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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 114, 2008 - Issue 5
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Original Article

Characterization of a novel obesity phenotype caused by interspecific hybridization

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Pages 301-330 | Received 08 Apr 2008, Accepted 14 Jul 2008, Published online: 05 Jan 2009

References

  • K Almind, and C R Kahn. (2004). Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53:3274–3285.
  • P Baldi, and A D Long. (2001). A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics 17:509–519.
  • O Bosello, and M Zamboni. (2000). Visceral obesity and metabolic syndrome. Obes Rev 1:47–56.
  • G A Brockmann, and M R Bevova. (2002). Using mouse models to dissect the genetics of obesity. Trends Genet 18:367–376.
  • L A Campfield, F J Smith, Y Guisez, R Devos, and P Burn. (1995). Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546–549.
  • M Chen, M Haluzik, N J Wolf, J Lorenzo, K R Dietz, M L Reitman, and L S Weinstein. (2004). Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance. Endocrinology 145:4094–4102.
  • D R Cool, E Normant, F Shen, H C Chen, L Pannell, Y Zhang, and Y P Loh. (1997). Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88:73–83.
  • C Coombes, P Arnaud, E Gordon, W Dean, E A Coar, C M Williamson, R Feil, J Peters, and G Kelsey. (2003). Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol Cell Biol 23:5475–5488.
  • J P Curley, S B Pinnock, S L Dickson, R Thresher, N Miyoshi, M A Surani, and E B Keverne. (2005). Increased body fat in mice with a targeted mutation of the paternally expressed imprinted gene Peg3. Faseb J 19:1302–1304.
  • K Eggan, H Akutsu, J Loring, L Jackson-Grusby, M Klemm, W M Rideout3rd, R Yanagimachi, and R Jaenisch. (2001). Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci USA 98:6209–6214.
  • R C Frederich, B Lollmann, A Hamann, A Napolitano-Rosen, B B Kahn, B B Lowell, and J S Flier. (1995). Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 96:1658–1663.
  • R Gottardo, J A Pannucci, C R Kuske, and T Brettin. (2003). Statistical analysis of microarray data: a Bayesian approach. Biostatistics 4:597–620.
  • J L Halaas, K S Gajiwala, M Maffei, S L Cohen, B T Chait, D Rabinowitz, R L Lallone, S K Burley, and J M Friedman. (1995). Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543–546.
  • T V Hansen, N A Hammer, J Nielsen, M Madsen, C Dalbaeck, U M Wewer, J Christiansen, and F C Nielsen. (2004). Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol 24:4448–4464.
  • D Houzelstein, S L Bullock, D E Lynch, E F Grigorieva, V A Wilson, and R S Beddington. (2002). Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Mol Cell Biol 22:3794–3802.
  • D Humpherys, K Eggan, H Akutsu, K Hochedlinger, W M Rideout3rd, D Biniszkiewicz, R Yanagimachi, and R Jaenisch. (2001). Epigenetic instability in ES cells and cloned mice. Science 293:95–97.
  • D Huszar, C A Lynch, V Fairchild-Huntress, J H Dunmore, Q Fang, L R Berkemeier, W Gu, R A Kesterson, B A Boston, R D Cone, F J Smith, L A Campfield, P Burn, and F Lee. (1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131–141.
  • M Ivanova, K M Dobrzycka, S Jiang, K Michaelis, R Meyer, K Kang, B Adkins, O A Barski, S Zubairy, J Divisova, and et al (2005). Scaffold attachment factor B1 functions in development, growth, and reproduction. Mol Cell Biol 25:2995–3006.
  • M A Janzen, D L Kuhlers, S B Jungst, and C F Louis. (2000). ARPP-16 mRNA is up-regulated in the longissimus muscle of pigs possessing an elevated growth rate. J Anim Sci 78:1475–1484.
  • M Karimi, S Johansson, D Stach, M Corcoran, D Grander, M Schalling, G Bakalkin, F Lyko, C Larsson, and T J Ekstrom. (2006). LUMA (LUminometric Methylation Assay) – a high throughput method to the analysis of genomic DNA methylation. Exp Cell Res 312:1989–1995.
  • S E Leff, C I Brannan, M L Reed, T Ozcelik, U Francke, N G Copeland, and N A Jenkins. (1992). Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region. Nat Genet 2:259–264.
  • M Lopez, C J Lelliott, and A Vidal-Puig. (2007). Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. Bioessays 29:248–261.
  • S W Luoh, P A Bain, R D Polakiewicz, M L Goodheart, H Gardner, R Jaenisch, and D C Page. (1997). Zfx mutation results in small animal size and reduced germ cell number in male and female mice. Development 124:2275–2284.
  • M Maffei, J Halaas, E Ravussin, R E Pratley, Gm Lee, Y Zhang, H Fei, S Kim, R Lallone, S Ranganathan, and et al (1995). Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155–1161.
  • M R Mann, S S Lee, A S Doherty, R I Verona, L D Nolen, R M Schultz, and M S Bartolomei. (2004). Selective loss of imprinting in the placenta following preimplantation development in culture. Development 131:3727–3735.
  • T Matsuura, J S Sutcliffe, P Fang, R J Galjaard, Y H Jiang, C S Benton, J M Rommens, and A L Beaudet. (1997). De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. Nat Genet 15:74–77.
  • S Migrenne, C Magnan, and C Cruciani-Guglielmacci. (2007). Fatty acid sensing and nervous control of energy homeostasis. Diabetes Metab 33:177–182.
  • Y Mizuno, Y Sotomaru, Y Katsuzawa, T Kono, M Meguro, M Oshimura, J Kawai, Y Tomaru, H Kiyosawa, I Nikaido, and et al (2002). Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray. Biochem Biophys Res Commun 290:1499–1505.
  • J K Naggert, L D Fricker, O Varlamov, P M Nishina, Y Rouille, D F Steiner, R J Carroll, B J Paigen, and E H Leiter. (1995). Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet 10:135–142.
  • M Nakamuta, B H Chang, E Zsigmond, K Kobayashi, H Lei, B Y Ishida, K Oka, E Li, and L Chan. (1996). Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1. J Biol Chem 271:25981–25988.
  • N Ogonuki, K Inoue, Y Yamamoto, Y Noguchi, K Tanemura, O Suzuki, H Nakayama, K Doi, Y Ohtomo, M Satoh, and et al (2002). Early death of mice cloned from somatic cells. Nat Genet 30:253–254.
  • J Perk, K Makedonski, L Lande, H Cedar, A Razin, and R Shemer. (2002). The imprinting mechanism of the Prader-Willi/Angelman regional control center. Embo J 21:5807–5814.
  • A Plagge, E Gordon, W Dean, R Boiani, S Cinti, J Peters, and G Kelsey. (2004). The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet 36:818–826.
  • J C Reyes, J Barra, C Muchardt, A Camus, C Babinet, and M Yaniv. (1998). Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha). Embo J 17:6979–6991.
  • S W Robinson, D M Dinulescu, and R D Cone. (2000). Genetic models of obesity and energy balance in the mouse. Annu Rev Genet 34:687–745.
  • W Shi, A Krella, A Orth, Y Yu, and R Fundele. (2005). Widespread disruption of genomic imprinting in adult interspecies mouse (Mus) hybrids. Genesis 43:100–108.
  • W Shi, L Lefebvre, Y Yu, S Otto, A Krella, A Orth, and R Fundele. (2004). Loss-of-imprinting of Peg1 in mouse interspecies hybrids is correlated with altered growth. Genesis 39:65–72.
  • U Singh, L E Fohn, T Wakayama, J Ohgane, C Steinhoff, B Lipkowitz, R Schulz, A Orth, H H Ropers, R R Behringer, and et al (2004). Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation. Dev Dyn 230:149–164.
  • U Singh, T Sun, W Shi, R Schulz, U A Nuber, A Varanou, M C Hemberger, R W Elliott, H Ohta, T Wakayama, and R Fundele. (2005). Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1. Dev Dyn 234:1034–1045.
  • F M Smith, A S Garfield, and A Ward. (2006). Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res 113:279–291.
  • E E Snyder, B Walts, L Perusse, Y C Chagnon, S J Weisnagel, T Rankinen, and C Bouchard. (2004). The human obesity gene map: the 2003 update. Obes Res 12:369–439.
  • L Song, and L D Fricker. (1995). Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary. J Biol Chem 270:25007–25013.
  • M Takahashi, Y Kamei, and O Ezaki. (2005). Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab 288:E117–E124.
  • K L Tamashiro, T Wakayama, H Akutsu, Y Yamazaki, J L Lachey, M D Wortman, R J Seeley, D A D'Alessio, S C Woods, R Yanagimachi, and et al (2002). Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med 8:262–267.
  • M L Varban, F Rinninger, N Wang, V Fairchild-Huntress, J H Dunmore, Q Fang, M L Gosselin, K L Dixon, J D Deeds, S L Acton, and et al (1998). Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 95:4619–4624.
  • C Voolstra, D Tautz, P Farbrother, L Eichinger, and B Harr. (2007). Contrasting evolution of expression differences in the testis between species and subspecies of the house mouse. Genome Res 17:42–49.
  • V Wallenius, K Wallenius, B Ahren, M Rudling, H Carlsten, S L Dickson, C Ohlsson, and J O Jansson. (2002). Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8:75–79.
  • L Yaswen, N Diehl, M B Brennan, and U Hochgeschwender. (1999). Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5:1066–1070.
  • L E Young, K Fernandes, T G McEvoy, S C Butterwith, C G Gutierrez, C Carolan, P J Broadbent, J J Robinson, I Wilmut, and K D Sinclair. (2001). Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat Genet 27:153–154.
  • U Zechner, M Reule, A Orth, F Bonhomme, B Strack, J-L Guenet, H Hameister, and R Fundele. (1996). An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrid. Nat Genet 12:398–403.
  • Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, and J M Friedman. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432.

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