Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 128, 2022 - Issue 6
299
Views
9
CrossRef citations to date
0
Altmetric
Review Article

Curcumin and blood lipid levels: an updated systematic review and meta-analysis of randomised clinical trials

ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon
Pages 1493-1502 | Received 29 Jan 2020, Accepted 02 Jun 2020, Published online: 06 Jul 2020

References

  • Abbood, M. S., et al., 2018. Hypolipidaemic and anti-inflammatory effects of curcumin versus atorvastatin in type 2 diabetic patients. International journal of pharmaceutical sciences review and research, 49 (1), 1–7.
  • Amin, F., et al., 2015. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial. Complementary therapies in medicine, 23 (2), 165–174.
  • Anand, P., et al., 2007. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics, 4 (6), 807–818.
  • Appendino, G., et al., 2011. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva medica, 53 (3 Suppl 1), 43–49.
  • Arsenault, B.J., et al., 2009. Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women. Journal of the American college of cardiology., 55 (1), 35–41.
  • Bonetti, P.O., et al., 2003. Statin effects beyond lipid lowering—are they clinically relevant? European heart journal, 24 (3), 225–248.
  • Calpe-Berdiel, L., Escolà-Gil, J.C., and Blanco-Vaca, F., 2006. Phytosterol-mediated inhibition of intestinal cholesterol absorption is independent of ATP-binding cassette transporter A1. The British journal of nutrition, 95 (3), 618–622.
  • Chalasani, N., et al., 2004. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology, 126 (5), 1287–1292.
  • Chandran, B., and Goel, A., 2012. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy research: PTR, 26 (11), 1719–1725.
  • Chashmniam, S., et al., 2019. A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. European journal of clinical nutrition, 73 (9), 1224–1235.
  • Dong, S.Z., et al., 2011. Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway. Molecular and cellular biochemistry, 358 (1–2), 281–285.
  • Ferguson, J.J.A., et al., 2018. Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism, 82, 22–35.
  • Friis, S., et al., 2005. Cancer risk among statin users: a population-based cohort study. International journal of cancer, 114 (4), 643–647.
  • Ghazimoradi, M., et al., 2017. The effects of curcumin and curcumin-phospholipid complex on the serum pro-oxidant-antioxidant balance in subjects with metabolic syndrome. Phytotherapy research, 31 (11), 1715–1721.
  • Hamaguchi, T., Ono, K., and Yamada, M., 2010. REVIEW: curcumin and Alzheimer's disease. CNS neuroscience & therapeutics, 16 (5), 285–297.
  • Jang, E.M., et al., 2008. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metabolism: clinical and Experimental, 57 (11), 1576–1583.
  • Javandoost, A., et al., 2018. The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: a randomized, placebo-controlled clinical trial. Avicenna journal of phytomedicine, 8 (4), 330–337.
  • Jimenez-Osorio, A.S., et al., 2016. The effect of dietary supplementation with curcumin on redox status and Nrf2 activation in patients with nondiabetic or diabetic proteinuric chronic kidney disease: a pilot study. Journal of renal nutrition, 26 (4), 237–244.
  • Kang, Q., and Chen, A., 2009. Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology, 150 (12), 5384–5394.
  • Kim, M., and Kim, Y., 2010. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutrition research and practice, 4 (3), 191–195.
  • Knodel, L.C., and Talbert, R.L., 1987. Adverse effects of hypolipidaemic drugs. Medical toxicology and toxicology, 2 (1), 10–32.
  • Kocher, A., et al., 2016. Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals. Molecular nutrition & food research, 60 (7), 1555–1563.
  • Manjunatha, H., and Srinivasan, K., 2007. Hypolipidemic and antioxidant effects of dietary curcumin and capsaicin in induced hypercholesterolemic rats. Lipids, 42 (12), 1133–1142.
  • Marczylo, T.H., et al., 2007. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer chemotherapy and pharmacology, 60 (2), 171–177.
  • Micallef, M.A., and Garg, M.L., 2009. Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia. The journal of nutritional biochemistry, 20 (12), 927–939.
  • Mirzabeigi, P., et al., 2015. The effect of curcumin on some of traditional and non-traditional cardiovascular risk factors: a pilot randomized, double-blind, placebo-controlled Trial. Iranian journal of pharmaceutical research: Ijpr, 14 (2), 479–486.
  • Moohebati, M., et al., 2014. Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: a randomized double-blind placebo-controlled cross-over trial. ARYA atherosclerosis, 10 (5), 280–286.
  • MS, A., 2018. Hypolipidaemic and anti-inflammatory effects of curcumin versus atorvastatin in type 2 diabetic patients. International journal of pharmaceutical sciences review and research, 49 (1), 1–7.
  • Musunuru, K., 2010. Atherogenic dyslipidemia: cardiovascular risk and dietary intervention. Lipids, 45 (10), 907–914.
  • Mythri, R.B., and Bharath, M.M., 2012. Curcumin: a potential neuroprotective agent in Parkinson's disease. Current pharmaceutical design, 18 (1), 91–99.
  • Panahi, Y., et al., 2016. Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial. Nutrition, 32 (10), 1116–1122.
  • Panahi, Y., et al., 2017. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial. Complementary therapies in medicine, 33, 1–5.
  • Panahi, Y., et al., 2016. Curcumin lowers serum lipids and uric acid in subjects with nonalcoholic fatty liver disease: a randomized controlled trial. Journal of cardiovascular pharmacology. 68 (3), 223–229.
  • Plat, J., and Mensink, R.P., 2009. Plant stanol esters lower serum triacylglycerol concentrations via a reduced hepatic VLDL-1 production. Lipids, 44 (12), 1149–1153.
  • Prakash, U.N., and Srinivasan, K., 2012. Fat digestion and absorption in spice-pretreated rats. Journal of the science of food and agriculture, 92 (3), 503–510.
  • Rejnmark, L., et al., 2004. Hip fracture risk in statin users-a population-based Danish case-control study. Osteoporosis international: a journal established as result of cooperation between the European foundation for osteoporosis and the national osteoporosis foundation of the USA, 15 (6), 452–458.
  • Roehrig, C., et al., 2009. National health spending by medical condition, 1996–2005. Health affairs (project hope), 28 (2), w358–367.
  • Saadati, S., et al., 2019. The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease. European journal of clinical nutrition, 73 (3), 441–449.
  • Sahebkar, A., 2014. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clinical nutrition (Edinburgh, Scotland), 33 (3), 406–414.
  • Salem, M.R., Sohrab, R., and Gillies, E., 2014. Curcumin, a promising anticancer therapeutic: a review of its chemical properties. RSC advances, 4 (21), 10815–10829.
  • Sattar, N., et al., 2010. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet (London, England), 375 (9716), 735–742.
  • Seo, K.I., et al., 2008. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Molecular nutrition & food research, 52 (9), 995–1004.
  • Shao, W., et al., 2012. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One, 7 (1), e28784.
  • Shattat, S.G., 2014. A review article on hyperlipidemia: types, treatments and new drug targets. Biomedical and pharmacology journal, 7 (2), 399–409.
  • Shin, S.K., et al., 2011. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Molecular nutrition & food research, 55 (12), 1829–1840.
  • Smith, S.C., et al. 2012. Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke). Journal of the American college of cardiology, 60 (22), 2343–2348.
  • Taylor, R.A., and Leonard, M.C., 2011. Curcumin for inflammatory bowel disease: a review of human studies. Alternative medicine review: a journal of clinical therapeutic, 16 (2), 152–156.
  • Thota, R.N., Acharya, S.H., and Garg, M.L., 2019. Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial. Lipids in health and disease, 18 (1), 31.
  • Wang, S., et al., 2014. Novel insights of dietary polyphenols and obesity. The journal of nutritional biochemistry, 25 (1), 1–18.
  • Wongcharoen, W., et al., 2012. Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. The American journal of cardiology, 110 (1), 40–44.
  • Yang, Y.S., et al., 2014. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytotherapy research, 28 (12), 1770–1777.
  • Ye, M.X., et al., 2012. Curcumin: updated molecular mechanisms and intervention targets in human lung cancer. International journal of molecular sciences, 13 (3), 3959–3978.
  • Yeh, C.H., et al., 2005. Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. Journal of surgical research, 125 (1), 109–116.
  • Zingg, J.M., Hasan, S.T., and Meydani, M., 2013. Molecular mechanisms of hypolipidemic effects of curcumin. BioFactors (Oxford, England), 39 (1), 101–121.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.