47
Views
10
CrossRef citations to date
0
Altmetric
Articles

Methylenetetrahydrofolate Reductase Genetic Polymorphisms in Patients with Primary Open-Angle Glaucoma

, , , , , & show all
Pages 47-50 | Received 29 Nov 2006, Accepted 27 Feb 2007, Published online: 08 Jul 2009

REFERENCES

  • Quigley H A. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996; 80: 389–393
  • Cioffi G A, Wang L. Optic nerve blood flow in glaucoma. Semin Ophthalmol. 1999; 14: 164–170
  • Flammer J, Orgul S, Costa V P. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002; 21: 359–393
  • Hayreh S S. Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res. 2001; 20: 595–624
  • Clarke R, Daly L, Robinson K. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991; 324: 1149–1155
  • McCully K S. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969; 56: 111–128
  • Perry I J, Refsum H, Morris R W. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995; 346: 1395–1398
  • Stampfer M J, Malinow M R, Willett W C. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992; 268: 877–881
  • Chua B, Kifley A, Wong T Y, Mitchell P. Homocysteine and retinal vein occlusion: a population-based study. Am J Ophthalmol. 2005; 139: 181–182
  • Weger M, Stanger O, Deutschmann H. The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677 T mutation in patients with retinal artery occlusion. Am J Ophthalmol. 2002; 134: 57–61
  • Vine A K. Hyperhomocysteinemia: a new risk factor for central retinal vein occlusion. Trans Am Ophthalmol Soc. 2000; 98: 493–503
  • Bleich S, Junemann A, von Ahsen N. Homocysteine and risk of open-angle glaucoma. J Neural Transm. 2002; 109: 1499–1504
  • Vessani R M, Ritch R, Liebmann J M, Jofe M. Plasma homocysteine is elevated in patients with exfoliation syndrome. Am J Ophthalmol. 2003; 136: 41–46
  • Bleich S, Roedl J, Von Ahsen N. Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma. Am J Ophthalmol. 2004; 138: 162–164
  • Frosst P, Blom H J, Milos R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995; 10: 111–113
  • van der Put N M, Gabreels F, Stevens E M. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet. 1998; 62: 1044–1051
  • Chango A, Boisson F, Barbe F. The effect of 677C– > T and 1298A– > C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects. Br J Nutr. 2000; 83: 593–596
  • Weisberg I, Tran P, Christensen B. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998; 64: 169–172
  • Friso S, Girelli D, Trabetti E. A1298 C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677 T polymorphism and homocysteine/folate metabolism. Clin Exp Med. 2002; 2: 7–12
  • Zetterberg H, Coppola A, D'Angelo A. No association between the MTHFR A1298 C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. Thromb Res. 2002; 108: 127–131
  • Fingert J H, Kwon Y H, Moore P A. The C677 T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa. Ophthalmic Genet. 2006; 27: 39–41
  • Junemann A G, von Ahsen N, Reulbach U. C677 T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma. Am J Ophthalmol. 2005; 139: 721–723
  • Mossbock G, Weger M, Faschinger C. Methylenetetrahydrofolatereductase (MTHFR) 677C > T polymorphism and open angle glaucoma. Mol Vis. 2006; 12: 356–359
  • Mabuchi F, Tang S, Kashiwagi K. Methylenetetrahydrofolate reductase gene polymorphisms c.677 C/T and c.1298 A/C are not associated with open angle glaucoma. Mol Vis. 2006; 12: 735–739
  • Zetterberg H, Regland B, Palmer M. Increased frequency of combined methylenetetrahydrofolate reductase C677 T and A1298 C mutated alleles in spontaneously aborted embryos. Eur J Hum Genet. 2002; 10: 113–118
  • Altman D G. Practical statistics for medical research. Chapman and Hall/CRC, London 1991; 588
  • Botto L D, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000; 151: 862–877
  • Copin B, Brezin A P, Valtot F. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Am J Hum Genet. 2002; 70: 1575–1581
  • Fingert J H, Heon E, Liebmann J M. Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum Mol Genet. 1999; 8: 899–905
  • Rezaie T, Child A, Hitchings R. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science. 2002; 295: 1077–1079
  • Pianka P, Almog Y, Man O. Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology. 2000; 107: 1588–1592
  • Leblhuber F, Walli J, Artner-Dworzak E. Hyperhomocysteinemia in dementia. J Neural Transm. 2000; 107: 1469–1474
  • Seshadri S, Beiser A, Selhub J. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002; 346: 476–483
  • Bayer A U, Ferrari F, Erb C. High occurrence rate of glaucoma among patients with Alzheimer's disease. Eur Neurol. 2002; 47: 165–168
  • Bayer A U, Keller O N, Ferrari F, Maag K P. Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer's disease and Parkinson's disease. Am J Ophthalmol. 2002; 133: 135–137
  • Moore P, El-sherbeny A, Roon P. Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine. Exp Eye Res. 2001; 73: 45–57
  • Zetterberg M, Tasa G, Prince J A. Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract. Am J Ophthalmol. 2005; 140: 932–934
  • Turacli M E, Tekeli O, Ozdemir F, Akar N. Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation. Clin Experiment Ophthalmol. 2005; 33: 505–508

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.