Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

References

• Baumann B, Bohnenstengel F, Siegmund D, Wajant H, Weber C, Herr I, Debatin K-M, Proksch P, Wirth T (2002): Rocaglamide derivatives are potent inhibitors of NF-KB activation in T-cells. J Biol Chem 277: 44791–44800.
   PubMed Web of Science ®Google Scholar
• Beutler JA, Hamel E, Vlietinck AJ, Haemers A, Rajan P, Roitman JN, Cardellina II JH, Boyd MR (1998): Structure activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem 41: 2333–2338.
   PubMed Web of Science ®Google Scholar
• Beutler JA, McCall KL, Herbert K, Herald D, Pettit GR, Johnson T, Shoemaker RH, Boyd MR (2000): Novel cytotoxic diter-penes from Casearia arborea. J Nat Prod 63: 657–661.
   PubMed Web of Science ®Google Scholar
• Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM (2003): Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activ-ity against human and murine cancer cells in mice. Cancer Res 63: 1270–1279.
   PubMed Web of Science ®Google Scholar
• Braca A, Armenise A, Morelli I, Mendez J, Mi Q, Chai H-B, Swanson SM, Kinghorn AD, De Tommasi N (2004): Struc-ture of kaurene type diterpenes from Parinari sprucei and their in vitro and in vivo biological activity. Planta Med, in press.
   Google Scholar
• Burslem DFRP, Garwood NC, Thomas SC (2001): Tropical forest biodiversity - the plot thickens. Science 291: 606–607.
   PubMed Web of Science ®Google Scholar
• Calderon Al, Anderhofer CK, Pezzuto JM, Farnsworth NR, Foster R, Condit R, Gupta MP, Soejarto DD (2000): Forest plot as a tool to demonstrate the pharmaceutical potential of plants in a tropical forest of Panama. Econ Bot 54: 278–294.
   Google Scholar
• Casciari JJ, Hollingshead MG, Alley MC, Mayo JG, Malspeis L, Miyauchi S, Greyer MR, Weinstein JN (1994): Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model. J Natl Cancer Inst 86: 1846–1852.
   Google Scholar
• Cassinelli G, Geroni C, Botta B, Delle Monache G, Delle Monache F (1986): Cytotoxic and antitumor activity of vismiones isolated from Vismieae. J Nat Prod 49: 929–931.
   PubMed Web of Science ®Google Scholar
• Chavez D, Chai H-B, Chagwedera TE, Gao Q, Farnsworth NR, Cordell GA, Pezzuto TM, Kinghorn AD (2001): Novel stil-benes isolated from the root bark of Ekebergia benguelen-sis. Tetrahedron Lett 42: 3685–3888.
   Web of Science ®Google Scholar
• Chavez D, Cui B, Chai H-B, Garcia R, Mejia M, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2002): Reversal of multidrug resistance by tropane alkaloids from the stems of Erythroxylum rotundifolium. J Nat Prod 65: 606–610.
   PubMed Web of Science ®Google Scholar
• Constant HL, Beecher CWW (1995): A method for the derepli-cation of natural product extracts using electrospray HPLC/MS. Nat Prod Lett 6: 193–196.
   Web of Science ®Google Scholar
• Cordell GA, ShinYG (1999): Finding the needle in the haystack: the dereplication of natural product extracts. Pure Appl Chem 71: 1089–1094.
   Web of Science ®Google Scholar
• Cordell GA, Farnsworth NR, Beecher CWW, Soejarto DD, Kinghorn AD, Pezzuto TM, Wall ME, Wani MC, Brown DM, O'Neill MJ, Lewis JA, Tait RM, Harris TJR (1993): Novel strategies for the discovery of plant-derived anti-cancer agents. In: Kinghorn AD, Balandrin MF, Eds., Human Medicinal Agents from Plants, Symposium Series No. 534. American Chemical Society, Washington, DC, pp. 191–204.
   Google Scholar
• Cordell GA, Beecher CWW, Kinghorn AD, Pezzuto TM, Constant HL, Chai H-B, Fang L, Seo E-K, Long L, Cui B, Slowing-Barillas K (1997): The dereplication of natural products. In: A-ur-Rahman, ed. Studies in Natural Products Chemistry, vol. 19, Structure and Chemistry (Part E). Else-vier Scientific Publishers, Amsterdam, pp. 749–791.
   Google Scholar
• Cox PA (2000): Will tribal knowledge survive the millennium? Science 287: 44–45.
   Google Scholar
• Cragg GM, Newman DJ (2000): Antineoplastic agents from natural sources: achievements and future directions. Exp Opin Invest Drugs 9: 2783–2797.
   PubMed Web of Science ®Google Scholar
• Cragg GM, Newman DJ (2002): Chemical diversity: a function of biodiversity. Trends Pharmacol Sci 23: 404–405.
   PubMed Web of Science ®Google Scholar
• Cragg GM, Boyd MR, Hallock YF, Newman DJ, Sausville EA, Wolpert MK (2000): Natural products discovery at the National Cancer Institute. Past achievements and new directions for the new millennium. In: Special Publication 257 (Biodiversity: New Leads for the Pharmaceutical and Agrochemical Industries). London, Royal Society of Chemistry, pp. 22–44.
   Google Scholar
• Cui B, Lee YH, Chai H, Tucker JC, Fairchild CW, Raventos-Saurez C, Long B, Lane KE, Menendez AT, Beecher CWW, Cordell GA, Pezzuto JM, Kinghorn AD (1999): Cytotoxic sequiterpenoids from Ratibida columnifèra. J Nat Prod 62: 1545–1550.
   PubMed Web of Science ®Google Scholar
• Diaz F, Chavez D, Lee D, Mi Q, Chai H-B, Tan GT, Kardono LBS, Riswan S, Fairchild CR, Wild R, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2003): Cytotoxic analogs of vitexicarpin, a constituent of the leaves of Vitex negundo. J Nat Prod 66: 865–867.
   PubMed Web of Science ®Google Scholar
• Diaz F, Chai H-B, Mi Q, Su B-N, Schunke Vigo J, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Pezzuto TM, Swanson SM, Kinghorn AD (2004): Anthrone and oxan-throne C-glycosides from the roots and leaves of Picram-nia latifolia collected in Peru. J Nat Prod 67: 352–356.
   PubMed Web of Science ®Google Scholar
• Govindachari TR, Visnanathan N, Pai BR (1974): Stereochem-istry of tylophorinidine and tylophorinine. Indian J Chem 12: 886–887.
   Google Scholar
• Graham JG, Quinn ML, Fabricant DS, Farnsworth NR (2000): Plants used against cancer - an extension of the work of Jonathan Hartwell. J Ethnopharmacol 73: 347–377.
   PubMed Web of Science ®Google Scholar
• Gu J-Q, Graf TN, Lee D, Chai H-B, Mi Q, Kardono LBS, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkingham III, JO, Wall ME, Wani MC, Kinghorn AD, Oberlies NH (2003): Variations in the cytotoxic and antimicrobial
   Google Scholar
• constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. 44th Annual Meeting of the American Society of Pharmacognosy, Chapel Hill, NC, July 12–16,2003, Abstract P–113.
   Google Scholar
• Hall, L-AM, Krauthauser CM, Wexler RS, Hollingshead MG, Slee AM, Kerr JS (2000): The hollow fiber assay: con-tinued characterization with novel approaches. Anticancer Res 20(2A): 903–911.
   Google Scholar
• Hollingshead MG, Alley MC, Camalier RF, Abbott BJ, Mayo JG, Malspeis L, Greyer MR (1995): In vivo cultivation of tumor cells in hollow fibers. Life Sci 57: 131–141.
   PubMed Web of Science ®Google Scholar
• Ito A, Chai H-B, Shin YG, Garcia R, Mejia M, Gao Q, Fairchild CR, Lane KE, Menendez AT, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2000): Cytotoxic constituents from the roots of Exostema acuminata. Tetrahedron 56: 6401–6405.
   Web of Science ®Google Scholar
• Ito A, Cui B, Chavez D, Chai H-B, Shin YG, Kawanishi K, Kardono LBS, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2001): Cytotoxic poly-acetylenes from the twigs of Ochanostachys amentacea. J Nat Prod 64: 246–248.
   PubMed Web of Science ®Google Scholar
• Ito A, Chai H-B, Lee D, Kardono LBS, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2002): Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeo-carpus mastersii. Phytochemistry 61: 171–174.
   PubMed Web of Science ®Google Scholar
• Itokawa H, Takeya K (1993): Antitumor substances from higher plants. Heterocycles 35: 1467–1501.
   Web of Science ®Google Scholar
• Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ (2003): Cancer statistics, 2003. CA Cancer J Clin 53: 5–26.
   Google Scholar
• Jones WP, Chai H-B, Mi Q, Farnsworth NR, Cordell GA, Swanson SM, Kinghorn AD (2003): Dereplication of plant extracts in natural product anticancer drug discovery. 44th Annual Meeting of the American Society of Pharmacog-nosy, Chapel Hill, NC, July 12–16, 2003, Abstract P–231.
   Google Scholar
• Kinghorn AD, Farnsworth NR, Beecher CWW, Soejarto DD, Cordell GA, Pezzuto TM, Wall ME, Wani MC, Brown DM, O'Neill MJ, Lewis JA, Besterman JM (1995): Novel strate-gies for plant-derived anticancer agents. Int J Pharmacog 33 (Suppl): 48–58.
   Google Scholar
• Kinghorn AD, Farnsworth NR, Beecher CWW, Soejarto DD, Cordell GA, Pezzuto TM, Wall ME, Wani MC, Brown DM, O'Neill MJ, Lewis JA, Besterman JM (1998): Novel strate-gies for the discovery of plant-derived anticancer agents. In: A-ur-Rahman, Choudhary MI, Eds. New Trends in Natural Products Chemistry. Amsterdam, Harwood Acad-emic Publishers, pp. 79–94.
   Google Scholar
• Kinghorn AD, Farnsworth NR, Soejarto DD, Cordell GA, Pezzuto TM, Udeani GO, Wani MC, Wall ME, Navarro HA, Kramer RA, Menendez AT, Fairchild CR, Lane KE, Forenza S, Vyas DM, Lam KS, Shu Y-Z (1999): Novel strategies for the discovery of plant-derived anticancer agents. Pure Appl Chem 71: 1611–1618.
   Google Scholar
• Ko WG, Kang TH, Lee SJ, Kim NY, Sohn DH, Lee BH (2000): Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem Toxicol 38: 861–865.
   PubMed Web of Science ®Google Scholar
• Lee I-S, Shamon LA, Chai H-B, Chagwedera TE, Besterman JM, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (1996): Cell-cycle cytotoxicity mediated by rearranged ent-kaurene diterpenoids isolated from Parinari cutatelli-folia. Chem-Biol Interactions 99: 193–204.
   PubMed Web of Science ®Google Scholar
• Lee J-H, Koo TH, Hwang BY, Lee JJ (2002): Kaurene diterpene, kamebakaurin, inhibits NF-KB by directly targeting the DNA-binding activity of p50 and blocks expression of antiapoptotic NF-KB target genes. J Biol Chem 277: 18411–18420.
   PubMed Web of Science ®Google Scholar
• Lee J-S, Paull K, Alvarez M, Hose C, Monks A, Greyer M, Tito Fojo A, Bates SE (1994): Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen. Mol Pharmacol 46: 627–638.
   PubMed Web of Science ®Google Scholar
• Li Y, Sun X, LaMont JT, Pardee AB, Li CJ (2003): Selective killing of cancer cells by fl-lapachone: direct checkpoint activation as a strategy against cancer. Proc Nall Acad Sci USA 100: 2674–2678.
   PubMed Web of Science ®Google Scholar
• Lobo-Echeverri T, Chai H-B, Rivero-Cruz F, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD, Soejarto DD (2003): Biodiversity-based plot inventory in the search for anticancer leads. 44th Annual Meeting of the American Society of Pharmacognosy, Chapel Hill, NC, July 12–16, 2003, Abstract P–10.
   Google Scholar
• Mann J (2002): Natural products in cancer chemotherapy: past, present and future. Nature Rev Cancer 2: 143–148.
   PubMed Web of Science ®Google Scholar
• Marko D, Schätzle S, Friedel A, Genzlinger A, Zankl H, Meijer L, Eisenbrand G (2001): Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells. Br J Cancer 84: 283–289.
   PubMed Web of Science ®Google Scholar
• Mi Q, Cui B, Silva GL, Lantvit D, Lim E, Chai H, You M, Hollingshead MG, Mayo JG, Kinghorn AD, Pezzuto JM (2001): Pervilleine A, a novel tropane alkaloid that reverses the multidrug-resistance phenotype. Cancer Res 61: 4030–4037.
   PubMed Web of Science ®Google Scholar
• Mi Q, Cui B, Chavez D, Chai H, Zhu H, Cordell GA, Hedayat S, Kinghorn AD, Pezzuto JM (2002a): Characterization of tropane alkaloid aromatic esters that reverse the mul-tidrug-resistance phenotype. Anticancer Res 22: 1385–1398.
   PubMed Web of Science ®Google Scholar
• Mi Q, Cui B, Silva GL, Lantvit D, Lim E, Chai H, Hollingshead MG, Mayo JG, Kinghorn AD, Pezzuto TM (2002b): Pervilleines B and C, new tropane alkaloid aromatic alkaloid esters that reverse the multidrug-resistance in the hollow fiber assay. Cancer Lett 184: 13–20.
   PubMed Web of Science ®Google Scholar
• Mi Q, Lantvit D, Reyes-Lim E, Chai H, Zhao W, Lee I-S, Peraza-Sanchez SR, Ngassapa O, Kardono LBS, Riswan S, Hollingshead MG, Mayo JG, Farnsworth NR, Cordell GA, Kinghorn AD, Pezzuto JM (2002c): Evaluation of the cancer chemotherapeutic efficacy of natural products employing in vivo hollow fiber tests. J Nat Prod 65: 842–850.
   PubMed Web of Science ®Google Scholar
• Mi Q, Cui B, Lantvit D, Reyes-Lim E, Chai H, Pezzuto JM, Kinghorn AD, Swanson SM (2003): Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance. Anticancer Res 23: 3607–3616.
   PubMed Web of Science ®Google Scholar
• Myers N, Mittermeier RA, Mittermeier CG, Da Fonseca GAB, Kent J (2000): Biodiversity hotspots for conservation priorities. Nature (Lond) 403: 853–858.
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM, Snader KM (2000): The influence of natural products upon drug discovery. Nat Prod Rep 17: 215–234.
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM, Holbeck S, Sausville EA (2002): Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy. Curr Cancer Drug Targets 2: 279–308.
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM, Snader KM (2003): Natural products as sources of new drugs over the period 1981–2002. J Nat Prod 66: 1022–1037.
   Google Scholar
• Oberlies NH, Burgess JP, Navarro HA, Pinos RE, Soejarto DD, Farnsworth NR, Kinghorn AD, Wani MC, Wall ME (2001): Bioactive constituents of the roots of Licania intrapetio-laris. J Nat Prod 64: 497–501.
   PubMed Web of Science ®Google Scholar
• Oberlies NH, Burgess JP, Navarro HA, Pinos RE, Fairchild CR, Peterson RW, Soejarto DD, Farnsworth NR, Kinghorn AD, Wani MC, Wall ME (2002): Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris. J Nat Prod 65: 95–99.
   PubMed Web of Science ®Google Scholar
• Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T (2002): New diterpenes and norditerpenes from fruits of Vitex rotundi-folia. J Nat Prod 65: 537–541.
   PubMed Web of Science ®Google Scholar
• Panthong A, Kanjanapothi D, Taylor WC (1986): Ethriobotani-cal review of medicinal plants from Thai traditional books. Part I. Plants with anti-inflammatory, antiasthmatic, and antihypertensive properties. J Ethnopharmacol 18: 213–228.
   Google Scholar
• Peraza-Sanchez SR, Chavez D, Chai H-B, Shin YG, Garcia R, Mejia M, Fairchild CR, Lane KE, Menendez AT, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2000): Cytotoxic constituents of the roots of Ekmanianthe longiflora. J Nat Prod 63: 492–495.
   PubMed Web of Science ®Google Scholar
• Peraza-Sanchez SR, Chai H-B, Shin YG, Santisuk T, Reutrakul V, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2002) Constituents of the leaves and twigs of Ficus hispida. Planta Med 68: 186–188.
   PubMed Web of Science ®Google Scholar
• Pisha E, Chai H, Lee I-S, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CWW, Fong HHS, Kinghorn AD, Brown DM, Wani MC, Wall ME, Heijken TJ, Das Gupta TK, Pezzuto JM (1995): Discovery of betulinic acid as a selective inhibitor of apoptosis that functions by induction of apoptosis. Nature Med 1: 1946–1051.
   Web of Science ®Google Scholar
• Pitman NCA, Jorgensen PM (2002): Estimating the size of the world's threatened flora. Science 298: 989.
   PubMed Web of Science ®Google Scholar
• Prakash CVS, Hoch TM, Kingston DGI (2002): Structure and stereochemistry of new cytotoxic diterpenoids from the bark of Casearia lucida from the Madagascar rainforest. J Nat Prod 65: 100–107.
   PubMed Web of Science ®Google Scholar
• Rao MM, Kingston DGI (1982): Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from Tabebuia cassinoides. J Nat Prod 45: 600–604.
   Google Scholar
• Rasmussen HB, Christensen SB, Kvist PK, Kharazmi A, Huansi AG (2000): Absolute configuration and antiprotozoal
   Google Scholar
• activity of minquartynoic acid. J Nat Prod 63: 1295-1296.
   Google Scholar
• Rose WC, Shurig JE, Meeker JB (1988): Correlation of in vitro cytotoxicity with preclinical in vivo antitumor activity. Anticancer Res 8: 355–367.
   PubMed Web of Science ®Google Scholar
• Rundle NT, Xu L, Andersen RJ, Roberge M (2001): G2 DNA damage checkpoint inhibition and antimitotic activity of 13 -hydroxy-15- oxozoapatlin. J Biol Chem 276: 48231–48236.
   Google Scholar
• Seo E-K, Kim N-C, Mi Q, Chai H, Wall ME, Wani MC, Navarro HA, Burgess JP, Graham JG, Cabieses F, Tan GT, Farnsworth NR, Pezzuto JM, Kinghorn AD (2001): Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum. J Nat Prod 64: 1483–1485.
   PubMed Web of Science ®Google Scholar
• Seo E-K, Kim N-C, Wani MC, Wall ME, Navarro HA, Burgess JP, Kawanishi K, Kardono LBS, Riswan S, Rose WC, Fairchild CR, Farnsworth NR, Kinghorn AD (2002): Cyto-toxic prenylated xanthones and the unusual compounds, anthraquinobenzophenones, from Cratoxylum sumatranum. J Nat Prod 65: 299–305.
   PubMed Web of Science ®Google Scholar
• Shen Z, Dong Z, Cheng P, Li L, Chen Z, Liu J (2003): Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. Planta Med 69: 605–609.
   PubMed Web of Science ®Google Scholar
• Shu Y-Z (1998): Recent natural products based drug develop-ment: a pharmaceutical industry perspective. J Nat Prod 61: 1053–1071.
   PubMed Web of Science ®Google Scholar
• Silva GL, Cui B, Chavez, You M, Chai H-B, Rasoanaivo P, Lynn SM, O'Neill MJ, Lewis JA, Besterman JM, Monks A, Farnsworth NR, Cordell GA, Pezzuto JM, Kinghorn AD (2001): Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei. J Nat Prod 64: 1514–1520.
   PubMed Web of Science ®Google Scholar
• Soejarto DD (2000): Forest plot as a tool in a biodiversity-based plant selection approach in a natural products drug discovery program. Adv Nat Sci (Hanoi) 1 (Suppl. 1): 9–15.
   Google Scholar
• Soejarto DD, Sorensen JAT, Gyllenhaal C, Cordell GA, Farnsworth NR, Fong HHS, Kinghorn AD, Pezzuto TM (2002): The evolution of the University of Illinois' policy of benefit-sharing in research on natural products. In: Stepp JR, Wyndham FS, Zarger RK, Eds., Ethnobiology and Bio-cultural Diversity. Proceedings of the Seventh International Congress on Ethnobiology. The International Society of Ethnobiology, University of Georgia Press, Athens, GA, pp. 21–30.
   Google Scholar
• Staerk D, Lykkeberg AK, Christensen J, Budnik BA, Abe F, Jaroszewski JW (2002): In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vince-toxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells. J Nat Prod 65: 1299–1302.
   PubMed Web of Science ®Google Scholar
• Su B-N, Park EJ, Mbwambo ZH, Santarsiero BD, Mesecar AD, Mehta RG, Fong MS, Pezzuto JM, Kinghorn AD (2002): New chemical constituents from Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. J Nat Prod 65: 1278–1282.
   PubMed Web of Science ®Google Scholar
• Suffness M, Cragg GM, Greyer MR, Grifo FJ, Johnson G, Mead JAR, Schepartz SA, Venditti JA, Wolpert M (1995): The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) and International Cooperative Biodi-versity Group (IGBG) Programs. Int J Pharmacog 33 (Suppl): 5–16.
   Google Scholar
• Tan YM, Yu R, Pezzuto JM (2003): Betulinic acid-induced pro-grammed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin Cancer Res 9: 2866–2875.
   PubMed Web of Science ®Google Scholar
• Tulp M, Bolhlin L (2002): Functional versus chemical diversity: is biodiversity important for drug discovery? Trends Phar-macol Sci 23: 225–231.
   PubMed Web of Science ®Google Scholar
• Wall ME (1998): Camptothecin and taxol: discovery to clinic. Med Res Rev 18: 299–314.
   PubMed Web of Science ®Google Scholar
• Wall ME, Wani MC (1996): Camptothecin and taxol: from dis-covery to clinic. J Ethnopharmacol 51: 239–254.
   PubMed Web of Science ®Google Scholar
• Wall ME, Wani MC, Brown DM, Fullas F, Oswald JB, Josephson FF, Thornton NM, Pezzuto JM, Beecher CWW, Farnsworth NR, Cordell GA, Kinghorn AD (1996): Effect of tarmins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal. Phytomedicine 3: 281–286.
   PubMed Web of Science ®Google Scholar
• Zamora JM, Pearce HL, Beck WJ (1988): Physical-chemical prop-erties shared by compounds that modulate multidrug resis-tance in human leukemic cells. Mol Pharmacol 33:454–462.
   PubMed Web of Science ®Google Scholar