependent phosphorylation of the G protein–coupled receptor kinase 2 (GRK2) by src tyrosine kinase. J Biol Chem 1999; 274: 34411–34416
   PubMed Web of Science ®Google Scholar
• Spiegel S, English D, Milstien S. Sphingosine 1-phosphate signaling: providing cells with a sense of direction. Trends Cell Biol 2002; 12: 236–242
   PubMed Web of Science ®Google Scholar
• Vroon A, Heijnen C J, Kavelaars A. GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol 2006; 80: 1214–1221
   PubMed Web of Science ®Google Scholar
• Vroon A, Heijnen C J, Lombardi M S, Cobelens P M, Mayor F, Jr, Caron M G, Kavelaars A. Reduced GRK2 level in t cells potentiates chemotaxis and signaling in response to CCl4. J Leukoc Biol 2004; 75: 901–909
   PubMed Web of Science ®Google Scholar
• Vroon A, Kavelaars A, Limmroth V, Lombardi M S, Goebel M U, Van dam A M, Caron M G, Schedlowski M, Heijnen C J. G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Immunol 2005; 174: 4400–4406
   PubMed Web of Science ®Google Scholar