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Research Article

Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels

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Pages 1670-1678 | Received 22 Aug 2020, Accepted 01 Aug 2022, Published online: 05 Sep 2022

References

  • Barone R, Macaluso F, Catanese P, Marino Gammazza A, Rizzuto L, Marozzi P, Lo Giudice G, Stampone T, Cappello F, Morici G, et al. 2013. Endurance exercise and conjugated linoleic acid (CLA) supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis. PLoS One. 8(11):e79686.
  • Baxa U. 2018. Imaging of liposomes by transmission electron microscopy. Methods Mol Biol. 1682:73–88.
  • Bedford TG, Tipton CM, Wilson NC, Oppliger RA, Gisolfi CV. 1979. Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol Respir Environ Exerc Physiol. 47(6):1278–1283.
  • Cai Z, Xi H, Pan Y, Jiang X, Chen L, Cai Y, Zhu K, Chen C, Xu X, Chen M. 2015. Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet. Lipids Health Dis. 14:18–174.
  • Chen Y, Li H, Mo J, Chen X, Wu K, Ge F, Ma L, Li X, Guo X, Zhao J, et al. 2019. Perfluorododecanoic acid blocks rat Leydig cell development during prepuberty. Chem Res Toxicol. 32:145–155.
  • Chung J-Y, Brown S, Chen H, Liu J, Papadopoulos V, Zirkin B. 2020. Effects of pharmacologically induced Leydig cell testosterone production on intratesticular testosterone and spermatogenesis. Biol Reprod. 102(2):489–498.
  • Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Bhasin S, Matsumoto AM, Parsons JK, Gill TM, Molitch MK, Farrar JT. 2016. Testosterone treatment and sexual function in older men with low testosterone levels. J Clin Endocr Metab. 101:34–41.
  • Ge RS, Dong Q, Sottas CM, Latif SA, Morris DJ, Hardy MP. 2005. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Mol Cell Endocrinol. 243(1–2):35–42.
  • Geniatulina MS, Korolev YN, Nikulina LA. 2016. The ultrastructure of Leydig cells under the influence of drinking mineral water and electromagnetic radiation under the stress conditions in the rats. Vopr Kurortol Fizioter Lech Fiz Kult. 93(5):34–37.
  • Guan S, Xie L, Ma T, Lv D, Jing W, Tian X, Song Y, Liu Z, Xiao X, Liu G. 2017. Effects of melatonin on early pregnancy in mouse: Involving the regulation of StAR, Cyp11a1, and IHH expression. IJMS. 18(8):1637.
  • Guan X, Chen F, Chen P, Zhao X, Mei H, Liu J. 2018. Effects of spermatogenic cycle on stem Leydig cell proliferation and differentiation. Mol Cell Endocrinol. 481:163–167.
  • Guan Y, Hao P, Tang C, Li P, Li S, Cheng X, Ba Y, Cui L. 2012. Effect of fluoride on the expression of StAR mRNA and P450scc mRNA in the progesterone synthesis of mouse Leydig tumor cells. J Hyg Res. 41:105–108.
  • Hatano M, Migita T, Ohishi T, Shima Y, Ogawa Y, Morohashi KI, Hasegawa Y, Shibasaki F. 2016. SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1. Endocrine. 54(2):484–496.
  • He H, Wang BH, Zhou ZH, Wang K, Song G. 2004. Effects of Bushen Yiyuan recipe on physiological and biochemical parameters of male rowing athletes. J Beijing Univ Phys Educ. 46:341–343.
  • Hooper DR, Tenforde AS, Hackney AC. 2018. Treating exercise-associated low testosterone and its related symptoms. Phys Sportsmed. 46(4):427–434.
  • Iwasa T, Matsuzaki T, Yano K, Yanagihara R, Mayila Y, Irahara M. 2018. The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats. Gynecol Endocrinol. 34(5):437–441.
  • Kaprara A, Huhtaniemi IT. 2018. The hypothalamus-pituitary-gonad axis: Tales of mice and men. Metabolism. 86:3–17.
  • Kumagai H, Yoshikawa T, Zempo-Miyaki A, Myoenzono K, Tsujimoto T, Tanaka K, Maeda S. 2018. Vigorous physical activity is associated with regular aerobic exercise-induced increased serum testosterone levels in overweight/obese men. Horm Metab Res. 50(01):73–79.
  • Lin H, Wang SW, Wang RY, Wang PS. 2001. Stimulatory effect of lactate on testosterone production by rat Leydig cells. J Cell Biochem. 83(1):147–154.
  • Lin YC, Chiu CH, Liu HC, Wang JY. 2018. Curcumin downregulates 8-Br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway. Endocr J. 65(8):833–840.
  • Liu TC, Lin CH, Huang CY, Ivy JL, Kuo CH. 2013. Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training. Eur J Appl Physiol. 113(7):1783–1792.
  • Liu YJ, Chu SF, Luo P, Peng Y, Liu TS, Chen NH. 2018. Effects of Bushen Yiyuan recipe on the HPA axis of exercise-induced hypotestosterone rats and the determination of ginsenosides. Acta Neuropharmacol. 8:47–47.
  • Luo DY, Yang G, Liu JJ, Yang YR, Dong Q. 2011. Effects of varicocele on testosterone, apoptosis and expression of StAR Mrna in rat Leydig cells. Asian J Androl. 13(2):287–291.
  • Luu-The V. 2013. Assessment of steroidogenesis and steroidogenic enzyme functions. J Steroid Biochem Mol Biol. 137:176–182.
  • National Research Council 2010. Guide for the Care and Use of Laboratory Animals, Eighth Edition. Pittsburgh: National Academies Press.
  • Ojo OO, Bhadauria S, Rath SK. 2013. Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice. PLoS One. 8(7):e69086.
  • Osaki Y, Nakagawa Y, Miyahara S, Iwasaki H, Ishii A, Matsuzaka T, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, et al. 2015. Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy. Biochem Biophys Res Commun. 466(3):536–540.
  • Purvis D, Gonsalves S, Deuster PA. 2010. Physiological and psychological fatigue in extreme conditions: overtraining and elite athletes. Pm R. 2(5):442–450.
  • Song G. 2002. [Study on the effect of Bushen Yiyuan recipe on improving the anti-fatigue ability of rowers and its mechanism]. [MS thesis]. Changsha: Hunan Normal University.
  • Wang YR, Zhou ZH, Tang CF. 2016. Effects of Bushen Yiyuan recipe on the HPG axis of exercise-induced hypotestosterone rats and the determination of active components. Chin Tradit Pat Med. 41:923–926.
  • Weng Z, Zhao Q. 2015. Utilizing ELISA to monitor protein-protein interaction. Methods Mol Biol. 1278:341–352.
  • Wong YF, Zhou H, Wang JR, Xie Y, Xu HX, Liu L. 2008. Anti-inflammatory and analgesic effects and molecular mechanisms of JCICM-6, a purified extract derived from an anti-arthritic Chinese herbal formula. Phytomedicine. 15(6-7):416–426.
  • Yeganehjoo H, DeBose-Boyd R, McFarlin BK, Mo H. 2017. Synergistic impact of d-γ-tocotrienol and geranylgeraniol on the growth and HMG-CoA reductase of human DU145 prostate Carcinoma cells. Nutr Cancer. 69(4):682–691.
  • Yu J, Dai L, Zhang R, Li Z, Pham T, Chen H. 2015. Isolation and expression of HMG-CoA synthase and HMG-CoA reductase genes in different development stages, tissues and treatments of the Chinese white pine beetle, Dendroctonus armandi (Curculionidae: Scolytinae). Comp Biochem Physiol B Biochem Mol Biol. 187:62–70.
  • Zhou HT, CAO JM, Lin Q, Zhao Z. 2013. Effect of Epimedium davidii on testosterone content, substance metabolism and exercise capacity in rats receiving exercise training. Chin Pharm J. 48:25–29.
  • Zhou ZH, Shi YQ, Liu JH, Jin YL, Zhu KJ, Luo XJ, Li YM. 2000. Effect of Bushen Yiyuan recipe on immune function of exercise mice. Chin J Sports Med. 19:202–204.
  • Zhou ZH, Shi YQ, Liu JH, Jin YL, Zhu KJ, Luo XJ, Li YM. 2001. Effect of Bushen Yiyuan recipe on anti-fatigue ability of exercise mice. Chin J Sports Med. 20:83–84.