References
- Leone Umberti Maggiore U, Cardozo L, Ferrero S, et al. Mirabegron in the treatment of overactive bladder. Expert Opin Pharmacother. 2014;15:873–887.
- Nitti VW, Khullar V, van Kerrebroeck P, et al. Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies. Int J Clin Pract. 2013;67:619–632.
- Arch JRS. Challenges in β3-adrenoreceptor agonist drug development. Ther Adv Endocrinol Metab. 2011;2:59–64.
- Cypess AM, Weiner LS, Roberts-Toler C, et al. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015;21:33–38.
- Chapple CR, Kaplan SA, Mitcheson D, et al. Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β (3)-adrenoreceptor agonist in overactive bladder. Eur Urol. 2013;63:296–305.
- Malik M, van Gelderen EM, Lee JH, et al. Proarrhythmic safety of repeat doses of mirabegron in healthy subjects: a randomized, double-blind, placebo-, and active-controlled thorough QT study. Clin Pharmacol Ther. 2012;92:696–706.
- Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nature Med. 2013;19:1252–1263.
- McMillan AC, White MD. Induction of thermogenesis in brown and beige adipose tissues: molecular markers, mild cold exposure and novel therapies. Curr Opin Endocrinol Diabetes Obes. 2015;22:347–352.
- Hainer V. Overview of new antiobesity drugs. Expert Opin Pharmacother. 2014;15:1975–1978.
- Van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009;360:1500–1508.
- Krhut J, Martan A, Zachoval R, et al. Impact of body mass index on treatment efficacy of mirabegron for overactive bladder. Eur J Obstet Gynecol Reprod Biol. 2016;196:64–68.
- Lee P, Smith S, Linderman J, et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes. 2014;63:3686–3698.
- Puar T, van Berkel A, Gotthardt M, et al. Genotype-dependent brown adipose tissue activation in patients with pheochromocytoma and paraganglioma. J Clin Endocrinol Metab. 2016;101:224–232.
- Galougahi KK, Liu CC, Garcia A, et al. β3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. J Am Heart Assoc. 2016 [ cited Feb 19]; 5(2). doi:10.1161/JAHA.115.002824
- Alexandre EC, Kiguti LR, Calmasini FB, et al. Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3-adrenoreceptor activation and α1-adrenoreceptor blockade. Brit J Pharmacol. 2016;173:415–428.