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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 129, 2023 - Issue 6
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Original Articles

Upregulation of PCSK9, rho kinase and cardiac troponin by Eucalyptus globulus leaf extract improves fructose-streptozotocin-induced diabetic cardiac dysfunction in rats

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Pages 1219-1228 | Received 10 Oct 2020, Accepted 12 May 2021, Published online: 16 Jul 2021

References

  • Ahlem, S., et al., 2009. Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats. Chemico-biological interactions, 181, 71–76.
  • Alipio, Z., et al., 2010. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic β-like cells. Proceedings of the national academy of sciences of the United States of America, 107, 13426–13431.
  • Amano, M., Nakayama, M., and Kaibuchi, K., 2010. Rho-kinase/ROCK: a key regulator of the cytoskeleton and cell polarity. Cytoskeleton, 67 (9), 545–554.
  • Babu, P.S., and Prince, P.S.M., 2004. Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. Journal of pharmacy and pharmacology, 56, 1435–1442.
  • Balogun, F.O., and Ashafa, A.O.T., 2017. Aqueous root extracts of Dicoma anomala (Sond.) extenuates postprandial hyperglycaemia in vitro and its modulation on the activities of carbohydrate-metabolizing enzymes in streptozotocin-induced diabetic Wistar rats. South African journal of botany, 112, 102–111.
  • Barry, S. P., and Townsend, P. A., 2010. What causes a broken heart—molecular insights into heart failure. International review of cell and molecular biology, 284, 113–179.
  • Belayneh, Y.M., and Birru, E.M., 2018. Antidiabetic activities of hydromethanolic leaf extract of Calpurnia aurea (Ait.) Benth. subspecies Aurea (Fabaceae) in mice. Evidence-based complementary and alternative medicine, 2018, 1–9.
  • Beutler, E., 1963. Improved method for the determination of blood glutathione. Journal of laboratory and clinical medicine, 61, 882–888.
  • Bharti, S.K., et al., 2018. Antidiabetic phytoconstituents and their mode of action on metabolic pathways. Therapeutic advances in endocrinology and metabolism, 9, 81–100.
  • Carmena, R., 2005. Type 2 diabetes, dyslipidemia, and vascular risk: rationale and evidence for correcting the lipid imbalance. American heart journal, 150, 859–870.
  • Cheng, D., Liang, B., and Li, Y., 2013. Antihyperglycemic effect of Ginkgo biloba extract in streptozotocin-induced diabetes in rats. BioMed research international, 2013, 1–7.
  • Cho, N.H., et al., 2018. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes research and clinical practice, 138, 271–281.
  • Criqui, M.H., and Golomb, B.A., 1998. Epidemiologic aspects of lipid abnormalities. American journal of medicine, 105, 48S–57S.
  • Culling, C.F., 1974. Hand book of histopathological and histochemical techniques. London: Butterworth and Co. (Publishers) Ltd.
  • Dubuc, G., et al., 2004. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology, 24, 1454–1459.
  • Eidi, A., et al., 2009. Hypolipidemic effects of alcoholic extract of eucalyptus (Eucalyptus globulus Labill.) leaves on diabetic and non-diabetic rats. Journal of diabetes & metabolic disorders, 8, 13.
  • Ghareeb, M.A., et al., 2019. Chemical profiling of polyphenolics in Eucalyptus globulus and evaluation of its hepato–renal protective potential against cyclophosphamide induced toxicity in mice. Antioxidants, 8 (9), 415.
  • Giustarini, D., et al., 2008. Nitrite and nitrate measurement by Griess reagent in human plasma: evaluation of interferences and standardization. Methods in enzymology, 440, 361–380.
  • Ji, X., et al., 2019. Bioactive compounds from herbal medicines to manage dyslipidemia. Biomedicine & pharmacotherapy, 118, 109338.
  • Kamalakkanan, N., Rajadurai, M., and Prince, P.S.M., 2003. Effect of Aegle marmelos fruits on normal and streptozotocin-diabetic Wistar rats. Journal of medicinal food, 6, 93–98.
  • Kamalakkannan, N., and Prince, P.S.M., 2006. Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid. Basic & clinical pharmacology & toxicology, 98 (1), 97–103.
  • Kobori, M., et al., 2011. Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Molecular nutrition & food research, 55, 530–540.
  • Leon, B.M., 2015. Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World journal of diabetes, 6, 1246.
  • Lobo, V., et al., 2010. Free radicals, antioxidants and functional foods: impact on human health. Pharmacognosy reviews, 4, 118.
  • Lotfy, M., et al., 2017. Chronic complications of diabetes mellitus: a mini review [WWW Document]. https://www.ingentaconnect.com/content/ben/cdr/2017/00000013/00000001/art00003. [Accessed 20 January 20].
  • Malviya, N., Jain, S., and Malviya, S., 2010. Antidiabetic potential of medicinal plants. Acta Poloniae Pharmaceutica, 67, 113–118.
  • Millán, J., et al., 2009. Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention. Vascular health and risk management, 5, 757.
  • Misra, H.P., and Fridovich, I., 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of biological chemistry, 247 (10), 3170–3175.
  • Obafemi, T.O., Olaleye, M.T., and Akinmoladun, A.C., 2019. Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate metabolizing enzymes. Journal of ethnopharmacology, 244, 112124.
  • Odbayar, T.-O., et al., 2006. Comparative studies of some phenolic compounds (quercetin, rutin, and ferulic acid) affecting hepatic fatty acid synthesis in mice. Journal of agricultural and food chemistry, 54, 8261–8265.
  • Ogurtsova, K., et al., 2017. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes research and clinical practice, 128, 40–50.
  • Papanas, N., and Maltezos, E., 2009. Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering? Current pharmaceutical design, 15, 3179–3192.
  • Podder, P.S., et al., 2018. Preclinical study on cardioprotective effect of ethanolic extract of Eucalyptus globulus against doxorubicin induced cardiotoxicity. International journal of herbal medicine, 6, 35–39.
  • Rastaldo, R., et al., 2007. Nitric oxide card. Functional life sciences, 81, 779–793.
  • Sen, S., Chakraborty, R., and De, B., 2011. Challenges and opportunities in the advancement of herbal medicine: India’s position and role in a global context. Journal of herbal medicine, 1 (3–4), 67–75.
  • Sharma, S., Jackson, P.G., and Makan, J., 2004. Cardiac troponins. Journal of clinical pathology, 57 (10), 1025–1026.
  • Taur, D., Kulkarni, V., and Patil, R., 2010. Chromatographic evaluation and anthelmintic activity of Eucalyptus globulus oil. Pharmacognosy research, 2, 125.
  • Tesfaye, A., Makonnen, E., and Gedamu, S., 2016. Hypoglycemic and antihyperglycemic activity of aqueous extract of Justicia schimperiana leaves in normal and streptozotocin-induced diabetic mice. International journal of pharma sciences and research, 7, 107–113.
  • Varshney, R., and Kale, R.K., 1990. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. International journal of radiation biology, 58, 733–743.
  • Williams, L.J., Nye, B.G., and Wende, A.R., 2017. Diabetes-related cardiac dysfunction. Endocrinology and metabolism, 32, 171.
  • Wilson, R.D., and Islam, M.S., 2012. Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Pharmacological reports, 64 (1), 129–139.
  • Zhang, Y., et al., 2016. Antidiabetic and antihyperlipidemic activities of Forsythia suspensa (Thunb.) Vahl (fruit) in streptozotocin-induced diabetes mice. Journal of ethnopharmacology, 192, 256–263.
  • Zofou, D., et al., 2011. In vitro antiplasmodial activity and cytotoxicity of extracts of selected medicinal plants used by traditional healers of Western Cameroon. Malaria research and treatment, 2011, 561342.

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