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Review

Therapeutic potential of naringin: an overview

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Pages 3203-3210 | Received 12 Sep 2015, Accepted 20 Jun 2016, Published online: 26 Aug 2016

References

  • Alam MA, Kauter K, Brown L. 2013. Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients. 5:637–650.
  • Alam MA, Subhan N, Rahman MM, Uddin SJ, Reza HM, Sarker SD. 2014. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr. 5:404–417.
  • Ang ES, Yang X, Chen H, Liu Q, Zheng MH, Xu J. 2011. Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation . FEBS Lett. 585:2755–2762.
  • Attia SM. 2008. Abatement by naringin of lomefloxacin-induced genomic instability in mice. Mutagenesis. 23:515–521.
  • Bacanli M, Basaran AA, Basaran N. 2015. The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin. Food Chem Toxicol. 81:160–170.
  • Bakheet SA, Attia SM. 2011. Evaluation of chromosomal instability in diabetic rats treated with naringin. Oxid Med Cell Longev. 2011:365292.
  • Baskaran G, Salvamani S, Ahmad SA, Shaharuddin NA, Pattiram PD, Shukor MY. 2015. HMG-CoA reductase inhibitory activity and phytocomponent investigation of Basella alba leaf extract as a treatment for hypercholesterolemia. Drug Des Devel Ther. 9:509–517.
  • Benavente-García O, Castillo J. 2008. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem. 56:6185–6205.
  • Bharti S, Rani N, Krishnamurthy B, Arya DS. 2014. Preclinical evidence for the pharmacological actions of naringin: a review. Planta Med. 80:437–451.
  • Chen JC, Li LJ, Wen SM, He YC, Liu HX, Zheng QS. 2011a. Quantitative analysis and simulation of anti-inflammatory effects from the active components of Paino Powder () in rats. Chin J Integr Med. [Epub ahead of print]. doi:10.1007/s11655-011-0882-0.
  • Chen F, Zhang N, Ma X, Huang T, Shao Y, Wu C, Wang Q. 2015. Naringin alleviates diabetic kidney disease through inhibiting oxidative stress and inflammatory reaction. PLoS One. 10:e0143868.
  • Chen KY, Lin KC, Chen YS, Yao CH. 2013. A novel porous gelatin composite containing naringin for bone repair. Evid Based Complement Alternat Med. 2013:283941. doi:10.1155/2013/283941.
  • Chen LL, Lei LH, Ding PH, Tang Q, Wu YM. 2011b. Osteogenic effect of Drynariae rhizoma extracts and naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. Arch Oral Biol. 56:1655–1662.
  • Chtourou Y, Gargouri B, Kebieche M, Fetoui H. 2015. Naringin abrogates cisplatin-induced cognitive deficits and cholinergic dysfunction through the down-regulation of AChE expression and iNOS signaling pathways in hippocampus of aged rats. J Mol Neurosci. 56:349–362.
  • Cordenonsi LM, Bromberger NG, Raffin RP, Scherman EE. 2015. Simultaneous separation and sensitive detection of naringin and naringenin in nanoparticles by chromatographic method indicating stability and photodegradation kinetics. Biomed Chromatogr. 30:155–162.
  • Dhanya R, Arun KB, Nisha VM, Syama HP, Nisha P, Santhosh Kumar TR, Jayamurthy P. 2015. Preconditioning L6 muscle cells with naringin ameliorates oxidative stress and increases glucose uptake. PLoS One. 10:e0132429.
  • Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. 2007. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 147:227–235.
  • Ghasemzadeh A, Jaafar HZ. 2013. Profiling of phenolic compounds and their antioxidant and anticancer activities in pandan (Pandanus amaryllifolius Roxb.) extracts from different locations of Malaysia. BMC Complement Altern Med. 13:341.
  • Golechha M, Sarangal V, Bhatia J, Chaudhry U, Saluja D, Arya DS. 2014. Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection. Epilepsy Behav. 41:98–102.
  • Gopinath K, Sudhandiran G. 2012. Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. Neuroscience. 227:134–143.
  • Habauzit V, Sacco SM, Gil-Izquierdo A, Trzeciakiewicz A, Morand C, Barron D, Pinaud S, Offord E, Horcajada MN. 2011. Differential effects of two citrus flavanones on bone quality in senescent male rats in relation to their bioavailability and metabolism. Bone. 49:1108–1116.
  • Jeong KH, Jung UJ, Kim SR. 2015. Naringin attenuates autophagic stress and neuroinflammation in kainic acid-treated hippocampus in vivo. Evid Based Complement Alternat Med. 2015:354326. doi:10.1155/2015/354326.
  • Ji Y, Wang L, Watts DC, Qiu H, You T, Deng F, Wu X. 2014. Controlled-release naringin nanoscaffold for osteoporotic bone healing. Dent Mater. 30:1263–1273.
  • Jin Y, Tian T, Ma Y, Xu H, Du Y. 2015. Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet. J Chromatogr B Analyt Technol Biomed Life Sci. 1000:112–119.
  • Johnson MK, Loo G. 2000. Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA. Mutat Res. 459:211–218.
  • Jung UJ, Kim SR. 2014. Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain. Neural Regen Res. 9:1514–1517.
  • Kanokorn S, Surachai P, Supason W. 2009. An efficient method for the large scale isolation of naringin from pomelo (Citrus grandis) peel. Int J Food Sci Tech. 44:1737–1742.
  • Kim DI, Lee SJ, Lee SB, Park K, Kim WJ, Moon SK. 2008. Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis. 29:1701–1709.
  • Kim YH, Tabata Y. 2015. Dual-controlled release system of drugs for bone regeneration. Adv Drug Deliv Rev. 94:28–40.
  • Kumar VS, Rajmane AR, Adil M, Kandhare AD, Ghosh P, Bodhankar SL. 2014. Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res. 28:132–145.
  • Kumar A, Prakash A, Dogra S. 2010. Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. Food Chem Toxicol. 48:626–632.
  • Lewinska A, Siwak J, Rzeszutek I, Wnuk M. 2015. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line. Toxicol in Vitro. 29:417–425.
  • Li F, Sun X, Ma J, Ma X, Zhao B, Zhang Y, Tian P, Li Y, Han Z. 2014a. Naringin prevents ovariectomy-induced osteoporosis and promotes osteoclasts apoptosis through the mitochondria-mediated apoptosis pathway. Biochem Biophys Res Commun. 452:629–635.
  • Li H, Yang B, Huang J, Xiang T, Yin X, Wan J, Luo F, Zhang L, Li H, Ren G. 2013a. Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting beta-catenin signaling pathway. Toxicol Lett. 220:219–228.
  • Li N, Jiang Y, Wooley PH, Xu Z, Yang SY. 2013b. Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis. J Orthop Sci. 18:478–485.
  • Li N, Xu Z, Wooley PH, Zhang J, Yang SY.. 2014b. Therapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments. Drug Des Devel Ther. 8:1–11.
  • Li P, Wang S, Guan X, Cen X, Hu C, Peng W, Wang Y, Su W. 2014c. Six months chronic toxicological evaluation of naringin in Sprague-Dawley rats. Food Chem Toxicol. 66:65–75.
  • Li P, Wang S, Guan X, Liu B, Wang Y, Xu K, Peng W, Su W, Zhang K. 2013c. Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats. Food Chem Toxicol. 60:1–9.
  • Li SG, Ding YS, Niu Q, Xu SZ, Pang LJ, Ma RL, Jing MX, Feng GL, Liu JM, Guo SX. 2015. Grape seed proanthocyanidin extract alleviates arsenic-induced oxidative reproductive toxicity in male mice. Biomed Environ Sci. 28:272–280.
  • Li SQ, Dong S, Su ZH, Zhang HW, Peng JB, Yu CY, Zou ZM. 2013d. Comparative pharmacokinetics of naringin in rat after oral administration of chaihu-shu-gan-san aqueous extract and naringin alone. Metabolites. 3:867–880.
  • Liu Y, Wu H, Nie YC, Chen JL, Su WW, Li PB. 2011. Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. Int Immunopharmacol. 11:1606–1612.
  • Lu Y, Li N, Deng Y, Zhao L, Guo X, Li F, Xiong Z. 2015. Simultaneous determination of icariin, naringin and osthole in rat plasma by UPLC-MS/MS and its application for pharmacokinetic study after oral administration of Gushudan capsules. J Chromatogr B Analyt Technol Biomed Life Sci. 993–994:75–80.
  • Luo YL, Zhang CC, Li PB, Nie YC, Wu H, Shen JG, Su WW. 2012. Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke. Int Immunopharmacol. 13:301–307.
  • Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM. 2012. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications. 26:483–490.
  • Manthey JA, Guthrie N, Grhmann K. 2001. Biological properties of Citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 8:135–153.
  • Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS. 2010. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. Br J Pharmacol. 159:1693–1703.
  • Pereira RM, Andrades NE, Paulino N, Sawaya AC, Eberlin MN, Marcucci MC, Favero GM, Novak EM, Bydlowski SP. 2007. Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. Molecules. 12:1352–1366.
  • Pu P, Gao DM, Mohamed S, Chen J, Zhang J, Zhou XY, Zhou NJ, Xie J, Jiang H. 2012. Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. Arch Biochem Biophys. 518:61–70.
  • Rajadurai M, Prince PS. 2007. Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: an in vivo and in vitro study. Toxicology. 232:216–225.
  • Ramesh E, Alshatwi AA. 2013. Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. Food Chem Toxicol. 51:97–105.
  • Saaby L, Jager AK. 2011. Flavonoids and the CNS. Molecules. 16:1471–1485.
  • Sachdeva AK, Kuhad A, Chopra K. 2014. Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction. Pharmacol Biochem Behav. 127:101–110.
  • Surampalli G, Nanjwade B, Patil P. 2015. Corroboration of naringin effects on the intestinal absorption and pharmacokinetic behavior of candesartan cilexetil solid dispersions using in-situ rat models. Drug Dev Ind Pharm. 41:1057–1065.
  • Tan TW, Chou YE, Yang WH, Hsu CJ, Fong YC, Tang CH. 2014. Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126. Int Immunopharmacol. 22:107–114.
  • Tsai Y, Tsai T. 2012. Mesenteric lymphatic absorption and the pharmacokinetics of naringin and naringenin in the rat. J Agric Food Chem. 60:12435–12442.
  • Wang C, Pan Y, Fan G, Chai Y, Wu Y. 2010. Application of an efficient strategy based on MAE, HPLC-DAD-MS/MS and HSCCC for the rapid extraction, identification, separation and purification of flavonoids from Fructus aurantii immaturus. Biomed Chromatogr. 24:235–244.
  • Wang D, Yan J, Chen J, Wu W, Zhu X, Wang Y. 2015. Naringin improves neuronal insulin signaling, brain mitochondrial function, and cognitive function in High-Fat Diet-induced obese mice. Cell Mol Neurobiol. 35:1061–1071.
  • Wang DM, Yang YJ, Zhang L, Zhang X, Guan FF, Zhang LF. 2013. Naringin enhances CaMKII activity and improves long-term memory in a mouse model of Alzheimer's disease. Int J Mol Sci. 14:5576–5586.
  • Wang SS, Liu L, Zhu L, Yang Y-X. 2011. Inhibition of TNF-alpha/IFN-gamma induced RANTES expression in HaCaT cell by naringin. Pharm Biol. 49:810–814.
  • Wei M, Yang Z, Li P, Zhang Y, Sse WC. 2007. Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model. Am J Chin Med. 35:663–667.
  • Wong KC, Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS. 2013. Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like protective effects in bone. Br J Nutr. 110:475–485.
  • Wu JB, Fong YC, Tsai HY, Chen YF, Tsuzuki M, Tang CH. 2008. Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. Eur J Pharmacol. 588:333–341.
  • Yin FM, Xiao LB, Zhang Y. 2015a. Research progress on Drynaria fortunei naringin on inflammation and bone activity. Zhongguo Gu Shang. 28:182–186.
  • Yin L, Cheng W, Qin Z, Yu H, Yu Z, Zhong M, Sun K, Zhang W. 2015b. Effects of naringin on proliferation and osteogenic differentiation of human periodontal ligament stem cells in vitro and In Vivo. Stem Cells Int. 2015:758706.
  • Yoon HY, Cho YS, Jin Q, Kim HG, Woo ER, Chung YS. 2012. Effects of ethyl acetate extract of Poncirus trifoliata fruit for glucocorticoid-induced osteoporosis. Biomol Ther (Seoul). 20:89–95.
  • Zhang J, Gao W, Liu Z, Zhang Z, Liu C. 2014. Systematic analysis of main constituents in rat biological samples after oral administration of the methanol extract of Fructus aurantii by HPLC-ESI-MS/MS. Iran J Pharm Res. 13:493–503.
  • Zhang P, Dai KR, Yan SG, Yan WQ, Zhang C, Chen DQ, Xu B, Xu ZW. 2009. Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. Eur J Pharmacol. 607:1–5.
  • Zhao BT, Kim EJ, Son KH, Son JK, Min BS, Woo MH. 2015a. Quality evaluation and pattern recognition analyses of marker compounds from five medicinal drugs of Rutaceae family by HPLC/PDA. Arch Pharm Res. 38:1512–1520.
  • Zhao P, Duan L, Guo L, Dou LL, Dong X, Zhou P, Li P, Liu EH. 2015b. Chemical and biological comparison of the fruit extracts of Citrus wilsonii Tanaka and Citrus medica L. Food Chem. 173:54–60.

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