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Invited Article

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

, , &
Pages 253-268 | Received 03 Jan 2018, Accepted 15 Mar 2018, Published online: 12 Apr 2018

References

  • Adom MB, Taher M, Mutalabisin MF, Amri MS, Kudos MBA, Sulaiman MWAW, Sengupta P, Susantic D. 2017. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 96:348–360.
  • Aherne SA, O’Brien NM. 2002. Dietary flavonols: chemistry, food content, and metabolism. Nutrition (Burbank, Los Angeles County, CA). 18:75–81.
  • Ahn EK, Jeon HJ, Lim EJ, Jung HJ, Park EH. 2007. Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J Ethnopharmacol. 110:476–482.
  • Alexandre-Moreira MS, Piuvezam MR, Araújo CC, Thomas G. 1999. Studies on the anti-inflammatory and analgesic activity of Curatella americana L. J Ethnopharmacol. 67:171–177.
  • Allen-Hall L, Arnasond JT, Cano P, Lafrenie RM. 2010. Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB. J Ethnopharmacol. 127:685–693.
  • Allen-Hall L, Cano P, Arnason JT, Rojas R, Locke O, Lafrenie RM. 2007. Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1 and TNF-α. J Ethnopharmacol. 109:312–317.
  • Andrade SF, Cardoso LGV, Carvalho JCT, Bastos JK. 2007. Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. J Ethnopharmacol. 109:464–471.
  • Aquila S, Giner RM, Recio MC, Spegazzini ED, Ríosa JL. 2009. Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots. J Ethnopharmacol. 121:333–337.
  • Ashley NT, Weil ZM, Nelson RJ. 2012. Inflammation: mechanisms, costs, and natural variation. Annu Rev Ecol Evol Syst. 43:385–406.
  • Azevedo LF, Da Silva SM, Navarro LB, Yamaguchi LF, Nascimento CGO, Soncini R, Ishikawa T. 2016. Evidence of anti-inflammatory and antinociceptive activities of Plinia edulis leaf infusion. J Ethnopharmacol. 192:178–182.
  • Bachiega TF, De Sousa JP, Bastos JK, Sforcin JM. 2014. Immunomodulatory/anti-inflammatory effects of Baccharis dracunculifolia leaves. Nat Prod Res. 27:1646–1650.
  • Bahiense JB, Marques FM, Figueira MM, Vargas TS, Kondratyuk TP, Endringer DC, Scherer R, Fronza M. 2017. Potential anti-inflammatory, antioxidant and antimicrobial activities of Sambucus australis. Pharm Biol. 55:991–997.
  • Bhattacharya S. 2017. Medicinal plants and natural products in amelioration of arsenic toxicity: a short review. Pharm Biol. 55:349–354.
  • Bolzani VS, Valli M, Pivatto M, Viegas C Jr. 2012. Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry. Pure Appl Chem. 84:1837–1846.
  • Burian M, Geisslinger G. 2005. COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites. Pharmacol Ther. 107:139–154.
  • Carvalho JCT, Ferreira LP, Santos LS, Corrêa MJC, Campos LMO, Bastos JK, Sarti SJ. 1999. Anti-inflammatory activity of flavone and some of its derivates from Virola michelli Heckel. J Ethnopharmacol. 64:173–177.
  • Carvalho JCT, Sertie JAA, Barbosa MVJ, Patrício KCM, Caputo LRG, Sarti SJ, Ferreira LP, Bastos JK. 1999. Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog. J Ethnopharmacol. 64:127–133.
  • Cestari SH, Bastos JK, Stasi LCD. 2011. Intestinal anti-inflammatory activity of baccharis dracunculifolia in the trinitrobenzenesulphonic acid model of rat colitis. J Evid Based Complementary Altern Med. 2011:524349
  • Chagas-Paula DA, Oliveira TB, Faleiro DPV, Oliveira RB, Da Costa FB. 2015. Outstanding anti-inflammatory potential of selected asteraceae species through the potent dual inhibition of cyclooxygenase-1 and 5-lipoxygenase. Planta Med. 81:296–1307.
  • Chan CK, Tan LTH, Andy SN, Kamarudin MNA, Goh BH, Kadir HA. 2017. Anti-neuroinflammatory activity of Elephantopus scaber L. via activation of Nrf2/HO-1 signaling and inhibition of p38 MAPK pathway in LPS-induced microglia BV-2 cells. Front Pharmacol. 8:397–411.
  • Chauhan A, Chauhan V. 2006. Oxidative stress in autism. Pathophysiology. 13:171–181.
  • Cosentino M, Bombelli R, Carcano E, Luini A, Marino F, Crema F, Dajas F, Lecchini S. 2008. Immunomodulatory properties of Achyrocline satureioides (Lam.) D.C. infusion: a study on human leukocytes. J Ethnopharmacol. 116:501–507.
  • Costa SS, De Souza MLM, Ibrahim T, De Melo GO, De Almeida AP, Guette C, Ferezou JP, Koatz VLG. 2006. Kalanchosine dimalate, an anti-inflammatory salt from Kalanchoe brasiliensis. J Nat Prod. 69:815–818.
  • Costa VB, Coube CS, Marinho BG, Matheus ME, Leitão SG, Fernandes PD. 2003. Anti-inflammatory and analgesic activity of Bouchea fluminensis. Fitoterapia. 74:364–371.
  • Coutinho HDM, Oliveira-Tintino CDM, Tintino SR, Pereira RLS, De Freitas TS, Da Silva MAP, Franco JL, Da Cunha FAB, Da Costa JGM, De Menezes IRA, et al. 2017. Toxicity against Drosophila melanogaster and antiedematogenic and antimicrobial activities of Alternanthera brasiliana (L.) Kuntze (Amaranthaceae). Environ Sci Pollut Res. 24:1–9.
  • D’Angelo LCA, Xavier HS, Torres LMB, Lapa AJ, Souccar C. 1997. Pharmacology of Piper marginatum Jacq. a folk medicinal plant used as an analgesic, anti-inflammatory and hemostatic. Phytomedicine. 4:33–40.
  • Da Silva Filho AA, Silva MLA, Carvalho JCT, Bastos JK. 2004. Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats. J Pharm Pharmacol. 56:1179–1184.
  • Da Silva LM, Farias JA, Boeing T, Somensi LB, Beber AP, Cury BJ, Santin JR, Andrade SF. 2016. Hydroalcoholic extract from inflorescences of Achyrocline satureioides (Compositae) ameliorates dextran sulphate sodium-induced colitis in mice by attenuation in the production of inflammatory cytokines and oxidative mediators. Evid Based Complement Alternat Med. 2016:3475356.
  • De Aquino PEA, Magalhães TR, Nicolau LAD, Kalyne L, Leal M, De Aquino NC, Dos Santos SM, Neves KRT, Silveira ER, Viana GSB. 2017. The anti-inflammatory effects of N-methyl-(2S,4R)-trans-4-hydroxy-l-proline from Syderoxylon obtusifolium are related to its inhibition of TNF-α and inflammatory enzymes. Phytomedicine. 24:14–23.
  • De Souza KCB, Bassani VL, Schapoval EES. 2007. Influence of excipients and technological process on anti-inflammatory activity of quercetin and Achyrocline satureioides (Lam.) D.C. extracts by oral route. Phytomedicine. 14:102–108.
  • Delaporte RH, Sanchez GM, Cuellar AC, Giuliani A, De Mello JCP. 2002. Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae). J Ethnopharmacol. 82:127–130.
  • Desmarchelier C, Romão RL, Coussio J, Ciccia G. 1999. Antioxidant and free radical scavenging activities in extracts from medicinal trees used in the ‘Caatinga’ region in northeastern Brazil. J Ethnopharmacol. 67:69–77.
  • Dos Santos DA, Fukui MJ, Nanayakkara NPD, Khan SI, Sousa JPB, Bastos JK, Andrade SF, Filho AAS, Quintão NLM. 2010. Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models. J Ethnopharmacol. 127:543–550.
  • Dutra RC, Campos MM, Santos ARS, Calixto JB. 2016. Medicinal plants in Brazil: pharmacological studies, drug discovery, challenges and perspectives. Pharmacol Res. 112:4–29.
  • Fakhrudin N, Waltenberger B, Cabaravdic M, Atanasov AG, Malainer C, Schachner D, Heiss EH, Liu R, Noha SM, Grzywacz AM, et al. 2013. Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Br J Pharmacol. 171:1676–1686.
  • Fernandes ES, Passos GF, Medeiros R, Cunha FM, Ferreira J, Campos MM, Pianowski LF, Calixto JB. 2007. Anti-inflammatory effects of compounds alpha-humulene and (–)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol. 569:228–236.
  • Ferreira LC, Guimarães AG, Paula CA, Michel MCP, Guimarães RG, Rezende SA, Filho JDS, Guimarães DAS. 2013. Anti-inflammatory and antinociceptive activities of Campomanesia adamantium. J Ethnopharmacol. 145:100–108.
  • Ferreira-Rodrigues SC, Rodrigues CM, Dos Santos MG, Gautuz JAA, Silva MG, Cogo JC, Silva CB, Dos Santos CP, Groppo FC, Cogo-Müller K, et al. 2016. Anti-inflammatory and antibothropic properties of Jatropha Elliptica, a plant from Brazilian Cerrado biome. Adv Pharm Bull. 6:573–579.
  • Fierro IM, Da Silva ACB, Lopes CS, De Moura RS, Barja-Fidalgo C. 1999. Studies on the anti-allergic activity of Mikania glomerata. J Ethnopharmacol. 66:19–24.
  • Formagio ELP, Mendel MT, Fracasso R, Knobloch JG, Teixeira PW, Kehl L, Maluf RW, Picoli SU, Ardenghi P, Suyenaga ES. 2012. Evaluation of the pharmacological activity of the Alternanthera brasiliana aqueous extract. Pharm Biol. 50:1442–1447.
  • Freitas ACC, Ximenes NCA, Aguiar JS, Nascimento SC, Lins TUL, Magalhães LR, Coelho LCBB, Cunha MGC, Silva TG, Correia MTS. 2012. Biological activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) L. P. Queiroz Pod preparations. J Evid Based Complementary Altern Med. 2012:514134.
  • Galceran CB, Sertie JAA, Lima CS, Carvalho JCT. 2011. Anti-inflammatory and analgesic effects of 6α,7β-dihydroxy-vouacapan-17b-oic acid isolated from Pterodon emarginatus Vog. fruits. Inflammopharmacology. 19:139–143.
  • Gebhard F, Pfetsch H, Steinbach G, Strecker W, Kinzl L, Brückner UB. 2000. Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg (Chicago, IL: 1960). 135:291–295.
  • Ghasemian M, Owlia S, Owlia MB. 2016. Review of anti-inflammatory herbal medicines. Adv Pharmacol Sci. 2016:9130979.
  • Guay J, Bateman K, Gordon R, Mancini J, Riendeau D. 2004. Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. J Biol Chem. 279:24866–24872.
  • Guenka LC, Gomes RC, Melo VL, Kitanishi CRR, Pereira PS, França SC, Couto LB, Beleboni RO. 2008. Anti-inflammatory and anti-nociceptive effects of Zeyheria montana (Bignoniaceae) ethanol extract. Mem Inst Oswaldo Cruz. 103:768–772.
  • Gushiken LFS, Hussni CA, Bastos JK, Rozza AL, Beserra FP, Vieira AJ, Padovani CR, Lemos M, Junior MP, Da Silva JJM, et al. 2017. Skin wound healing potential and mechanisms of the hydroalcoholic extract of leaves and oleoresin of Copaifera langsdorffii Desf. Kuntze in rats. J Evid Based Complementary Altern Med. 2017:6589270.
  • Gusman GS, Campana PRV, Castro LC, Castilho RO, Teixeira MM, Braga FC. 2015. Evaluation of the effects of some Brazilian medicinal plants on the production of TNF-α and CCl4 by THP-1 cells. J Evid Based Complementary Altern Med. 2015:497123.
  • Gutierrez RMP, Hoyo-Vadillo C. 2017. Anti-inflammatory potential of Petiveria alliacea on activated RAW264.7 murine macrophages. Pharmacogn Mag. 13:174–178.
  • Henriques BO, Corrêa O, Azevedo EPC, Pádua RM, Oliveira VLS, Oliveira THC, Boff A, Dias ACF, Souza DG, Amaral FA, et al. 2016. In vitro TNF-α inhibitory activity of Brazilian plants and anti-inflammatory effect of Stryphnodendron adstringens in an acute arthritis model. J Evid Based Complementary Altern Med. 2016:9872598.
  • Henriques MG, Penido C. 2014. The therapeutic properties of Carapa guianensis. Curr Pharm Des. 20:850–856.
  • Kassuya CAL, Cremoneze A, Barros LFL, Simas AS, Lapa FR, Mello-Silva R, Stefanello MEA, Zampronio AR. 2009. Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). J Ethnopharmacol. 124:369–376.
  • Kawabata A. 2011. Prostaglandin E2 and pain—an update. Biol Pharm Bull. 34:1170–1173.
  • Kim HP, Son KH, Chang HW, Kang SS. 2004. Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci. 96:229–245.
  • Kotas ME, Medzhitov R. 2015. Homeostasis, inflammation, and disease susceptibility. Cell. 160:816–827.
  • Koyama J, Morita I, Tagahara K, Hirai KI. 2000. Cyclopentene dialdehydes from Tabebuia impetiginosa. Phytochemistry. 53:869–872.
  • Kundu JK, Surh YJ. 2012. Emerging avenues linking inflammation and cancer. Free Radic Biol Med. 52:2013–2037.
  • Küpeli E, Kosar M, Yesilada E, Baser KHC, Baser C. 2002. A comparative study on the antiinflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. Life Sci. 72:645–657.
  • Leal LKAM, Canuto KM, Costa KCS, Nobre-Júnior HV, Vasconcelos SM, Silveira ER, Ferreira MVP, Fontenele JB, Andrade GM, Viana GSB. 2008. Effects of amburoside A and isokaempferide, polyphenols from Amburana cearensis, on rodent inflammatory processes and myeloperoxidase activity in human neutrophils. Basic Clin Pharmacol Toxicol. 104:198–205.
  • Leal LKAM, Ferreira AAG, Bezerra GA, Matos FJA, Viana GSB. 2000. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J Ethnopharmacol. 70:151–159.
  • Leal LKAM, Nechio M, Silveira ER, Canuto KM, Fontenele JB, Ribeiro RA, Viana GSB. 2003. Anti-inflammatory and smooth muscle relaxant activities of the hydroalcoholic extract and chemical constituents from Amburana cearensis A. C. Smith. Phytother Res. 17:335–340.
  • Lima LM, Perazzo FF, Carvalho JCT, Bastos JK. 2007. Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark. J Pharm Pharmacol. 59:1151–1158.
  • Lin E, Calvano SE, Lowry SF. 2000. Inflammatory cytokines and cell response in surgery. Surgery. 127:117–126.
  • Lopes AA, Magalhães TR, Uchôa DEA, Silveira ER, Azzolini AECS, Kabeya LM, Lucisano-Valim YM, Vasconcelos SMM, Viana GSB, Leal LKAM. 2013. Afrormosin, an isoflavonoid from Amburana cearensis A. C. Smith, modulates the inflammatory response of stimulated human neutrophils. Basic Clin Pharmacol Toxicol. 113:363–369.
  • Lopes-Martins RAB, Pegoraro DH, Woisky R, Penna SC, Sertié JAA. 2002. The anti-inflammatory and analgesic effects of a crude extract of Petiveria alliacea L. (Phytolaccaceae). Phytomedicine. 9:245–248.
  • Lorenzi H, Matos FJA. 2002. Plantas medicinais no Brasil: nativas e exóticas. São Paulo, Brasil: Instituto Plantarum.
  • Lourenço AM, Ferreira LM, Branco PS. 2012. Molecules of natural origin, semi-synthesis and synthesis with anti-inflammatory and anticancer utilities. Curr Pharm Des. 18:3979–4046.
  • Magalhães A, Dos Santos GB, Verdam MCS, Fraporti L, Malheiro A, Lima ES, Dos-Santos MC. 2011. Inhibition of the inflammatory and coagulant action of Bothrops atrox venom by the plant species Marsypianthes chamaedrys. J Ethnopharmacol. 134:82–88.
  • Marmitt DJ, Rempel C, Goettert MI, Silva AC. 2015. Plantas medicinais da RENISUS com potencial antiinflamatório: revisão sistemática em três bases de dados científicas. Rev Fitos. 9:73–159.
  • Matheus MT, Rodrigues-Junio AG, Oliveira DMT, Garcia QS. 2017. Seed longevity and physical dormancy break of two endemic species of Dimorphandra from Brazilian biodiversity hotspots. Seed Sci Res. 27:199–205.
  • Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. 2007. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol. 151:618–627.
  • Medzhitov R. 2008. Origin and physiological roles of inflammation. Nature. 454:428–435.
  • Mello SVV, Da Rosa JS, Facchin BM, Luz AB, Vicente G, Faqueti LG, Rosa DW, Biavatti MW, Fröde TS. 2016. Beneficial effect of Ageratum conyzoides Linn (Asteraceae) upon inflammatory response induced by carrageenan into the mice pleural cavity. J Ethnopharmacol. 194:337–347.
  • Melo PS, Cavalcante HMM, Barbosa-Filho JM, Diniz MFFM, Medeiros IA, Haun M. 2003. Warifteine and milonine, alkaloids isolated from Cissampelos sympodialis Eichl: cytotoxicity on rat hepatocyte culture and in V79 cells. Toxicol Lett. 142:143–151.
  • Miller RJ, Jung H, Bhangoo SK, White FA. 2009. Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol. 194:417–449.
  • Montefusco-Pereira CV, Maria José de Carvalho MJ, Boleti APA, Teixeira LS, Matos HR, Lima ES. 2013. Antioxidant, anti-inflammatory, and hypoglycemic effects of the leaf extract from Passiflora nitida Kunth. Appl Biochem Biotechnol. 170:1367–1378.
  • Moraes WF, Galdino PM, Nascimento MVM, Vanderlinde FA, Bara MTF, Costa EA, Paula JR. 2012. Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark. J Nat Med. 66:202–207.
  • Moreira LQ, Vilela FC, Orlandi L, Dias DF, Santos ALA, Silva MA, Paiva R, Silva GA, Paiva AG. 2011. Anti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in rats. J Ethnopharmacol. 138:610–615.
  • Mourão RHV, Santos FO, Franzotti EM, Moreno MPN, Antoniolli AR. 1999. Anti-inflammatory activity and acute toxicity (LD50) of the juice of kalanchoe brasiliensis (Comb.) Leaves picked before and during blooming. Phytother Res. 13:352–354.
  • Munroe ME, Businga TR, Kline JN, Bishop GA. 2010. Anti-inflammatory effects of the neurotransmitter agonist honokiol in a mouse model of allergic asthma. J Immunol. 185:5586–5597.
  • Nardi GM, Felippi R, DalBó S, Siqueira-Junior JM, Arruda DC, Monache FD, Timbola AK, Pizzolatti MG, Ckless K, Ribeiro-do-Valle RM. 2003. Anti-inflammatory and antioxidant effects of Croton celtidifolius bark. Phytomedicine. 10:176–184.
  • Nardi GM, Siqueira-Junior JM, Monache FD, Pizzolatti MG, Ckless K, Ribeiro-do-Valle RM. 2007. Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats. Phytomedicine. 14:115–122.
  • Nascimento KF, Moreira FMF, Santos JA, Kassuya CAL, Croda JHR, Cardoso CAL, Vieira MC, Ruiz ALTG, Foglio MA, Carvalho JE, et al. 2018. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol. J Ethnopharmacol. 210:351–358.
  • Newman DJ. 2017. The influence of Brazilian biodiversity on searching for human use pharmaceuticals. J Braz Chem Soc. 28:402–414.
  • Olabissi OAF, Moussa O, Moustapha O, Edgard ZF, Eléonore K, Marius L, Pierre GI. 2011. Acute toxicity and anti-inflammatory activity of aqueous ethanol extract of root bark of Ximenia americana L. (Olacaceae). Afr J Pharm Pharmacol. 5:806–811.
  • Olajide OA, Aderogba MA, Fiebich BL. 2013. Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: inhibition of NF-κB and MAPK signalling in the microglia. J Ethnopharmacol. 145:42–49.
  • Orlandia L, Vilela FC, Santa-Cecília FV, Dias DF, Da-Silva GA, Paiva AG. 2011. Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss. J Ethnopharmacol. 137:1469–1476.
  • Panthong A, Kanjanapothi D, Thitiponpunt Y, Taesotikul T, Arbain D. 1998. Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum. Planta Med. 64:530–535.
  • Passos GF, Fernandes ES, Cunha FM, Ferreira J, Pianowski LF, Camposa MM, Calixto JB. 2007. Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea. J Ethnopharmacol. 110:323–333.
  • Penido C, Conte FP, Chagas MSS, Rodrigues CAB, Pereira JFG, Henriques MGMO. 2006. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflam Res. 55:457–464.
  • Penido C, Costa KA, Futuro DO, Paiva SR, Kaplan MAC, Figueiredo MR, Henriques MGMO. 2006. Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl. J Ethnopharmacol. 104:225–233.
  • Pereira LP, Silva RO, Bringel PHSF, Silva KESS, Assreuy AMS, Pereira MG. 2012. Polysaccharide fractions of Caesalpinia ferrea pods: potential anti-inflammatory usage. J Ethnopharmacol. 139:642–648.
  • Pereira LP, Mota MRL, Brizeno LAC, Nogueira FC, Ferreira EGM, Pereira MG, Assreuy AM. 2016. Modulator effect of a polysaccharide-rich extractfrom Caesalpinia ferrea stem barks in rat cutaneous wound healing: role of TNF-α, IL-1β, NO, TGF-β. J Ethnopharmacol. 187:213–223.
  • Peters RR, Krepsky PB, Siqueira-Junior JM, Rocha JCS, Bezerra MM, Ribeiro RA, Brum-Fernandes AJ, Farias MR, Rocha FAC, Ribeiro-do-Valle RM. 2003. Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata. Life Sci. 73:2185–2197.
  • Pimentel SP, Barrella GE, Casarin RCV, Cirano FR, Casati MZ, Foglio MA, Figueira GM, Ribeiro FV. 2012. Protective effect of topical Cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays. BMC Complementary Altern Med. 12:224–232.
  • Rates SMK, Schapoval EES, Souza IA, Henriques AT. 1993. Chemical constituents and pharmacological activities of Peschiera australis. Int J Pharmacog. 31:288–294.
  • Raymundo LJRP, Guilhon CC, Alviano DS, Matheus ME, Antoniolli AR, Cavalcanti SCH, Alves PB, Alviano CS, Fernandes PD. 2011. Characterisation of the anti-inflammatory and antinociceptive activities of the Hyptis pectinata (L.) Poit essential oil. J Ethnopharmacol. 134:725–732.
  • Recio MC, Prieto M, Bonucelli M, Orsi C, Mañez S, Giner RM, Cerdá-Nicolás M. Ríos JL. 2004. Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya Roots. Planta med. 70:414–420.
  • Rice-Evans CA, Miller NJ, Paganga G. 1997. Antioxidant properties of phenolic compounds. Trends Plant Sci. 2:152–159.
  • Rojas-Duran R, Lez-Aspajo GG, Ruiz-Martel C, Bourdy G, Doroteo-Ortega VH, Alban-Castillo J, Robert G, Auberger P, Deharo E. 2012. Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. J Ethnopharmacol. 143:801–804.
  • Salvemini D, Doyle TM, Cuzzocrea S. 2006. Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. Biochem Soc Trans. 34:965–970.
  • Santiago KB, Conti BJ, Andrade BFMT, Silva JJM, Rogez HLG, Crevelin EJ, Beraldo de Moraes LA, Veneziani RCS, Ambrósio SR, Bastos JK, et al. 2015. Immunomodulatory action of Copaifera spp. oleoresins on cytokine production by human monocytes. Biomed Pharmacother. 70:12–18.
  • Santos CCS, Guilhon CC, Moreno DSA, Alviano CS, Estevam CS, Blank AF, Fernandes PD. 2018. Anti-inflammatory, antinociceptive and antioxidant properties of Schinopsis brasiliensis bark. J Ethnopharmacol. 213:176–182.
  • Santos NKA, Viana GSB, Cunha WEM, Campos AR, Da Costa JGM. 2015. The essential oil from Vanillosmopsis arborea Baker (Asteraceae) presents antinociceptive, anti-inflammatory, and sedative effects. Int J Green Pharm. 9:138–143.
  • Santos SJ, Marinho RR, Valentim EE, Rodrigues L, Yamamoto MH, Teixeira SA, Muscara MN, Costa SK, Thomazzi SM. 2013. Beneficial effects of Anadenanthera colubrina (Vell.) Brenan extract on the inflammatory and nociceptive responses in rodent models. J Ethnopharmacol. 148:218–222.
  • Schumacher NSG, Colomeu TC, Figueiredo D, Carvalho VC, Cazarin CBB, Prado MA, Meletti LMM, Zollner RL. 2015. Identification and antioxidant activity of the extracts of eugenia uniflora Leaves. Characterization of the anti-inflammatory properties of aqueous extract on diabetes expression in an experimental model of spontaneous type 1 diabetes (NOD Mice). Antioxidants. 4:662–680.
  • Sfikakis PP. 2010. The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions. Curr Dir Autoimmun. 11:180–210.
  • Shettar AK, Kotresha K, Kaliwal BB, Vedamurthy AB. 2015. Evaluation of in vitro antioxidant and anti-inflammatory activities of Ximenia americana extracts. Asian Pac J Trop Dis. 5:918–923.
  • Silva LR, Alves AF, Cavalcante-Silva LHA, Braga RM, Almeida RN, Barbosa-Filho JM, Piuvezam MR. 2017. Milonine, a morphinandienone alkaloid, has anti-inflammatory and analgesic effects by inhibiting TNF-α and IL-1β production. Inflammation. 40:2074–2085.
  • Singh VK, Mehrotra S, Narayan P, Pandey CM, Agarwal SS. 2000. Modulation of autoimmune diseases by nitric oxide. Immunol Res. 22:1–19.
  • Siqueira JM Jr, Peters RR, Gazola AC, Krepsky PB, Farias MR, Rae GA, Brum-Fernandes AJ, Ribeiro-do-Valle RM. 2007. Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn. Life Sci. 80:1382–1387.
  • Souza MC, Siani AC, Ramos MFS, Menezes-de-Lima O Jr, Henriques MGMO. 2003. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. Die Pharm. 58:582–586.
  • Souza SMC, Aquino LCM, Milach AC Jr, Bandeira MAM, Nobre MEP, Viana GSB. 2007. Anti-inflammatory and antiulcer properties of tannins from Myracrodruon urundeuva Allemão (Anacardiaceae) in rodents. Phytother Res. 21:220–225.
  • Torres LRO, Santana FC, Torres-Leal FL, Melo ILP, Yoshime LT, Matos-Neto EM, Seelaender MCL, Araújo CMM, Cogliati B, Mancini-Filho J. 2016. Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbono tetrachloride-induced acute hepatic injury in rats: antioxidant and anti-inflammatory effects. Food Chem Toxicol. 97:205–216.
  • Tsai JC, Peng WH, Chiu TH, Lai SC, Lee CY. 2011. Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. Am J Chin Med. 39:943–956.
  • Ulloa L, Tracey KJ. 2005. The “cytokine profile”: a code for sepsis. Trends Mol Med. 11:56–63.
  • Vargas FS, Almeida PDO, Boleti APA, Pereira MM, Souza TP, Vasconcellos MC, Nunez CV, Pohlit AM, Lima ES. 2016. Antioxidant activity and peroxidase inhibition of Amazonian plants extracts traditionally used as anti-inflammatory. BMC Complementary Altern Med. 16:83–91.
  • Vasconcelos MAL, Royo VA, Ferreira DS, Crotti AEM, Silva MLA, Carvalho JCT, Bastos JK, Cunha WR. 2006. In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanoic acid from Miconia albicans (Melastomataceae). Z Naturforsch. 61:477–482.
  • Vasconcelos MS, Gomes-Rochette NF, Oliveira MLM, Nunes-Pinheiro DCS, Tome AR, Sousa FYM, Pinheiro FGM, Moura CFH, Miranda MRA, Mota EF, et al. 2015. Anti-inflammatory and wound healing potential of cashew apple juice (Anacardium occidentale L.) in mice. Exp Biol Med. 240:1648–1655.
  • Viana GSB, Bandeira MAM, Matos FJA. 2003. Analgesic and antiinflammatory effects of chalcones isolated from Myracrodruon urundeuva Allemão. Phytomedicine. 10:189–195.
  • Viegas CJ, Alexandre-Moreira MS, Fraga CA, Barreiro EJ, Bolzani VS, Miranda AL. 2008. Antinociceptive profile of 2,3,6-trisubstituted piperidine alkaloids: 3-O-acetyl-spectaline and semi-synthetic derivatives of (–)-spectaline. Chem Pharm Bull. 56:407–412.
  • Veiga Junior VF, Rosas EC, Carvalho MV, Henriques MGMO, Pinto AC. 2007. Chemical composition and anti-inflammatory activity of copaiba oils from Copaifera cearensis Huber ex Ducke, Copaifera reticulata Ducke and Copaifera multijuga Hayne-A comparative study. J Ethnopharmacol. 112:248–254.
  • Winter CA, Risley EA, Nuss GW. 1962. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med. 3:544–547.
  • Wiseman H, Halliwell B. 1996. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J. 313:17–29.
  • Yang R, Yuan BC, Ma YS, Zhou S, Liu Y. 2017. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 55:5–18.
  • Zhang JM, Jianxiong AN. 2007. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 45:27–37.