Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 129, 2023 - Issue 2
355
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Maca modulates fat and liver energy metabolism markers insulin, IRS1, leptin, and SIRT1 in rats fed normal and high-fat diets

ORCID Icon
Pages 323-329 | Received 02 Jul 2020, Accepted 03 Sep 2020, Published online: 19 Sep 2020

References

  • Akar, F., et al., 2012. High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: protective effect of resveratrol. Food and chemical toxicology, 50 (6), 2135–2141.
  • Austin, J. and Marks, D., 2009. Hormonal regulators of appetite. International journal of pediatric endocrinology, 2009 (2009), 141753.
  • Azzini, E., Giacometti, J., and Russo, G.L., 2017. Antioxidant phytochemicals at the pharma–nutrition interface. Oxidative medicine and cellular longevity, 2017 (2017), 6986143.
  • Bektur, E., Sahin, E., and Baycu, C., 2019. Mirtazapine may show anti-hyperglycemic effect by decreasing GLUT2 through leptin and galanin expressions in the liver of type 1 diabetic rats. Iran journal basic medical science, 22 (6), 676–682.
  • Berger, R.G., et al., 2012. Antioxidants in food: mere myth or magic medicine? Critical reviews in food science and nutrition, 52 (2), 162–171.
  • Broussy, S., Laaroussi, H., and Vidal, M., 2020. Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat). Journal of enzyme inhibition and medicinal chemistry, 35 (1), 1124–1136.
  • Coelho, M., Oliveira, T., and Fernandes, R., 2013. Biochemistry of adipose tissue: an endocrine organ. Archives of medical science, 9 (2), 191–200.
  • Czech, M.P., 2017. Insulin action and resistance in obesity and type 2 diabetes. Nature medicine, 23 (7), 804–814.
  • Dalby, M.J., et al., 2018. Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N. Scientific reports, 8 (1), 1–15.
  • Domínguez-Vías, G., et al., 2020. The role of high fat diets and liver peptidase activity in the development of obesity and insulin resistance in wistar rats. Nutrients, 12 (3), 636.
  • Gencoglu, H., Orhan, C., and Sahin, K., 2017. Phytochemical therapies in vascular functioning: a molecular approach. Current vascular pharmacology, 15 (4), 327–338.
  • Gencoglu, H., et al., 2015. Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters. International journal of food sciences and nutrition, 66 (3), 314–320.
  • Ginsberg, H.N. and MacCallum, P.R., 2009. The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus. Journal of the cardiometabolic syndrome, 4 (2), 113–119.
  • Gonzales, G.F., 2012. Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the Peruvian highlands. Evidence-based complementary and alternative medicine, 2012, 193496.
  • Gonzales, G.F., et al., 2001. Lepidium meyenii (Maca) improved semen parameters in adult men. Asian journal of andrology, 3 (4), 301–303.
  • Gonzales, G.F., Gonzales-Castañeda, C., and Gasco, M., 2013. A mixture of extracts from Peruvian plants (black maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabetes. Toxicology mechanisms and methods, 23 (7), 509–518.
  • Haigis, M.C. and Sinclair, D.A., 2010. Mammalian sirtuins: biological insights and disease relevance. Annual review of pathology, 5, 253–295.
  • Hruby, A. and Hu, F.B., 2015. The epidemiology of obesity: a big picture. PharmacoEconomics, 33 (7), 673–689.
  • Huang, Y.-J., Peng, X.-R., and Qiu, M.-H., 2018. Progress on the chemical constituents derived from glucosinolates in Maca (Lepidium meyenii). Natural products and bioprospecting, 8 (6), 405–412.
  • Lang, P., et al., 2019. Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice. Scientific reports, 9 (1), 1–14.
  • Lasker, S., et al., 2019. High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Scientific reports, 9 (1), 1–15.
  • Lee, M.S., et al., 2011. Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review. Maturitas, 70 (3), 227–233.
  • Li, J., et al., 2017. The composition analysis of Maca (Lepidium meyenii Walp.) from Xinjiang and its antifatigue activity. Journal of food quality, 2017, 1–7.
  • Manna, P. and Jain, S.K., 2015. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metabolic syndrome and related disorders, 13 (10), 423–444.
  • Margetic, S., et al., 2002. Leptin: a review of its peripheral actions and interactions. International journal of obesity and related metabolic disorders: journal of the international association for the study of obesity, 26 (11), 1407–1433.
  • Marseglia, L., et al., 2014. Oxidative stress in obesity: a critical component in human diseases. International journal of molecular sciences, 16 (1), 378–400.
  • Meissner, H.O., et al., 2005. Use of gelatinized Maca (Lepidium peruvianum) in early postmenopausal women. International journal of biomedical science, 1 (1), 33–45.
  • Meissner, H.O., et al., 2015. Peruvian Maca: two scientific names Lepidium meyenii Walpers and Lepidium peruvianum Chacon – are they phytochemically-synonymous? International journal of biomedical science, 11 (1), 1–15.
  • Paliyath, G., Bakovic, M., and Shetty, K., 2011. Functional foods, nutraceuticals, and degenerative disease prevention. New York: John Wiley & Sons.
  • Pallauf, K., et al., 2013. Nutrition and healthy ageing: calorie restriction or polyphenol-rich “MediterrAsian” diet? Oxidative medicine and cellular longevity, 2013, 707421
  • Ramos-Lobo, A.M., and Donato, J., 2017. The role of leptin in health and disease. Temperature (Austin, TX), 4 (3), 258–291.
  • Rui, L., 2014. Energy metabolism in the liver. Comprehensive physiology, 4 (1), 177–197.
  • Sánchez, I., Reynoso-Camacho, R., and Salgado, L.M., 2015. The diet-induced metabolic syndrome is accompanied by whole-genome epigenetic changes. Genes & nutrition, 10 (4), 471
  • Sandoval, M., et al., 2002. Antioxidant activity of the cruciferous vegetable Maca (Lepidium meyenii). Food chemistry, 79 (2), 207–213.
  • Shin, B.-C., et al., 2010. Maca (L. meyenii) for improving sexual function: a systematic review. BMC complementary medicine and therapies, 10, 44.
  • Slavin, J.L. and Lloyd, B., 2012. Health benefits of fruits and vegetables. Advances in nutrition, 3 (4), 506–516.
  • Smith, U. and Kahn, B.B., 2016. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. Journal of internal medicine, 280 (5), 465–475.
  • Sui, M., et al., 2019. Gegen Qinlian decoction ameliorates hepatic insulin resistance by silent information regulator1 (SIRT1)-dependent deacetylation of Forkhead Box O1 (FOXO1). Medical science monitor : international medical journal of experimental and clinical research, 25, 8544–8553.
  • Tang, B.L., 2016. Sirt1 and the mitochondria. Molecules and cells, 39 (2), 87–95.
  • Troya-Santos, J., Ale-Borja, N., and Suárez-Cunza, S., 2017. Capacidad antioxidante in vitro y efecto hipoglucemiante de la maca negra (Lepidium meyenii) preparada tradicionalmente. Revista de la Sociedad Química Del Perú, 83 (1), 40–51.
  • van der Heijden, R.A., et al., 2015. High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. Aging, 7 (4), 256–268.
  • Vásquez‐Velásquez, C., et al., 2020. Inflammatory pathway employed by Red Maca to treat induced benign prostatic hyperplasia in rats. Andrologia, 52 (3), e13516.
  • Vassilopoulos, A., et al., 2011. The human sirtuin family: evolutionary divergences and functions. Human Genomics, 5 (5), 485–496.
  • Vecera, R., et al., 2007. The influence of Maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant foods for human nutrition (Dordrecht, Netherlands), 62 (2), 59–63.
  • Wan, W., et al., 2018. Aqueous extract of black maca prevents metabolism disorder via regulating the glycolysis/gluconeogenesis-TCA cycle and PPARα signaling activation in golden hamsters fed a high-fat, high-fructose diet. Frontiers in pharmacology, 9, 333.
  • Wang, Z., et al., 2009. Influence of Lepidium meyemii walp on lipid and bone mass in ovariectomized rats. Wei Sheng Yan Jiu = journal of hygiene research, 38 (4), 420–422, 425.
  • Webster, B.R., et al., 2012. The role of sirtuins in modulating redox stressors. Free radical biology & medicine, 52 (2), 281–290.
  • Wilcox, G., 2005. Insulin and insulin resistance. Clinical biochemist reviews, 26 (2), 19–39.
  • Zha, S., et al., 2014. Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). Carbohydrate polymers, 111, 584–587.
  • Zhang, J., 2007. The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. Journal of biological chemistry, 282 (47), 34356–34364.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.