Hypoxia and the endocrine and signalling role of white adipose tissue

References

• Y Arita, S Kihara, N Ouchi, M Takahashi, K Maeda, J Miyagawa, K Hotta, I Shimomura, T Nakamura, K Miyaoka, and et al (1999). Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79–83.
   PubMed Web of Science ®Google Scholar
• D Arsenijevic, H Onuma, C Pecqueur, S Raimbault, B S Manning, B Miroux, E Couplan, M C Alves-Guerra, M Goubern, R Surwit, and et al (2000). Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genetics 26:435–439.
   PubMed Web of Science ®Google Scholar
• A H Berg, T P Combs, X Du, M Brownlee, and P E Scherer. (2001). The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7:947–953.
   PubMed Web of Science ®Google Scholar
• M C Bosco, M Puppo, S Pastorino, Z Mi, G Melillo, S Massazza, A Rapisarda, and L Varesio. (2004). Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages. J Immunol 172:1681–1690.
   PubMed Web of Science ®Google Scholar
• M C Brahimi-Horn, and J Pouysségur. (2007). Oxygen, a source of life and stress. FEBS Lett 581:3582–3591.
   PubMed Web of Science ®Google Scholar
• M Bulló, M R Peeraully, and P Trayhurn. (2005). Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Δ12-PGJ2. Am J Physiol Endocrinol Metab 289:E62–E67.
   Google Scholar
• P Calabro, D W Chang, J T Willerson, and E T Yeh. (2005). Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol 46:1112–1123.
   PubMed Web of Science ®Google Scholar
• F Caldefie-Chezet, M Damez, M de Latour, G Konska, F Mishellani, C Fusillier, M Guerry, F Penault-Llorca, J Guillot, and M-P Vasson. (2005). Leptin: A proliferative factor for breast cancer?: Study on human ductal carcinoma. Biochem Biophys Res Commun 334:737–741.
   PubMed Web of Science ®Google Scholar
• A Carriere, M-C Carmona, Y Fernandez, M Rigoulet, R H Wenger, L Penicaud, and L Casteilla. (2004). mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect. J Biol Chem 279:40462–40469.
   PubMed Web of Science ®Google Scholar
• B Chen, K SL Lam, Y Wang, D Wu, M C Lam, J Shen, L Wong, R LC Hoo, J Zhang, and A Xu. (2006). Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem Biophys Res Commun 341:549–556.
   PubMed Web of Science ®Google Scholar
• S Chung, K LaPoint, K Martinez, A Kennedy, M Boysen Sandberg, and M K McIntosh. (2006). preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147:5340–5351.
   PubMed Web of Science ®Google Scholar
• K S Cook, H Y Min, D Johnson, R J Chaplinsky, J S Flier, C R Hunt, and B M Spiegelman. (1987). Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science 237:402–405.
   PubMed Web of Science ®Google Scholar
• B Cousin, O Munoz, M Andre, A M Fontanilles, C Dani, J L Cousin, P Laharrague, L Casteilla, and L Penicaud. (1999). A role for preadipocytes as macrophage-like cells. FASEB J 13:305–312.
   PubMed Web of Science ®Google Scholar
• E P Cummins, and C T Taylor. (2005). Hypoxia-responsive transcription factors. Pflügers Arch Eur J Physiol 450:363–371.
   PubMed Web of Science ®Google Scholar
• R Del Toro, K L Levitsky, J López-Barneo, and M D Chiara. (2003). Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem 278:22316–22324.
   PubMed Web of Science ®Google Scholar
• M Di Girolamo, N S SkinnerJr., H G Hanley, and R G Sachs. (1971). Relationship of adipose tissue blood flow to fat cell size and number. Am J Physiol 220:932–937.
   PubMed Web of Science ®Google Scholar
• M S Do, S Y Nam, S E Hong, K W Kim, J S Duncan, J H Beattie, and P Trayhurn. (2002). Metallothionein gene expression in human adipose tissue from lean and obese subjects. Horm Metab Res 34:348–351.
   PubMed Web of Science ®Google Scholar
• M Ehrhart-Bornstein, V Lamounier-Zepter, A Schraven, J Langenbach, H S Willenberg, A Barthel, H Hauner, S M McCann, W A Scherbaum, and S R Bornstein. (2003). Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci USA 100:14211–14216.
   PubMed Web of Science ®Google Scholar
• M Erecinska, and I A Silver. (2001). Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 128:263–276.
   PubMedGoogle Scholar
• J N Fain, A K Madan, M L Hiler, P Cheema, and S W Bahouth. (2004). Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145:2273–2282.
   PubMed Web of Science ®Google Scholar
• J N Fain. (2006). Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74:443–477.
   PubMed Web of Science ®Google Scholar
• E Fleischmann, A Kurz, M Niedermayr, K Schebesta, O Kimberger, D I Sessler, B Kabon, and G Prager. (2005). Tissue oxygenation in obese and non-obese patients during laparoscopy. Obesity Surg 15:813–819.
   PubMed Web of Science ®Google Scholar
• J Folkman, P Hahnfeldt, and L Hlatky. (2000). Cancer: looking outside the genome. Nat Rev Mol Cell Biol 1:76–79.
   PubMed Web of Science ®Google Scholar
• R A Gatenby, and R J Gillies. (2004). Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 4:891–899.
   PubMed Web of Science ®Google Scholar
• C C Gerhardt, I A Romero, R Cancello, L Camoin, and A D Strösberg. (2001). Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol 175:81–92.
   PubMed Web of Science ®Google Scholar
• A J Glassford, P Yue, A Y Sheikh, H J Chun, S Zarafshar, D A Chan, G M Reaven, T Quertermous, and P S Tsao. (2007). HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Am J Physiol Endocrinol Metab 293:E1590–E1596.
   PubMed Web of Science ®Google Scholar
• K B Goralski, T C McCarthy, E A Hanniman, B A Zabel, E C Butcher, S D Parlee, S Muruganandan, and C J Sinal. (2007). Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 282:28175–28188.
   PubMed Web of Science ®Google Scholar
• A Green, J M Rumberger, C A Stuart, and M S Ruhoff. (2004). Stimulation of lipolysis by tumor necrosis factor-α in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis. Diabetes 53:74–81.
   PubMed Web of Science ®Google Scholar
• M F Gregor, and G S Hotamisligil. (2007). Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 48:1905–1914.
   PubMed Web of Science ®Google Scholar
• E A Gulve, J M Ren, B A Marshall, J Gao, P A Hansen, J O Holloszy, and M Mueckler. (1994). Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4. J Biol Chem 269:18366–18370.
   PubMed Web of Science ®Google Scholar
• J M Harkins, N Moustaid-Moussa, Y-J Chung, K M Penner, J J Pestka, C M North, and K J Claycombe. (2004). Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice. J Nutr 134:2673–2677.
   PubMed Web of Science ®Google Scholar
• D B Hausman, M Di Girolamo, T J Bartness, G J Hausman, and R J Martin. (2001). The biology of white adipocyte proliferation. Obesity Rev 2:239–254.
   PubMedGoogle Scholar
• G Höpfl, O Ogunshola, and M Gassmann. (2004). HIFs and tumors – causes and consequences. Am J Physiol Reg Integr Comp Physiol 286:R608–R623.
   PubMed Web of Science ®Google Scholar
• N Hosogai, A Fukuhara, K Oshima, Y Miyata, S Tanaka, K Segawa, S Furukawa, Y Tochino, R Komuro, M Matsuda, and et al (2007). Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56:901–911.
   PubMed Web of Science ®Google Scholar
• G S Hotamisligil, N S Shargill, and B M Spiegelman. (1993). Adipose expression of tumor necrosis factor-alpha – direct role in obesity-linked insulin resistance. Science 259:87–91.
   PubMed Web of Science ®Google Scholar
• G S Hotamisligil. (2006). Inflammation and metabolic disorders. Nature 444:860–867.
   PubMed Web of Science ®Google Scholar
• N Houstis, E D Rosen, and E S Lander. (2006). Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944–948.
   PubMed Web of Science ®Google Scholar
• N Iiyori, L C Alonso, J Li, M H Sanders, A Garcia-Ocana, R M O'Doherty, V Y Polotsky, and C P O'Donnell. (2007). Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med 175:851–857.
   PubMed Web of Science ®Google Scholar
• M S Ip, B Lam, M M Ng, W K Lam, K W Tsang, and K S Lam. (2002). Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165:670–676.
   PubMed Web of Science ®Google Scholar
• M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane, and W G KaelinJr. (2001). HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292:464–468.
   PubMed Web of Science ®Google Scholar
• P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield, P H Maxwell, C W Pugh, and P J Ratcliffe. (2001). Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468–472.
   PubMed Web of Science ®Google Scholar
• B Kabon, A Nagele, D Reddy, C Eagon, J W Fleshman, D I Sessler, and A Kurz. (2004). Obesity decreases perioperative tissue oxygenation. Anesthesiol 100:274–280.
   PubMed Web of Science ®Google Scholar
• T Kadowaki, T Yamauchi, and N Kubota. (2008). The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett 582:74–80.
   PubMed Web of Science ®Google Scholar
• F Karpe, B A Fielding, V Ilic, I A Macdonald, L KM Summers, and K N Frayn. (2002). Impaired Postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes 51:2467–2473.
   PubMed Web of Science ®Google Scholar
• E E Kershaw, and J S Flier. (2004). Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548–2556.
   PubMed Web of Science ®Google Scholar
• K H Kim, M J Song, J Chung, H Park, and J B Kim. (2005). Hypoxia inhibits adipocyte differentiation in a HDAC-independent manner. Biochem Biophys Res Commun 333:1178–1184.
   PubMed Web of Science ®Google Scholar
• P G Kopelman. (2000). Obesity as a medical problem. Nature 404:635–643.
   PubMed Web of Science ®Google Scholar
• C Koumenis, C Naczki, M Koritzinsky, S Rastani, A Diehl, N Sonenberg, A Koromilas, and B G Wouters. (2002). Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α. Mol Cell Biol 22:7405–7416.
   PubMed Web of Science ®Google Scholar
• J S Lewis, J A Lee, J C Underwood, A L Harris, and C E Lewis. (1999). Macrophage responses to hypoxia: relevance to disease mechanisms. J Leukoc Biol 66:889–900.
   PubMed Web of Science ®Google Scholar
• Q Lin, Y-J Lee, and Z Yun. (2006). Differentiation arrest by hypoxia. J Biol Chem 281:30678–30683.
   PubMed Web of Science ®Google Scholar
• K Lolmède, V de Saint Front Durand, J Galitzky, M Lafontan, and A Bouloumié. (2003). Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obesity 27:1187–1195.
   PubMed Web of Science ®Google Scholar
• J López-Barneo, R del Toro, K L Levitsky, M D Chiara, and P Ortega-Sáenz. (2004). Regulation of oxygen sensing by ion channels. J Appl Physiol 96:1187–1195.
   PubMed Web of Science ®Google Scholar
• B Memoli, A Procino, P Calabro, P Esposito, G Grandaliano, G Pertosa, M D Prete, M Andreucci, S D Lillo, G Ferulano, and et al (2007). Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor. Am J Physiol Endocrinol Metab 293:E1030–E1035.
   PubMed Web of Science ®Google Scholar
• N Nanduri, and N R Prabhakar. (2007). Cellular mechanisms associated with intermittent hypoxia. Essays Biochem 43:91–104.
   PubMed Web of Science ®Google Scholar
• T Nomiyama, D Perez-Tilve, D Ogawa, F Gizard, Y Zhao, E B Heywood, K L Jones, R Kawamori, L A Cassis, M H Tschöp, and et al (2007). Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 117:2877–2888.
   PubMed Web of Science ®Google Scholar
• T Oda, K Hirota, K Nishi, S Takabuchi, S Oda, H Yamada, T Arai, K Fukuda, T Kita, T Adachi, and et al (2006). Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol 291:C104–C113.
   PubMed Web of Science ®Google Scholar
• N Ouchi, S Kihara, Y Arita, K Maeda, H Kuriyama, Y Okamoto, K Hotta, M Nishida, M Takahashi, T Nakamura, and et al (1999). Novel modulator for endothelial adhesion molecules – Adipocyte-derived plasma protein adiponectin. Circulation 100:2473–2476.
   PubMed Web of Science ®Google Scholar
• N Ouchi, S Kihara, Y Arita, Y Okamoto, K Maeda, H Kuriyama, K Hotta, M Nishida, M Takahashi, M Muraguchi, and et al (2000). Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-KB signaling through a cAMP-dependent pathway. Circulation 102:1296–1301.
   PubMed Web of Science ®Google Scholar
• N Ouchi, S Kihara, T Funahashi, T Nakamura, M Nishida, M Kumada, Y Okamoto, K Ohashi, H Nagaretani, K Kishida, and et al (2003). Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107:67167–67174.
   Google Scholar
• U Ozcan, Q Cao, E Yilmaz, A H Lee, N N Iwakoshi, E Ozdelen, G Tuncman, C Gorgun, L H Glimcher, and G S Hotamisligil. (2004). Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457–461.
   PubMed Web of Science ®Google Scholar
• M R Peeraully, H Sievert, M Bulló, B Wang, and P Trayhurn. (2006). Prostaglandin D2 and J2-series (PGJ2, Δ12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Pflügers Archiv Eur J Physiol 453:177–187.
   PubMed Web of Science ®Google Scholar
• V Y Polotsky, J Li, N M Punjabi, A E Rubin, P L Smith, A R Schwartz, and C P O'Donnell. (2003). Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol 552:253–264.
   PubMed Web of Science ®Google Scholar
• J B Prins, C U Niesler, C M Winterford, N A Bright, K Siddle, S O'Rahilly, N I Walker, and D P Cameron. (1997). Tumor necrosis factor-α induces apoptosis of human adipose cells. Diabetes 46:1939–1944.
   PubMed Web of Science ®Google Scholar
• N M Punjabi, E Shahar, S Redline, D J Gottlieb, R Givelber, and H E Resnick. (2004). Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol 160:521–530.
   PubMed Web of Science ®Google Scholar
• M W Rajala, and P E Scherer. (2003). The adipocyte – at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765–3773.
   PubMed Web of Science ®Google Scholar
• M E Rausch, S P Weisberg, P Vardhana, and D V Tortorielllo. (2008). Obesity in C57BL/6J mice is characterised by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obesity 32:451–463.
   PubMed Web of Science ®Google Scholar
• S Rocha. (2007). Gene regulation under low oxygen: holding your breath for transcription. Trends Biochem Sci 32:389–397.
   PubMed Web of Science ®Google Scholar
• E D Rosen, and B M Spiegelman. (2006). Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444:847–853.
   PubMed Web of Science ®Google Scholar
• S Ryan, C T Taylor, and W T McNicholas. (2005). Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112:2660–2667.
   PubMed Web of Science ®Google Scholar
• S Ryan, W T McNicholas, and C T Taylor. (2007). A critical role for p38 MAP kinase in NF-KB signaling during intermittent hypoxia/reoxygenation. Biochem Biophys Res Commun 355:728–733.
   PubMed Web of Science ®Google Scholar
• M Ryden, E Arvidsson, L Blomqvist, L Perbeck, A Dicker, and P Arner. (2004). Targets for TNF-α-induced lipolysis in human adipocytes. Biochem Biophys Res Commun 318:168–175.
   PubMed Web of Science ®Google Scholar
• N K Saxena, P M Vertino, F A Anania, and D Sharma. (2007). Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to cyclin D1 promoter via activation of STAT3. J Biol Chem 282:13316–13325.
   PubMed Web of Science ®Google Scholar
• K Segawa, A Fukuhara, N Hosogai, K Morita, Y Okuno, M Tanaka, Y Nakagawa, S Kihara, T Funahashi, and R Komuro. (2006). Visfatin in adipocytes is upregulated by hypoxia through HIF1α-dependent mechanism. Biochem Biophys Res Commun 349:875–882.
   PubMed Web of Science ®Google Scholar
• H Sell, D Dietze-Schroeder, and J Eckel. (2006a). The adipocyte-myocyte axis in insulin resistance. Trends Endocrinol Metab 17:416–422.
   PubMed Web of Science ®Google Scholar
• H Sell, D Dietze-Schroeder, U Kaiser, and J Eckel. (2006b). Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle. Endocrinology 147:2458–2467.
   PubMed Web of Science ®Google Scholar
• G L Semenza. (2001). HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13:167–171.
   PubMed Web of Science ®Google Scholar
• G L Semenza. (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721–732.
   PubMed Web of Science ®Google Scholar
• P J Simons, P S van den Pangaart, C P van Roomen, J M Aerts, and L Boon. (2005). Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: Evidence that tumor necrosis factor-α- and interleukin-1β-treated human preadipocytes are potent leptin producers. Cytokine 32:94–103.
   PubMed Web of Science ®Google Scholar
• T Skurk, C Alberti-Huber, C Herder, and H Hauner. (2007). Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92:1023–1033.
   PubMed Web of Science ®Google Scholar
• K Tanji, Y Irie, Y Uchida, F Mori, K Satoh, Y Mizushima, and K Wakabayashi. (2003). Expression of metallothionein-III induced by hypoxia attenuates hypoxia-induced cell death in vitro. Brain Res 976:125–129.
   PubMed Web of Science ®Google Scholar
• P Trayhurn. (2005a). Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 184:285–293.
   PubMedGoogle Scholar
• P Trayhurn. (2005b). The biology of obesity. Proc Nutr Soc 64:31–38.
   PubMed Web of Science ®Google Scholar
• P Trayhurn, and J H Beattie. (2001). Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 60:329–339.
   PubMed Web of Science ®Google Scholar
• P Trayhurn, and I S Wood. (2004). Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347–355.
   PubMed Web of Science ®Google Scholar
• P Trayhurn, and I S Wood. (2005). Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33:1078–1081.
   PubMed Web of Science ®Google Scholar
• P Trayhurn, B Wang, and I S Wood. (2008). Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?. Br J Nutr 100:227–235.
   PubMed Web of Science ®Google Scholar
• P Trayhurn, J S Duncan, A M Wood, and J H Beattie. (2000). Metallothionein gene expression and secretion by white adipose tissue. Am J Physiol Reg Integr Comp Physiol 279:R2329–R2335.
   Google Scholar
• K A Virtanen, P Lonnroth, R Parkkola, P Peltoniemi, M Asola, T Viljanen, T Tolvanen, J Knuuti, T Ronnemaa, R Huupponen, and et al (2002). Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J Clin Endocrinol Metab 87:3902–3910.
   PubMed Web of Science ®Google Scholar
• B Wang, J R Jenkins, and P Trayhurn. (2005). Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: Integrated response to TNF-α. Am J Physiol Endocrinol Metab 288:E731–E740.
   PubMed Web of Science ®Google Scholar
• B Wang, and P Trayhurn. (2006). Acute and prolonged effects of TNF-α on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. Pflügers Archiv Eur J Physiol 452:418–427.
   PubMed Web of Science ®Google Scholar
• B Wang, I S Wood, and P Trayhurn. (2007). Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflügers Archiv Eur J Physiol 455:479–492.
   PubMed Web of Science ®Google Scholar
• B Wang, I S Wood, and P Trayhurn. (2008). PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes. Biochem Biophys Res Commun 368:88–93.
   PubMed Web of Science ®Google Scholar
• S P Weisberg, D McCann, M Desai, M Rosenbaum, R L Leibel, and A W FerranteJr. (2003). Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808.
   PubMed Web of Science ®Google Scholar
• K E Wellen, and G S Hotamisligil. (2005). Inflammation, stress, and diabetes. J Clin Invest 115:1111–1119.
   PubMed Web of Science ®Google Scholar
• A Williams, and S M Scharf. (2007). Obstructive sleep apnea, cardiovascular disease, and inflammation––is NF–KB the key. Sleep Breathing 11:69–76.
   PubMed Web of Science ®Google Scholar
• I S Wood, B Wang, S Lorente-Cebrián, and P Trayhurn. (2007). Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes. Biochem Biophys Res Commun 361:468–473.
   PubMed Web of Science ®Google Scholar
• H Xu, G T Barnes, Q Yang, G Tan, D Yang, C J Chou, J Sole, A Nichols, J S Ross, L A Tartaglia, and et al (2003). Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821–1830.
   PubMed Web of Science ®Google Scholar
• T Yamauchi, J Kamon, H Waki, Y Terauchi, N Kubota, K Hara, Y Mori, T Ide, K Murakami, N Tsuboyama-Kasaoka, and et al (2001). The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941–946.
   PubMed Web of Science ®Google Scholar
• J Ye, Z Gao, J Yin, and Q He. (2007). Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293:E1118–E1128.
   PubMed Web of Science ®Google Scholar
• G Yuan, J Nanduri, C R Bhasker, G L Semenza, and N R Prabhakar. (2005). Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem 280:4321–4328.
   PubMed Web of Science ®Google Scholar
• J S Yudkin. (2003). Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obesity 27 (Suppl 3):S25–S28.
   Google Scholar
• Z Yun, H L Maecker, R S Johnson, and A J Giaccia. (2002). Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2:331–341.
   PubMed Web of Science ®Google Scholar
• Y Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, and J M Friedman. (1994). Positional cloning of the mouse obese gene and its human homolog. Nature 372:425–432.
   PubMed Web of Science ®Google Scholar
• L Zhou, H Sell, K Eckardt, Z Yang, and J Eckel. (2007). Conditioned medium obtained from in vitro differentiated adipocytes and resistin induce insulin resistance in human hepatocytes. FEBS Lett 581:4303–4308.
   PubMed Web of Science ®Google Scholar
• S Zhou, S Lechpammer, J S Greenberger, and J Glowacki. (2005). Hypoxia Inhibition of Adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-β/Smad3 signaling. J Biol Chem 280:22688–22696.
   PubMed Web of Science ®Google Scholar