Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways

References

• Agarwal A, Hamada A, Esteves SC. 2012. Insight into oxidative stress in varicocele-associated male infertility: Part 1. Nat Rev Urol. 9:678–690.
   PubMed Web of Science ®Google Scholar
• Agarwal A, Prabakaran SA, Said TM. 2005. Prevention of oxidative stress injury to sperm. J Androl. 26:654–660.
   PubMed Web of Science ®Google Scholar
• Allamaneni SS, Naughton CK, Sharma RK, Thomas AJ Jr, Agarwal A. 2004. Increased seminal reactive oxygen species levels in patients with varicoceles correlate with varicocele grade but not with testis size. Fertil Steril. 82:1684–1686.
   PubMed Web of Science ®Google Scholar
• Benedetti S, Tagliamonte MC, Catalani S, Primiterra M, Canestrari F, De Stefani S, Palini S, Bulletti C. 2012. Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality. Reprod Biomed Online. 25:300–306.
   PubMed Web of Science ®Google Scholar
• Bhandary B, Marahatta A, Kim HR, Chae HJ. 2012. An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases. Int J Mol Sci. 14:434–456.
   PubMed Web of Science ®Google Scholar
• Cao SS, Kaufman RJ. 2014. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal. 21:396–413.
   PubMed Web of Science ®Google Scholar
• Chiba K, Fujisawa M. 2016. Clinical outcomes of varicocele repair in infertile men: a review. World J Mens Health. 34:101–109.
   PubMedGoogle Scholar
• Choi J, Lee KT, Choi MY, Nam JH, Jung HJ, Park SK, Park HJ. 2005. Antinociceptive anti-inflammatory effect of monotropein isolated from the root of Morinda officinalis. Biol Pharm Bull. 28:1915–1918.
   PubMed Web of Science ®Google Scholar
• Collodel G, Moretti E, Micheli L, Menchiari A, Moltoni L, Cerretani D. 2015. Semen characteristics and malondialdehyde levels in men with different reproductive problems. Andrology. 3:280–286.
   PubMed Web of Science ®Google Scholar
• Das P, Choudhari AR, Singh AK, Singh R. 2009. Correlation among routine semen parameters, sperm viability and malondialdehyde levels in human subjects with different fertility potential. Indian J Physiol Pharmacol. 53:253–258.
   PubMedGoogle Scholar
• Dogan F, Armagan A, Oksay T, Akman T, Aylak F, Bas E. 2014. Impact of micronised purified flavonoid fraction on increased malondialdehyde and decreased metalloproteinase-2 and metalloproteinase-9 levels in varicocele: outcome of an experimentally induced varicocele. Andrologia. 46:380–385.
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration. 2005. Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Center for Drug Evaluation and Research (CDER); p. 7.
   Google Scholar
• Giustarini D, Dalle-Donne I, Milzani A, Fanti P, Rossi R. 2013. Analysis of GSH and GSSG after derivatization with N-ethylmaleimide. Nat Protoc. 8:1660–1669.
   PubMed Web of Science ®Google Scholar
• Inci K, Gunay LM. 2013. The role of varicocele treatment in the management of non-obstructive azoospermia. Clinics (Sao Paulo). 68(Suppl. 1):89–98.
   PubMed Web of Science ®Google Scholar
• Jarow JP, Sharlip ID, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, Schlegel PN, Howards SS, Nehra A, Damewood MD, et al. 2002. Best practice policies for male infertility. J Urol. 167:2138–2144.
   PubMed Web of Science ®Google Scholar
• Jung JH, Kim MH, Kim J, Baik SK, Koh SB, Park HJ, Seo JT. 2016. Treatment of leukocytospermia in male infertility: a systematic review. World J Mens Health. 34:165–172.
   PubMedGoogle Scholar
• Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, Krausz C. 2012. European association of urology guidelines on male infertility: the 2012 update. Eur Urol. 62:324–332.
   PubMed Web of Science ®Google Scholar
• Kadowaki H, Nishitoh H. 2013. Signaling pathways from the endoplasmic reticulum and their roles in disease. Genes (Basel). 4:306–333.
   PubMed Web of Science ®Google Scholar
• Kantartzi PD, Goulis CD, Goulis GD, Papadimas I. 2007. Male infertility and varicocele: myths and reality. Hippokratia. 11:99–104.
   PubMedGoogle Scholar
• Kaufman RJ, Back SH, Song B, Han J, Hassler J. 2010. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells. Diabetes Obes Metab. 12 Suppl. 2:99–107.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Lee JY, Kim SM, Nho CW, Jung SH, Song DG, Kim CY, Pan CH. 2010. Inhibitory effects of dicaffeoylquinic acids from Artemisia dubia on aldo-keto reductase family 1b10. JKSABC. 53:826–830.
   Web of Science ®Google Scholar
• Löffler C, Czygan FC, Proksch P. 1997. Phenolic constituents as taxonomic markers in the genus Cuscuta (Cuscutaceae). Biochem Syst Ecol. 25:297–303.
   Web of Science ®Google Scholar
• Lombardo F, Sansone A, Romanelli F, Paoli D, Gandini L, Lenzi A. 2011. The role of antioxidant therapy in the treatment of male infertility: an overview. Asian J Androl. 13:690–697.
   PubMed Web of Science ®Google Scholar
• Ly TN, Hazama C, Shimoyamada M, Ando H, Kato K, Yamauchi R. 2005. Antioxidative compounds from the outer scales of onion. J Agric Food Chem. 53:8183–8189.
   PubMed Web of Science ®Google Scholar
• Madgar I, Weissenberg R, Lunenfeld B, Karasik A, Goldwasser B. 1995. Controlled trial of high spermatic vein ligation for varicocele in infertile men. Fertil Steril. 63:120–124.
   PubMed Web of Science ®Google Scholar
• Miyaoka R, Esteves SC. 2012. A critical appraisal on the role of varicocele in male infertility. Adv Urol. 2012:597495.
   PubMedGoogle Scholar
• Nallella KP, Allamaneni SS, Pasqualotto FF, Sharma RK, Thomas AJ Jr, Agarwal A. 2004. Relationship of interleukin-6 with semen characteristics and oxidative stress in patients with varicocele. Urology. 64:1010–1013.
   PubMed Web of Science ®Google Scholar
• Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H. 2002. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16:1345–1355.
   PubMed Web of Science ®Google Scholar
• Ozgur R, Uzilday B, Sekmen AH, Turkan I. 2015. The effects of induced production of reactive oxygen species in organelles on endoplasmic reticulum stress and on the unfolded protein response in arabidopsis. Ann Bot. 116:541–553.
   PubMed Web of Science ®Google Scholar
• Saypol DC. 1981. Varicocele. J Androl. 2:61–71.
   Google Scholar
• Shin JS, Yun KJ, Chung KS, Seo KH, Park HJ, Cho YW, Baek NI, Jang D, Lee KT. 2013. Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-κB inactivation. Food Chem Toxicol. 53:263–271.
   PubMed Web of Science ®Google Scholar
• Singh BN, Singh BR, Singh RL, Prakash D, Singh DP, Sarma BK, Upadhyay G, Singh HB. 2009. Polyphenolics from various extracts/fractions of red onion (Allium cepa) peel with potent antioxidant and antimutagenic activities. Food Chem Toxicol. 47:1161–1167.
   PubMed Web of Science ®Google Scholar
• Soni KK, Zhang LT, You JH, Lee SW, Kim CY, Cui WS, Chae HJ, Kim HK, Park JK. 2015. The effects of MOTILIPERM on cisplatin induced testicular toxicity in Sprague-Dawley rats. Cancer Cell Int. 15:1–11.
   PubMed Web of Science ®Google Scholar
• Tawadrous GA, Aziz AA, Mostafa T. 2013. Seminal soluble fas relationship with oxidative stress in infertile men with varicocele. Urology. 82:820–823.
   PubMed Web of Science ®Google Scholar
• Tremellen K. 2008. Oxidative stress and male infertility—a clinical perspective. Hum Reprod Update. 14:243–258.
   PubMed Web of Science ®Google Scholar
• Tulloch WS. 1951. A consideration of sterility factors in the light of subsequent pregnancies. II. Sub fertility in the male. (Tr. Edinburgh Obst. Soc. Session 104). Edinb Med J. 59:29–34.
   PubMedGoogle Scholar
• Wright EJ, Young GP, Goldstein M. 1997. Reduction in testicular temperature after varicocelectomy in infertile men. Urology. 50:257–259.
   PubMed Web of Science ®Google Scholar
• Yang L, Chen Q, Wang F, Zhang G. 2011. Antiosteoporotic compounds from seeds of Cuscuta chinensis. J Ethnopharmacol. 135:553–560.
   PubMed Web of Science ®Google Scholar
• Zeeshan HM, Lee GH, Kim HR, Chae HJ. 2016. Endoplasmic reticulum stress and associated ROS. IJMS. 17:1–20.
   Google Scholar
• Zhang LT, Kim HK, Choi BR, Zhao C, Lee SW, Jang KY, Park JK. 2014. Analysis of testicular-internal spermatic vein variation and the recreation of varicocoele in a Sprague-Dawley rat model. Andrology. 2:466–473.
   PubMed Web of Science ®Google Scholar
• Zini A, Dohle G. 2011. Are varicoceles associated with increased deoxyribonucleic acid fragmentation? Fertil Steril. 96:1283–1287.
   PubMed Web of Science ®Google Scholar