Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 125, 2019 - Issue 4
126
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Chronic testosterone administration improves cardiac contractility and has a beneficial effect on the haemostatic system by enhancing fibrinolytic activity and inducing hypocoagulation in healthy rats

&
Pages 311-320 | Received 02 Feb 2018, Accepted 24 Mar 2018, Published online: 04 Apr 2018

References

  • Agledahl, I., et al., 2008. Low serum testosterone in men is inversely associated with non-fasting serum triglycerides: the Tromsø study. Nutrition, metabolism, and cardiovascular diseases, 18, 256–262.
  • Ajayi, A.A., Mathur, R., and Halushka, P.V., 1995. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation, 91, 2742–2747.
  • Anderson, R.A., Ludlam, C.A., and Wu, F.C., 1995. Haemostatic effects of supraphysiological levels of testosterone in normal men. Thrombosis and haemostasis, 74 (2), 693–697.
  • Angelakos, E.T., King, M.P., and Millard, R.W., 1969. Regional distribution of catecholamines in the hearts of various species. Annals of the New York Academy of Sciences, 156, 219–240.
  • Bachman, E., et al., 2014. Testosterone induces erythrocytosisvia increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin setpoint. The journal of gerontology. Series A, biological sciences and medical sciences, 69, 725–735.
  • Bavenholm, P., et al., 1998. Progression of coronary artery disease in young male post-infarction patients is linked to disturbances of carbohydrate and lipoprotein metabolism and to impaired fibrinolytic function. European heart journal, 19, 402–410.
  • Beguin, S., et al., 1992. The mode of action of CY216 and CY222 in plasma. Thrombosis and haemostasis, 67, 33–41.
  • Campelo, A.E., Cutini, P.H., and Massheimer, V.L., 2012. Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway. The journal of endocrinology, 213, 77–87.
  • Campo, G., et al., 2006. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arteriosclerosis, thrombosis, and vascular biology, 26, 2800–2806.
  • Chan, M.Y., Andreotti, F., and Becker, R.C., 2008. Hypercoagulable states in cardiovascular disease. Circulation, 118, 2286–2297.
  • Cutini, P.H., et al., 2012. The role of sex steroids on cellular events involved in vascular disease. The journal of steroid biochemistry and molecular biology, 132, 322–330.
  • De Pergola, G., et al., 1997. Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men. Metabolism: clinical and experimental, 46, 1287–1293.
  • Dejana, E., et al., 1979b. Bleeding time in laboratory animals. III – do tail bleeding times in rats only measure a platelet defect? (The aspirin puzzle). Thrombosis research, 15, 199–207.
  • Dejana, E., Villa, S., and de Gartano, G., 1979a. Bleeding time in rats: a comparison of different experimental conditions. Thrombosis research, 15, 191–197.
  • Doggen, C.J., Rosendaal, F.R., and Meijers, J.C., 2006. Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII. Blood, 108, 4045–4051.
  • Ernst, E., and Koenig, W., 1997. Fibrinogen and cardiovascular risk. Vascular medicine (London, England), 2, 115–125.
  • Farhat, M.Y., Lavigne, M.C., and Ramwell, P.W., 1996. The vascular protective effects of estrogen. FASEB journal, 10, 615–624.
  • Gale, A., 2011. Continuing education course #2: current understanding of hemostasis. Toxicologic pathology, 39, 273–280.
  • Glueck, C.J., et al., 1993. Endogenous testosterone, fibrinolysis, and coronary heart disease risk in hyperlipidemic men. Journal of laboratory and clinical medicine, 122, 412–420.
  • Golden, K.L., marsh, J.D., and jiang, Y., 2004. Testosterone regulates mRNA levels of calcium regulatory proteins in cardiac myocytes. Hormone and metabolic research, 36, 197–202.
  • Golden, K.L., marsh, J.D., and Jiang, Y., 2005. Acute actions of testosterone on contractile function of isolated rat ventricular myocytes. European journal of endocrinology, 152, 479–483.
  • Golomb, M.R., Dick, P.T., and MacGregor, D.L., 2004. Neonatal arterial ischemic stroke and cerebral sinovenous thrombosis are more commonly diagnosed in boys. Journal of child neurology, 19, 493–497.
  • Golomb, M.R., et al., 2009. Male predominance in childhood ischaemic stroke and cerebral sinovenous thrombosis: findings from the international pediatric stroke study. Stroke, 40, 52–57.
  • Haddad, R., et al., 2007. Testosterone and cardiovascular risk in men: a systemic review and meta-analysis of randomized placebo-controlled trials. Mayo clinic proceedings, 81, 29–39.
  • Hak, A.E., et al., 2002. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. The journal of clinical endocrinology and metabolism, 87, 3632–3639.
  • Harrison, P., 2009. Assessment of platelet function in the laboratory. Hämostaseologie, 29, 25–31.
  • Hemker, H.C., and Be´guin, S., 1995. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thrombosis and haemostasis, 74, 134–138.
  • Hoffman, C.J., et al., 1989. Elevation of factor VII activity and mass in young adults at risk of ischemic heart disease. Journal of the American college of cardiology, 14, 941–946.
  • Isidori, A.M., et al., 2005. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clinical endocrinology, 63, 280–293.
  • Jansson, I.H., Nilsson, T.K., and hnson, O., 1991. Von Wille brand factor in plasma: a novel risk factor for recurrent myocardial infarction and death. British heart journal, 66, 351–355.
  • Jin, H., et al., 2007. Physiological testosterone stimulates tissue plasminogen activator and tissue factor pathway inhibitor and inhibits plasminogen activator inhibitor type 1 release in endothelial cells. Biochemistry and cell biology, 85, 246–251.
  • Jones, R.D., et al., 2003. The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action? British journal of pharmacology, 138, 733–744.
  • Juhan-Vague, I., et al., 1996. Fibrinolytic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. ECAT Study Group. European Concerted Action on Thrombosis and Disabilities. Circulation, 94, 2057–2063.
  • Khaw, K.T., Dowsett, M., and Folkerd, E., 2007. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) prospective population study. Circulation, 116, 2694–2701.
  • Kluft, C., et al., 1985. The postoperative fibrinolytic shutdown: a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma. Scandinavian journal of clinical and laboratory investigation, 45, 605–610.
  • Koenig, W., 1998. Haemostatic risk factors for cardiovascular disease. European heart journal, 19, C39–C43.
  • Koepke, J.A., 1986. Partial thromboplastin time test-proposed performance guidelines. ICSH Panel on the PTT. Thrombosis and haemostasis, 55, 143– 144.
  • Lane, D.A., and Grant, P.J., 2000. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood, 95, 1517–1532.
  • Laughlin, G.A., Barrett-Connor, E., and Bergstrom, J., 2008. Low serum testosterone and mortality in older men. The journal of clinical endocrinology and metabolism, 93, 68–75.
  • Liu, P.Y., Death, A.K., and Handelsman, D.J., 2003. Androgens and cardiovascular disease. Endocrine reviews, 24, 313–340.
  • Malkin, C.J., Pugh, P.J., and West, J.N., 2006. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. European heart journal, 27, 57–64.
  • Marquardt, R., 1979. Effect of dopamine and metaproterenol on serum free fatty acids in regard to induction of cardiac arrhythmia. Die medizinische welt, 30, 707–708.
  • Marsh, J.D., et al., 1998. Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation, 98, 256–261.
  • Meydan, S., et al., 2010. Effects of testosterone on orchidectomy-induced oxidative damage in the rat hippocampus. Journal of chemical neuroanatomy, 40, 281–285.
  • Mitropoulos, K.A., 1988. Hypercoagulability and factor VII in hypertriglyceridemia. Seminars in thrombosis and hemostasis, 14, 246–252.
  • Nettleship, J.E., et al., 2009. Testosterone and coronary artery disease. Frontiers of hormone research, 37, 91–107.
  • Nieuwenhuys, C.M., et al., 1998. Hypocoagulant and lipid-lowering effects of dietary n-3 polyunsaturated fatty acids with unchanged platelet activation in rats. Arteriosclerosis, thrombosis, and vascular biology, 18, 1480–1489.
  • Pawlowitzki, I.C.H., Diekstall, P., Ming, P., and Balleisen, L., 1986. Abnormal platelet function in Kallman syndrome. Lancet, 8499, 166.
  • Phillips, G.B., Pinkernell, B.H., and Jing, T.Y., 1994. The association of hypotestosteronemia with coronary artery disease in men. Arteriosclerosis and thrombosis, 14, 701–706.
  • Pilo, R., Aharony, D., and Raz, A., 1981. Testosterone potentiation of ionophore and ADP induced platelet aggregation: relationship to arachidonic acid and metabolism. Thrombosis and haemostasis, 46, 538–542.
  • Pop, G.A.M., et al., 2002. The clinical significance of whole blood viscosity in (cardio)vascular medicine. Netherlands heart journal, 10, 512–516.
  • Quick, A.J., 1935. The prothrombin time in hemophilia and in obstructive jaundice. Journal of biological chemistry, 109, 73–74.
  • Quigley, R., 2008. Androgens stimulate proximal tubule transport. Gender medicine, 5(Suppl A), S114–S120.
  • Reshmi, S., Faraday, N., and Dobs, A., 2014. Testosterone and arterial thrombosis. Journal of endocrinology, diabetes & obesity, 2, 1041.
  • Rodak, B.F., 2002. Hematology, clinical principles and applications. 2nd ed. Philadelphia: W.B Saunders, 609–753.
  • Rosano, G.M.C., et al., 1999. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation, 99, 1666–1670.
  • Saldeen, P., Nilsson, I.M., and Saldeen, T., 1983. Increased synthesis of thromboxane B2 and 6-keto-PGF1 alphas in hand veins from patients with deep venous thrombosis. Thrombosis research, 32, 461–467.
  • Shatoor, A.S., et al., 2012. Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. Thrombosis research, 130, 75–80.
  • Stella, L., Donati, M.B., and de Gaetano, G., 1975. Bleeding time in laboratory animals. I. Aspirin does not prolong bleeding time in rats. Thrombosis research, 7, 709–716.
  • Tracy, R.P., 1997. Atherosclerosis, thrombosis and inflammation: a question of linkage. Fibrinolysis proteol, 11, 137–142.
  • Tracy, R.P., and Bovill, E. G., 1995. Hemostasis and risk of ischemic disease: epidemiological evidence with emphasis on the elderly. In: R. Califf, D. Mark, G. Wagner, eds. Acute coronary care in the thrombolytic era. St Louis, MO: Mosby-Year Book, Inc, 27–43.
  • Viallard, J.F., Marit, G., and Mercie, P., 2000. Polycythaemia as a complication of transdermal testosterone therapy. British journal of haematology, 110, 237–238.
  • Webb, C.M., et al., 1999. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation, 100, 1690–1696.
  • Whitsel, E.A., et al., 2001. Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. The American journal of medicine, 111, 261–269.
  • Winkler, U.H., 1996. Effects of androgens on haemostasis. Maturitas, 24, 147–155.
  • Yildiz, O., and Seyrek, M., 2007. Vasodilating mechanisms of testosterone. Experimental and clinical endocrinology & diabetes, 115, 1–6.
  • Yu, C., et al., 2014. Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats. PLoS One, 9, e110124.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.