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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 129, 2023 - Issue 2
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Original Articles

Exogenous glutamine ameliorates diabetic nephropathy in a rat model of type 2 diabetes mellitus through its antioxidant and anti-inflammatory activities

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Pages 363-372 | Received 01 Jun 2020, Accepted 18 Sep 2020, Published online: 06 Oct 2020

References

  • Abboud, K.Y., et al., 2019. Oral glutamine supplementation reduces obesity, pro-inflammatory markers, and improves insulin sensitivity in DIO wistar rats and reduces waist circumference in overweight and obese humans. Nutrients, 11 (3), 536.
  • Aboonabi, A., Rahmat, A., and Othman, F.J.T.R., 2014. Antioxidant effect of pomegranate against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Toxicology reports, 1, 915–922.
  • Ahmadvand, H., et al., 2019. Effect of alpha-lipoic acid on antioxidant gene expression and kidney injury in alloxan-induced diabetic rats. Journal of Nephropathology, 8, 6–6.
  • Ahmadvand, H., et al., 2017. Protective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study. Journal of nephropathology, 6 (3), 204–209.
  • Ahmadvand, H., et al., 2012. Amelioration of altered antioxidant enzymes activity and glomerulosclerosis by coenzyme Q10 in alloxan-induced diabetic rats. Journal of diabetes and its complications, 26 (6), 476–482.
  • Anandan, R., et al., 2015. Protective effect of l-glutamine on lysosomal integrity in isoproterenol-induced myocardial infarction in rats. Acta biologica szegediensis, 59, 205–209.
  • Badole, S.L., et al., 2013. Oral l-glutamine increases active GLP-1 (7–36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats. Chemico-biological interactions, 203 (2), 530–541.
  • Bahmani, F., et al., 2012. Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats. Molecular vision, 18, 439–448.
  • Bhattacharya, S., et al., 2013. D-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling. Toxicology and applied pharmacology, 267 (1), 16–29.
  • Bouairi, E., et al., 2004. Respiratory sinus arrhythmia in freely moving and anesthetized rats. Journal of applied physiology, 97 (4), 1431–1436.
  • Chen, T., et al., 2016. Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations. Scientific reports, 6, 20594.
  • Chevalier, S.P., et al., 2005. Whole-body protein anabolic response is resistant to the action of insulin in obese women. The American journal of clinical nutrition, 82, 355–365.
  • Doi, M., et al., 2007. Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. American journal of physiology-endocrinology and metabolism, 292 (6), E1683–E1693.
  • Faddah, L.M., et al., 2012. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. BMC complementary and alternative medicine, 12 (1), 60.
  • Friedewald, W.T., Levy, R.I., and Fredrickson, D.S., 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry, 18 (6), 499–502.
  • Gannon, M.C., and Nuttall, F.Q.J.I.L., 2010. Amino acid ingestion and glucose metabolism-a review. Iubmb life, 62 (9), 660–668.
  • Hou, Y., and Wu, G.J.A.A., 2018. L-Glutamate nutrition and metabolism in swine. Amino acids, 50 (11), 1497–1510.
  • Ikewuchi, C., 2009. Alteration of plasma lipid profiles and atherogenic indices by Stachytarpheta jamaicensis L.(Vahl). Biokemistri, 21 (2), 71–77.
  • Jadhav, R., and Puchchakayala, G., 2012. Hypoglycemic and antidiabetic activity of flavonoids: Boswellic acid, Ellagic acid, Quercetin, Rutin on streptozotocin-nicotinamide induced type 2 diabetic rats. International journal of pharmacy and pharmaceutical sciences., 4, 251–256.
  • Kashihara, N., et al., 2010. Oxidative stress in diabetic nephropathy. Current medicinal chemistry, 17 (34), 4256–4269.
  • Kumar, R., et al., 2011. Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin–nicotinamide induced type 2 diabetic rats. Asian pacific journal of tropical medicine, 4 (11), 904–909.
  • Lampropoulou, I.T., et al., 2014. TNF-α and microalbuminuria in patients with type 2 diabetes mellitus. Journal of diabetes research, 2014, 2014. 394206–394206.
  • Lee, B.T., et al., 2015. Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease. BMC nephrology, 16 (1), 77.
  • Lee, Y.T., et al., 2005. Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. European journal of pharmacology. 513 (1–2), 145–150.
  • Limaye, P.V., Raghuram, N., and Sivakami, S., 2003. Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin-induced diabetic rats. Molecular and cellular biochemistry, 243 (1–2), 147–152.
  • Lin, Z., et al., 2014. Effects of glutamine on oxidative stress and nuclear factor-κB expression in the livers of rats with nonalcoholic fatty liver disease. Experimental and therapeutic medicine, 7 (2), 365–370.
  • Mahdavifard, S., et al., 2014. L-cysteine is a potent inhibitor of protein glycation on both albumin and LDL, and prevents the diabetic complications in diabetic–atherosclerotic rat. Food research international, 62, 909–916.
  • Masiello, P., et al., 1998. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes, 47, 224–229.
  • Matsunami, T., et al., 2009. Oxidative stress and gene expression of antioxidant enzymes in the streptozotocin-induced diabetic rats under hyperbaric oxygen exposure. International journal of clinical and experimental pathology, 3, 177–188.
  • Nasri, M., et al., 2020. Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats. Iranian journal of basic medical sciences, 23 (6), 714–723.
  • Nelson, D. L., Lehninger, A. L., and Cox, M. M., 2008. Lehninger principles of biochemistry. Macmillan. New York, NY: W.H. Freeman.
  • Nimni, M.E., Han, B., and Cordoba, F., 2007. Are we getting enough sulfur in our diet? Nutrition & metabolism, 4, 24.
  • Ogurtsova, K., et al., 2017. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes research and clinical practice, 128, 40–50.
  • Peng, C.-C., et al., 2014. Therapeutic effect of amino acid mixture on type 1 diabetes mellitus with impaired renal methionine reabsorption. Journal of diabetes research and clinical metabolism, 3 (1), 5.
  • Pham-Huy, L.A., He, H., and Pham-Huy, C., 2008. Free radicals, antioxidants in disease and health. International journal of biomedical science, 4 (2), 89–96.
  • Pinheiro, M.S., et al., 2017. Effect of Bauhinia holophylla treatment in Streptozotocin-induced diabetic rats. Anais da academia brasileira de ciencias, 89 (1), 263–272.
  • Raizel, R., et al., 2016. Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise. British journal of nutrition, 116 (3), 470–479.
  • Reddi, A.S., and Bollineni, J.S., 1997. Renal cortical expression of mRNAs for antioxidant enzymes in normal and diabetic rats. Biochemical and biophysical research communications, 235 (3), 598–601.
  • Robson, R., et al., 2018. Oxidative stress biomarkers in type 2 diabetes mellitus for assessment of cardiovascular disease risk. Diabetes & metabolic syndrome, 12 (3), 455–462.
  • Rumberger, J.M., et al., 2003. Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels. Journal of biological chemistry, 278, 28547–28552.
  • Sadar, S., Kaspate, D., and Vyawahare, N., 2016. Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: role of KIM-1, NGAL, TGF-β1, and collagen-1. Renal failure, 38 (9), 1483–1495.
  • Satheesh, M.A., and Pari, L., 2008. Effect of pterostilbene on lipids and lipid profiles in streptozotocin-nicotinamide induced type 2 diabetes mellitus. Journal of applied biomedicine, 6 (1), 31–37.
  • Schena, F.P., and Gesualdo, L., 2005. Pathogenetic mechanisms of diabetic nephropathy. Journal of the American society of nephrology, 16 (3 Suppl 1), S30–S3.
  • Spector, A.C., and Grill, H.J., 1992. Salt taste discrimination after bilateral section of the chorda tympani or glossopharyngeal nerves. The American journal of physiology, 263 (1 Pt 2), R169–76.
  • Tangvarasittichai, S.J.W.J.O.D., 2015. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World journal of diabetes, 6 (3), 456–480.
  • Tavafi, M., et al., 2011. Satureja khozestanica essential oil ameliorates progression of diabetic nephropathy in uninephrectomized diabetic rats. Tissue and cell, 43 (1), 45–51.
  • Truong, V.L., Jun, M., and Jeong, W.S.J.B., 2018. Role of resveratrol in regulation of cellular defense systems against oxidative stress. BioFactors, 44 (1), 36–49.
  • Tsai, P.-H., et al., 2012. Effects of glutamine supplementation on oxidative stress-related gene expression and antioxidant properties in rats with streptozotocin-induced type 2 diabetes. The British journal of nutrition, 107 (8), 1112–1118.
  • Vasavada, N., and Agarwal, R., 2005. Role of oxidative stress in diabetic nephropathy. Advances in chronic kidney disease, 12 (2), 146–154.
  • Watanabe, M., et al., 2008. Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality. The American journal of clinical nutrition, 87 (6), 1860–1866.
  • Wu, G., et al., 2004. Glutathione metabolism and its implications for health. The journal of nutrition, 134 (3), 489–492.
  • Yan, P., et al., 2011. Changes of serum omentin levels and relationship between omentin and adiponectin concentrations in type 2 diabetes mellitus. Experimental and clinical endocrinology & diabetes, 119 (04), 257–263.
  • Yatzidis, H., 2004. Oral supplement of six selective amino acids arrest progression renal failure in uremic patients. International urology and nephrology, 36 (4), 591–598.
  • Young, V., et al., 1994. The biochemistry and physiology of protein and amino acid metabolism, with reference to protein nutrition. Nestle nutrition workshop series (USA), 33, 1–28.
  • Zhang, H., and Tsao, R.J.C.O.I.F.S., 2016. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Current opinion in food science, 8, 33–42.
  • Zhang, S., et al., 2017. Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes. Experimental and therapeutic medicine, 14 (1), 383–390.

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