Publication Cover
Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 26, 2023 - Issue 5
155
Views
2
CrossRef citations to date
0
Altmetric
Review Articles

In vitro effects of pentoxifylline and coenzyme Q10 on the sperm of oligoasthenoteratozoospermia patients

, , ORCID Icon, , & ORCID Icon
Pages 908-917 | Received 30 Mar 2021, Accepted 12 Oct 2021, Published online: 21 Dec 2021

References

  • Aitken, R. J., & Koppers, A. J. (2011). Apoptosis and DNA damage in human spermatozoa. Asian Journal of Andrology, 13(1), 36–42. https://doi.org/10.1038/aja.2010.68
  • Alahmar, A. T. (2017). Effect of vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 in infertile men with idiopathic oligoasthenozoospermia. International Journal of Infertility & Fetal Medicine, 8(2), 45–49. https://doi.org/10.5005/jp-journals-10016-1147
  • Alahmar, A. T. (2019). The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clinical and Experimental Reproductive Medicine, 46(3), 112–118. https://doi.org/10.5653/cerm.2019.00136
  • Alahmar, A. T., & Sengupta, P. (2021). Impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in men with idiopathic infertility. Biological Trace Element Research, 199(4), 1246–1252. https://doi.org/10.1007/s12011-020-02251-3
  • Amdani, S. N., Jones, C., & Coward, K. (2013). Phospholipase C zeta (PLCζ): Oocyte activation and clinical links to male factor infertility. Advances in Biological Regulation, 53(3), 292–308. https://doi.org/10.1016/j.jbior.2013.07.005
  • Amer, M., Metawae, B., Hosny, H., & Raef, A. (2013). The beneficial effect of adding pentoxifylline to processed semen samples on ICSI outcome in infertile males with mild and moderate asthenozoospermia: A randomized controlled prospective crossover study. Iranian Journal of Reproductive Medicine, 11(11), 939–944. http://resolver.scholarsportal.info/resolve/16806433/v11i0011/939_beoaptarcpcs.xml
  • Azad, N., Nazarian, H., Novin, M. G., Farahani, R. M., Piryaei, A., Heidari, M. H., & Alitappeh, M. A. (2017). Oligoasthenoteratozoospermic (OAT) men display altered phospholipase C ζ (PLCζ) localization and a lower percentage of sperm cells expressing PLCζ and post-acrosomal sheath WW domain-binding protein (PAWP). Bosnian Journal of Basic Medical Sciences, 18(2), 178–184. https://doi.org/10.17305/bjbms.2017.2208
  • Balercia, G., Buldreghini, E., Vignini, A., Tiano, L., Paggi, F., Amoroso, S., Ricciardo-Lamonica, G., Boscaro, M., Lenzi, A., & Littarru, G. (2009). Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: A placebo-controlled, double-blind randomized trial. Fertility and Sterility, 91(5), 1785–1792. https://doi.org/10.1016/j.fertnstert.2008.02.119
  • Banihani, S. A., & Alawneh, R. F. (2019). Human semen samples with high antioxidant reservoir may exhibit lower post-cryopreservation recovery of sperm motility. Biomolecules, 9(3), 111. https://doi.org/10.3390/biom9030111
  • Barbagallo, F., La Vignera, S., Cannarella, R., Aversa, A., Calogero, A. E., & Condorelli, R. A. (2020). Evaluation of sperm mitochondrial function: A key organelle for sperm motility. Journal of Clinical Medicine, 9(2), 363. https://doi.org/10.3390/jcm9020363
  • Chavoshi Nezhad, N., Vahabzadeh, Z., Allahveisie, A., Rahmani, K., Raoofi, A., Rezaie, M. J., Rezaei, M., & Partovyan, M. (2021). The effect of L-carnitine and coenzyme Q10 on the sperm motility, DNA fragmentation, chromatin structure and oxygen free radicals during, before and after freezing in oligospermia men. Urology Journal, 18(3), 330–336. https://doi.org/10.22037/uj.v16i7.6400
  • Chaouat, G., Menu, E., Delage, G., Moreau, J. F., Khrishnan, L., Hui, L., Meliani, A. A., Martal, J., Raghupathy, R., Lelaidier, C., Bertrand, C., Freitas, S., Hambartsumian, E., Wegmann, T. G., & Frydman, R. (1995). Immuno-endocrine interactions in early pregnancy. Human Reproduction, 10(Suppl 2), 55–59. https://doi.org/10.1093/humrep/10.suppl_2.55
  • Dávila-Esqueda, M. E., Vertiz-Hernández, A. A., & Martínez-Morales, F. (2005). Comparative analysis of the renoprotective effects of pentoxifylline and vitamin E on streptozotocin-induced diabetes mellitus. Renal Failure, 27(1), 115–122. https://doi.org/10.1081/JDI-42728
  • Faja, F., Carlini, T., Coltrinari, G., Finocchi, F., Nespoli, M., Pallotti, F., Lenzi, A., Lombardo, F., & Paoli, D. (2019). Human sperm motility: a molecular study of mitochondrial DNA, mitochondrial transcription factor A gene and DNA fragmentation. Molecular Biology Reports, 46(4), 4113–4121. https://doi.org/10.1007/s11033-019-04861-0
  • Fernández, J. L., Muriel, L., Rivero, M. T., Goyanes, V., Vazquez, R., & Alvarez, J. G. (2003). The sperm chromatin dispersion test: A simple method for the determination of sperm DNA fragmentation. Journal of Andrology, 24(1), 59–66. https://doi.org/10.1002/J.1939-4640.2003.TB02641.X
  • Franken, D. R., Franken, C. J., De La Guerre, H., & De Villiers, A. (1999). Normal sperm morphology and chromatin packaging: Comparison between aniline blue and chromomycin A3 staining. Andrologia, 31(6), 361–366. https://doi.org/10.1046/j.1439-0272.1999.00290.x
  • Garrido-Maraver, J., Cordero, M. D., Oropesa-Ávila, M., Fernández Vega, A., de la Mata, M., Delgado Pavón, A., de Miguel, M., Pérez Calero, C., Villanueva Paz, M., Cotán, D., & Sánchez-Alcázar, J. A. (2014). Coenzyme q10 therapy. Molecular Syndromology, 5(3–4), 187–197. https://doi.org/10.1159/000360101
  • Gil, M. A., Hernandez, M., Roca, J., Almiñana, C., Lucas, X., Cuello, C., Vazquez, J. M., & Martínez, E. A. (2010). Pentoxifylline added to freezing or post-thaw extenders does not improve the survival or in vitro fertilising capacity of boar spermatozoa. Reproduction, 139(3), 557–564. https://doi.org/10.1530/REP-09-0274
  • Gvozdjáková, A., Kucharská, J., Ostatníková, D., Babinská, K., Nakládal, D., & Crane, F. L. (2014). Ubiquinol improves symptoms in children with autism. Oxidative Medicine and Cellular Longevity, 2014, 798957. https://doi.org/10.1155/2014/798957
  • Henkel, R., Sandhu, I. S., & Agarwal, A. (2019). The excessive use of antioxidant therapy: A possible cause of male infertility? Andrologia, 51(1), e13162. https://doi.org/10.1111/and.13162
  • Hrudka, F. (1987). Cytochemical and ultracytochemical demonstration of cytochrome c oxidase in spermatozoa and dynamics of its changes accompanying ageing or induced by stress. International Journal of Andrology, 10(6), 809–828. https://doi.org/10.1111/j.1365-2605.1987.tb00385.x
  • Ioannou, D., Miller, D., Griffin, D. K., & Tempest, H. G. (2016). Impact of sperm DNA chromatin in the clinic. Journal of Assisted Reproduction and Genetics, 33(2), 157–166. https://doi.org/10.1007/s10815-015-0624-x
  • Irez, T., Usta, T. A., Zebitay, G., Oral, E., Senol, H., & Sahmay, S. (2013). Evaluation of subgroups of the human sperm hypoosmotic swelling test in normozoospermic male cases with recurrent fertilization failure: A prospective case-controlled study. Archives of Gynecology and Obstetrics, 287(4), 797–801. https://doi.org/10.1007/s00404-012-2634-6
  • Khalili, M. A., Mir-Rokni, F., & Kalantar, S. M. (1999). Application of vitality tests on asthenozoospermic semen from infertile men. Iranian Biomedical Journal, 3(3–4), 77–81. http://ibj.pasteur.ac.ir/article-1-836-en.html
  • Kobori, Y., Ota, S., Sato, R., Yagi, H., Soh, S., Arai, G., & Okada, H. (2014). Antioxidant cosupplementation therapy with vitamin C, vitamin E, and coenzyme Q10 in patients with oligoasthenozoospermia. Archivio Italiano di Urologia, Andrologia, 86(1), 1–4. https://doi.org/10.4081/aiua.2014.1.1
  • Lee, B. J., Huang, Y. C., Chen, S. J., & Lin, P. T. (2012). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition, 28(3), 250–255. https://doi.org/10.1016/j.nut.2011.06.004
  • Lee, D., Shim, M. S., Kim, K. Y., Noh, Y. H., Kim, H., Kim, S. Y., Weinreb, R. N., & Ju, W. K. (2014). Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Investigative Ophthalmology & Visual Science, 55(2), 993–1005. https://doi.org/10.1167/iovs.13-12564
  • Lewin, A., & Lavon, H. (1997). The effect of coenzyme Q10 on sperm motility and function. Molecular Aspects of Medicine, 18(SUPPL), 213–219. https://doi.org/10.1016/S0098-2997(97)00036-8
  • Lewis, S. E. M., Moohan, J. M., & Thompson, W. (1993). Effects of pentoxifylline on human sperm motility in normospermic individuals using computer-assisted analysis. Fertility and Sterility, 59(2), 418–423. https://doi.org/10.1016/S0015-0282(16)55708-2
  • Littarru, G. P., & Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: Recent developments. Molecular Biotechnology, 37(1), 31–37. https://doi.org/10.1007/s12033-007-0052-y
  • Liu, Z., Ren, Z., Zhang, J., Chuang, C. C., Kandaswamy, E., Zhou, T., & Zuo, L. (2018). Role of ROS and nutritional antioxidants in human diseases. Frontiers in Physiology, 9, 477. https://doi.org/10.3389/fphys.2018.00477
  • Lusignan, M. F., Li, X., Herrero, B., Delbes, G., & Chan, P. T. K. (2018). Effects of different cryopreservation methods on DNA integrity and sperm chromatin quality in men. Andrology, 6(6), 829–835. https://doi.org/10.1111/andr.12529
  • McKinney, K. A., Lewis, S. E. M., & Thompson, W. (1994). Persistent effects of pentoxifylline on human sperm motility, after drug removal, in normozoospermic and asthenozoospermic individuals. Andrologia, 26(4), 235–240. https://doi.org/10.1111/j.1439-0272.1994.tb00794.x
  • Micic, S., Lalic, N., Djordjevic, D., Bojanic, N., Bogavac-Stanojevic, N., Busetto, G. M., Virmani, A., & Agarwal, A. (2019). Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. Andrologia, 51(6), e13267. https://doi.org/10.1111/and.13267
  • Nabi, A., Khalili, M. A., Fesahat, F., Talebi, A., & Ghasemi-Esmailabad, S. (2017). Pentoxifylline increase sperm motility in devitrified spermatozoa from asthenozoospermic patient without damage chromatin and DNA integrity. Cryobiology, 76, 59–64. https://doi.org/10.1016/j.cryobiol.2017.04.008
  • Qi, X., Wang, K., Zhou, G., Xu, Z., Yu, J., & Zhang, W. (2016). The role of testicular artery in laparoscopic varicocelectomy: a systematic review and meta-analysis. International Urology and Nephrology, 48(6), 955–965. https://doi.org/10.1007/s11255-016-1254-7
  • Rahman, K. (2007). Studies on free radicals, antioxidants, and co-factors. Clinical Interventions in Aging, 2(2), 219–236. https://www.dovepress.com/articles.php?article_id=167
  • Ribeiro, T. M., Bertolla, R. P., Spaine, D. M., Fraietta, R., Ortiz, V., & Cedenho, A. P. (2008). Sperm nuclear apoptotic DNA fragmentation in men with testicular cancer. Fertility and Sterility, 90(5), 1782–1786. https://doi.org/10.1016/j.fertnstert.2007.08.012
  • Ruiz-Pesini, E., Diez, C., Lapeña, A. C., Pérez-Martos, A., Montoya, J., Alvarez, E., Arenas, J., & López-Pérez, M. J. (1998). Correlation of sperm motility with mitochondrial enzymatic activities. Clinical Chemistry, 44(8 Pt 1), 1616–1620. https://doi.org/10.1093/clinchem/44.8.1616
  • Safarinejad, M. R., & Safarinejad, S. (2009). Efficacy of selenium and/or N-Acetyl-cysteine for improving semen parameters in infertile men: A double-blind, placebo controlled, randomized study. The Journal of Urology, 181(2), 741–751. https://doi.org/10.1016/j.juro.2008.10.015
  • Samlaska, C. P., & Winfield, E. A. (1994). Pentoxifylline. Journal of the American Academy of Dermatology, 30(4), 603–621. https://doi.org/10.1016/S0190-9622(94)70069-9
  • Talevi, R., Barbato, V., Fiorentino, I., Braun, S., Longobardi, S., & Gualtieri, R. (2013). Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation. Reproductive Biology and Endocrinology, 11(1), 81. https://doi.org/10.1186/1477-7827-11-81
  • Tardif, S., Madamidola, O. A., Brown, S. G., Frame, L., Lefièvre, L., Wyatt, P. G., Barratt, C. L. R., & Da Silva, S. J. M. (2014). Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity. Human Reproduction, 29(10), 2123–2135. https://doi.org/10.1093/humrep/deu196
  • Tesarik, J., Mendoza, C., & Carreras, A. (1992). Effects of phosphodiesterase inhibitors caffeine and pentoxifylline on spontaneous and stimulus-induced acrosome reactions in human sperm. Fertility and Sterility, 58(6), 1185–1190. https://doi.org/10.1016/S0015-0282(16)55567-8
  • Tournaye, H., Krausz, C., & Oates, R. D. (2017). Novel concepts in the aetiology of male reproductive impairment. The Lancet. Diabetes & Endocrinology, 5(7), 544–553. https://doi.org/10.1016/S2213-8587(16)30040-7
  • Wang, M.-J., Ou, J.-X., Chen, G.-W., Wu, J.-P., Shi, H.-J., O, W.-S., Martin-DeLeon, P. A., & Chen, H. (2012). Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? Antioxidants & Redox Signaling, 17(3), 513–519. https://doi.org/10.1089/ars.2012.4514
  • World Health Organization. (2010). WHO laboratory manual for the examination and processing of human semen. 5th Edition.
  • Yousef, A. O. S., Fahad, A. A., Moneim, A. E. A., Metwally, D. M., El-Khadragy, M. F., & Kassab, R. B. (2019). The neuroprotective role of coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities. International Journal of Environmental Research and Public Health, 16(16), 2895. https://doi.org/10.3390/ijerph16162895
  • Zhang, G., Wang, Z., Ling, X., Zou, P., Yang, H., Chen, Q., Zhou, N., Sun, L., Gao, J., Zhou, Z., Cao, J., & Ao, L. (2016). Mitochondrial biomarkers reflect semen quality: Results from the MARCHS study in Chongqing, China. PLOS One, 11(12), e0168823. https://doi.org/10.1371/journal.pone.0168823

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.