Co Q10 improves vascular reactivity in male diabetic rats by enhancing insulin sensitivity and antioxidant effect

References

• Akbarzadeh, A., et al., 2007. Induction of diabetes by streptozotocin in rats. Indian journal of clinical biochemistry: IJCB, 22 (2), 60–64.
   PubMedGoogle Scholar
• Albus, U., 2012. Guide for the care and use of laboratory animals (8th edn). London, England: SAGE Publications Sage UK.
   Google Scholar
• Amin, M.M., et al., 2014. Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, Tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats. PloS One, 9 (2), e89169.
   PubMed Web of Science ®Google Scholar
• Asmat, U., Abad, K., and Ismail, K., 2016. Diabetes mellitus and oxidative stress-A concise review. Saudi pharmaceutical journal, 24 (5), 547–553.
   PubMed Web of Science ®Google Scholar
• Association, A. D. 2014. Diagnosis and classification of diabetes mellitus. Diabetes care, 37, S81–S90.
   PubMed Web of Science ®Google Scholar
• Aulbach, F., et al., 1999. Insulin stimulates the L-type Ca2+ current in rat cardiac myocytes. Cardiovascular research, 42 (1), 113–120.
   PubMed Web of Science ®Google Scholar
• Baradaran, A., Nasri, H., and Rafieian-Kopaei, M., 2014. Oxidative stress and hypertension: possibility of hypertension therapy with antioxidants. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19, 358.
   PubMed Web of Science ®Google Scholar
• Bhagavan, H.N., and Chopra, R.K., 2007. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion, 7, S78–S88.
   PubMed Web of Science ®Google Scholar
• Chen, H.H., et al., 2019. Antihypertensive potential of coenzyme Q10 via free radical scavenging and enhanced Akt‐nNOS signaling in the nucleus tractus solitarii in rats. Molecular nutrition & food research, 63, 1801042.
   Web of Science ®Google Scholar
• Coldiron, A.D., Sanders, R.A., and Watkins, J.B., 2002. Effects of combined quercetin and coenzyme Q10 treatment on oxidative stress in normal and diabetic rats. Journal of biochemical and molecular toxicology, 16 (4), 197–202.
   PubMed Web of Science ®Google Scholar
• Cryer, P.E., Davis, S.N., and Shamoon, H., 2003. Hypoglycemia in diabetes. Diabetes care, 26 (6), 1902–1912.
   PubMed Web of Science ®Google Scholar
• Davel, A.P., Rossoni, L.V., and Vassallo, D.V., 2000. Effects of ouabain on the pressor response to phenylephrine and on the sodium pump activity in diabetic rats. European journal of pharmacology, 406 (3), 419–427.
   PubMed Web of Science ®Google Scholar
• Draper, H., et al., 1993. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free radical biology & medicine, 15 (4), 353–363.
   PubMed Web of Science ®Google Scholar
• El-Latif, A., et al., 2014. Effect of different doses of vitamin e on body weight and serum malondialdehyde in streptozotocin-induced diabetic rats. Al-Azhar medical journal, 331, 1–11.
   Google Scholar
• El-Sheikh, A.A., et al., 2012. Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats. Advances in pharmacological sciences, 2012, 1–8.
   Google Scholar
• Falk, E., 2006. Pathogenesis of atherosclerosis. Journal of the American college of cardiology, 47 (8 Suppl), C7–C12.
   PubMed Web of Science ®Google Scholar
• Firoozrai, M., Nourbakhsh, M., and Razzaghy-Azar, M., 2007. Erythrocyte susceptibility to oxidative stress and antioxidant status in patients with type 1 diabetes. Diabetes research and clinical practice, 77 (3), 427–432.
   PubMed Web of Science ®Google Scholar
• Gao, L., et al., 2012. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis, 221 (2), 311–316.
   PubMed Web of Science ®Google Scholar
• Husain, K., et al., 2015. Inflammation, oxidative stress and renin angiotensin system in atherosclerosis. World journal of biological chemistry, 6 (3), 209–217.
   PubMedGoogle Scholar
• Ishizaki, N., et al., 2009. Improvement in glucose tolerance as a result of enhanced insulin sensitivity during electroacupuncture in spontaneously diabetic Goto-Kakizaki rats. Metabolism: clinical and experimental, 58 (10), 1372–1378.
   PubMed Web of Science ®Google Scholar
• Judzewitsch, R.G., et al., 1982. Chronic chlorpropamide therapy of noninsulin-dependent diabetes augments basal and stimulated insulin secretion by increasing islet sensitivity to glucose. The journal of clinical endocrinology and metabolism, 55 (2), 321–328.
   PubMed Web of Science ®Google Scholar
• Kashihara, N., et al., 2010. Oxidative stress in diabetic nephropathy. Current medicinal chemistry, 17 (34), 4256–4269.
   PubMed Web of Science ®Google Scholar
• Kobayashi, T., and Kamata, K., 1999. Effect of insulin treatment on smooth muscle contractility and endothelium-dependent relaxation in rat aortae from established STZ-induced diabetes. British journal of pharmacology, 127 (4), 835–842.
   PubMed Web of Science ®Google Scholar
• Koracevic, D., et al., 2001. Method for the measurement of antioxidant activity in human fluids. Journal of clinical pathology, 54 (5), 356–361.
   PubMed Web of Science ®Google Scholar
• Laakso, M., et al., 1990. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. Journal of clinical investigation, 85 (6), 1844–1852.
   PubMed Web of Science ®Google Scholar
• Liu, H.-Y., et al., 2009. Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM). The journal of biological chemistry, 284 (40), 27090–27100.
   PubMed Web of Science ®Google Scholar
• Luo, K., et al., 2019. Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury. Nephrology dialysis transplantation, 34, gfz103.
   Web of Science ®Google Scholar
• Maheshwari, R., et al., 2017. Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. Renal failure, 39 (1), 130–139.
   PubMed Web of Science ®Google Scholar
• Mather, K.J., Steinberg, H.O., and Baron, A.D., 2013. Insulin resistance in the vasculature. The journal of clinical investigation, 123 (3), 1003–1004.
   PubMed Web of Science ®Google Scholar
• Mcgee, P., et al., 2014. Insulin secretion measured by stimulated C-peptide in long-established Type 1 diabetes in the Diabetes Control and Complications Trial (DCCT)/ Epidemiology of Diabetes Interventions and Complications (EDIC) cohort: a pilot study. Diabetic medicine: a journal of the british diabetic association, 31 (10), 1264–1268.
   PubMed Web of Science ®Google Scholar
• Modi, K. P., et al., 2006. Beneficial effect of coenzyme Q10 in streptozotocin-induced type I diabetic rats. Iranian journal of pharmacology and therapeutics, 5 (1), 61–65.
   Google Scholar
• Montezano, A.C., and Touyz, R.M., 2012. Oxidative stress, Noxs, and hypertension: experimental evidence and clinical controversies. Annals of medicine, 44 (sup1), S2–S16.
   PubMed Web of Science ®Google Scholar
• Okamoto, M.M., et al., 2011. Intensive insulin treatment induces insulin resistance in diabetic rats by impairing glucose metabolism-related mechanisms in muscle and liver. The journal of endocrinology, 211 (1), 55–64.
   PubMed Web of Science ®Google Scholar
• Paneni, F., et al., 2013. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. European heart journal, 34 (31), 2436–2443.
   PubMed Web of Science ®Google Scholar
• Parasuraman, S., and Raveendran, R., 2012. Measurement of invasive blood pressure in rats. Journal of pharmacology & pharmacotherapeutics, 3 (2), 172–177.
   PubMedGoogle Scholar
• Perlstein, T.S., et al., 2012. Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose. Clinical science (London, England: 1979)), 122 (4), 193–202.
   PubMed Web of Science ®Google Scholar
• Pop-Busui, R., et al., 2002. Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. Diabetes, 51 (8), 2619–2628.
   PubMed Web of Science ®Google Scholar
• Rajendran, P., et al., 2013. The vascular endothelium and human diseases. International Journal of biological sciences, 9 (10), 1057–1069.
   PubMed Web of Science ®Google Scholar
• Rask-Madsen, C., and King, G.L., 2007. Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes. Nature clinical practice. endocrinology & metabolism, 3 (1), 46–56.
   PubMedGoogle Scholar
• Röder, P.V., et al., 2016. Pancreatic regulation of glucose homeostasis. Experimental & molecular medicine, 48, e219–e219.
   PubMed Web of Science ®Google Scholar
• Saleh, D.O., et al., 2013. Streptozotocin-induced vascular and biochemical changes in rats: Effects of rosiglitazone vs. metformin. Bulletin of faculty of pharmacy, Cairo university, 51, 131–138.
   Google Scholar
• Selvin, E., et al., 2010. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. The New England journal of medicine, 362 (9), 800–811.
   PubMed Web of Science ®Google Scholar
• Sivitz, W.I., and Yorek, M.A., 2010. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxidants & redox signaling, 12 (4), 537–577.
   PubMed Web of Science ®Google Scholar
• Tijssen, P., 1985. Practice and theory of enzyme immunoassays. Amsterdam, Netherlands: Elsevier.
   Google Scholar
• Trivelli, L.A., Ranney, H.M., and Lai, H.-T., 1971. Hemoglobin components in patients with diabetes mellitus. The New England journal of medicine, 284 (7), 353–357.
   PubMed Web of Science ®Google Scholar
• Tsai, K.-L., et al., 2012. A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways. The journal of nutritional biochemistry, 23 (5), 458–468.
   PubMed Web of Science ®Google Scholar
• Ventura-Sobrevilla, J., et al., 2011. Effect of varying dose and administration of streptozotocin on blood sugar in male CD1 mice. Proceedings of the western pharmacology society, 54, 5–9.
   PubMedGoogle Scholar
• Wada, A., et al., 2005. New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. Journal of pharmacological sciences, 99 (2), 128–143.
   PubMed Web of Science ®Google Scholar
• Wang, W., et al., 2011. Oxidized low‐density lipoprotein inhibits nitric oxide‐mediated coronary arteriolar dilation by up‐regulating endothelial arginase I. Microcirculation (New York, N.Y.: 1994), 18 (1), 36–45.
   PubMed Web of Science ®Google Scholar
• Wt, W.M.A.C., 1987. Carbohydrates. In: N. W. Tietz, ed. Fundamentals of clinical chemistry. 3rd ed. Philadelphia: Saunders, 422–447.
   Google Scholar
• Xu, P., et al., 2014. Distribution of C-peptide and its determinants in North American children at risk for type 1 diabetes. Diabetes care, 37 (7), 1959–1965.
   PubMed Web of Science ®Google Scholar
• Yoo, J.-Y., and Yum, K.-S., 2018. Effect of coenzyme Q10 on insulin resistance in Korean patients with prediabetes: a pilot single-center, randomized, double-blind, placebo-controlled study. BioMed research international, 2018, 1–6.
   Web of Science ®Google Scholar
• Zabielski, P., et al., 2014. Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice. American journal of physiology, endocrinology and metabolism), 306 (5), E529–E542.
   PubMed Web of Science ®Google Scholar
• Zahedi, H., et al., 2014. Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with Type 2 diabetes: a randomized, double blind, placebo-controlled trial. Journal of diabetes and metabolic disorders, 13, 81.
   PubMedGoogle Scholar
• Zobalı, F., et al., 2002. Effects of vitamin A and insulin on the antioxidative state of diabetic rat heart: a comparison study with combination treatment. Cell biochemistry and function, 20 (2), 75–80.
   PubMed Web of Science ®Google Scholar
• Zourek, M., et al., 2008. The relationship between glycemia, insulin and oxidative stress in hereditary hypertriglyceridemic rat. Physiological research, 57 (4), 531–538.
   PubMed Web of Science ®Google Scholar