Metabolomics coupled with network pharmacology study on the protective effect of Keguan-1 granules in LPS-induced acute lung injury

References

• Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA. 2017. Platelet-specific chemokines contribute to the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 56(2):261–270.
   PubMed Web of Science ®Google Scholar
• Bhatia M, Zemans RL, Jeyaseelan S. 2012. Role of chemokines in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 46(5):566–572.
   PubMed Web of Science ®Google Scholar
• Boucherat O, Franco-Montoya ML, Thibault C, Incitti R, Chailley-Heu B, Delacourt C, Bourbon JR. 2007. Gene expression profiling in lung fibroblasts reveals new players in alveolarization. Physiol Genomics. 32(1):128–141.
   PubMed Web of Science ®Google Scholar
• Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B. 2020. Oxygen-mediated lung injury in mice lacking the gene for NRF2: rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med. 160:208–218.
   PubMed Web of Science ®Google Scholar
• Cao Z, Liu JR, Xie X, Zhan SE, Song W, Wu SW, Sun Z, Dong Y, Tang GD, Liu YL, et al. 2020. Lipidomic profiling of amniotic fluid and its application in fetal lung maturity prediction. J Clin Lab Anal. 34(4):e23109.
   PubMed Web of Science ®Google Scholar
• Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J. 10(9):940–954.
   PubMed Web of Science ®Google Scholar
• Channappanavar R, Perlman S. 2017. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 39(5):529–539.
   PubMed Web of Science ®Google Scholar
• Cohen J, Normile D. 2020. New SARS-like virus in China triggers alarm. Science. 367(6475):234–235.
   PubMed Web of Science ®Google Scholar
• Cuykx M, Claes L, Rodrigues RM, Vanhaecke T, Covaci A. 2018. Metabolomics profiling of steatosis progression in HepaRG® cells using sodium valproate. Toxicol Lett. 286:22–30.
   PubMed Web of Science ®Google Scholar
• Dagvadorj J, Shimada K, Chen S, Jones HD, Tumurkhuu G, Zhang W, Wawrowsky KA, Crother TR, Arditi M. 2015. Lipopolysaccharide induces alveolar macrophage necrosis via CD14 and the P2X7 receptor leading to interleukin-1α Release. Immunity. 42(4):640–653.
   PubMed Web of Science ®Google Scholar
• Deng GM, He H, Chen Z, Ou-Yang LQ, Xiao XQ, Ge JW, Xiang B, Jiang SC, Cheng SW. 2017. Lianqinjiedu decoction attenuates LPS-induced inflammation and acute lung injury in rats via TLR4/NF-κB pathway. Biomed Pharmacother. 96:148–152.
   PubMed Web of Science ®Google Scholar
• Fornoni A, Merscher S, Kopp JB. 2014. Lipid biology of the podocyte-new perspectives offer new opportunities. Nat Rev Nephrol. 10(7):379–388.
   PubMed Web of Science ®Google Scholar
• Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. 2020. Polycyclic aromatic hydrocarbon-induced pulmonary carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-null mice: roles of CYP1A1 and CYP1A2. Toxicol Sci. 177(2):347–361.
   PubMed Web of Science ®Google Scholar
• Gessner C, Wirtz H, Sack U, Winkler J, Stiehl P, Schauer J, Wolff G. 2002. BALF N-Acetylglucosaminidase and beta-galactosidase activities in idiopathic pulmonary fibrosis. Respir Med. 96(9):751–756.
   PubMed Web of Science ®Google Scholar
• Gomez-Muñoz A, Presa N, Gomez-Larrauri A, Rivera IG, Trueba M, Ordoñez M. 2016. Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res. 61:51–62.
   PubMed Web of Science ®Google Scholar
• Hu LQ, Wang YQ, Sun HJ, Xiong Y, Zhong LY, Wu ZF, Yang M. 2020. An untargeted metabolomics approach to investigate the wine-processed mechanism of Scutellariae radix in acute lung injury. J Ethnopharmacol. 253:112665.
   PubMed Web of Science ®Google Scholar
• Huang CL, Wang YM, Li XW, Ren LL, Zhao JP, Hu Y, Zhang L, Fan GH, Xu JY, Gu XY, et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395(10223):497–506.
   PubMed Web of Science ®Google Scholar
• Jia ZQ, Zhou WR, Zhang GJ, Fu JK, Li DX, Ren L. 2020. CYP3A4 genetic variants are associated with susceptibility of non-small cell lung cancer in a Shaanxi Han population. Genomics. 112(5):3465–3472.
   PubMed Web of Science ®Google Scholar
• Kalkhof S, Dautel F, Loguercio S, Baumann S, Trump S, Jungnickel H, Otto W, Rudzok S, Potratz S, Luch A, et al. 2015. Pathway and time-resolved benzo[a]pyrene toxicity on Hepa1c1c7 cells at toxic and subtoxic exposure. J Proteome Res. 14(1):164–182.
   PubMed Web of Science ®Google Scholar
• Kimura T, Bier DM, Taylor CL. 2012. Summary of workshop discussions on establishing upper limits for amino acids with specific attention to available data for the essential amino acids leucine and tryptophan. J Nutr. 142(12):2245S–2248S.
   PubMed Web of Science ®Google Scholar
• Kiuchi K, Mutoh T, Naoi M. 1984. A fluorometric microassay procedure for monitoring the enzymatic activity of GM1-ganglioside beta-galactosidase by use of high-performance liquid chromatography. Anal Biochem. 140(1):146–151.
   PubMed Web of Science ®Google Scholar
• Lambeau G, Lazdunski M. 1999. Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol Sci. 20(4):162–170.
   PubMed Web of Science ®Google Scholar
• Li CY, Chen W, Zhang MY, Zhang CE, Cao B, Dong B, Qi SY, Zhang YJ, Fei XF, Li XJ, et al. 2020. Modulatory effects of Xihuang Pill on lung cancer treatment by an integrative approach. Biomed Pharmacother. 130:110533.
   PubMed Web of Science ®Google Scholar
• Li CY, Niu M, Wang RL, Zhou XW, Dong B, Qi SY, Chen W, Zhang MY, Shi YF, Li RS, et al. 2019. The modulatory properties of Si Jun Zi Tang enhancing anticancer of gefitinib by an integrating approach. Biomed Pharmacother. 111:1132–1140.
   PubMed Web of Science ®Google Scholar
• Li S, Zhang B. 2013. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 11(2):110–120.
   PubMed Web of Science ®Google Scholar
• Maceyka M, Spiegel S. 2014. Sphingolipid metabolites in inflammatory disease. Nature. 510(7503):58–67.
   PubMed Web of Science ®Google Scholar
• Medeiros SR, Pinheiro-Rosa N, Lemos L, Loli FG, Pereira AG, Santiago AF, Pinter EC, Alves AC, Oliveira JS, Cara DC, et al. 2015. Vitamin A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice. Nutrition. 31(10):1260–1265.
   PubMed Web of Science ®Google Scholar
• Nagase T, Uozumi N, Ishii S, Kume K, Izumi T, Ouchi Y, Shimizu T. 2000. Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nat Immunol. 1(1):42–46.
   PubMed Web of Science ®Google Scholar
• Navarrete A, Rupérez FJ, Mendes TO, Pérez-Rial S, Girón-Martínez A, Terrón-Expósito R, Díaz-Gil JJ, Peces-Barba G, Barbas C, García A. 2017. A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. J Pharm Biomed Anal. 139:238–246.
   PubMed Web of Science ®Google Scholar
• Niu M, Wang RL, Wang ZX, Zhang P, Bai ZF, Jing J, Guo YM, Zhao X, Zhan XY, Zhang ZT, et al. 2020. Rapid establishment of traditional Chinese medicine prevention and treatment of 2019-nCoV based on clinical experience and molecular docking. China J Chin Mater Med. 45:1213–1218.
   Google Scholar
• Olsvik PA, Skjaerven KH, Søfteland L. 2017. Metabolic signatures of bisphenol A and genistein in Atlantic salmon liver cells. Chemosphere. 189:730–743.
   PubMed Web of Science ®Google Scholar
• Ramanathan K, Antognini D, Combes A, Paden M, Zakhary B, Ogino M, MacLaren G, Brodie D, Shekar K. 2020. Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases. Lancet Respir Med. 8(5):518–526.
   PubMed Web of Science ®Google Scholar
• Ross AC, Zolfaghari R. 2004. Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. J Nutr. 134(1):269S–275S.
   PubMed Web of Science ®Google Scholar
• Taherkhani A, Kalantari S, Nafar M. 2018. Prediction of molecular signature, potential biomarkers, and molecular pathways associated with membranous nephropathy based on protein protein interactions. Rev Invest Clin. 70(4):184–191.
   PubMedGoogle Scholar
• Tang MJ, Tian YH, Li DL, Lv JW, Li Q, Kuang CC, Hu PC, Wang Y, Wang J, Su K, et al. 2014. TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI). PLoS One. 9(7):e102967.
   PubMed Web of Science ®Google Scholar
• Wang JB, Wang ZX, Jing J, Zhao P, Dong JH, Zhou YF, Yang G, Niu M, Zhao X, Jiang TJ, et al. 2020. Exploring an integrative therapy for treating COVID-19: a randomized controlled trial. Chin J Integr Med. 26(9):648–655.
   PubMed Web of Science ®Google Scholar
• Wang TY, Lin S, Liu R, Li H, Liu ZH, Zhang XN, Xu HR, Li Q, Bi KS. 2020. Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS. Anal Bioanal Chem. 412(5):1215–1234.
   PubMed Web of Science ®Google Scholar
• Weinacker AB, Vaszar LT. 2001. Acute respiratory distress syndrome: physiology and new management strategies. Annu Rev Med. 52:221–237.
   PubMed Web of Science ®Google Scholar
• Wishart DS. 2019. Metabolomics for investigating physiological and pathophysiological processes. Physiol Rev. 99(4):1819–1875.
   PubMed Web of Science ®Google Scholar
• Yang YX, Li FY, Wei SZ, Liu XY, Wang YY, Liu HH, Wang JB, Li HT, Cai HD, Zhao YL. 2019. Metabolomics profiling in a mouse model reveals protective effect of Sancao granule on Con A-induced liver injury. J Ethnopharmacol. 238:111838.
   PubMed Web of Science ®Google Scholar
• Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH. 2013. High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med. 368(9):806–813.
   PubMed Web of Science ®Google Scholar
• Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, et al. 2013. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest. 123(3):1019–1031.
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu XY, Tu C, Li CY, Song D, Zhu JX, Zhou YY, Wang XH, Li RS, Xiao XH, et al. 2020. Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum. Xenobiotica. 50(5):515–525.
   PubMed Web of Science ®Google Scholar
• Zhang XX, Ritchie SR, Rainey PB. 2014. Urocanate as a potential signaling molecule for bacterial recognition of eukaryotic hosts. Cell Mol Life Sci. 71(4):541–547.
   PubMed Web of Science ®Google Scholar
• Zhou XS, Wang RP, Zhang T, Liu F, Zhang W, Wang GL, Gu GR, Han QQ, Xu DM, Yao CL, et al. 2019. Identification of lysophosphatidylcholines and sphingolipids as potential biomarkers for acute aortic dissection via serum metabolomics. Eur J Vasc Endovasc Surg. 57(3):434–441.
   PubMed Web of Science ®Google Scholar
• Zhu N, Zhang DY, Wang WL, Li XW, Yang B, Song JD, Zhao X, Huang BY, Shi WF, Lu RJ, et al. 2020. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 382(8):727–733.
   PubMed Web of Science ®Google Scholar