Inflammation, oxidative stress and altered heat shock response in type 2 diabetes: the basis for new pharmacological and non-pharmacological interventions

References

• Abo-Salem, O.M., et al., 2009. Experimental diabetic nephropathy can be prevented by propolis: effect on metabolic disturbances and renal oxidative parameters. Pakistan journal of pharmaceutical sciences, 22 (2), 205–210.
   PubMed Web of Science ®Google Scholar
• Adamis, A.P., 2002. Is diabetic retinopathy an inflammatory disease? British journal of ophthalmology, 86 (4), 363–365.
   PubMed Web of Science ®Google Scholar
• Afzal, S., et al., 2013. Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. Clinical chemistry, 59 (2), 381–391.
   PubMed Web of Science ®Google Scholar
• Ahmadian, M., et al., 2013. PPARgamma signaling and metabolism: the good, the bad and the future. Nature medicine, 19 (5), 557–566.
   PubMed Web of Science ®Google Scholar
• Ahmed, O.M., et al., 2010. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetologia croatica, 39 (1), 15–35.
   Google Scholar
• Akash, M.S.H., et al., 2018. Biochemical investigation of gender-specific association between insulin resistance and inflammatory biomarkers in types 2 diabetic patients. Biomedicine & pharmacotherapy, 106, 285–291.
   PubMed Web of Science ®Google Scholar
• Akerfelt, M., et al., 2010. Heat shock factors: integrators of cell stress, development and lifespan. Nature reviews molecular cell biology, 11 (8), 545–555.
   PubMed Web of Science ®Google Scholar
• Albers, J.W.H., et al., 2007. Subclinical neuropathy among diabetes control and complications trial participants without diagnosable neuropathy at trial completion: possible predictors of incident neuropathy? Diabetes care, 30 (10), 2613–2618.
   PubMed Web of Science ®Google Scholar
• Al-Enazi, M.M., 2014. Protective effects of combined therapy of Rutin with Silymarin on experimentally-induced diabetic neuropathy in rats. Pharmacology & pharmacy, 5 (9), 876.
   Google Scholar
• Alzamil, H., et al., 2018. Physical fitness and its relationship to plasma leptin, leptin soluble receptor, and free leptin index in a Saudi population: a comparison between diabetic and non-diabetic individuals. Medical science monitor basic research, 24, 113–119.
   PubMed Web of Science ®Google Scholar
• Anderson, D., et al., 1998. Comet assay responses as indicators of carcinogen exposure. Mutagenesis, 13 (6), 539–555.
   PubMed Web of Science ®Google Scholar
• Arif, M., et al., 2010. DNA damage and plasma antioxidant indices in Bangladeshi type 2 diabetic patients. Diabetes & metabolism, 36 (1), 51–57.
   PubMed Web of Science ®Google Scholar
• Armstrong, D., et al., 1981. The distribution of peroxide regulating enzymes in the canine eye. Current eye research, 1 (4), 225–242.
   PubMed Web of Science ®Google Scholar
• Association, A.D., 2013. Executive summary: standards of medical care in diabetes 2013. Diabetes care, 36, S4eS10.
   Web of Science ®Google Scholar
• Association, A.D., 2016. Standards of medical care in diabetes-2016. USA. Clinical diabetes, 34, 3e5.
   Google Scholar
• Auwerx, J., 1999. PPARgamma, the ultimate thrifty gene. Diabetologia, 42 (9), 1033–1049.
   PubMed Web of Science ®Google Scholar
• Babu, P.V., et al., 2013. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. The journal of nutritional biochemistry, 24 (11), 1777–1789.
   PubMed Web of Science ®Google Scholar
• Baldissera, F.G., et al., 2018. Subacute exposure to residual oil fly ash (ROFA) increases eHSP70 content and extracellular-to-intracellular HSP70 ratio: a relation with oxidative stress markers. Cell stress chaperones, 26 (6), 1185–1192.
   Google Scholar
• Baur, J.A., 2010. Biochemical effects of SIRT1 activators. Biochimica et biophysica acta (Bba) - proteins and proteomics, 1804 (8), 1626–1634.
   PubMed Web of Science ®Google Scholar
• Beckmann, R.P.L.M., and Welch, W.J., 1992. Examining the function and regulation of HSP 70 in cells subjected tometabolic stress. The journal of cell biology, 117 (6), 1137–1150.
   PubMed Web of Science ®Google Scholar
• Belia, S., et al., 2009. Oxidative-induced membrane damage in diabetes lymphocytes: effects on intracellular Ca (2+) homeostasis. Free radical research, 43 (2), 138–148.
   PubMed Web of Science ®Google Scholar
• Bellaye, P.S., et al., 2014. Heat shock proteins in fibrosis and wound healing: good or evil? Pharmacology & therapeutics, 143 (2), 119–132.
   PubMed Web of Science ®Google Scholar
• Bellini, S., et al., 2017. Heat shock proteins in vascular diabetic complications: review and future perspective. International journal of molecular science, 18 (12), 2709.
   Web of Science ®Google Scholar
• Boni-Schnetzler, M., et al., 2009. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology, 150 (12), 5218–5229.
   PubMed Web of Science ®Google Scholar
• Boule, N.G., et al., 2001. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA, 286 (10), 1218–121227.
   PubMed Web of Science ®Google Scholar
• Boveris, A., et al., 1972. [The function of liver mitochondria after steroid administration]. Revista de la sociedad argentina de biologia, 48–49 (1–8), 73–83.
   PubMedGoogle Scholar
• Brinkmann, C., et al., 2018. Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus. Endocrine research, 44 (1–2), 1–8.
   PubMed Web of Science ®Google Scholar
• Brownlee, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414 (6865), 813–820.
   PubMed Web of Science ®Google Scholar
• Brownlee, M., 2005. The pathobiology of diabetic complications: a unifying mechanism. Diabetes, 54 (6), 1615–1625.
   PubMed Web of Science ®Google Scholar
• Bruschi, LKMdR., et al., 2017. Diabetes mellitus and diabetic peripheral neuropathy. Open journal of endocrine and metabolic diseases, 7 (1), 12–21.
   Google Scholar
• Burke, S.J., et al., 2015. IL-1beta reciprocally regulates chemokine and insulin secretion in pancreatic beta-cells via NF-kappaB. American journal of physiology-endocrinology and metabolism, 309 (8), E715–726.
   PubMed Web of Science ®Google Scholar
• Calderwood, S.K., et al., 2016. Extracellular HSPs: the complicated roles of extracellular HSPs in immunity. Frontiers in immunology, 7, 159.
   PubMed Web of Science ®Google Scholar
• Callaghan, B.C., et al., 2012. Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane database of systematic review, 13 (6), CD007543.
   Google Scholar
• Cani, P.D., et al., 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes, 57 (6), 1470–1481.
   PubMed Web of Science ®Google Scholar
• Castorina, C., et al., 1992. Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age. Neurochemical research, 17 (6), 599–604.
   PubMed Web of Science ®Google Scholar
• Catano Canizales, Y.G., et al., 2018. Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes. Iran journal of immunology, 15 (2), 142–155.
   PubMed Web of Science ®Google Scholar
• Chen, F., et al., 2012. Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production. Arteriosclerosis, thrombosis, and vascular biology, 32 (12), 2989–2999.
   PubMed Web of Science ®Google Scholar
• Chen, L., et al., 2016. Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation. Scientific reports, 6 (1), 31656.
   PubMedGoogle Scholar
• Ciapaite, J., et al., 2011. Differential effects of short- and long-term high-fat diet feeding on hepatic fatty acid metabolism in rats. Biochimica et biophysica acta (Bba) - molecular and cell biology of lipids, 1811 (7-8), 441–451.
   PubMed Web of Science ®Google Scholar
• Colbert, L.H., et al., 2004. Physical activity, exercise, and inflammatory markers in older adults: findings from the health, aging and body composition study. Journal of the American geriatrics society, 52 (7), 1098–1104.
   PubMed Web of Science ®Google Scholar
• Collins, A.R., et al., 1998. DNA damage in diabetes: correlation with a clinical marker. Free radical biology and medicine, 25 (3), 373–377.
   PubMed Web of Science ®Google Scholar
• Creager, M.A., et al., 2003. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation, 108 (12), 1527–1532.
   PubMed Web of Science ®Google Scholar
• Dandona, P., et al., 1996. Oxidative damage to DNA in diabetes mellitus. The lancet, 347 (8999), 444–445.
   PubMed Web of Science ®Google Scholar
• De Vita, F., et al., 2014. Relationship between vitamin D and inflammatory markers in older individuals. Age, 36 (4), 9694.
   PubMedGoogle Scholar
• Di Naso, F.C., et al., 2015. Obesity depresses the anti-inflammatory HSP70 pathway, contributing to NAFLD progression. Obesity (silver spring), 23 (1), 120–129.
   PubMed Web of Science ®Google Scholar
• Dimitrovska, M., et al., 2018. Physiological and pharmacological inductors of HSP70 enhance the antioxidative defense mechanisms of the liver and pancreas in diabetic rats. Canadian journal of physiology and pharmacology, 96 (2), 158–164.
   PubMed Web of Science ®Google Scholar
• Dobretsov, M., et al., 2007. Early diabetic neuropathy: triggers and mechanisms. World journal of gastroenterology, 13 (2), 175–191.
   PubMed Web of Science ®Google Scholar
• Domingueti, C.P., et al., 2016. Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. Journal of diabetes and its complications, 30 (4), 738–745.
   PubMed Web of Science ®Google Scholar
• Donath, M.Y., and Shoelson, S.E., 2011. Type 2 diabetes as an inflammatory disease. Nature reviews immunology, 11 (2), 98–107.
   PubMed Web of Science ®Google Scholar
• Dong, Y., et al., 2011. SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. Molecular genetics and metabolism, 104 (4), 661–665.
   PubMed Web of Science ®Google Scholar
• Du, S., et al., 2018. Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China. Diabetologia, 61 (9), 1985–1995.
   PubMed Web of Science ®Google Scholar
• Ehses, J.A., et al., 2007. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes, 56 (9), 2356–2370.
   PubMed Web of Science ®Google Scholar
• Eid, A.H., et al., 2016. Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation. Archives of pharmacal research, 39 (12), 1693–1702.
   PubMed Web of Science ®Google Scholar
• Evans, J.L., et al., 2002. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocrine reviews, 23 (5), 599–622.
   PubMed Web of Science ®Google Scholar
• Evans, R.M., et al., 2004. PPARs and the complex journey to obesity. Nature medicine, 10 (4), 355–361.
   PubMed Web of Science ®Google Scholar
• Foretz, M., et al., 2014. Metformin: from mechanisms of action to therapies. Cell metabolism, 20 (6), 953–966.
   PubMed Web of Science ®Google Scholar
• Frank, R.N., 2004. Diabetic retinopathy. New England journal of medicine, 350 (1), 48–58.
   PubMed Web of Science ®Google Scholar
• Ghosh, S., and Hayden, M.S., 2012. Celebrating 25 years of NF-kappaB research. Immunological reviews, 246 (1), 5–13.
   PubMedGoogle Scholar
• Gillum, M.P., et al., 2011. Sirtuin-1 regulation of mammalian metabolism. Trends in molecular medicine, 17 (1), 8–13.
   PubMed Web of Science ®Google Scholar
• Gimbrone, M.A., Jr., and Garcia-Cardena, G., 2016. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circulation research, 118 (4), 620–636.
   PubMed Web of Science ®Google Scholar
• Goettems-Fiorin, P.B., et al., 2016. Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis. Journal of physiology and biochemistry, 72 (4), 643–656.
   PubMed Web of Science ®Google Scholar
• Goettems-Fiorin, P.B., et al., 2019. Ovariectomy predisposes female rats to fine particulate matter exposure's effects by altering metabolic, oxidative, pro-inflammatory, and heat-shock protein levels. Environmental science and pollution research, 26 (2), 20581–20594.
   PubMedGoogle Scholar
• Gomes, I.B., et al., 2015. The protective effects of oral low-dose quercetin on diabetic nephropathy in hypercholesterolemic mice. Frontiers in physiology, 6, 247.
   PubMed Web of Science ®Google Scholar
• Gorgens, S.W., et al., 2014. Chitinase-3-like protein 1 protects skeletal muscle from TNFalpha-induced inflammation and insulin resistance. The biochemical journal, 459 (3), 479–488.
   PubMedGoogle Scholar
• Grisham, M.B., and Granger, D.N., 1989. Metabolic sources of reactive oxygen metabolites during oxidant stress and ischemia with reperfusion. Clinics in chest medicine, 10 (1), 71–81.
   PubMed Web of Science ®Google Scholar
• Gupta, S.K., et al., 2011. Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. Journal of ocular pharmacology and therapeutics, 27 (2), 123–130.
   PubMed Web of Science ®Google Scholar
• Gurler, B., et al., 2000. The role of oxidative stress in diabetic retinopathy. Eye (Lond), 14 (Pt 5), 730–735.
   PubMedGoogle Scholar
• Haspula, D., et al., 2019. Influence of a hyperglycemic microenvironment on a diabetic versus healthy rat vascular endothelium reveals distinguishable mechanistic and phenotypic responses. Frontiers in physiology, 10, 558.
   PubMed Web of Science ®Google Scholar
• Heck, T.G., et al., 2011. HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain? Cell biochemistry and function, 29 (3), 215–226.
   PubMed Web of Science ®Google Scholar
• Heck, T.G., et al., 2017. Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio. Cell stress and chaperones, 22 (2), 271–291.
   PubMed Web of Science ®Google Scholar
• Hooper, P.L., et al., 2014. The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell stress and chaperones, 19 (4), 447–464.
   PubMed Web of Science ®Google Scholar
• Hotamisligil, G.S., et al., 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 259 (5091), 87–91.
   PubMed Web of Science ®Google Scholar
• Hotamisligil, G.S., et al., 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Journal of clinical investigation, 95 (5), 2409–2415.
   PubMed Web of Science ®Google Scholar
• Husemoen, L.L., et al., 2012. Serum 25 (OH) D and incident type 2 diabetes: a cohort study. European journal of clinical nutrition, 66 (12), 1309–1314.
   PubMed Web of Science ®Google Scholar
• Iikuni, N., et al., 2008. Leptin and inflammation. Current immunology reviews, 4 (2), 70–79.
   PubMedGoogle Scholar
• Iskender, H., et al., 2017. The effect of hesperidin and quercetin on oxidative stress, NF-kappaB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomedicine & pharmacotherapy, 90, 500–508.
   PubMed Web of Science ®Google Scholar
• Ito, S., et al., 2017. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. Journal of biological chemistry, 292 (49), 20076–20085.
   PubMed Web of Science ®Google Scholar
• Jadhav, R.P.G., 2012. Hypoglycemic and antidiabetic activity of flavonoids: boswellic acid, ellagic acid, quercetin, rutin on streptozotocin-nicotinamide induced type 2 diabetic rats. International journal of pharmacy and pharmaceutical sciences, 4 (2), 251–256.
   Google Scholar
• Jimenez-Pavon, D., et al., 2012. Physical activity, fitness, and serum leptin concentrations in adolescents. The journal of pediatrics, 160 (4), 598–603. e592.
   PubMed Web of Science ®Google Scholar
• Jo, S.K.L.E.H., et al., 2009. Comparison of antioxidant potential and rat intestinal α-glucosidases inhibitory activities of quercetin, rutin, and isoquercetin. International journal of applied research in natural products, 2 (4), 52–60.
   Google Scholar
• Jones, D.P., and Go, Y.M., 2010. Redox compartmentalization and cellular stress. Diabetes, obesity and metabolism, 12 (Suppl 2), 116–125.
   PubMed Web of Science ®Google Scholar
• Jones, Q., et al., 2011. Heat shock proteins protect against ischemia and inflammation through multiple mechanisms. Inflammation & allergy - drug targets, 10 (4), 247–259.
   PubMedGoogle Scholar
• Kagan, V.E., et al., 1994. Assay of ubiquinones and ubiquinols as antioxidants. Methods in enzymology, 234, 343–354.
   PubMed Web of Science ®Google Scholar
• Kandimalla, R., et al., 2017. Bioactive fraction of Annona reticulata bark (or) Ziziphus jujuba root bark along with insulin attenuates painful diabetic neuropathy through inhibiting NF-kappaB inflammatory cascade. Frontiers in cellular neuroscience, 11, 73.
   PubMed Web of Science ®Google Scholar
• Kawasaki, K., et al., 2015. Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells. Journal of biological chemistry, 290 (6), 3639–3646.
   PubMed Web of Science ®Google Scholar
• Kelly, B., et al., 2015. Metformin inhibits the production of reactive oxygen species from NADH: ubiquinone oxidoreductase to limit induction of interleukin-1beta (IL-1beta) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS) -activated macrophages. Journal of biological chemistry, 290 (33), 20348–20359.
   PubMed Web of Science ®Google Scholar
• Kern, T.S., 2007. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Experimental diabetes research, 2007, 1.
   Google Scholar
• Klok, M.D., et al., 2007. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity reviews, 8 (1), 21–34.
   PubMed Web of Science ®Google Scholar
• Knowler, W.C., et al., 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The new england journal of medicine, 346 (6), 393–403.
   PubMed Web of Science ®Google Scholar
• Kowaltowski, A.J., and Vercesi, A.E., 1999. Mitochondrial damage induced by conditions of oxidative stress. Free radical biology and medicine, 26 (3-4), 463–471.
   PubMed Web of Science ®Google Scholar
• Kowluru, R.A., and Koppolu, P., 2002. Termination of experimental galactosemia in rats, and progression of retinal metabolic abnormalities. Investigative ophthalmology & visual science, 43 (10), 3287–3291.
   PubMed Web of Science ®Google Scholar
• Kowluru, R.A., et al., 2001. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes, 50 (8), 1938–1942.
   PubMed Web of Science ®Google Scholar
• Kowluru, R.A., et al., 2003. Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free radical research, 37 (11), 1169–1180.
   PubMed Web of Science ®Google Scholar
• Kowluru, V., and Kowluru, R.A., 2007. Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina. Molecular vision, 13, 602–610.
   PubMed Web of Science ®Google Scholar
• Krause, M., et al., 2007. MRP1/GSX pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress-induced redox imbalance in comparison to skeletal muscle cells? Cell biochemistry and function, 25 (1), 23–32.
   PubMed Web of Science ®Google Scholar
• Krause, M., et al., 2015. The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management. Mediators of inflammation, 2015, 1.
   Web of Science ®Google Scholar
• Kumar, A., and Mittal, R., 2017. Nrf2: a potential therapeutic target for diabetic neuropathy. Inflammopharmacology, 25 (4), 393–402.
   PubMed Web of Science ®Google Scholar
• Kumar, B., et al., 2013. Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats. Microvascular research, 87, 65–74.
   PubMed Web of Science ®Google Scholar
• Kurucz, I., et al., 2002. Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance. Diabetes, 51 (4), 1102–1109.
   PubMed Web of Science ®Google Scholar
• Kusano, A.F.B., 2008. Total antioxidant capacity: a biomarker in biomedical and nutritional studies. Journal of cell and molecular biology, 7, 1–15.
   Google Scholar
• La Cava, A., and Matarese, G., 2004. The weight of leptin in immunity. Nature reviews immunology, 4 (5), 371–379.
   PubMed Web of Science ®Google Scholar
• Laird, E., et al., 2014. Vitamin D deficiency is associated with inflammation in older Irish adults. The Journal of Clinical Endocrinology & Metabolism, 99 (5), 1807–1815.
   PubMed Web of Science ®Google Scholar
• LeBrasseur, N.K., et al., 2006. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. American journal of physiology-endocrinology and metabolism, 291 (1), E175–181.
   PubMed Web of Science ®Google Scholar
• Lee, S.H., et al., 2013. Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion. Endocrinology, 154 (3), 1029–1038.
   PubMed Web of Science ®Google Scholar
• Levinthal, G.N.T.A.S., 1999. Liver disease and diabetes mellitus. Clinical diabetes, 17, 245–250.
   Google Scholar
• Ley, R.E., et al., 2005. Obesity alters gut microbial ecology. Proceedings of the national academy of sciences, 102 (31), 11070–11075.
   PubMed Web of Science ®Google Scholar
• Li, H., et al., 2014. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis, 237 (1), 208–219.
   PubMed Web of Science ®Google Scholar
• Li, Y.Q., et al., 2009. Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of α-glucosidase. Journal of agricultural and food chemistry, 57 (24), 11463–11468.
   PubMed Web of Science ®Google Scholar
• Liu, D., et al., 2001. The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats. The histochemical journal, 33 (11/12), 621–628.
   PubMedGoogle Scholar
• Lodovici, M., et al., 2008. Oxidative DNA damage and plasma antioxidant capacity in type 2 diabetic patients with good and poor glycaemic control. Mutation research/fundamental and molecular mechanisms of mutagenesis, 638 (1-2), 98–102.
   PubMed Web of Science ®Google Scholar
• Loeffler, I., and Wolf, G., 2015. Epithelial-to-mesenchymal transition in diabetic nephropathy: fact or fiction? Cells, 4 (4), 631–652.
   PubMed Web of Science ®Google Scholar
• Lu, C.H., et al., 2016. Additional effect of metformin and celecoxib against lipid dysregulation and adipose tissue inflammation in high-fat fed rats with insulin resistance and fatty liver. European journal of pharmacology, 789, 60–67.
   PubMed Web of Science ®Google Scholar
• Maedler, K., et al., 2002. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. Journal of clinical investigation, 110 (6), 851–860.
   PubMed Web of Science ®Google Scholar
• Mahmoud, A.M., et al., 2012. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. Journal of diabetes and its complications, 26 (6), 483–490.
   PubMed Web of Science ®Google Scholar
• Mahmoud, F.F., et al., 2018. Correlation between heat shock proteins, adiponectin, and T lymphocyte cytokine expression in type 2 diabetics. Cell stress and chaperones, 23 (5), 955–965.
   PubMed Web of Science ®Google Scholar
• Mai, A.S., et al., 2017. Exercise training under exposure to low levels of fine particulate matter: effects on heart oxidative stress and extra-to-intracellular HSP70 ratio. Oxidative medicine and cellular longevity, 2017, 9067875.
   PubMed Web of Science ®Google Scholar
• Mandosi, E., et al., 2015. Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes. Expert opinion on therapeutic targets, 19 (12), 1617–1622.
   PubMed Web of Science ®Google Scholar
• Maritim, A.C., et al., 2003. Diabetes, oxidative stress, and antioxidants: a review. Journal of biochemical and molecular toxicology, 17 (1), 24–38.
   PubMed Web of Science ®Google Scholar
• Martinez-Gomez, D., et al., 2012. Associations of physical activity and fitness with adipocytokines in adolescents: the AFINOS Study. Nutrition, metabolism & cardiovascular disease, 22 (3), 252–259.
   PubMed Web of Science ®Google Scholar
• Masuzawa, K., et al., 2006. An endothelin type A receptor antagonist reverses upregulated VEGF and ICAM-1 levels in streptozotocin-induced diabetic rat retina. Current eye research, 31 (1), 79–89.
   PubMed Web of Science ®Google Scholar
• Mayer, M.P., and Bukau, B., 2005. Hsp70 chaperones: cellular functions and molecular mechanism. Cellular and molecular life sciences, 62 (6), 670–684.
   PubMed Web of Science ®Google Scholar
• Melloul, D., 2008. Role of NF-kappaB in beta-cell death. Biochemical society transactions, 36 (3), 334–339.
   PubMedGoogle Scholar
• Memisogullari, R., et al., 2003. Antioxidant status and lipid peroxidation in type II diabetes mellitus. Cell biochemistry and function, 21 (3), 291–296.
   PubMed Web of Science ®Google Scholar
• Meza, C.A., et al., 2019. Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS? International journal of molecular sciences, 20 (15), pii:3775.
   Web of Science ®Google Scholar
• Miragem, A.A., and Homem de Bittencourt, P.I., Jr., 2017. Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response. Human reproduction update, 23 (5), 600–628.
   PubMed Web of Science ®Google Scholar
• Mondal, L.K., et al., 2018. Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus. Indian journal of ophthalmology, 66 (4), 535–540.
   PubMed Web of Science ®Google Scholar
• Moustafa, P.E., et al., 2018. Extracellular matrix remodeling and modulation of inflammation and oxidative stress by sulforaphane in experimental diabetic peripheral neuropathy. Inflammation, 41 (4), 1460–1476. doi:https://doi.org/10.1007/s10753-018-0792-9
   PubMed Web of Science ®Google Scholar
• Montonen, J., et al., 2004. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes care, 27 (2), 362–366.
   PubMed Web of Science ®Google Scholar
• Muthenna, P., et al., 2012. Inhibition of advanced glycation end-product formation on eye lens protein by rutin. British journal of nutrition, 107 (7), 941–949.
   PubMed Web of Science ®Google Scholar
• Nagasawa, T., et al., 2003. Dietary G-rutin suppresses glycation in tissue proteins of streptozotocin-induced diabetic rats. Molecular and cellular biochemistry, 252 (1/2), 141–147.
   PubMed Web of Science ®Google Scholar
• Nakhjavani, M., et al., 2010. Increased serum HSP70 levels are associated with the duration of diabetes. Cell stress and chaperones, 15 (6), 959–964.
   PubMed Web of Science ®Google Scholar
• Nasser, Z.S., et al., 2011. Effects of melatonin in prevention of neuropathy in STZ-induced diabetic rats. American journal of pharmacology and toxicology, 6, 59–67.
   Google Scholar
• NCCIH: National Center for Complementary and Integrative Health. Complementary or Integrative Health: What’s In a Name? (2016). NCCIH: National Center for Complementary and Integrative Health. Complementary, Alternative, or Integrative Health: What’s In a Name? Available from https://nccih.nih.gov/health/integrativehealth.
   Google Scholar
• Ngo, D.T., et al., 2010. Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations? The American journal of medicine, 123 (4), 335–341.
   PubMed Web of Science ®Google Scholar
• Nguyen, M.T., et al., 2007. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. Journal of biological chemistry, 282 (48), 35279–35292.
   PubMed Web of Science ®Google Scholar
• Niture, N.T., et al., 2014. Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers. Indian journal of experimental biology, 52 (7), 720–727.
   PubMed Web of Science ®Google Scholar
• Noble, E.G., Milne, K.J., and Melling, C.W.J., 2008. Heat shock proteins and exercise: a primer. Applied physiology, nutrition, and metabolism, 33 (5), 1050–1065.
   PubMed Web of Science ®Google Scholar
• Noda, K., et al., 2012. Leukocyte adhesion molecules in diabetic retinopathy. Journal of ophthalmology, 2012, 1.
   Web of Science ®Google Scholar
• Nogueiras, R., et al., 2012. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. physiological reviews, 92 (3), 1479–1514.
   PubMed Web of Science ®Google Scholar
• Oh, Y.S., 2016. Bioactive compounds and their neuroprotective effects in diabetic complications. Nutrients, 8 (8), 472–420. pii: E472.
   Web of Science ®Google Scholar
• Ohashi, S., et al., 2004. Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy. Journal of biological chemistry, 279 (19), 19816–19823.
   PubMed Web of Science ®Google Scholar
• Oyenihi, A.B., et al., 2015. Antioxidant strategies in the management of diabetic neuropathy. BioMed research international, 2015, 1.
   Web of Science ®Google Scholar
• Paz-Filho, G.M., et al., 2012. Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications. Arquivos brasileiros de endocrinologia & metabologia, 56 (9), 597–607.
   PubMedGoogle Scholar
• Peterson, C.A., and Heffernan, M.E., 2008. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25 (OH) D concentrations in healthy women. Journal of inflammation, 5 (1), 10.
   Google Scholar
• Pittaluga, M., et al., 2015. Physical exercise and redox balance in type 2 diabetics: effects of moderate training on biomarkers of oxidative stress and DNA damage evaluated through comet assay. Oxidative medicine and cellular longevity, 2015, 1.
   Web of Science ®Google Scholar
• Plonka, M., et al., 2011. Association of the physical activity with leptin blood serum level, body mass indices and obesity in schoolgirls. Journal of physiology and pharmacology, 62 (6), 647–656.
   PubMed Web of Science ®Google Scholar
• Pollack, R.M., et al., 2016. Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications. Diabetes care, 39 (Supplement 2), S244–S252.
   PubMedGoogle Scholar
• Ramasamy, R., et al., 2008. Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis. Annals of the New York academy of sciences, 1126 (1), 7–13.
   PubMedGoogle Scholar
• Razzaque, M.S., and Taguchi, T., 1997. Collagen-binding heat shock protein (HSP) 47 expression in anti-thymocyte serum (ATS) -induced glomerulonephritis. The journal of pathology, 183 (1), 24–29.
   PubMed Web of Science ®Google Scholar
• Richardson, S.J., et al., 2009. Islet-associated macrophages in type 2 diabetes. Diabetologia, 52 (8), 1686–1688.
   PubMed Web of Science ®Google Scholar
• Richter, K., et al., 2010. The heat shock response: life on the verge of death. Molecular cell, 40 (2), 253–266.
   PubMed Web of Science ®Google Scholar
• Ringsholt, M., et al., 2007. YKL-40 protein expression in normal adult human tissues–an immunohistochemical study. Journal of molecular histology, 38 (1), 33–43.
   PubMed Web of Science ®Google Scholar
• Rodrigues-Krause, J., et al., 2012. Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? Cell stress and chaperones, 17 (3), 293–302.
   PubMed Web of Science ®Google Scholar
• Romeo, G., et al., 2002. Activation of nuclear factor-kB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes. Diabetes, 51 (7), 2241–2248.
   PubMed Web of Science ®Google Scholar
• Rubsam, A., et al., 2018. Role of inflammation in diabetic retinopathy. International journal of molecular science, 19 (4), E942.
   PubMed Web of Science ®Google Scholar
• Saberi Firouzi, S., et al., 2018. Sildenafil protective effects on high glucose-induced neurotoxicity in PC12 cells: the role of oxidative stress, apoptosis, and inflammation pathways in an in vitro cellular model for diabetic neuropathy. Neurological research, 40 (8), 1–13.
   PubMed Web of Science ®Google Scholar
• Saghizadeh, M., et al., 1996. The expression of TNF alpha by human muscle. Relationship to insulin resistance. Journal of clinical investigation, 97 (4), 1111–1116.
   PubMed Web of Science ®Google Scholar
• Saisho, Y., 2015. Metformin and inflammation: its potential beyond glucose-lowering effect. Endocrine, metabolic & immune disorders-drug targets, 15 (3), 196–205.
   PubMed Web of Science ®Google Scholar
• Samuel, V.T., and Shulman, G.I., 2012. Mechanisms for insulin resistance: common threads and missing links. Cell, 148 (5), 852–871.
   PubMed Web of Science ®Google Scholar
• Santi, D., et al., 2015. Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis. European journal of endocrinology, 172 (3), R103–114.
   PubMed Web of Science ®Google Scholar
• Scott, J.A., and King, G.L., 2004. Oxidative stress and antioxidant treatment in diabetes. Annals of the New York academy of sciences, 1031 (1), 204–213.
   PubMedGoogle Scholar
• Serafini, M., and Del Rio, D., 2004. Understanding the association between dietary antioxidants, redox status and disease: is the total antioxidant capacity the right tool? Redox report, 9 (3), 145–152.
   PubMed Web of Science ®Google Scholar
• Sethi, J.K., and Hotamisligil, G.S., 1999. The role of TNF alpha in adipocyte metabolism. Seminars in cell & developmental biology, 10 (1), 19–29.
   PubMed Web of Science ®Google Scholar
• Shah, M.S., and Brownlee, M., 2016. Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circulation research, 118 (11), 1808–1829.
   PubMed Web of Science ®Google Scholar
• Shaikh, A.S., and Somani, R.S., 2010. Animal models and biomarkers of neuropathy in diabetic rodents. Indian journal of pharmacology, 42 (3), 129–134.
   PubMed Web of Science ®Google Scholar
• Shakil-Ur-Rehman, S., et al., 2018. Response to a supervised structured aerobic exercise training program in patients with type 2 diabetes mellitus - does gender make a difference? A randomized controlled clinical trial. Journal of the national medical association, 110 (5), 431–439.
   PubMed Web of Science ®Google Scholar
• Shan, Z., et al., 2016. U-Shaped association between plasma manganese levels and type 2 diabetes. Environmental health perspectives, 124 (12), 1876–1881.
   PubMed Web of Science ®Google Scholar
• Sharma, A., et al., 2017. The nuclear factor (erythroid-derived 2) -like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction. Cardiovascular diabetology, 16 (1), 33.
   PubMedGoogle Scholar
• Shenouda, S.M., et al., 2011. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation, 124 (4), 444–453.
   PubMed Web of Science ®Google Scholar
• Shurtz-Swirski, R., et al., 2001. Involvement of peripheral polymorphonuclear leukocytes in oxidative stress and inflammation in type 2 diabetic patients. Diabetes care, 24 (1), 104–110.
   PubMed Web of Science ®Google Scholar
• Singh, K., et al., 2015. Decreased expression of heat shock proteins may lead to compromised wound healing in type 2 diabetes mellitus patients. Journal of diabetes and its complications, 29 (4), 578–588.
   PubMed Web of Science ®Google Scholar
• Soares, M., et al., 2019. Heat shock response in noise-induced hearing loss: effects of alanyl-glutamine dipeptide supplementation on heat shock proteins status. Brazilian journal of otorhinolaryngology. Available from: http://www.sciencedirect.com/science/article/pii/S1808869419300400
   Web of Science ®Google Scholar
• Solmaz, V., et al., 2017. Neuroprotective effects of octreotide on diabetic neuropathy in rats. Biomedicine & pharmacotherapy, 89, 468–472.
   PubMed Web of Science ®Google Scholar
• Srinivasan, K.K., and Ramarao, P., 2005. Partial protective effect of rutin on multiple low dose streptozotocin-induced diabetes in mice. Indian journal of pharmacology, 37 (5), 327.
   Google Scholar
• Stolar, M.W., and Chilton, R.J., 2003. Type 2 diabetes, cardiovascular risk, and the link to insulin resistance. Clinical therapeutics, 25 (Suppl B), B4–31.
   PubMedGoogle Scholar
• Sunamoto, M., et al., 1998. Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis. Laboratory investigations, 78 (8), 967–972.
   PubMed Web of Science ®Google Scholar
• Tanaka, T., et al., 1989. Changes of electron spin resonance membrane fluidity in hexadecane-induced hyperproliferative epidermis. Journal of investigative dermatology, 93 (5), 682–686.
   PubMed Web of Science ®Google Scholar
• Taniguchi, N., 1992. Clinical significances of superoxide dismutases: changes in aging, diabetes, ischemia, and cancer. Advances in clinical chemistry, 29, 1–59.
   PubMed Web of Science ®Google Scholar
• Thomas, D.E., et al., 2006. Exercise for type 2 diabetes mellitus. Cochrane database of systematic reviews, (3), CD002968. Available from: http://www.cochranelibrary.com/cdsr/doi/https://doi.org/10.1002/14651858.CD002968.pub2/full
   Google Scholar
• Togo, M., et al., 2018. Effects of a high-fat diet on superoxide anion generation and membrane fluidity in liver mitochondria in rats. Journal of international society of sports nutrition, 15 (13), 2–8.
   PubMedGoogle Scholar
• Tuomilehto, J., et al., 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New england journal of medicine, 344 (18), 1343–1350.
   PubMed Web of Science ®Google Scholar
• Turkmen, K., et al., 2014. Sirtuins as novel players in the pathogenesis of diabetes mellitus. World journal of diabetes, 5 (6), 894–900.
   PubMedGoogle Scholar
• Vial, G., et al., 2011. Effects of a high-fat diet on energy metabolism and ROS production in rat liver. Journal of hepatology, 54 (2), 348–356.
   PubMed Web of Science ®Google Scholar
• Victor, V.M., et al., 2003. N-acetylcysteine protects mice from lethal endotoxemia by regulating the redox state of immune cells. Free radical research, 37 (9), 919–929.
   PubMed Web of Science ®Google Scholar
• Victor, V.M., et al., 2004. Immune cells: free radicals and antioxidants in sepsis. International immunopharmacology, 4 (3), 327–347.
   PubMed Web of Science ®Google Scholar
• Victor, V.M., et al., 2005. Role of free radicals in sepsis: antioxidant therapy. Current pharmaceutical design, 11 (24), 3141–3158.
   PubMed Web of Science ®Google Scholar
• Vincent, A.M., et al., 2004. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocrine reviews, 25 (4), 612–628.
   PubMed Web of Science ®Google Scholar
• Vincent, A.M., et al., 2011. Diabetic neuropathy: cellular mechanisms as therapeutic targets. Nature reviews neurology, 7 (10), 573–583.
   PubMed Web of Science ®Google Scholar
• Wajchenberg, B.L., 2007. beta-cell failure in diabetes and preservation by clinical treatment. Endocrine reviews, 28 (2), 187–218.
   PubMed Web of Science ®Google Scholar
• Wang, Y.B., et al., 2015. Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Experimental and therapeutic medicine, 9 (2), 451–455.
   PubMed Web of Science ®Google Scholar
• Wang, Z., and Li, L., 2009. The plasmid encoding HSP47 enhances collagen expression and promotes skin wound healing in an alloxan-induced diabetic model. Cell biology international, 33 (7), 705–710.
   PubMed Web of Science ®Google Scholar
• Wauters, M., et al., 2000. Human leptin: from an adipocyte hormone to an endocrine mediator. European journal of endocrinology, 143 (3), 293–311.
   PubMed Web of Science ®Google Scholar
• Wellen, K.E., and Hotamisligil, G.S., 2005. Inflammation, stress, and diabetes. Journal of clinical investigation, 115 (5), 1111–1119.
   PubMed Web of Science ®Google Scholar
• Xia, Z., et al., 2008. Suppression of renal tubulointerstitial fibrosis by small interfering RNA targeting heat shock protein 47. American journal of nephrology, 28 (1), 34–46.
   PubMed Web of Science ®Google Scholar
• Xiao, H.B., et al., 2012. HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-beta1 through ERK1/2 and JNK MAPK pathways. American journal of physiology-renal physiology, 303 (5), F757–765.
   PubMed Web of Science ®Google Scholar
• Xie, K., et al., 2018. A multi-method evaluation of the effects of Inflammatory cytokines (IL-1beta, IFN-gamma, TNF-alpha) on pancreatic beta-cells. Journal of cellular physiology, 233 (12), 9375–9382.
   PubMed Web of Science ®Google Scholar
• Xu, P., et al., 2017. DBZ is a putative PPARgamma agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis. Biochimica et biophysica acta (BBA) - general subjects, 1861 (11), 2690–2701.
   PubMed Web of Science ®Google Scholar
• Yagihashi, S., Mizukami, H., and Sugimoto, K., 2011. Mechanism of diabetic neuropathy: where are we now and where to go? Journal of diabetes investigation, 2 (1), 18–32.
   PubMed Web of Science ®Google Scholar
• Ye, J., 2009. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. International journal of obesity, 33 (1), 54–66.
   PubMed Web of Science ®Google Scholar
• Yu, Y., et al., 2018. Effect of vitamin D supplementation on some inflammatory biomarkers in type 2 diabetes mellitus subjects: a systematic review and meta-analysis of randomized controlled trials. Annals of nutrition and metabolism, 73 (1), 62–73.
   PubMed Web of Science ®Google Scholar
• Zanetti, M., et al., 2014. Ability of vitamin D to reduce inflammation in adults without acute illness. Nutrition reviews, 72 (2), 95–98.
   PubMed Web of Science ®Google Scholar
• Zernecke, A., and Weber, C., 2010. Chemokines in the vascular inflammatory response of atherosclerosis. Cardiovascular research, 86 (2), 192–201.
   PubMed Web of Science ®Google Scholar
• Zhang, H., and Zhang, C., 2010. Adipose “talks” to distant organs to regulate insulin sensitivity and vascular function. Obesity ( Obesity), 18 (11), 2071–2076.
   PubMed Web of Science ®Google Scholar
• Zhang, W., et al., 2011. Inflammation and diabetic retinal microvascular complications. Journal of cardiovascular disease research, 2 (2), 96–103.
   PubMedGoogle Scholar
• Zhou, R., et al., 2010. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nature immunology, 11 (2), 136–140.
   PubMed Web of Science ®Google Scholar
• Zhu, Y., et al., 2016. Overexpression of miR-29b reduces collagen biosynthesis by inhibiting heat shock protein 47 during skin wound healing. Translational research, 178, 38.e36–53.e36.
   Web of Science ®Google Scholar
• Ziegler, D., et al., 2004. Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy. Diabetes care, 27 (9), 2178–2183.
   PubMed Web of Science ®Google Scholar
• Zilliox, L., and Russell, J.W., 2011. Treatment of diabetic sensory polyneuropathy. Current treatment options in neurology, 13 (2), 143–159.
   PubMed Web of Science ®Google Scholar
• Zinman, B., et al., 1999. Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus. The journal of clinical endocrinology & metabolism, 84 (1), 272–278.
   PubMed Web of Science ®Google Scholar