Advanced search
Publication Cover
Modern Rheumatology Volume 30, 2020 - Issue 4
Journal homepage
286
Views
14
CrossRef citations to date
0
Altmetric
Connective tissue diseases and related disorders

The influence of HLA-B51 on clinical manifestations among Japanese patients with Behçet’s disease: A nationwide survey

Yuki MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Nobuyuki HoritaDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Correspondence[email protected]
View further author information
,
Yukihiro HorieDepartment of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan; View further author information
,
Masaki TakeuchiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Takehito IshidoDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Ryuta MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Tatsukata KawagoeDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Etsuko ShibuyaDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Kentaro YudaDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Mizuho IshidoDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Kaoru MinegishiDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Ryusuke YoshimiDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Yohei KirinoDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
,
Shingo KatoDepartment of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan; View further author information
,
Jun ArimotoDepartment of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan; View further author information
,
Takeshi FukumotoGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA; View further author information
,
Michiko KurosawaFaculty of Medicine, Department of Epidemiology and Environmental Health, Juntendo University, Tokyo, Japan; View further author information
,
Nobuyoshi KitaichiDepartment of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan; View further author information
,
Mitsuhiro TakenoDepartment of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, JapanView further author information
,
Takeshi KanekoDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
&
Nobuhisa MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan; View further author information
 show all
Pages 708-714 | Received 22 May 2019, Accepted 23 Jul 2019, Published online: 06 Aug 2019

References

  • Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's disease. Lancet. 1990;335(8697):1078–80.
  • The International Criteria for Behcet's Disease (ICBD). A collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2014;28(3):338–47.
  • Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med. 1999;341(17):1284–91.
  • Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, et al. Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet. 2013;45(2):202–7.
  • Takeuchi M, Mizuki N, Meguro A, Ombrello MJ, Kirino Y, Satorius C, et al. Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility. Nat Genet. 2017;49(3):438–43.
  • Kirino Y, Ideguchi H, Takeno M, Suda A, Higashitani K, Kunishita Y, et al. Continuous evolution of clinical phenotype in 578 Japanese patients with Behcet's disease: a retrospective observational study. Arthritis Res Ther. 2016;18(1):217.
  • Pehlivan M, Kurtuncu M, Tuzun E, Shugaiv E, Mutlu M, Eraksoy M, et al. The comparison of socio-economic conditions and personal hygiene habits of neuro-Behcet's disease and multiple sclerosis patients. Int J Hyg Environ Health. 2011;214(4):335–7.
  • Mumcu G, Niazi S, Stewart J, Hagi-Pavli E, Gokani B, Seoudi N, et al. Oral health and related quality of life status in patients from UK and Turkey: a comparative study in Behcet's disease. J Oral Pathol Med. 2009;38(5):406–9.
  • Aramaki K, Kikuchi H, Hirohata S. HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behcet's disease. Mod Rheumatol. 2007;17(1):81–2.
  • Ishido T, Horita N, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, et al. Clinical manifestations of Behcet's disease depending on sex and age: results from Japanese nationwide registration. Rheumatology. 2017;56(11):1918–27.
  • Suwa A, Horita N, Ishido T, Takeuchi M, Kawagoe T, Shibuya E, et al. The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behcet's disease. Mod Rheumatol. 2019;29(2):357–62.
  • Suzuki T, Horita N, Takeuchi M, Ishido T, Mizuki Y, Mizuki R, et al. Clinical features of early-stage possible Behcet's disease patients with a variant-type major organ involvement in Japan. Mod Rheumatol. 2019;29(4):640–6.
  • Japanese Ministry of Health, Labour and Welfare. Statutory intractable diseases. Implemented on January 1st, 2015. [Japanese]. Available from: http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/0000062437.html [last accessed 1 Aug, 2019].
  • Japan Intractable Diseases Information Center, Behcet Disease. [Japanese]. Avilable from: www.nanbyou.or.jp/entry/330 [last accessed 1 Aug, 2019].
  • Japanese Ministry of Health, Labour and Welfare. Ethical Guidelines for Medical and Health Research Involving Human Subjects. 2015. Available from: http://www.lifescience.mext.go.jp/files/pdf/n1500_01.pdf#search='Ethics+Review+Procedures+concerning+Research+with+Human+Subjects+published+in+2015+by+Ministry+of+Health%2C+Labour+and+Welfare%2C+Japan'. [last accessed 1 Aug, 2019].
  • Maldini C, Lavalley MP, Cheminant M, de Menthon M, Mahr A. Relationships of HLA-B51 or B5 genotype with Behcet's disease clinical characteristics: systematic review and meta-analyses of observational studies. Rheumatology. 2012;51(5):887–900.
  • Horie Y, Meguro A, Ohta T, Lee EB, Namba K, Mizuuchi K, et al. HLA-B51 carriers are susceptible to ocular symptoms of Behcet disease and the association between the two becomes stronger towards the east along the Silk Road: A literature survey. Ocul Immunol Inflamm. 2017;25(1):37–40.
  • Nishiyama M, Nakae K, Umehara T. A study of familial occurrence of Behçet's disease with and without ocular lesions. Jpn J Ophthalmol. 2001;45(3):313–6.
  • Arimoto J, Endo H, Kato T, Umezawa S, Fuyuki A, Uchiyama S, et al. Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behcet's disease. Dig Endosc. 2016;28(2):179–85.
  • de Menthon M, Lavalley MP, Maldini C, Guillevin L, Mahr A. HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum. 2009;61(10):1287–96.
  • Kaburaki T, Takamoto M, Numaga J, Kawashima H, Araie M, Ohnogi Y, et al. Genetic association of HLA-A*2601 with ocular Behçet's disease in Japanese patients. Clin Exp Rheumatol. 2010;28(4 Suppl 60):S39–S44.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.