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Pharmaceutical Biology Volume 58, 2020 - Issue 1
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Research Article

Cyclocarya paliurus extract attenuates hepatic lipid deposition in HepG2 cells by the lipophagy pathway

Wanwei Yanga Clinical Laboratory, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaView further author information
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Cuihua Jiangb Laboratory of Translational Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaORCID Iconhttps://orcid.org/0000-0001-9207-9737View further author information
ORCID Icon,
Zhiguo Wanga Clinical Laboratory, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaView further author information
,
Jian Zhangb Laboratory of Translational Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaORCID Iconhttps://orcid.org/0000-0002-8402-9753View further author information
ORCID Icon,
Xiaodong Maoc Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaView further author information
,
Guofang Chenc Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaView further author information
,
Xiaoming Yaoa Clinical Laboratory, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaCorrespondence[email protected]
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Chao Liuc Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, PR ChinaCorrespondence[email protected]
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Pages 838-844 | Received 26 Oct 2019, Accepted 26 Jul 2020, Published online: 02 Sep 2020

References

  • Buzzetti E, Pinzani M, Tsochatzis EA. 2016. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metab Clin Exp. 65:1038–1048.
  • Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. 2011. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 141:1249–1253.
  • Cobbina E, Akhlaghi F. 2017. Non-alcoholic fatty liver disease (NAFLD) – pathogenesis, classification, and effect on drug metabolizing enzymes and transporters. Drug Metab Rev. 49:197–211.
  • Deter RL, Baudhuin P, De Duve C. 1967. Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J Cell Biol. 35:C11–C16.
  • Ding WX, Li M, Chen X, Ni HM, Lin CW, Gao W, Lu B, Stolz DB, Clemens DL, Yin XM. 2010. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology. 139:1740–1752.
  • Dong H, Czaja MJ. 2011. Regulation of lipid droplets by autophagy. Trends Endocrinol Metab. 22:234–240.
  • Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillon J, Lo Iacono O, Corazzari M, Fimia GM, et al. 2014. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 5:e1179.
  • Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell. 149:274–293.
  • Levine B, Klionsky DJ. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 6:463–477.
  • Li J, Lu Y, Su X, Li F, She Z, He X, Lin Y. 2008. A norsesquiterpene lactone and a benzoic acid derivative from the leaves of Cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activities. Planta Med. 74:287–289.
  • Li J, Zhang Q, Zeng W, Wu Y, Luo M, Zhu Y, Guo AY, Yang X. 2018. Integrating transcriptome and experiments reveals the anti-diabetic mechanism of Cyclocarya paliurus formula. Mol Ther Nucleic Acids. 13:419–430.
  • Lin Z, Wu ZF, Jiang CH, Zhang QW, Ouyang S, Che CT, Zhang J, Yin ZQ. 2016. The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. Phytomedicine. 23:1475–1483.
  • Lomonaco R, Sunny NE, Bril F, Cusi K. 2013. Nonalcoholic fatty liver disease: current issues and novel treatment approaches. Drugs. 73:1–14.
  • Ma Y, Jiang C, Yao N, Li Y, Wang Q, Fang S, Shang X, Zhao M, Che C, Ni Y, et al. 2015. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. J Ethnopharmacol. 166:286–296.
  • Mizushima N, Komatsu M. 2011. Autophagy: renovation of cells and tissues. Cell. 147:728–741.
  • Ning ZW, Zhai LX, Huang T, Peng J, Hu D, Xiao HT, Wen B, Lin CY, Zhao L, Bian ZX. 2019. Identification of α-glucosidase inhibitors from cyclocarya paliurus tea leaves using UF-UPLC-Q/TOF-MS/MS and molecular docking. Food Funct. 10:1893–1902.
  • Shu RG, Xu CR, Li LN, Yu ZL. 1995. Cyclocariosides II and III: two secodammarane triterpenoid saponins from Cyclocarya paliurus. Planta Med. 61:551–553.
  • Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ. 2009. Autophagy regulates lipid metabolism. Nature. 458:1131–1135.
  • Wang Q, Jiang C, Fang S, Wang J, Ji Y, Shang X, Ni Y, Yin Z, Zhang J. 2013. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J Ethnopharmacol. 150:1119–1127.
  • Wu D, Wang X, Zhou R, Cederbaum A. 2010. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochem Biophys Res Commun. 402:116–122.
  • Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. 2010. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11:467–478.
  • Yao X, Lin Z, Jiang C, Gao M, Wang Q, Yao N, Ma Y, Li Y, Fang S, Shang X, et al. 2015. Cyclocarya paliurus prevents high fat diet induced hyperlipidemia and obesity in Sprague-Dawley rats. Can J Physiol Pharmacol. 93:677–686.

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