Indirect modulation of the endocannabinoid system by specific fractions of nutmeg total extract

References

• Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, et al. 2012. Automated design of ligands to polypharmacological profiles. Nature. 492:215–220.
   PubMed Web of Science ®Google Scholar
• Beyer J, Ehlers D, Maurer HH. 2006. Abuse of nutmeg (Myristica fragrans Houtt.): studies on the metabolism and the toxicologic detection of its ingredients elemicin, myristicin, and safrole in rat and human urine using gas chromatography/mass spectrometry. Ther Drug Monit. 28:568–575.
   PubMed Web of Science ®Google Scholar
• Blankman JL, Cravatt BF. 2013. Chemical probes of endocannabinoid metabolism. Pharmacol Rev. 65:849–871.
   PubMed Web of Science ®Google Scholar
• Braun UKD. 1973. Evidence for the biogenic formation of amphetamine derivatives from components of nutmeg. Pharmacology. 9:312–316.
   PubMed Web of Science ®Google Scholar
• Cao GY, Xu W, Yang XW, Gonzalez FJ, Li F. 2015. New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. Food Chem. 173:231–237.
   PubMed Web of Science ®Google Scholar
• Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A. 2007. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet. 370:1706–1713.
   PubMed Web of Science ®Google Scholar
• Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, et al. 2010. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 13:1265–1270.
   PubMed Web of Science ®Google Scholar
• Cuong TD, Hung TM, Han HY, Roh HS, Seok JH, Lee JK, Jeong JY, Choi JS, Kim JA, Min BS. 2014. Potent acetylcholinesterase inhibitory compounds from Myristica fragrans. Nat Prod Commun. 9:499–502.
   PubMed Web of Science ®Google Scholar
• Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. 2005. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J. 22:223–225.
   PubMed Web of Science ®Google Scholar
• Dhingra D, Parle M, Kulkarni SK. 2006. Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice. J Med Food. 9:281–283.
   PubMed Web of Science ®Google Scholar
• Dhingra D, Sharma A. 2006. Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. J Med Food. 9:84–89.
   PubMed Web of Science ®Google Scholar
• Ehrenpreis JE, DesLauriers C, Lank P, Armstrong PK, Leikin JB. 2014. Nutmeg poisonings: a retrospective review of 10 years experience from the Illinois poison center, 2001-2011. J Med Toxicol. 10:148–151.
   PubMedGoogle Scholar
• El-Alfy AT, Wilson L, ElSohly MA, Abourashed EA. 2009. Towards a better understanding of the psychopharmacology of nutmeg: activities in the mouse tetrad assay. J Ethnopharmacol. 126:280–286.
   PubMed Web of Science ®Google Scholar
• Evans WC. 1996. Trease and Evans Pharmacognosy. 14th ed. Singapore: Harcourt Brace & Co. pp. 273.
   Google Scholar
• Forrester MB. 2005. Nutmeg intoxication in Texas, 1998–2004. Hum Exp Toxicol. 24:563–566.
   PubMed Web of Science ®Google Scholar
• Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. 2002. Pharmacological studies on Myristica fragrans–antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 24:675–680.
   PubMedGoogle Scholar
• Hayfaa AA, Sahar AM, Awatif MA. 2013. Evaluation of analgesic activity and toxicity of alkaloids in Myristica fragrans seeds in mice. J Pain Res. 6:611–615.
   PubMed Web of Science ®Google Scholar
• Kareem MA, Krushna GS, Hussain SA, Devi KL. 2009. Effect of aqueous extract of nutmeg on hyperglycemia, hyperlipidemia and cardiac histology associated with isoproterenol-induced myocardial infarction in rats. Tropical J Pharmaceut Res. 8:337–344.
   Web of Science ®Google Scholar
• Kasture SB, Gujar KN. 2005. Depressant effect of trimyristin and its inhibition by some antidepressant in mice. In: ISHS Acta Horticulturae 675: III WOCMAP Congress on Medicinal and Aromatic Plants – Volume 1: Bioprospecting and Ethnopharmacology. DOI: 10.17660/ActaHortic.2005.675.21.
   Google Scholar
• Khan IA, Abourashed EA. 2010. Nutmeg (and Mace). In: Khan IA, Abourashed EA, editors. Leung's encyclopedia of common natural ingredients used in food, drugs, and cosmetics. Hoboken (NJ): Wiley. pp. 467–470.
   Google Scholar
• Leiter E, Hitchcock G, Godwin S, Johnson M, Sedgwick W, Jones W, McCall S, Ceremuga TE. 2011. Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat. Aana J. 79:109–114.
   PubMedGoogle Scholar
• López V, Gerique J, Langa E, Berzosa C, Valero MS, Gómez-Rincón C. 2015. Antihelmintic effects of nutmeg (Myristica fragans) on Anisakis simplex L3 larvae obtained from Micromesistius potassou. Res Vet Sci. 100:148–155.
   PubMed Web of Science ®Google Scholar
• Mechoulam R, Parker LA. 2003. The endocannabinoid system and the brain. Annu Rev Psychol. 64:21–47.
   Web of Science ®Google Scholar
• Moinuddin G, Devi K, Kumar Khajuria D. 2012. Evaluation of the anti-depressant activity of Myristica fragrans (nutmeg) in male rats. Avicenna J Phytomed. 2:72–78.
   PubMedGoogle Scholar
• Moreira FA, Wotjak CT. 2010. Cannabinoids and anxiety. Curr Top Behav Neurosci. 2:429–425.
   PubMedGoogle Scholar
• Morita T, Jinno K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, Sugiyama K. 2003. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury. J Agric Food Chem. 51:1560–1565.
   PubMed Web of Science ®Google Scholar
• Nadkarni K. 1998. Indian Materia Medica. Mumbai (India): Bombay Popular Prakashan. p. 830.
   Google Scholar
• Nagaraju B, Sahar SH, Bolouri A, Neha KZ, Zahra A, Zothanmawia C, Surendranatha A. 2013. Anxiolytic effect of Myristica fragrans. Int J Phytother Res. 1:1–7.
   Google Scholar
• Ozaki Y, Soedigdo S, Wattimena YR, Suganda AG. 1989. Antiinflammatory effect of mace, aril of Myristica fragrans Houtt., and its active principles. Jpn J Pharmacol. 49:155–163.
   PubMedGoogle Scholar
• Sagar DR, Gaw AG, Okine BN, Woodhams SG, Wong A, Kendall DA, Chapman V. 2009. Dynamic regulation of the endocannabinoid system: implications for analgesia. Mol Pain. 5:1–13.
   PubMed Web of Science ®Google Scholar
• Sangalli BC, Chiang W. 2000. Toxicology of nutmeg abuse. J Toxicol Clin Toxicol. 38:671–678.
   PubMed Web of Science ®Google Scholar
• Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, Mikics E, Haller J, Yasar S, Tanda G, et al. 2008a. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. 54:129–140.
   PubMed Web of Science ®Google Scholar
• Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinova Z, Mikics E, Haller J, Medalie J, et al. 2008b. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3′-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. J Pharmacol Exp Ther. 327:482–490.
   PubMed Web of Science ®Google Scholar
• Servan J, Chochon F, Duclos H. 1998. Hallucinations after voluntary ingestion of nutmeg: an unrecognized drug abuse. Rev Neurol (Paris). 154:708.
   PubMed Web of Science ®Google Scholar
• Sharma PV. 2001. Dravyaguna Vijnana (vegetable drugs). Vol. 1. Varanasi (India): Chaukambha Bharti Academy. pp. 151–160.
   Google Scholar
• Shulgin AT. 1966. Possible implication of myristicin as a psychotropic substance. Nature. 210:380–384.
   PubMed Web of Science ®Google Scholar
• Sonavane GS, Sarveiya V, Kasture V, Kastre SB. 2001. Behavioral actions of Myristica fragrans seeds. Indian J Pharmacol. 33:417–424.
   Google Scholar
• Sonavane GS, Sarveiya VP, Kasture VS, Kasture SB. 2002. Anxiogenic activity of Myristica fragrans seeds. Pharmacol Biochem Behav. 71:239–244.
   PubMed Web of Science ®Google Scholar
• Stein U, Greyer H, Hentschel H. 2001. Nutmeg (myristicin) poisoning–report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int. 118:87–90.
   PubMed Web of Science ®Google Scholar
• Tajuddin Ahmad S, Latif A, Qasmi IA Amin KM. 2005. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med. 5:16–23.
   PubMedGoogle Scholar
• Takikawa A, Abe K, Yamamoto M, Ishimaru S, Yasui M, Okubo Y, Yokoigawa K. 2002. Antimicrobial activity of nutmeg against Escherichia coli O157. J Biosci Bioeng. 94:315–320.
   PubMed Web of Science ®Google Scholar
• Truitt EB, Duritz G, Ebersberger EM. 1963. Evidence of monoamine oxidase inhibition by myristicin and nutmeg. Proc Soc Exp Biol Med. 112:647–650.
   PubMed Web of Science ®Google Scholar
• Truitt EB, Callaway E, Braude MC, Krantz JC. 1961. The pharmacology of myristicin. A contribution to the psychopharmacology of nutmeg. J Neuropsychiatr. 2:205–210.
   PubMed Web of Science ®Google Scholar
• Wu N, Xu W, Yang YF, Yang XB, Yang XW. 2016. The blood-brain barrier permeability of lignans and malabaricones from the seeds of Myristica fragrans in the MDCK-pHaMDR cell monolayer model. Molecules. 21:134–143.
   PubMed Web of Science ®Google Scholar