References
- Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, et al. Vision loss expert group of the global burden of disease study. Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. Lancet Glob Health. 2017;5(12):e1221–e1234. doi:https://doi.org/10.1016/S2214-109X(17)30393-5.
- Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond). 2015;2:17. doi:https://doi.org/10.1186/s40662-015-0026-2.
- Li Y, Wu QH, Jiao ML, Fan XH, Hu Q, Hao YH, Liu RH, Zhang W, Cui Y, Han LY. Gene-environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy. J Diabetes Investig. 2015;6(1):56–66. doi:https://doi.org/10.1111/jdi.12249.
- Zietz B, Buechler C, Kobuch K, Neumeier M, Schölmerich J, Schäffler A. Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes. 2008;116(9):532–36. doi:https://doi.org/10.1055/s-2008-1058086.
- Siasos G, Gouliopoulos N, Moschos MM, Oikonomou E, Kollia C, Konsola T, Athanasiou D, Siasou G, Mourouzis K, Zisimos K, et al. Role of endothelial dysfunction and arterial stiffness in the development of diabetic retinopathy. Diabetes Care. 2015;38:9–10.
- Gouliopoulos N, Antonopoulos AS, Siasos G, Moschos MM, Oikonomou E, Kassi E, Tousoulis D. Macrovascular function indices for the prediction of diabetic retinopathy development in patients with type 2 diabetes. Eur J Prev Cardiol. 2017;24:1405–07. doi:https://doi.org/10.1177/2047487317717823.
- Kollia C, Antonopoulos AS, Siasos G, Konsola T, Oikonomou E, Gouliopoulos N, Tsigkou V, Papapanagiotou A, Kassi E, Tentolouris N, et al. Associations between adiponectin gene variability, proinflammatory and angiogenetic markers: implications for microvascular disease development in type 2 diabetes mellitus? Curr Vasc Pharmacol. 2019;17(2):204–08. doi:https://doi.org/10.2174/1570161116666180108113825.
- Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun. 1996;221(2):286–89. doi:https://doi.org/10.1006/bbrc.1996.0587.
- Martinez-Huenchullan SF, Tam CS, Ban LA, Ehrenfeld-Slater P, Mclennan SV, Twigg SM. Skeletal muscle adiponectin induction in obesity and exercise. Metabolism. 2020;102:154008. doi:https://doi.org/10.1016/j.metabol.2019.154008.
- Antoniades C, Antonopoulos AS, Tousoulis D, Stefanadis C. Adiponectin: from obesity to cardiovascular disease. Obes Rev. 2009;10(3):269–79. doi:https://doi.org/10.1111/j.1467-789X.2009.00571.x.
- Antonopoulos AS, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, Psarros C, Nasrallah H, Coutinho P, Akoumianakis I, et al. Mutual regulation of epicardial adipose tissue and myocardial redox state by PPAR-γ/adiponectin signalling. Circ Res. 2016;118(5):842–55. doi:https://doi.org/10.1161/CIRCRESAHA.115.307856.
- Sikka R, Raina P, Matharoo K, Bandesh K, Bhatia R, Chakrabarti S, Bhanwer AJ. TNF-α (g.-308 G > A) and ADIPOQ (g. + 45 T > G) gene polymorphisms in type 2 diabetes and microvascular complications in the region of Punjab (North-West India). Curr Eye Res. 2014;39(10):1042–51. doi:https://doi.org/10.3109/02713683.2014.892998.
- Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, Kumada M, Hotta K, Nishida M, Takahashi M, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105(24):2893–98. doi:https://doi.org/10.1161/01.CIR.0000018622.84402.FF.
- Gouliopoulos NS, Kalogeropoulos C, Lavaris A, Rouvas A, Asproudis I, Garmpi A, Damaskos C, Garmpis N, Kostakis A, Moschos MM. Association of serum inflammatory markers and diabetic retinopathy: a review of literature. Eur Rev Med Pharmacol Sci. 2018;22:7113–28. doi:https://doi.org/10.26355/eurrev_201811_16243.
- Frystyk J, Tarnow L, Hansen TK, Parving HH, Flyvbjerg A. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia. 2005;48(9):1911–18. doi:https://doi.org/10.1007/s00125-005-1850-z.
- Nishimura M, Hashimoto T, Kobayashi H, Fukukda T, Okino K, Yamamoto N, Nakamura N, Yoshikawa T, Takahashi H, Ono T. Possible involvement of TNF-alpha in left ventricular remodeling in hemodialysis patients. J Nephrol. 2003;16(5):641–49.
- Satoh J, Yagihashi S, Toyota T. The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy. Exp Diabesity Res. 2003;4(2):65–71. doi:https://doi.org/10.1155/EDR.2003.65.
- Fu Z, Gong Y, Löfqvist C, Hellström A, Smith LE. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016;1862(8):1392–400. doi:https://doi.org/10.1016/j.bbadis.2016.05.002.
- Antonopoulos AS, Margaritis M, Coutinho P, Shirodaria C, Psarros C, Herdman L, Sanna F, De Silva R, Petrou M, Sayeed R, et al. Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes. 2015;64(6):2207–19. doi:https://doi.org/10.2337/db14-1011.
- Choe EY, Wang HJ, Kwon O, Kim KJ, Kim BS, Lee BW, Ahn CW, Cha BS, Lee HC, Kang ES, et al. Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes. Metabolism. 2013;62(5):677–85. doi:https://doi.org/10.1016/j.metabol.2012.11.005.
- Macías-Gómez NM, Hernández-Terrones MC, Ramírez-Guerrero AA, Leal-Ugarte E, Gutiérrez-Angulo M, Peregrina-Sandoval J. ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population. PLoS One. 2019;14(3):e0214080. doi:https://doi.org/10.1371/journal.pone.0214080.
- Yoshioka K, Yoshida T, Takakura Y, Umekawa T, Kogure A, Toda H, Yoshikawa T. Adiponectin gene polymorphism (G276T) and diabetic retinopathy in Japanese patients with Type 2 diabetes. Diabet Med. 2004;21(10):1158–59. doi:https://doi.org/10.1111/j.1464-5491.2004.01308.x.
- Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Leprêtre F, Dupont S, et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 2002;11(21):2607–14. doi:https://doi.org/10.1093/hmg/11.21.2607.
- Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 2002;51(2):536–40. doi:https://doi.org/10.2337/diabetes.51.2.536.
- Wassel CL, Pankow JS, Jacobs DR Jr, Steffes MW, Li N, Schreiner PJ. Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) study. Obesity (Silver Spring). 2010;18(12):2333–38. doi:https://doi.org/10.1038/oby.2010.85.
- Antonopoulos AS, Tousoulis D, Antoniades C, Miliou A, Hatzis G, Papageorgiou N, Demosthenous M, Tentolouris C, Stefanadis C. Genetic variability on adiponectin gene affects myocardial infarction risk: the role of endothelial dysfunction. Int J Cardiol. 2013;168(1):326–30. doi:https://doi.org/10.1016/j.ijcard.2012.09.053.
- Obeid S, Hebbard L. Role of adiponectin and its receptors in cancer. Cancer Biol Med. 2012;9(4):213–20. doi:https://doi.org/10.7497/j.2095-3941.2012.04.001.
- Sonmez B, Seker M, Bilici A, Yavuz Erkal F, Oven Ustaalioglu BB, Gumus M, Ozturk Guler D, Karaduman M, Gezen C, Eser M, et al. Is there any correlation among adiponectin levels in serum, tumor tissue and normal tissue of the same patients with breast cancer? J BUON 2011;16:227–32.
- Hou WK, Xu YX, Yu T, Zhang L, Zhang WW, Fu CL, Sun Y, Wu Q, Chen L. Adipocytokines and breast cancer risk. Chin Med J (Engl). 2007;120(18):1592–96. doi:https://doi.org/10.1097/00029330-200709020-00009.
- Katira A, Tan PH. Evolving role of adiponectin in cancer-controversies and update. Cancer Biol Med. 2016;13(1):101–19. doi:https://doi.org/10.20892/j.2095-3941.2015.0092.
- Housa D, Housová J, Vernerová Z, Haluzík M. Adipocytokines and cancer. Physiol Res. 2006;55(3):233–44.
- Panno ML, Naimo GD, Spina E, Andò S, Mauro L. Different molecular signaling sustaining adiponectin action in breast cancer. Curr Opin Pharmacol. 2016;31:1–7. doi:https://doi.org/10.1016/j.coph.2016.08.001.
- Tahergorabi Z, Khazaei M, Moodi M, Chamani E. From obesity to cancer: a review on proposed mechanisms. Cell Biochem Funct. 2016;34(8):533–45. doi:https://doi.org/10.1002/cbf.3229.
- Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: a systematic review. Br J Cancer. 2006;94(9):1221–25. doi:https://doi.org/10.1038/sj.bjc.6603051.
- American Diabetes Association. Standards of medical care in diabetes—2014. Diabetes Care. 2014;37(suppl 1):S14–S80. doi:https://doi.org/10.2337/dc14-S014.
- Jerums G, Panagiotopoulos S, Premaratne E, MacIsaac RJ. Integrating albuminuria and GFR in the assessment of diabetic nephropathy. Nat Rev Nephrol. 2009;5(7):397–406. doi:https://doi.org/10.1038/nrneph.2009.91.
- Gouliopoulos N, Siasos G, Moschos MM, Oikonomou E, Rouvas A, Bletsa E, Stampouloglou P, Siasou G, Paraskevopoulos T, Vlasis K, et al. Endothelial dysfunction and impaired arterial wall properties in patients with retinal vein occlusion. Vasc Med. 2020;25(4):302–08. doi:https://doi.org/10.1177/1358863X20913609.
- Xie J, Fenwick EK, Taouk Y, Nicolaou TE, Wang JJ, Wong TY, Lamoureux EL . Relative importance and contribution of risk factors for diabetic retinopathy and macular edema. J Diabetes Metab. 2014;5:2.
- Looker HC, Nelson RG, Chew E, Klein R, Klein BE, Knowler WC, Hanson RL . Genome-wide linkage analyses to identify loci for diabetic retinopathy. Diabetes. 2007;56:1160–66.
- Hietala K, Forsblom C, Summanen P, Groop PH; FinnDiane Study Group. Heritability of proliferative diabetic retinopathy. Diabetes. 2008;57:2176–80.
- Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, et al. Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci. 2008;49(9):3839–45. doi:https://doi.org/10.1167/iovs.07-1633.
- Gouliopoulos N, Siasos G, Oikonomou D, Oikonomou E, Konsola T, Kollia C, Athanasiou D, Dimitropoulos S, Rouvas A, Kassi E, et al. The association of T786C and G894T polymorphisms of eNOS gene with diabetic retinopathy in Greece. Eur J Ophthalmol. 2021 November. doi:https://doi.org/10.1177/11206721211054724.
- Sharma A, Valle ML, Beveridge C, Liu Y, Sharma S. Unraveling the role of genetics in the pathogenesis of diabetic retinopathy. Eye (Lond). 2019;33(4):534–41. doi:https://doi.org/10.1038/s41433-019-0337-y.
- Zhao N, Li N, Zhang S, Ma Q, Ma C, Yang X, Yin J, Zhang R, Li J, Yang X, et al. Associations between two common single nucleotide polymorphisms (rs2241766 and rs1501299) of ADIPOQ gene and coronary artery disease in type 2 diabetic patients: a systematic review and meta-analysis. Oncotarget. 2017;8(31):51994–2005. doi:https://doi.org/10.18632/oncotarget.18317.
- Jang Y, Lee JH, Kim OY, Koh SJ, Chae JS, Woo JH, Cho H, Lee JE, Ordovas JM. The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism. 2006;55(1):59–66. doi:https://doi.org/10.1016/j.metabol.2005.07.007.