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Original Article

Non-adherence to non-insulin glucose-lowering drugs: Prevalence, predictors and impact on glycemic control and insulin initiation. A longitudinal cohort study in a large primary care database in Spain

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Article: 2268838 | Received 12 Nov 2022, Accepted 03 Oct 2023, Published online: 24 Oct 2023

References

  • IDF. International Diabetes Federation. 10th ed. Brussels, Belgium: IDF Diabetes Atlas; 2021. [cited 2023 Oct 4]. Available from: https://www.diabetesatlas.org.
  • Draznin B, Aroda VR, Bakris G, et al. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2022. Diabetes Care. 2022;45(Suppl 1):S125–s143. doi: 10.2337/dc22-S009.
  • De Geest S, Zullig LL, Dunbar-Jacob J, et al. ESPACOMP medication adherence reporting guideline (EMERGE). Ann Intern Med. 2018;169(1):30–35. doi: 10.7326/m18-0543.
  • Krass I, Schieback P, Dhippayom T. Adherence to diabetes medication: a systematic review. Diabet Med. 2015;32(6):725–737. doi: 10.1111/dme.12651.
  • Iglay K, Cartier SE, Rosen VM, et al. Meta-analysis of studies examining medication adherence, persistence, and discontinuation of oral antihyperglycemic agents in type 2 diabetes. Curr Med Res Opin. 2015;31(7):1283–1296. doi: 10.1185/03007995.2015.1053048.
  • Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med. 2006;166(17):1836–1841. doi: 10.1001/archinte.166.17.1836.
  • Brunton SA, Polonsky WH. Medication adherence in type 2 diabetes mellitus: real-world strategies for addressing a common problem. J Fam Pract. 2017;66(4 Suppl):S46–S51.
  • De León AC, Del Castillo Rodrí Guez JC, Coello SD, et al. Lifestyle and treatment adherence of type 2 diabetes mellitus people in the Canary Islands. Rev Esp Salud Publica. 2009;83(4):567–575.
  • Gutiérrez-Angulo ML, Lopetegi-Uranga P, Sánchez-Martín I, et al. Cumplimiento terapéutico en pacientes con hipertensión arterial y diabetes mellitus 2. Rev Calid Asist. 2012;27(2):72–77. doi: 10.1016/j.cali.2011.09.008.
  • López-Simarro F, Brotons C, Moral I, et al. Inertia and therapeutic compliance in patients with type 2 diabetes mellitus in primary care. Med Clin. 2012;138(9):377–384. doi: 10.1016/j.medcli.2011.07.023.
  • Márquez Contreras E, Martell Claros N, Gil Guillén V, et al. Therapeutic compliance with insulin in the treatment of type 2 diabetes mellitus: CUMINDIAB study. Aten Primaria. 2012;44(2):74–81. doi: 10.1016/j.aprim.2010.11.013.
  • Piñeiro F, Gil V, Donis M, et al. Relationship between medical treatment compliance and the degree of control in patients with high blood pressure, non-insulin dependent diabetes mellitus and dyslipidemia. Med Clin. 1998;111(15):565–567.
  • Capoccia K, Odegard PS, Letassy N. Medication adherence with diabetes medication: a systematic review of the literature. Diabetes Educ. 2016;42(1):34–71. doi: 10.1177/0145721715619038.
  • Peh KQE, Kwan YH, Goh H, et al. An adaptable framework for factors contributing to medication adherence: results from a systematic review of 102 conceptual frameworks. J Gen Intern Med. 2021;36(9):2784–2795. doi: 10.1007/s11606-021-06648-1.
  • Barba EL, Mijares AH, Moreno FA, et al. Medication adherence and persistance in type 2 diabetes mellitus (T2dm): patients perspective in the Spanish health care system. Value Health. 2016;19(7):A351.
  • Gomez-Peralta F, Fornos Pérez JA, Molinero A, et al. Adherence to antidiabetic treatment and impaired hypoglycemia awareness in type 2 diabetes mellitus assessed in Spanish community pharmacies: the ADHIFAC study. BMJ Open Diabetes Res Care. 2021;9(2):e002148. doi: 10.1136/bmjdrc-2021-002148.
  • Llorca CV, Cortés Castell E, Ribera Casado JM, et al. Factors associated with non-adherence to drugs in patients with chronic diseases who go to pharmacies in Spain. Int J Environ Res Public Health. 2021;18(8):4308. doi: 10.3390/ijerph18084308.
  • Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004;27(5):1218–1224. doi: 10.2337/diacare.27.5.1218.
  • Duque I, Domínguez-Berjón MF, Cebrecos A, et al. Deprivation index by enumeration district in Spain, 2011. Gac Sanit. 2021;35(2):113–122. doi: 10.1016/j.gaceta.2019.10.008.
  • Akaike H. Information theory and the maximum likelihood principle. In: Petrov BN, Csäki F, editors. 2nd International Symposium on information theory. Budapest: akailseoniai-Kiudo.
  • Schwarz G. Estimating the dimension of a model. Ann. Statist. 1978;6(2):461–464. doi: 10.1214/aos/1176344136.
  • Rubin DB. Multiple imputation for survey nonresponse. New York: John Wiley and Son; 1987.
  • Wood AM, White IR, Royston P. How should variable selection be performed with multiply imputed data? Stat Med. 2008;27(17):3227–3246. doi: 10.1002/sim.3177.
  • Brier GW. Verification of forecasts expressed in terms of probability. Mon Wea Rev. 1950;78(1):1–3. doi: 10.1175/1520-0493(1950)078<0001:VOFEIT>2.0.CO;2.
  • Steyerberg EW, Vickers AJ, Cook NR, et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology. 2010;21(1):128–138. doi: 10.1097/EDE.0b013e3181c30fb2.
  • Moreno Juste A, Gimeno Miguel A, Poblador Plou B, et al. Adherence to treatment of hypertension, hypercholesterolaemia and diabetes in an elderly population of a Spanish cohort. Med Clin. 2019;153(1):1–5. doi: 10.1016/j.medcli.2018.10.023.
  • Farmer AJ, Rodgers LR, Lonergan M, et al. Adherence to oral glucose-Lowering therapies and associations with 1-year HbA1c: a retrospective cohort analysis in a large primary care database. Diabetes Care. 2016;39(2):258–263. doi: 10.2337/dc15-1194.
  • McGovern A, Tippu Z, Hinton W, et al. Comparison of medication adherence and persistence in type 2 diabetes: a systematic review and meta-analysis. Diabetes Obes Metab. 2018;20(4):1040–1043. doi: 10.1111/dom.13160.
  • Ogundipe O, Mazidi M, Chin KL, et al. Real-world adherence, persistence, and in-class switching during use of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis involving 594,138 patients with type 2 diabetes. Acta Diabetol. 2021;58(1):39–46. doi: 10.1007/s00592-020-01590-w.
  • Vlacho B, Mata-Cases M, Mundet-Tudurí X, et al. Analysis of the adherence and safety of second oral glucose-lowering therapy in routine practice from the Mediterranean area: a retrospective cohort study. Front Endocrinol. 2021;12:708372. doi: 10.3389/fendo.2021.708372.
  • Dankers M, Nelissen-Vrancken M, Hart BH, et al. Alignment between outcomes and minimal clinically important differences in the Dutch type 2 diabetes mellitus guideline and healthcare professionals’ preferences. Pharmacol Res Perspect. 2021;9(3):e00750. doi: 10.1002/prp2.750.
  • Monami M, Liistro F, Scatena A, et al. Short and medium-term efficacy of sodium glucose co-transporter-2 (SGLT-2) inhibitors: a meta-analysis of randomized clinical trials. Diabetes Obes Metab. 2018;20(5):1213–1222. doi: 10.1111/dom.13221.
  • McSharry J, McGowan L, Farmer AJ, et al. Perceptions and experiences of taking oral medications for the treatment of type 2 diabetes mellitus: a systematic review and meta-synthesis of qualitative studies. Diabet Med. 2016;33(10):1330–1338. doi: 10.1111/dme.13152.
  • Shields BM, Hattersley AT, Farmer AJ. Identifying routine clinical predictors of non-adherence to second-line therapies in type 2 diabetes: a retrospective cohort analysis in a large primary care database. Diabetes Obes Metab. 2020;22(1):59–65. doi: 10.1111/dom.13865.
  • Clifford S, Perez-Nieves M, Skalicky AM, et al. A systematic literature review of methodologies used to assess medication adherence in patients with diabetes. Curr Med Res Opin. 2014;30(6):1071–1085. doi: 10.1185/03007995.2014.884491.